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1. 发明授权

US5460949A Method and composition for increasing the accumulation of squalene and specific sterols in yeast 失效
标题翻译：增加酵母中角鲨烯和特定甾醇积累的方法和组成
公开(公告)号：US5460949A
公开(公告)日：1995-10-24
申请号：US783861
申请日：1991-10-28
申请人： Court A. Saunders , Fred R. Wolf , Indrani Mukharji
发明人： Court A. Saunders , Fred R. Wolf , Indrani Mukharji
IPC分类号： C12N1/19 , C12N9/04 , C12N15/09 , C12N15/53 , C12N15/81 , C12P5/02 , C12P33/00 , C12R1/865 , C12N9/02 , C12P33/16
CPC分类号： C12N9/0006 , C12N15/81 , C12P33/00 , C12P5/007 , C12R1/865
摘要： A method of increasing the accumulation of squalene and specific sterols in yeast comprising increasing the expression level of a structural gene encoding a polypeptide having HMG-CoA reductase activity in a mutant yeast having single or double defects in the expression of sterol biosynthetic enzymes is provided. The expression level of a structural gene is preferably increased by transforming yeast with a recombinant DNA molecule comprising a vector operatively linked to an exogenous DNA segment that encodes a polypeptide having HMG-CoA reductase activity and a promoter that is suitable for driving the expression of the encoded polypeptide in the transformed yeast. The polypeptide having HMG-CoA reductase activity is preferably a truncated, active HMG-CoA reductase enzyme. Recombinant DNA molecules useful for transforming yeast and mutant yeast transformed with such recombinant DNA molecules are also disclosed.
摘要翻译：提供增加酵母中角鲨烯和特定甾醇的积累的方法，包括增加在具有单一或双缺陷的甾醇生物合成酶的突变体中具有HMG-CoA还原酶活性的多肽的结构基因的表达水平。结构基因的表达水平优选通过用包含可编码具有HMG-CoA还原酶活性的多肽的外源DNA片段有效连接的载体的重组DNA分子和适于驱动在转化的酵母中编码的多肽。具有HMG-CoA还原酶活性的多肽优选为截短的活性HMG-CoA还原酶。还公开了用于转化酵母的重组DNA分子和用这种重组DNA分子转化的突变酵母。

2. 发明授权

US5589619A Process and composition for increasing squalene and sterol accumulation in higher plants 失效
标题翻译：在高等植物中增加角鲨烯和甾醇积累的方法和组合物
公开(公告)号：US5589619A
公开(公告)日：1996-12-31
申请号：US308551
申请日：1994-12-08
申请人： Joseph Chappell , Court A. Saunders , Fred R. Wolf
发明人： Joseph Chappell , Court A. Saunders , Fred R. Wolf
IPC分类号： A01H5/00 , C12N5/10 , C12N9/04 , C12N15/09 , C12N15/53 , C12N15/82 , C12P33/00 , C12N15/00
CPC分类号： C12N9/0006 , C12N15/8243 , C12N15/8286
摘要： A process of increasing squalene and sterol accumulation in a transgenic plant by increasing the amount of a gene encoding a polypeptide having HMG-CoA reductase activity is disclosed. The amount is preferably increased by transforming plant cells with a recombinant DNA molecule comprising a vector operatively linked to an exogenous DNA segment that encodes a polypeptide having HMG-CoA reductase activity, and a promoter suitable for driving the expression of said polypeptide to form a transformed plant cell and regenerating a transgenic plant from that transformed cell. Also disclosed are a process of increasing pest resistance in a transgenic plant, transgenic plants and transgenic seeds capable of germinating into transgenic plants.
摘要翻译：公开了通过增加编码具有HMG-CoA还原酶活性的多肽的基因的量来增加转基因植物中角鲨烯和甾醇积累的方法。优选通过用包含可操作地连接到编码具有HMG-CoA还原酶活性的多肽的外源DNA区段的载体的重组DNA分子和适于驱动所述多肽的表达以形成转化的载体的启动子来转化植物细胞来增加量植物细胞并从转化细胞再生转基因植物。还公开了在转基因植物，转基因植物和能够发芽转化植物的转基因种子中增加害虫抗性的方法。

