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1. 发明授权

US06860900B2 Stent and stent-graft for treating branched vessels 失效
标题翻译：支架和支架移植物用于治疗分枝血管
公开(公告)号：US06860900B2
公开(公告)日：2005-03-01
申请号：US10607741
申请日：2003-06-27
申请人： Claude O. Clerc , Paul F. Chouinard , Leonard Pinchuk , Paul J. Thompson
发明人： Claude O. Clerc , Paul F. Chouinard , Leonard Pinchuk , Paul J. Thompson
IPC分类号： A61F2/90 , A61F2/06
CPC分类号： A61F2/90 , A61F2/07 , A61F2/856 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2220/0016 , A61F2230/0008
摘要： An implantable stent and stent-graft for treating a patient having a relatively healthy first aorta portion upstream from a renal artery branch, and a diseased aorta portion downstream from the renal artery branch. One embodiment of the device includes a fixation section, a renal artery branch section and a diseased aorta section, all of which can be tubular, radially compressible and self-expandable structures formed from a plurality of filaments which are helically wound in a braided configuration. When the device is implanted and in its expanded state, the fixation section engages the first aorta portion upstream from a renal artery branch to provide substantial anchoring support. The diseased aorta section engages the portion of the aorta downstream from the renal artery branch and extends across the diseased portion of the aorta for purposes of treatment. The renal artery branch section extends across the renal artery branch and connects the diseased aorta section to the fixation section while allowing blood flow between the aorta and renal artery branch.
摘要翻译：一种可植入支架和支架移植物，用于治疗患有在肾动脉分支上游具有相对健康的第一主动脉部分的患者，以及在肾动脉分支下游的患病主动脉部分。该装置的一个实施例包括固定部分，肾动脉分支部分和患病主动脉部分，所有这些部分都可以是由以编织构造螺旋缠绕的多根细丝形成的管状，径向可压缩和自扩张结构。当装置植入并处于其膨胀状态时，固定部分与肾动脉分支上游的第一主动脉部分接合以提供实质的锚定支撑。患病的主动脉段与肾动脉分支下游的主动脉的部分接合，并延伸穿过主动脉的患病部分以用于治疗。肾动脉分支部分延伸穿过肾动脉分支，并将患病主动脉部分连接到固定部分，同时允许主动脉和肾动脉分支之间的血液流动。

2. 发明授权

US07993387B2 Stent with reduced weld profiles and a closed-end wire configuration 有权
标题翻译：支架具有减小的焊接形状和闭合端的线材配置
公开(公告)号：US07993387B2
公开(公告)日：2011-08-09
申请号：US10845844
申请日：2004-05-14
申请人： Claude O. Clerc , Paul K. Norton , Michael Zupkofska , Gary J. Leanna , George Tom Roberts
发明人： Claude O. Clerc , Paul K. Norton , Michael Zupkofska , Gary J. Leanna , George Tom Roberts
IPC分类号： A61F2/86
CPC分类号： A61F2/90 , A61F2220/005 , A61F2220/0058 , A61F2230/001 , A61F2230/0013 , B23H9/02 , B23K9/0026 , B23K11/008 , B23K15/008 , B23K26/12 , B23K26/123 , B23K26/211 , B23K37/08 , B23K2101/06 , B23K2101/22 , B23K2101/32 , C23F3/04 , C25F3/16 , D04C1/06 , D04C3/48 , D10B2403/0112 , D10B2509/06
摘要： A method for making an implantable stent includes the steps of (i) providing a plurality of elongate stent wires; (ii) forming said wires into a hollow tubular structure having opposed first and second open ends; (iii) terminating said wires at the second end; (iv) aligning the wires at the second end into a plurality of mated adjacent wires to define a plurality of abutting regions; (v) welding the mated adjacent wires to one and the other at the abutting regions to define a plurality of welds; and optionally (vi) chemically or electro-chemically removing a portion of the welds. The method may further include the steps of (a) extending at least one of the mated stent wires to provide an extended stent wire; (b) looping the extended stent wire so the extended end abuts a proximal pair of stent wires; and (c) welding the extended and looped wire to the proximal pair of wires. The step of looping may include the forming of the wire into an equilaterally arched loop having an apex, but not having other sharp bends.
摘要翻译：一种用于制造可植入支架的方法包括以下步骤：（i）提供多个细长的支架线; （ii）将所述导线形成为具有相对的第一和第二开口端的中空管状结构; （iii）在第二端终止所述电线; （iv）将所述第二端处的所述线对齐成多个配合的相邻线，以限定多个邻接区域; （v）在邻接区域将配合的相邻电线焊接到一个并且另一个以限定多个焊缝; 和（vi）化学或电化学去除一部分焊缝。该方法还可以包括以下步骤：（a）延伸至少一个配合的支架线，以提供延伸的支架线; （b）使扩展的支架线圈环绕，使得延伸端邻接近端的一对支架线; 并且（c）将延伸的和环形的焊丝焊接到近侧的一对电线。循环的步骤可以包括将线形成为具有顶点但没有其它尖锐弯曲的平衡拱形环。

