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1. 发明授权

US06270984B1 Modulating robo: ligand interactions 失效
标题翻译：调节robo：配体相互作用
公开(公告)号：US06270984B1
公开(公告)日：2001-08-07
申请号：US09540245
申请日：2000-03-31
申请人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
发明人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
IPC分类号： G01N3383
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/4702 , G01N33/566 , G01N33/68 , G01N2333/43573 , G01N2500/02
摘要： Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the agent modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.
摘要翻译：公开了用于鉴定调节Robo和Robo配体的相互作用并调节Robo和Robo配体的相互作用的试剂的方法和组合物。用于鉴定Robo：配体调节剂的方法在商业药物筛选中发现具体应用。这些方法通常包括（1）在条件下组合Robo多肽，狭缝多肽和候选试剂，但是对于所述试剂的存在，所述Robo和狭缝多肽参与第一相互作用，和（2）确定第二相互作用的Robo和Slit多肽，其中所述第一和第二相互作用之间的差异指示所述试剂调节所述Robo和Slit多肽的相互作用。调节Robo和Robo配体的相互作用的主题方法包括在条件下组合Robo多肽，狭缝多肽和调节剂，但是对于调节剂的存在，Robo和Slit多肽参与第一相互作用，由此 Robo和Slit多肽参与与第一相互作用不同的第二相互作用。在一个具体实施方案中，调节剂是Robo或Slit多肽的显性阴性形式。

2. 发明授权

US6046015A Modulating Robo: ligand interactions 失效
标题翻译：调制Robo：配体相互作用
公开(公告)号：US6046015A
公开(公告)日：2000-04-04
申请号：US191647
申请日：1998-11-13
申请人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
发明人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/68 , G01N33/53 , C07K7/08 , C12N5/02
CPC分类号： C07K14/70503 , C07K14/4702 , G01N33/566 , G01N33/68 , A61K38/00 , G01N2333/43573 , G01N2500/02
摘要： Disclosed are methods and compositions for identifing agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the agent modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.
摘要翻译：公开了用于调节Robo和Robo配体的相互作用并用于调节Robo和Robo配体的相互作用的识别剂的方法和组合物。用于鉴定Robo：配体调节剂的方法在商业药物筛选中发现具体应用。这些方法通常包括（1）在条件下组合Robo多肽，狭缝多肽和候选试剂，但是对于所述试剂的存在，所述Robo和狭缝多肽参与第一相互作用，和（2）确定第二相互作用的Robo和Slit多肽，其中所述第一和第二相互作用之间的差异指示所述试剂调节所述Robo和Slit多肽的相互作用。调节Robo和Robo配体的相互作用的主题方法包括在条件下组合Robo多肽，狭缝多肽和调节剂，但是对于调节剂的存在，Robo和Slit多肽参与第一相互作用，由此 Robo和Slit多肽参与与第一相互作用不同的第二相互作用。在一个具体实施方案中，调节剂是Robo或Slit多肽的显性阴性形式。

3. 发明授权

US06270995B1 Recombinant polynucleotides encoding a slit polypeptide 失效
标题翻译：编码狭缝多肽的重组多核苷酸
公开(公告)号：US06270995B1
公开(公告)日：2001-08-07
申请号：US09540153
申请日：2000-03-31
申请人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
发明人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
IPC分类号： C12P2102
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/4702 , G01N33/566 , G01N33/68 , G01N2333/43573 , G01N2500/02
摘要： Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.
摘要翻译：公开了用于鉴定调节Robo和Robo配体的相互作用并调节Robo和Robo配体的相互作用的试剂的方法和组合物。用于鉴定Robo：配体调节剂的方法在商业药物筛选中发现具体应用。这些方法通常包括（1）在条件下组合Robo多肽，狭缝多肽和候选试剂，但是对于所述试剂的存在，所述Robo和狭缝多肽参与第一相互作用，和（2）确定第二相互作用的Robo和Slit多肽，其中所述第一和第二相互作用之间的差异指示所述琼脂调节所述Robo和Slit多肽的相互作用。调节Robo和Robo配体的相互作用的主题方法包括在条件下组合Robo多肽，狭缝多肽和调节剂，但是对于调节剂的存在，Robo和Slit多肽参与第一相互作用，由此 Robo和Slit多肽参与与第一相互作用不同的第二相互作用。在一个具体实施方案中，调节剂是Robo或Slit多肽的显性阴性形式。