3. 发明授权

US06977269B1 Method of improving animal tissue quality 失效
标题翻译：改善动物组织质量的方法
公开(公告)号：US06977269B1
公开(公告)日：2005-12-20
申请号：US10136472
申请日：2002-05-01
申请人： Court A. Saunders , Fred R. Wolf , Thomas E. Sauber , Fredric N. Owens
发明人： Court A. Saunders , Fred R. Wolf , Thomas E. Sauber , Fredric N. Owens
IPC分类号： A61K31/355
CPC分类号： A61K31/355
摘要： A novel method for improving the tissue quality of an animal is provided. The method comprises feeding the animal a diet supplemented with gamma-tocopherol in an amount effective to improve the tissue quality. The gamma-tocopherol may be fed alone or in combination with other antioxidants, such as alpha-tocopherol. The method may be practiced on ruminants and non-ruminants.
摘要翻译：提供了一种改善动物组织质量的新方法。该方法包括以有效提高组织质量的量向动物喂食补充有γ-生育酚的饮食。 γ-生育酚可以单独或与其它抗氧化剂如α-生育酚组合进料。该方法可以在反刍动物和非反刍动物上实施。

4. 发明授权

US5306862A Method and composition for increasing sterol accumulation in higher plants 失效
标题翻译：增加高等植物中甾醇积累的方法和组成
公开(公告)号：US5306862A
公开(公告)日：1994-04-26
申请号：US596467
申请日：1990-10-12
申请人： Joseph Chappell , Court A. Saunders , Fred R. Wolf , Richard E. Cuellar
发明人： Joseph Chappell , Court A. Saunders , Fred R. Wolf , Richard E. Cuellar
IPC分类号： A01H5/00 , C12N5/10 , C12N9/04 , C12N15/09 , C12N15/53 , C12N15/82 , C12P33/00 , A01H1/04 , A01H1/02 , C12N15/00 , C12P7/22
CPC分类号： C12N9/0006 , C12N15/8243 , C12N15/8286
摘要： A method of increasing sterol accumulation in a plant by increasing the copy number of a gene encoding a polypeptide having HMG-CoA reductase activity is disclosed. The copy number is preferably increased by transforming plants with a recombinant DNA molecule comprising a vector operatively linked to an exogenous DNA segment that encodes a polypeptide having HMG-CoA reductase activity, and a promoter suitable for driving the expression of said polypeptide. Also disclosed are a method of increasing cycloartenol accumulation in a plant, a method of increasing the resistance of plants to pests and the transformed plants themselves.
摘要翻译：公开了通过增加编码具有HMG-CoA还原酶活性的多肽的基因的拷贝数增加植物中甾醇积累的方法。优选通过用包含可操作地连接到编码具有HMG-CoA还原酶活性的多肽的外源DNA片段的载体的重组DNA分子和适于驱动所述多肽表达的启动子来转化植物来增加拷贝数。还公开了增加植物中环戊烯醇积累的方法，增加植物对害虫和转化植物本身的抵抗力的方法。