3. 发明申请

US20110079315A1 ATRAUMATIC STENT WITH REDUCED DEPLOYMENT FORCE, METHOD FOR MAKING THE SAME AND METHOD AND APPARATUS FOR DEPLOYING AND POSITIONING THE STENT 审中-公开
标题翻译：具有减少部署力的ATRAUMATIC STENT，其制造方法以及用于分配和定位该装置的方法和装置
公开(公告)号：US20110079315A1
公开(公告)日：2011-04-07
申请号：US12966089
申请日：2010-12-13
申请人： Paul K. Norton , Michael Zupkofska , Peter Brady , Gary J. Leanna , Claude O. Clerc , William Bertolino , Grainne Hanley
发明人： Paul K. Norton , Michael Zupkofska , Peter Brady , Gary J. Leanna , Claude O. Clerc , William Bertolino , Grainne Hanley
IPC分类号： B21F45/06
CPC分类号： A61F2/90 , A61F2220/0058 , A61F2250/0039 , A61F2250/0098 , D04C1/06 , D10B2509/06
摘要： An implantable stent includes a plurality of elongate wires braided to form a hollow tubular structure having a tubular wall to define an interior surface and an exterior surface and having opposed open first and second ends, wherein the opposed open first and second ends are atraumatic ends. The atraumatic ends of the stent are desirably free of any loose wire ends. The wires include composite wires to enhance visibility of the wires to provide improved external imaging of the wires in the body. The elongate composite wires of the stent may be metallic wires having an outer metallic portion including a first metal, such as nitinol, and an inner metallic core portion including a second metal, which is a radiopaque material, such as gold, barium sulfate, ferritic particles, platinum, platinum-tungsten, palladium, platinum-iridium, rhodium, tantalum or combinations thereof.
摘要翻译：可植入支架包括编织成多个细长丝线以形成中空管状结构，其具有管状壁以限定内表面和外表面并且具有相对的开放的第一和第二端，其中相对的开放的第一和第二端是无创伤端。支架的无创末端理想地没有任何松散的线端。电线包括复合线，以增强电线的可视性，以提供改进的身体线材的外部成像。支架的细长复合线可以是金属线，其具有包括诸如镍钛诺的第一金属的外部金属部分和包括第二金属的内部金属芯部分，第二金属是不透射线的材料，例如金，硫酸钡，铁素体颗粒，铂，铂 - 钨，钯，铂 - 铱，铑，钽或其组合。

4. 发明授权

US06254425B1 Electrical connector for cardiac devices 有权
标题翻译：用于心脏装置的电连接器
公开(公告)号：US06254425B1
公开(公告)日：2001-07-03
申请号：US09451591
申请日：1999-11-30
申请人： Semyon Shchervinsky , Claude O. Clerc , Alex Ilori
发明人： Semyon Shchervinsky , Claude O. Clerc , Alex Ilori
IPC分类号： H01R1100
CPC分类号： A61N1/3752 , A61N1/0587
摘要： A temporary cardiac pacing wire, or a similar device, includes a pair of flexible electrode wires extending conjointly from a distal end of the pacing wire to its proximal end, where two electrically conductive sections are located. The conductive sections are suitable for connection to a power source adapted to generate electrical signals for stimulating, pacing, sensing, monitoring or defibrillating the heart of a patient. One conductive section results from the distal end of a Keith-type needle that breaks away from the rest of the needle. The other conductive section is arranged at the free end of a third electrode wire which is movable independently of the other two electrode wires, thereby permitting its connection to the power source in a plug-like fashion.
摘要翻译：临时心脏起搏线或类似装置包括一对柔性电极线，其从起搏线的远端到其近端，其中两个导电部分位于其上。导电部分适于连接到适于产生用于刺激，起搏，感测，监测或去纤维化患者心脏的电信号的电源。一个导电部分来自Keith型针的远端，其远离针的其余部分。另一个导电部分布置在可以独立于其它两个电极线移动的第三电极线的自由端，从而允许其以插塞状方式连接到电源。

