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1. 发明授权

US08192442B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US08192442B2
公开(公告)日：2012-06-05
申请号：US12502163
申请日：2009-07-13
申请人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
发明人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
IPC分类号： A61B17/00 , A61F2/44
CPC分类号： A61B17/8836 , A61B17/864 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating osteoplasty procedures such as vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the geometry of fill material introduced into cancellous bone. A method of treating bone includes injecting a volume of fill material into a bone and selectively modifying a viscosity of the bone filler to control the direction of flow of the fill material within the bone. A system for treating bone using this method includes an introducer for delivering fill material into the bone and an energy source selectively coupleable to the fill material to alter the viscosity of the fill material via an energy emitter in the introducer.
摘要翻译：本发明在某些实施例中涉及用于治疗诸如椎体压缩性骨折的骨整形术程序的医疗装置。更具体地，本发明的实施例涉及通过控制引入松质骨的填充材料的几何形状来可控地恢复椎体高度的仪器和方法。治疗骨的方法包括将一定体积的填充材料注入骨骼中，并选择性地改变骨填充物的粘度以控制骨中填充材料的流动方向。使用该方法治疗骨的系统包括用于将填充材料输送到骨中的导引器和能够选择性地与填充材料相连的能量源，以经由引入器中的能量发射器改变填充材料的粘度。

2. 发明授权

US07678116B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US07678116B2
公开(公告)日：2010-03-16
申请号：US11165651
申请日：2005-06-24
申请人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
发明人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
IPC分类号： A61B17/00
CPC分类号： A61B17/8836 , A61B17/7095 , A61B17/7098 , A61B17/864 , A61B17/8811 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating osteoplasty procedures such as vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the geometry of fill material introduced into cancellous bone. An exemplary system utilizes Rf energy in combination a conductive bone fill material for polymerizing the surface of the inflow plume to control the geometry of the fill material and the application of force caused by inflows of fill material. In another embodiment, method of treating bone includes injecting a volume of fill material into a bone and selectively modifying a viscosity of a selected portion of the bone filler to control the direction of flow of the fill material within the bone. A system for treating bone using this method includes an introducer for delivering fill material into the bone and an energy source selectively coupleable to the fill material to alter the viscosity of the fill material as it flows out of the introducer.
摘要翻译：本发明在某些实施例中涉及用于治疗诸如椎体压缩性骨折的骨整形术程序的医疗装置。更具体地，本发明的实施例涉及通过控制引入松质骨的填充材料的几何形状来可控地恢复椎体高度的仪器和方法。示例性系统利用Rf能量组合导电骨填充材料，用于聚合流入羽流的表面以控制填充材料的几何形状以及由填充材料的流入引起的力的施加。在另一个实施方案中，治疗骨的方法包括将一定体积的填充材料注入骨中，并选择性地改变骨填充物的选定部分的粘度以控制填充材料在骨内的流动方向。使用这种方法治疗骨骼的系统包括用于将填充材料输送到骨骼中的导引器，以及选择性地与填充材料耦合的能量源，以改变填充材料流出导引器时的粘度。

3. 发明授权

US07559932B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US07559932B2
公开(公告)日：2009-07-14
申请号：US11165652
申请日：2005-06-24
申请人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
发明人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
IPC分类号： A61B17/00
CPC分类号： A61B17/8836 , A61B17/864 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating osteoplasty procedures such as vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the geometry of fill material introduced into cancellous bone. An exemplary system utilizes Rf energy in combination a conductive bone fill material for polymerizing the surface of the inflow plume to control the geometry of the fill material and the application of force caused by inflows of fill material. In another embodiment, method of treating bone includes injecting a volume of fill material into a bone and selectively modifying a viscosity of a selected portion of the bone filler to control the direction of flow of the fill material within the bone. A system for treating bone using this method includes an introducer for delivering fill material into the bone and an energy source selectively coupleable to the fill material to alter the viscosity of the fill material as it flows out of the introducer.
摘要翻译：本发明在某些实施例中涉及用于治疗诸如椎体压缩性骨折的骨整形术程序的医疗装置。更具体地，本发明的实施例涉及通过控制引入松质骨的填充材料的几何形状来可控地恢复椎体高度的仪器和方法。示例性系统利用Rf能量组合导电骨填充材料，用于聚合流入羽流的表面以控制填充材料的几何形状以及由填充材料的流入引起的力的施加。在另一个实施方案中，治疗骨的方法包括将一定体积的填充材料注入骨中，并选择性地改变骨填充物的选定部分的粘度以控制填充材料在骨内的流动方向。使用这种方法治疗骨骼的系统包括用于将填充材料输送到骨骼中的导引器，以及选择性地与填充材料耦合的能量源，以改变填充材料流出导引器时的粘度。

