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    • 3. 发明申请
    • Synthesis of Cyclosporin H
    • 环孢菌素H的合成
    • US20120253007A1
    • 2012-10-04
    • US13355673
    • 2012-01-23
    • Craig WhitakerStephanie Caspe
    • Craig WhitakerStephanie Caspe
    • C07K1/113
    • C07K7/645
    • A method of preparing purified cyclosporin H includes dissolving cyclosporin A in a first organic solvent and heating the first organic solvent in the presence of an acid catalyst; adding a base to the first organic solvent; recrystallizing cyclosporin H in a second solvent; and purifying the recrystallized cyclosporin H via chromatography to obtain purified cyclosporin H, while excluding recrystallizing the cyclosporin H in the presence of ether. In a further aspect, the method includes, after adding the base and before the recrystallizing, mixing the first organic solvent with a solvent more polar than the first organic solvent, separating the first organic solvent, and drying the first organic solvent. Cyclosporin H prepared as described herein was found to be biologically active, unlike that prepared using a previously-described method.
    • 制备纯化的环孢菌素H的方法包括将环孢菌素A溶解在第一有机溶剂中并在酸催化剂存在下加热第一有机溶剂; 向第一有机溶剂中加入碱; 在第二溶剂中重结晶环孢菌素H; 并通过色谱法纯化重结晶的环孢菌素H,得到纯化的环孢菌素H,同时排除在醚存在下重结晶环孢菌素H. 另一方面,所述方法包括在添加碱后,在重结晶之前,将第一有机溶剂与比第一有机溶剂更极性的溶剂混合,分离第一有机溶剂,并干燥第一有机溶剂。 发现如本文所述制备的环孢菌素H与使用前述方法制备的不同,发现其具有生物活性。
    • 5. 发明申请
    • CONNECTABLE-DISCONNECTABLE SHROUD-CONNECTOR-ADAPTER
    • 连接不连接的连接器 - 适配器
    • US20080148509A1
    • 2008-06-26
    • US11955690
    • 2007-12-13
    • Joseph C. BacarellaVan T. WalworthCraig WhitakerWilliam McGinnDavid B. Hook
    • Joseph C. BacarellaVan T. WalworthCraig WhitakerWilliam McGinnDavid B. Hook
    • B60S1/04
    • B60S1/40B60S1/3806B60S1/3856B60S1/3863B60S1/3867B60S1/4003
    • A shroud-adapter for attaching a windshield wiper blade/beam assembly to a windshield wiper arm, comprising either a unitary or two-piece shroud-adapter which is detachably attachable to a connector element by snapping means, the connector element being attached to a wiper blade/beam assembly. The connector is of formed steel with crimp tabs bendable to impinge upon the wiper beam, but can be made from plastics or other suitably-engineered polymers or castings known in the field. The shroud-adapter portion can be molded from plastic or suitably-engineered materials or cast from any one of numerous materials. If a separate adapter portion is used in cooperation with the shroud, it can be molded from a plastic or suitably-engineered material, as well, but also can be cast, machined or formed by other appropriate methods. The shroud-adapter is designed to be compatible with many of the popular side pin, J-hook, and European style wiper arms.
    • 一种用于将挡风玻璃刮水器叶片/梁组件附接到挡风玻璃刮水器臂的护罩适配器,包括可通过卡扣装置可拆卸地附接到连接器元件的单件或两件式护罩适配器,连接器元件附接到刮水器 叶片/梁组件。 连接器是成形钢,其具有弯曲突片,其可弯曲以撞击擦拭器梁,但是可以由本领域已知的塑料或其它合适的工程聚合物或铸件制成。 护罩适配器部分可以由塑料或适当设计的材料模制,或者从许多材料中的任何一种铸造。 如果与护罩配合使用单独的适配器部分,则它也可以由塑料或适当设计的材料模制,也可以通过其它合适的方法铸造,机加工或形成。 护罩适配器设计为与许多受欢迎的侧销,J型钩和欧式雨刷臂兼容。
    • 7. 发明授权
    • Functionalization of carbon nanotubes
    • 碳纳米管的功能化
    • US07807127B1
    • 2010-10-05
    • US11417294
    • 2006-04-14
    • Farhad ForoharCraig WhitakerWilliam M. Koppes
    • Farhad ForoharCraig WhitakerWilliam M. Koppes
    • D01F9/12
    • B82Y40/00B82Y10/00B82Y30/00C01B32/174C01B2202/02H01L51/0049Y10S977/745Y10S977/748
    • The present invention relates to a carbon nanotube that contains nitrogen based functional groups (such as nitro, nitroso, N-oxide, oxime, hydroxylamine, diazo, azo, and azide) that are covalently attached to lattice carbons of the carbon nanotube, directly or via a chemical linker. The present invention also relates to methods for the preparation of the carbon nanotube from an amino-functionalized carbon nanotube via an amino oxidation reaction. The synthetic methods of the present invention allow the nitrogen based functional groups to be attached selectively to one of two distinct regions of the carbon nanotube, the ends or the sidewall, and thus enable the synthesis of a carbon nanotube having nitrogen based functional groups substantially concentrated on either the ends or the sidewall of the carbon nanotube.
    • 本发明涉及碳纳米管,其直接或间接地共价连接到碳纳米管的格子状碳上的氮基官能团(例如硝基,亚硝基,N-氧化物,肟,羟胺,重氮,偶氮和叠氮化物) 通过化学接头。 本发明还涉及通过氨基氧化反应从氨基官能化的碳纳米管制备碳纳米管的方法。 本发明的合成方法允许氮基官能团选择性地连接到碳纳米管,末端或侧壁的两个不同区域中的一个,从而能够合成具有基本上浓度的基于氮的官能团的碳纳米管 在碳纳米管的两端或侧壁上。