5. 发明授权

US06183508B2 Method for treating a vessel with a titanium alloy stent 有权
标题翻译：用钛合金支架处理容器的方法
公开(公告)号：US06183508B2
公开(公告)日：2001-02-06
申请号：US09190716
申请日：1998-11-12
申请人： Jonathan S. Stinson , Claude O. Clerc , David W. Mayer
发明人： Jonathan S. Stinson , Claude O. Clerc , David W. Mayer
IPC分类号： A61F206
CPC分类号： A61F2/966 , A61F2/90 , A61F2/95 , A61F2250/0098 , A61L31/022
摘要： A method for treating a body vessel using a stent formed from filaments of titanium or titanium alloys such as Ti—13Zr—13Nb.
摘要翻译：使用由钛或钛合金如Ti-13Zr-13Nb的细丝形成的支架来治疗体内血管的方法。

6. 发明申请

US20090220677A1 METHOD OF MANUFACTURING A COVERED STENT 审中-公开
标题翻译：制造一个覆盖的方法
公开(公告)号：US20090220677A1
公开(公告)日：2009-09-03
申请号：US12465804
申请日：2009-05-14
申请人： Claude O. Clerc , Kathleen M. Miller
发明人： Claude O. Clerc , Kathleen M. Miller
IPC分类号： B05D3/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/606
摘要： A method of manufacturing a covered stent having a sufficiently thick covering to retain a therapeutically effective amount of a therapeutic agent. The covering is applied to the entire outer surface of the stent to provide sufficient volume for retention of the therapeutic agent. In certain embodiments, the stent has a plurality of openings that are covered by the covering. The invention is particularly suited for certain applications, such as for the manufacture of non-vascular stents.
摘要翻译：一种制造具有足够厚的覆盖物以覆盖治疗有效量的治疗剂的覆盖支架的方法。将覆盖物施加到支架的整个外表面以提供足够的体积用于保持治疗剂。在某些实施例中，支架具有被覆盖物覆盖的多个开口。本发明特别适用于某些应用，例如用于制造非血管支架。

7. 发明授权

US06991646B2 Method and apparatus for delivering a stent into a body lumen 失效
标题翻译：用于将支架输送到体腔中的方法和装置
公开(公告)号：US06991646B2
公开(公告)日：2006-01-31
申请号：US10024920
申请日：2001-12-18
申请人： Claude O. Clerc , Kimberly Ann Fischer
发明人： Claude O. Clerc , Kimberly Ann Fischer
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/966 , A61F2002/9665
摘要： Method and apparatus for delivering a stent, including, but not limited to, a self expanding stent, into a body lumen. The apparatus comprises an outer tube having a proximal end and a distal end and sized to hold a stent therein in a radially constricted condition, an inner tube within the outer tube and having a proximal end and a distal end, and a holding element comprising one or more inflatable balloons carried on the inner tube at the location of the loaded stent. The balloon can be inflated prior to the procedure so that the balloon presses against the inner surface of the outer tube trapping the stent in its longitudinal position between the inner and outer tubes. Accordingly, the outer tube can be slid proximally to release the stent or distally to retract the stent back into the delivery device without the stent inadvertently sliding.
摘要翻译：将支架（包括但不限于自扩张支架）输送到体腔中的方法和装置。该装置包括外管，该外管具有近端和远端，并且其尺寸适于将支架保持在径向收缩的状态中，内管内管并具有近端和远端，并且保持元件包括一个或更多的充气气球承载在内管上，在加载的支架的位置。气囊可以在手术之前充气，使得球囊压靠外管的内表面，将外支管的内表面捕获在内管和外管之间的纵向位置。因此，外管可以向近侧滑动以释放支架或远端以将支架缩回到输送装置中，而不会使支架无意中滑动。

8. 发明授权

US06251135B1 Radiopaque marker system and method of use 有权
标题翻译：不透射线标记系统及使用方法
公开(公告)号：US06251135B1
公开(公告)日：2001-06-26
申请号：US09264549
申请日：1999-03-08
申请人： Jonathan S. Stinson , Claude O. Clerc
发明人： Jonathan S. Stinson , Claude O. Clerc
IPC分类号： A61F200
CPC分类号： A61F2/90 , A61F2/82 , A61F2/86 , A61F2220/005 , A61F2250/0059 , A61F2250/0098
摘要： A temporary and retrievable radiopaque marker and discrete radiopaque marker for use on an implantable endoprosthesis. The elongate marker has a proximal end, a distal end, and a thickness. At least a portion of the marker is radiopaque and the marker is removably-attached to the implantable endoprosthesis.
摘要翻译：临时和可回收的不透射线标记和用于可植入内置假体的离散不透射线标记。细长标记具有近端，远端和厚度。标记物的至少一部分是不透射线的，并且标记物可移除地附着到可植入内置假体。