5. 发明授权

US5349126A Process and composition for increasing squalene and sterol accumulation in higher plants 失效
标题翻译：在高等植物中增加角鲨烯和甾醇积累的方法和组合物
公开(公告)号：US5349126A
公开(公告)日：1994-09-20
申请号：US934374
申请日：1992-08-14
申请人： Joseph Chappell , Court A. Saunders , Fred R. Wolf
发明人： Joseph Chappell , Court A. Saunders , Fred R. Wolf
IPC分类号： A01H5/00 , C12N5/10 , C12N9/04 , C12N15/09 , C12N15/53 , C12N15/82 , C12P33/00 , A01H1/04 , A01H5/10 , C12N15/00 , C12P21/04
CPC分类号： C12N9/0006 , C12N15/8243 , C12N15/8286
摘要： A process of increasing squalene and sterol accumulation in a transgenic plant by increasing the amount of a gene encoding a polypeptide having HMG-CoA reductase activity is disclosed. The amount is preferably increased by transforming plant cells with a recombinant DNA molecule comprising a vector operatively linked to an exogenous DNA segment that encodes a polypeptide having HMG-CoA reductase activity, and a promoter suitable for driving the expression of said polypeptide to form a transformed plant cell and regenerating a transgenic plant from that transformed cell. Also disclosed are a process of increasing pest resistance in a transgenic plant, transgenic plants and transgenic seeds capable of germinating into transgenic plants.
摘要翻译：公开了通过增加编码具有HMG-CoA还原酶活性的多肽的基因的量来增加转基因植物中角鲨烯和甾醇积累的方法。优选通过用包含可操作地连接到编码具有HMG-CoA还原酶活性的多肽的外源DNA区段的载体的重组DNA分子和适于驱动所述多肽的表达以形成转化的载体的启动子来转化植物细胞来增加量植物细胞并从转化细胞再生转基因植物。还公开了在转基因植物，转基因植物和能够发芽转化植物的转基因种子中增加害虫抗性的方法。

6. 发明授权

US08709526B2 Use of a high-oleic and high-tocol diet in combination with a non-tocol antioxidant for improving animal meat quality 失效
标题翻译：使用高油酸和高蛋白饮食与非抗皱抗氧化剂联合，以改善动物肉质
公开(公告)号：US08709526B2
公开(公告)日：2014-04-29
申请号：US11530075
申请日：2006-09-08
申请人： Fred R. Wolf , Cindi S. Zimmermann , Court A. Saunders
发明人： Fred R. Wolf , Cindi S. Zimmermann , Court A. Saunders
IPC分类号： A23K1/00 , A23K1/18
CPC分类号： A23B4/20 , A23K20/158 , A23K20/174 , A23K50/10 , A23K50/30 , A23L3/3481 , A23L13/42 , A23L13/428 , A61K31/22 , A61K31/355
摘要： A novel method for improving the meat quality of an animal is provided. In one embodiment, the method comprises feeding the animal a diet supplemented with oleic acid and tocols and subsequently formulating the meat with a non-tocol antioxidant such as rosemary extract. The source of the oleic acid and/or tocols may be transgenic corn that employs the FAD-2 gene as a silencing agent for a high-oleic phenotype and/or expresses the HGGT gene for a high-tocotrienol phenotype. The method improves the quality of meat from both non-ruminants and ruminants.
摘要翻译：提供了一种改善动物肉质的新方法。在一个实施方案中，该方法包括向动物喂食补充有油酸和奶油的饮食，并随后用非蛋白抗氧化剂如迷迭香提取物配制肉。油酸和/或多酚的来源可以是使用FAD-2基因作为高油酸表型的沉默剂和/或表达高生育三烯酚表型的HGGT基因的转基因玉米。该方法提高了非反刍动物和反刍动物的肉质量。

7. 发明授权

US5365017A Method and composition for increasing sterol accumulation in higher plants 失效
公开(公告)号：US5365017A
公开(公告)日：1994-11-15
申请号：US119263
申请日：1993-09-09
申请人： Joseph Chappell , Court A. Saunders , Fred R. Wolf , Richard E. Cuellar
发明人： Joseph Chappell , Court A. Saunders , Fred R. Wolf , Richard E. Cuellar
IPC分类号： A01H5/00 , C12N5/10 , C12N9/04 , C12N15/09 , C12N15/53 , C12N15/82 , C12P33/00 , A01H1/04 , C12N15/00 , C12N9/02 , C07H21/04
CPC分类号： C12N9/0006 , C12N15/8243 , C12N15/8286
摘要： A method of increasing sterol accumulation in a plant by increasing the copy number of a gene encoding a polypeptide having HMG-CoA reductase activity is disclosed. The copy number is preferably increased by transforming plants with a recombinant DNA molecule comprising a vector operatively linked to an exogenous DNA segment that encodes a polypeptide having HMG-CoA reductase activity, and a promoter suitable for driving the expression of said polypeptide. Also disclosed are a method of increasing cycloartenol accumulation in a plant, a method of increasing the resistance of plants to pests and the transformed plants themselves.