4. 发明申请

US20090275995A1 BONE TREATMENT SYSTEMS AND METHODS 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20090275995A1
公开(公告)日：2009-11-05
申请号：US12502163
申请日：2009-07-13
申请人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
发明人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
IPC分类号： A61B17/56 , A61N1/00
CPC分类号： A61B17/8836 , A61B17/864 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating osteoplasty procedures such as vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the geometry of fill material introduced into cancellous bone. A method of treating bone includes injecting a volume of fill material into a bone and selectively modifying a viscosity of the bone filler to control the direction of flow of the fill material within the bone. A system for treating bone using this method includes an introducer for delivering fill material into the bone and an energy source selectively coupleable to the fill material to alter the viscosity of the fill material via an energy emitter in the introducer.
摘要翻译：本发明在某些实施例中涉及用于治疗诸如椎体压缩性骨折的骨整形术程序的医疗装置。更具体地，本发明的实施例涉及通过控制引入松质骨的填充材料的几何形状来可控地恢复椎体高度的仪器和方法。治疗骨的方法包括将一定体积的填充材料注入骨骼中，并选择性地改变骨填充物的粘度以控制骨中填充材料的流动方向。使用该方法治疗骨的系统包括用于将填充材料输送到骨中的导引器和能够选择性地与填充材料相连的能量源，以经由引入器中的能量发射器改变填充材料的粘度。

5. 发明申请

US20080269761A1 BONE TREATMENT SYSTEMS AND METHODS 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20080269761A1
公开(公告)日：2008-10-30
申请号：US12112477
申请日：2008-04-30
申请人： Csaba Truckai , John H. Shadduck , Robert Luzzi
发明人： Csaba Truckai , John H. Shadduck , Robert Luzzi
IPC分类号： A61B17/58 , A61N1/00 , A61B19/00
CPC分类号： A61B17/8822 , A61B17/88 , A61B17/8805 , A61B17/8811 , A61B17/8816 , A61B17/8836
摘要： The present invention relates in certain embodiments to systems and methods for treating bone, such as vertebral compression fractures. In one embodiment, a method includes controllably applying energy from an energy source to a bone cement volume outside of a patient's body to selectively accelerate the polymerization rate of the bone fill material volume prior to introduction of the bone fill material into a bone. The method further includes sequentially introducing a plurality of cement carrying structures with said accelerated polymerization rate bone cement volume into the bone. A system for use in said method includes at least one elongated cement-carrying structure sized to carry a bone cement volume therein and an energy source operatively coupleable to the cement-carrying structure. The energy source applies energy to the bone cement volume to selectively accelerate a polymerization rate thereof. An elongated injector is insertable into the bone and has a passageway that removably receives the elongated cement-carrying structure to allow delivery of the accelerated polymerization rate bone cement into the bone.
摘要翻译：本发明在某些实施方案中涉及用于治疗骨骼的系统和方法，例如椎体压缩性骨折。在一个实施例中，一种方法包括将能量源可控地施加到患者身体外部的骨水泥体积，以在将骨填充材料引入骨骼之前选择性地加速骨填充材料体积的聚合速率。该方法还包括将具有所述加速聚合速率骨水泥体积的多个水泥承载结构顺序地引入骨中。用于所述方法的系统包括尺寸适于承载骨水泥体积的至少一个细长的水泥承载结构，以及可操作地连接到承载结构的能量源。能量源将能量施加到骨水泥体积以选择性地加速其聚合速率。细长的注射器可插入到骨中并且具有可移除地容纳细长的水泥承载结构以允许将加速的聚合速率骨水泥递送到骨中的通道。