9. 发明授权

US06217369B1 Electrical connector for cardiac devices 有权
标题翻译：用于心脏装置的电连接器
公开(公告)号：US06217369B1
公开(公告)日：2001-04-17
申请号：US09451590
申请日：1999-11-30
申请人： Semyon Shchervinsky , Claude O. Clerc , Alex Ilori
发明人： Semyon Shchervinsky , Claude O. Clerc , Alex Ilori
IPC分类号： H01R1358
CPC分类号： A61N1/0587 , A61N1/3752 , H01R11/12 , H01R11/32 , H01R13/025 , Y10S439/909
摘要： A temporary cardiac pacing wire, or a similar device, includes an electrically conductive lead which is folded over on itself so as to be adapted for connection to a pacing or monitoring apparatus. In the case of a bipolar temporary cardiac pacing wire, flexible wires are employed having two elongated conductive sections at a proximal end. The conductive sections are suitable for connecting to a power source adapted to generate electrical signals for stimulating, pacing, sensing, monitoring or defibrillating the heart of a patient. One conductive section results from the distal end of a Keith-type needle that breaks away from the rest of the needle. This section is suitable for directly connecting to the power source. The other conductive section is suitable for connecting to the power source when folded over on itself.
摘要翻译：临时心脏起搏线或类似装置包括导电引线，该引导线自身折叠以适于与起搏或监测装置连接。在双相临时心脏起搏线的情况下，使用在近端具有两个细长导电部分的柔性线。导电部分适于连接到适于产生用于刺激，起搏，感测，监测或去纤维化患者心脏的电信号的电源。一个导电部分来自Keith型针的远端，其远离针的其余部分。本节适用于直接连接电源。另一个导电部分适合在自身折叠时连接到电源。

10. 发明授权

US07857844B2 Atraumatic stent with reduced deployment force, method for making the same and method and apparatus for deploying and positioning the stent 有权
标题翻译：具有降低部署力的无创支架，制造方法以及用于展开和定位支架的方法和装置
公开(公告)号：US07857844B2
公开(公告)日：2010-12-28
申请号：US12261474
申请日：2008-10-30
申请人： Paul K. Norton , Michael Zupkofska , Peter Brady , Gary L. Leanna , Claude O. Clerc , William Bertolino , Grainne Hanley
发明人： Paul K. Norton , Michael Zupkofska , Peter Brady , Gary L. Leanna , Claude O. Clerc , William Bertolino , Grainne Hanley
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2220/0058 , A61F2250/0039 , A61F2250/0098 , D04C1/06 , D10B2509/06
摘要： An implantable stent includes a plurality of elongate wires braided to form a hollow tubular structure having a tubular wall to define an interior surface and an exterior surface and having opposed open first and second ends, wherein the opposed open first and second ends are atraumatic ends The atraumatic ends of the stent are desirably free of any loose wire ends. The wires include composite wires to enhance visibility of the wires to provide improved external imaging of the wires in the body. The elongate composite wires of the stent may be metallic wires having an outer metallic portion including a first metal, such as nitinol, and an inner metallic core portion including a second metal, which is a radiopaque material, such as gold, barium sulfate, ferritic particles, platinum, platinum-tungsten, palladium, platinum-iridium, rhodium, tantalum or combinations thereof.
摘要翻译：可植入支架包括编织成多个细长丝线以形成中空管状结构，其具有管状壁以限定内表面和外表面并且具有相对开放的第一和第二端，其中相对的敞开的第一和第二端是无创伤的端部支架的无创末端理想地没有任何松散的线末端。电线包括复合线，以增强电线的可视性，以提供改进的身体线材的外部成像。支架的细长复合线可以是金属线，其具有包括诸如镍钛诺的第一金属的外部金属部分和包括第二金属的内部金属芯部分，第二金属是不透射线的材料，例如金，硫酸钡，铁素体颗粒，铂，铂 - 钨，钯，铂 - 铱，铑，钽或其组合。

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