8. 发明申请

US20120264822A1 METHOD OF IMPROVING ANIMAL TISSUE QUALITY BY SUPPLEMENTING THE ANIMAL DIET WITH OLEIC ACID AND SELECTED TOCOLS 失效
标题翻译：通过用油酸和选择性的植物油补充动物饮料来改善动物组织质量的方法
公开(公告)号：US20120264822A1
公开(公告)日：2012-10-18
申请号：US13536226
申请日：2012-06-28
申请人： William D. Hitz , Thomas E. Sauber , Court Saunders , Fred R. Wolf
发明人： William D. Hitz , Thomas E. Sauber , Court Saunders , Fred R. Wolf
IPC分类号： A61K31/355 , A61P21/00
CPC分类号： A61K31/202 , A23K20/111 , A23K20/158 , A23K20/174 , A23K50/10 , A23K50/30 , A23K50/75
摘要： A novel method for improving the meat quality of an animal is provided. The method comprises feeding the animal a diet supplemented with oleic acid and selected tocols in amounts effective to improve the meat quality. The method may be practiced on non-ruminants and ruminants.
摘要翻译：提供了一种改善动物肉质的新方法。该方法包括以足以提高肉质的量给动物喂食补充有油酸的食物和选定的奶制品。该方法可以在非反刍动物和反刍动物上实施。

9. 发明授权

US07078066B2 Chewing gum containing physiological cooling agents and method of making 失效
标题翻译：含有生理凉味剂的口香糖及其制作方法
公开(公告)号：US07078066B2
公开(公告)日：2006-07-18
申请号：US10678025
申请日：2003-09-30
申请人： Fred R. Wolf , Gordon N. McGrew , Jeffrey S. Hook , Lindell C. Richey , Mansukh M. Patel , Robert J. Yatka , David L. Witkewitz , Michael J. Greenberg , Henry T. Tyrpin , Kathryn T. Nelson
发明人： Fred R. Wolf , Gordon N. McGrew , Jeffrey S. Hook , Lindell C. Richey , Mansukh M. Patel , Robert J. Yatka , David L. Witkewitz , Michael J. Greenberg , Henry T. Tyrpin , Kathryn T. Nelson
IPC分类号： A23G3/30 , A23L1/226
CPC分类号： A23G4/06 , A23G4/062 , A23G4/068 , A23G4/20 , A23G2200/00
摘要： A method for producing a chewing gum, as well as the chewing gum so produced, incorporates a physiological cooling agent, such as acyclic carboxamide, or combinations of physiological cooling agents. In another embodiment a combination of physiological cooling agents is made in a modified release structure. The modified release/cooling agents combination is preferably obtained by physically modifying the properties of the combination of cooling agents by coating and drying. When incorporated into gum, these particles are adapted to enhance the shelf stability of the flavor and/or produce a modified release when the gum is chewed. In another embodiment, the physiological cooling agent is present with menthol and menthone. In another embodiment, coated chewing gum has a coating that comprises a physiological cooling agent.
摘要翻译：用于生产口香糖的方法以及如此制备的口香糖包含生理冷却剂，例如无环羧酰胺，或生理冷却剂的组合。在另一个实施方案中，将生理冷却剂的组合制成改性释放结构。改性释放/冷却剂组合优选通过涂覆和干燥来物理改变冷却剂组合的性质来获得。当掺入胶中时，这些颗粒适于增强风味剂的贮存稳定性和/或当咀嚼口香糖时产生改性释放物。在另一个实施方案中，生理冷却剂存在薄荷醇和薄荷酮。在另一个实施方案中，涂覆的口香糖具有包含生理冷却剂的涂层。