6. 发明授权

US08556910B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US08556910B2
公开(公告)日：2013-10-15
申请号：US12062345
申请日：2008-04-03
申请人： Csaba Truckai , Robert Luzzi , John H. Shadduck
发明人： Csaba Truckai , Robert Luzzi , John H. Shadduck
IPC分类号： A61B17/58 , A61B17/60 , A61F2/00
CPC分类号： A61B17/8836 , A61B17/8822 , A61B2017/00022
摘要： Systems and methods for delivering bone cement into a bone can include a handle body defining a flow path, a thermal emitter in the handle body to apply energy to bone cement passing through the flow path, a source of bone cement and an injection cannula. The cannula can be in communication with the flow path such that inserting the cannula into a bone can allow a flow of bone cement therethrough to an opening at a distal end of the cannula. Other systems and methods for delivering bone cement into a bone can include an injector body with a handle portion, and a cannula, a bone cement container, a low pressure drive mechanism configured to effect a flow of bone cement from said container to the injector body and a high pressure drive mechanism configured to effect a flow of bone cement through the injector body into the bone.
摘要翻译：用于将骨水泥输送到骨中的系统和方法可以包括限定流路的手柄主体，手柄主体中的热发射器，以将能量施加到通过流路的骨水泥，骨水泥源和注射套管。套管可以与流动路径连通，使得将套管插入骨头可以允许骨水泥通过其穿过套管远端的开口。用于将骨水泥输送到骨头中的其它系统和方法可以包括具有手柄部分的注射器主体和套管，骨水泥容器，低压驱动机构，其被配置为实现骨粘固剂从所述容器流到喷射器主体以及高压驱动机构，其构造成使得骨水泥通过所述注射器主体流入所述骨中。

7. 发明授权

US08109933B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US08109933B2
公开(公告)日：2012-02-07
申请号：US12062384
申请日：2008-04-03
申请人： Csaba Truckai , Robert Luzzi , John H. Shadduck
发明人： Csaba Truckai , Robert Luzzi , John H. Shadduck
IPC分类号： A61B17/58 , A61B17/60 , A61F2/00
CPC分类号： A61B17/8836 , A61B17/8822 , A61B2017/00022
摘要： Systems and methods for delivering bone cement into a bone can include a handle body defining a flow path, a thermal emitter in the handle body to apply energy to bone cement passing through the flow path, a source of bone cement and an injection cannula. The cannula can be in communication with the flow path such that inserting the cannula into a bone can allow a flow of bone cement therethrough to an opening at a distal end of the cannula. Other systems and methods for delivering bone cement into a bone can include an injector body with a handle portion, and a cannula, a bone cement container, a low pressure drive mechanism configured to effect a flow of bone cement from said container to the injector body and a high pressure drive mechanism configured to effect a flow of bone cement through the injector body into the bone.
摘要翻译：用于将骨水泥输送到骨中的系统和方法可以包括限定流路的手柄主体，手柄主体中的热发射器，以将能量施加到通过流路的骨水泥，骨水泥源和注射套管。套管可以与流动路径连通，使得将套管插入骨头可以允许骨水泥通过其穿过套管远端的开口。用于将骨水泥输送到骨头中的其它系统和方法可以包括具有手柄部分的注射器主体和套管，骨水泥容器，低压驱动机构，其被配置为实现骨粘固剂从所述容器流到喷射器主体以及高压驱动机构，其构造成使得骨水泥通过所述注射器主体流入所述骨中。

8. 发明申请

US20080255570A1 BONE TREATMENT SYSTEMS AND METHODS 有权
公开(公告)号：US20080255570A1
公开(公告)日：2008-10-16
申请号：US12062345
申请日：2008-04-03
申请人： Csaba Truckai , Robert Luzzi , John H. Shadduck
发明人： Csaba Truckai , Robert Luzzi , John H. Shadduck
IPC分类号： A61B17/58 , A61B18/04
CPC分类号： A61B17/8836 , A61B17/8822 , A61B2017/00022
摘要： Systems and methods for delivering bone cement into a bone can include a handle body defining a flow path, a thermal emitter in the handle body to apply energy to bone cement passing through the flow path, a source of bone cement and an injection cannula. The cannula can be in communication with the flow path such that inserting the cannula into a bone can allow a flow of bone cement therethrough to an opening at a distal end of the cannula. Other systems and methods for delivering bone cement into a bone can include an injector body with a handle portion, and a cannula, a bone cement container, a low pressure drive mechanism configured to effect a flow of bone cement from said container to the injector body and a high pressure drive mechanism configured to effect a flow of bone cement through the injector body into the bone.