4. 发明申请

US20090155928A1 Modulating robo: ligand interactions 审中-公开
标题翻译：调节robo：配体相互作用
公开(公告)号：US20090155928A1
公开(公告)日：2009-06-18
申请号：US11891963
申请日：2007-08-13
申请人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
发明人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
IPC分类号： G01N33/566 , C07K14/00 , C12N15/11
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/4702 , G01N33/566 , G01N33/68 , G01N2333/43573 , G01N2500/02
摘要： Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.
摘要翻译：公开了用于鉴定调节Robo和Robo配体的相互作用并调节Robo和Robo配体的相互作用的试剂的方法和组合物。用于鉴定Robo：配体调节剂的方法在商业药物筛选中发现具体应用。这些方法通常包括（1）在条件下组合Robo多肽，狭缝多肽和候选试剂，但是对于所述试剂的存在，所述Robo和狭缝多肽参与第一相互作用，和（2）确定第二相互作用的Robo和Slit多肽，其中所述第一和第二相互作用之间的差异指示所述琼脂调节所述Robo和Slit多肽的相互作用。调节Robo和Robo配体的相互作用的主题方法包括在条件下组合Robo多肽，狭缝多肽和调节剂，但是对于调节剂的存在，Robo和Slit多肽参与第一相互作用，由此 Robo和Slit多肽参与与第一相互作用不同的第二相互作用。在一个具体实施方案中，调节剂是Robo或Slit多肽的显性阴性形式。

5. 发明授权

US06861228B2 Modulating Robo: ligand interactions 失效
标题翻译：调制Robo：配体相互作用
公开(公告)号：US06861228B2
公开(公告)日：2005-03-01
申请号：US10289776
申请日：2002-11-06
申请人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
发明人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/68 , G01N33/53 , A61K39/395
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/4702 , G01N33/566 , G01N33/68 , G01N2333/43573 , G01N2500/02
摘要： Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.
摘要翻译：公开了用于鉴定调节Robo和Robo配体的相互作用并调节Robo和Robo配体的相互作用的试剂的方法和组合物。用于鉴定Robo：配体调节剂的方法在商业药物筛选中发现具体应用。这些方法通常包括（1）在条件下组合Robo多肽，狭缝多肽和候选试剂，但是对于所述试剂的存在，所述Robo和狭缝多肽参与第一相互作用，和（2）确定第二相互作用的Robo和Slit多肽，其中所述第一和第二相互作用之间的差异指示所述琼脂调节所述Robo和Slit多肽的相互作用。调节Robo和Robo配体的相互作用的主题方法包括在条件下组合Robo多肽，狭缝多肽和调节剂，但是对于调节剂的存在，Robo和Slit多肽参与第一相互作用，由此 Robo和Slit多肽参与与第一相互作用不同的第二相互作用。在一个具体实施方案中，调节剂是Robo或Slit多肽的显性阴性形式。

6. 发明申请

US20050196783A1 Modulating Robo: ligand interactions 审中-公开
公开(公告)号：US20050196783A1
公开(公告)日：2005-09-08
申请号：US11022546
申请日：2004-12-23
申请人： Corey Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
发明人： Corey Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/68 , C12Q1/68 , A61K39/395 , C07H21/04 , C07K16/28 , G01N33/53 , G01N33/567
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/4702 , G01N33/566 , G01N33/68 , G01N2333/43573 , G01N2500/02
摘要： Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.

7. 发明申请

US20110223630A1 METHOD FOR SCREENING FOR COMPOUNDS THAT INHIBIT NEURODEGENERATION 审中-公开
标题翻译：用于筛选不抑制神经元的化合物的方法
公开(公告)号：US20110223630A1
公开(公告)日：2011-09-15
申请号：US12997297
申请日：2009-06-12
申请人： Anatoly Nikolaev , Marc Tessier-Lavigne
发明人： Anatoly Nikolaev , Marc Tessier-Lavigne
IPC分类号： C12Q1/02
CPC分类号： G01N33/5058 , G01N33/6896
摘要： Methods for screening for compounds that inhibit neurodegeneration are presented. Shedding of APP can be a useful marker for neurodegeneration and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful in treatment and/or prevention of various neurological diseases, disorders and neuronal damage and may enhance growth, regeneration or survival of mammalian neuronal cells or tissue.
摘要翻译：提出了筛选抑制神经变性的化合物的方法。 APP的脱落可能是神经变性的有用标志物，并且抑制APP脱落的化合物可用作神经退行性抑制剂。这样的化合物可用于治疗和/或预防各种神经疾病，病症和神经元损伤，并且可以增强哺乳动物神经细胞或组织的生长，再生或存活。