10. 发明授权

US4935468A Thermoplastic elastomer blends of a polyvinyl chloride-acrylate copolymer and a cured acrylate elastomer 失效
标题翻译：聚氯乙烯 - 丙烯酸酯共聚物和固化的丙烯酸酯弹性体的热塑性弹性体共混物
公开(公告)号：US4935468A
公开(公告)日：1990-06-19
申请号：US242997
申请日：1988-09-09
申请人： William S. Greenlee , Josef C. Vyvoda , Fred R. Wolf
发明人： William S. Greenlee , Josef C. Vyvoda , Fred R. Wolf
IPC分类号： C08L9/02 , C08L19/00 , C08L27/06 , C08L33/04 , C08L33/08
CPC分类号： C08L27/06 , C08L19/003 , C08L33/04 , C08L33/08 , C08L9/02
摘要： Thermoplastic elastomer blends containing polyvinyl chloride having improved oil resistance, exceptionally low compression set and softness are made by mixing a polyvinyl chloride-acrylate copolymer with effective amounts of cured acrylate elastomers. The polyvinyl chloride-acrylate copolymer has an inherent viscosity of from about 0.3 to about 4.0 and is made from a vinyl constituent which is a vinyl chloride monomer with an optional vinyl component comonomer and one or more acrylate monomers having the formula ##STR1## wherein R.sup.1 is an aliphatic, an aromatic, or combinations thereof, having from 1 to 18 carbon atoms, or a halogen derivative thereof, or hydrogen, and R.sup.2 is an aliphatic, an aromatic, an alkyl hydroxyl, or combinations thereof, having from 1 to 18 carbon atoms, or a halogen derivative thereof; or a hydrocarbyl ether such as an alkoxyalkyl, a phenoxyaryl, a phenoxyalkyl, or combinations thereof, having from 2 to 1,000 carbon atoms, or a substituted halogen, oxygen, sulfur, or nitrogen derivative thereof, and wherein the acrylate elastomer is made from one or more acrylate monomers having the formula ##STR2## wherein R.sup.3 is an aliphatic, an aromatic, or combinations thereof, having from 1 to 18 carbon atoms, or a halogen derivative thereof, or hydrogen, and R.sup.4 is an aliphatic, an aromatic, an alkyl hydroxyl, or combinations thereof, having from 1 to 18 carbon atoms, or a halogen derivative thereof; or a hydrocarbyl ether such as an alkoxyalkyl, a phenoxyaryl, a pheloxyalkyl, or combinations thereof having from 2 to 1,000 carbon atoms, or a substituted halogen, oxygen, sulfur, or nitrogen derivative thereof.
摘要翻译：通过将聚氯乙烯 - 丙烯酸酯共聚物与有效量的固化的丙烯酸酯弹性体混合，制备含有改善的耐油性，特别低的压缩永久变形和柔软度的聚氯乙烯的热塑性弹性体共混物。聚氯乙烯 - 丙烯酸酯共聚物的特性粘度为约0.3至约4.0，并且由乙烯基成分制成，该乙烯基成分是具有任选的乙烯基成分共聚单体的氯乙烯单体和一种或多种具有式I的丙烯酸酯单体其中R 1是具有1至18个碳原子的脂族，芳族或其组合，或其卤素衍生物或氢，并且R 2是脂族，芳族，烷基羟基或其组合，其具有1 至18个碳原子，或其卤素衍生物; 或具有2至1,000个碳原子的烃基醚如烷氧基烷基，苯氧基芳基，苯氧基烷基或其组合，或其取代的卤素，氧，硫或氮衍生物，其中丙烯酸酯弹性体由一种或更多具有式II的丙烯酸酯单体，其中R 3是具有1至18个碳原子的脂族，芳族或其组合，或其卤素衍生物或氢，并且R 4是脂族，芳族，具有1至18个碳原子的烷基羟基或其组合，或其卤素衍生物; 或具有2至1,000个碳原子的烃基醚如烷氧基烷基，苯氧基芳基，对羟基烷基或其组合，或其取代的卤素，氧，硫或氮衍生物。

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