9. 发明申请

US20090149878A1 BONE TREATMENT SYSTEMS AND METHODS 审中-公开
标题翻译：骨治疗系统和方法
公开(公告)号：US20090149878A1
公开(公告)日：2009-06-11
申请号：US11952942
申请日：2007-12-07
申请人： Csaba Truckai , Robert Luzzi , John H. Shadduck
发明人： Csaba Truckai , Robert Luzzi , John H. Shadduck
IPC分类号： A61B17/34 , A61B17/58
CPC分类号： A61B17/1642 , A61B17/1671 , A61B17/3472 , A61B17/8836 , A61B2017/00088 , A61B2017/003 , A61B2017/0084 , A61B2017/3405
摘要： The present invention relates in certain embodiments to systems for treating vertebral compression fractures. In one embodiment, a trocar with a flexible tip is provided to create a curved path in cancellous bone. An injector can be introduced into the vertebra in communication with the curved path for delivery of bone fill material into the curved path. Optionally, thermal energy can be applied to the bone fill material prior to injection into the curved path in cancellous bone to alter a property (e.g., viscosity) of the bone fill material.
摘要翻译：本发明在某些实施例中涉及用于治疗脊柱压缩性骨折的系统。在一个实施例中，提供具有柔性尖端的套针针以在松质骨中产生弯曲路径。可以将注射器引入到与弯曲路径连通的椎骨中，以将骨填充材料递送到弯曲路径中。任选地，可以在将注入到松质骨内的弯曲路径中之前将热能施加到骨填充材料，以改变骨填充材料的性质（例如粘度）。

10. 发明授权

US09066769B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US09066769B2
公开(公告)日：2015-06-30
申请号：US12345937
申请日：2008-12-30
申请人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
发明人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
IPC分类号： A61B17/88 , A61B17/00 , A61B19/00
CPC分类号： A61B17/8836 , A61B17/8816 , A61B17/8822 , A61B2017/00022 , A61B2017/00411 , A61B2017/00955 , A61B2017/8844 , A61B2090/064
摘要： Systems and methods for treating vertebral compression fractures are discussed. In an embodiment, a method includes mixing bone cement precursors thereby causing a first chemical curing reaction characterized by a first time-viscosity profile, controllably applying energy to the bone cement from an external source to modify the first time-viscosity profile to a second time-viscosity profile, and injecting the cement into bone at a substantially constant viscosity greater than about 1000 Pa·s to greater than about 5000 Pa·s over an extended working time. In another embodiment, a bone cement injector system is provided that includes a first handle component that is detachably coupled to a second sleeve component having a distal end for positioning in bone and a flow channel extending through the first and second components. The system includes first and second thermal energy emitters for delivering energy to bone cement flows in a flow channel portion in the first and second components, respectively.
摘要翻译：讨论了治疗椎体压缩骨折的系统和方法。在一个实施方案中，一种方法包括混合骨水泥前体，从而引起第一化学固化反应，其特征在于第一时间粘度分布，可控地从外部来源向骨粘固剂施加能量以将第一时间粘度分布修改为第二次 - 粘度分布，并且在延长的工作时间内以大于约1000Pa·s至大于约5000Pa·s的基本上恒定的粘度将骨水泥注入骨中。在另一个实施例中，提供一种骨粘固剂注射器系统，其包括第一手柄部件，该第一手柄部件可拆卸地联接到具有用于定位在骨头中的远端的第二套筒部件和延伸穿过第一和第二部件的流动通道。该系统包括第一和第二热能发射器，用于分别在第一和第二部件中的流动通道部分中向骨水泥流输送能量。

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