8. 发明申请

US20100203044A1 DR6 ANTAGONISTS AND USES THEREOF IN TREATING NEUROLOGICAL DISORDERS 审中-公开
标题翻译： DR6拮抗剂及其在治疗神经疾病中的应用
公开(公告)号：US20100203044A1
公开(公告)日：2010-08-12
申请号：US12520044
申请日：2007-12-21
申请人： Anatoly Nikolaev , Marc Tessier-Lavigne
发明人： Anatoly Nikolaev , Marc Tessier-Lavigne
IPC分类号： A61K39/395 , C12N5/00 , A61K38/16 , A61P25/00 , G01N33/53 , C07K16/00 , C07K14/00 , G01N33/68
CPC分类号： C07K16/18 , A61K38/00 , C07K14/70578 , C07K16/2878 , C07K2317/76 , C07K2319/02 , C07K2319/30 , C07K2319/61 , C12N15/1138 , C12N2310/14
摘要： Methods and compositions comprising DR6 antagonists for use in treating neurological disorders, including Alzheimer's disease, are provided. The DR6 antagonists include anti-APP antibodies, anti-DR6 antibodies, DR6 immunoadhesins and DR6 variants (and fusion proteins thereof) which enhance growth, regeneration or survival of mammalian neuronal cells or tissue.
摘要翻译：提供了包含用于治疗神经障碍（包括阿尔茨海默氏病）的DR6拮抗剂的方法和组合物。 DR6拮抗剂包括增强哺乳动物神经细胞或组织的生长，再生或存活的抗APP抗体，抗DR6抗体，DR6免疫粘附素和DR6变体（及其融合蛋白）。

9. 发明申请

US20090232794A1 Modulators of neuronal regeneration 审中-公开
标题翻译：神经元再生调节剂
公开(公告)号：US20090232794A1
公开(公告)日：2009-09-17
申请号：US12316130
申请日：2008-12-09
申请人： Marc Tessier-Lavigne , Jasvinder Atwal , Julie Pinkston-Gosse
发明人： Marc Tessier-Lavigne , Jasvinder Atwal , Julie Pinkston-Gosse
IPC分类号： A61K39/395 , G01N33/566 , G01N33/567 , C07K16/00 , C07H21/02 , C12N5/06 , A61K31/7105
CPC分类号： G01N33/5058 , G01N33/5073 , G01N2333/525 , G01N2333/705 , G01N2500/00
摘要： The present invention provides methods and compositions related to CNS function and diseases.
摘要翻译：本发明提供了与CNS功能和疾病有关的方法和组合物。

10. 发明授权

US06512004B2 Promoters of neural regeneration 失效
公开(公告)号：US06512004B2
公开(公告)日：2003-01-28
申请号：US09900268
申请日：2001-07-06
申请人： Hong-jun Song , Mu-ming Poo , Guo-li Ming , Marc Tessier-Lavigne , Zhigang He
发明人： Hong-jun Song , Mu-ming Poo , Guo-li Ming , Marc Tessier-Lavigne , Zhigang He
IPC分类号： A61K3135
CPC分类号： A61K31/70
摘要： The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent protein kinase a neural cell subject to growth repulsion mediated by a neural cell growth repulsion factor. The activator may comprise a direct or an indirect activator of the protein kinase; the repulsion factor typically comprises one or more natural, endogenous proteins mediating localized repulsion or inhibition of neural cell growth; and the target cells are generally vertebrate neurons, typically injured mammalian neurons. The subject compositions include mixtures comprising a neural cell, an activator of a cyclic nucleotide dependent protein kinase and a neural cell growth repulsion factor.

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