专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06559185B2 Nitromethyl ketone compounds having aldose reduction inhibiting properties and methods for their use 失效
标题翻译：具有醛糖还原抑制性质的硝基甲基酮化合物及其使用方法
公开(公告)号：US06559185B2
公开(公告)日：2003-05-06
申请号：US09438979
申请日：1999-11-12
申请人： Claude Lardy , Jaques Barbanton , Herve Dumas , Francois Collonges , Philippe Durbin
发明人： Claude Lardy , Jaques Barbanton , Herve Dumas , Francois Collonges , Philippe Durbin
IPC分类号： A61K3118
CPC分类号： C07D209/48 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/61 , C07C233/76 , C07C235/24 , C07C235/56 , C07C237/22 , C07C255/56 , C07C311/21 , C07C311/60 , C07C317/24 , C07C323/22 , C07C2601/02 , C07C2601/04 , C07C2602/08 , C07D307/84 , C07D333/22 , C07D333/56 , C07D333/62 , C07D333/68
摘要： The present invention relates to the compounds of formula: in which R1, R2, R3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.
摘要翻译：本发明涉及下式的化合物：其中R1，R2，R3，E，A，X，Z，p和n如本文所定义。这些化合物是醛糖还原酶抑制剂。

2. 发明授权

US6043281A Nitromethyl ketones, process for preparing them and compositions containing them 失效
标题翻译：硝基乙基酮，其制备方法和含有它们的组合物
公开(公告)号：US6043281A
公开(公告)日：2000-03-28
申请号：US257046
申请日：1999-02-25
申请人： Claude Lardy , Jaques Barbanton , Herve Dumas , Francois Collonges , Philippe Durbin
发明人： Claude Lardy , Jaques Barbanton , Herve Dumas , Francois Collonges , Philippe Durbin
IPC分类号： C07D333/16 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/48 , A61K31/12 , A61K31/16 , A61K31/167 , A61K31/18 , A61K31/343 , A61K31/381 , A61K31/4035 , A61K31/45 , A61P3/10 , A61P9/10 , A61P13/12 , A61P27/12 , A61P43/00 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/61 , C07C233/76 , C07C235/24 , C07C235/38 , C07C235/56 , C07C237/22 , C07C255/56 , C07C311/21 , C07C311/60 , C07C317/24 , C07C323/22 , C07D209/48 , C07D211/76 , C07D307/79 , C07D307/84 , C07D307/85 , C07D333/20 , C07D333/22 , C07D333/56 , C07D333/62 , C07D333/68 , C07D333/70 , A61K31/04
CPC分类号： C07D209/48 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/61 , C07C233/76 , C07C235/24 , C07C235/56 , C07C237/22 , C07C255/56 , C07C311/21 , C07C311/60 , C07C317/24 , C07C323/22 , C07D307/84 , C07D333/22 , C07D333/56 , C07D333/62 , C07D333/68 , C07C2101/02 , C07C2101/04 , C07C2102/08
摘要： The present invention relates to the compounds of formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.
摘要翻译：本发明涉及下式的化合物：其中R1，R2，R3，E，A，X，Z，p和n如本文所定义。这些化合物是醛糖还原酶抑制剂。

3. 发明授权

US5932765A Nitromethyl ketones, process for preparing them and compositions containing them 失效
公开(公告)号：US5932765A
公开(公告)日：1999-08-03
申请号：US955624
申请日：1997-10-22
申请人： Claude Lardy , Jaques Barbanton , Herve Dumas , Francois Collonges , Phillippe Durbin
发明人： Claude Lardy , Jaques Barbanton , Herve Dumas , Francois Collonges , Phillippe Durbin
IPC分类号： C07D333/16 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/48 , A61K31/12 , A61K31/16 , A61K31/167 , A61K31/18 , A61K31/343 , A61K31/381 , A61K31/4035 , A61K31/45 , A61P3/10 , A61P9/10 , A61P13/12 , A61P27/12 , A61P43/00 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/61 , C07C233/76 , C07C235/24 , C07C235/38 , C07C235/56 , C07C237/22 , C07C255/56 , C07C311/21 , C07C311/60 , C07C317/24 , C07C323/22 , C07D209/48 , C07D211/76 , C07D307/79 , C07D307/84 , C07D307/85 , C07D333/20 , C07D333/22 , C07D333/56 , C07D333/62 , C07D333/68 , C07D333/70 , C07C233/00
CPC分类号： C07D209/48 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/61 , C07C233/76 , C07C235/24 , C07C235/56 , C07C237/22 , C07C255/56 , C07C311/21 , C07C311/60 , C07C317/24 , C07C323/22 , C07D307/84 , C07D333/22 , C07D333/56 , C07D333/62 , C07D333/68 , C07C2101/02 , C07C2101/04 , C07C2102/08
摘要： The present invention relates to the compounds of formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.

4. 发明授权

US5489592A 3,4-dihydro-4-oxo-3-(2-propenyl)-1-phthalazineacetic acids and derivatives, their preparations and medicines containing them 失效
标题翻译： 3,4-二氢-4-氧代-3-（2-丙烯基）-1-酞嗪乙酸及其衍生物，其制剂和含有它们的药物
公开(公告)号：US5489592A
公开(公告)日：1996-02-06
申请号：US211427
申请日：1994-06-20
申请人： Francois Collonges , Herve Dumas , Philippe Durbin , Daniel Guerrier
发明人： Francois Collonges , Herve Dumas , Philippe Durbin , Daniel Guerrier
IPC分类号： A61K31/50 , A61P3/08 , A61P13/02 , A61P15/00 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07C17/00 , C07C17/14 , C07C17/16 , C07C17/26 , C07C17/38 , C07C22/04 , C07C22/08 , C07C25/02 , C07C25/13 , C07C25/24 , C07C45/44 , C07C45/56 , C07D237/32 , C07D241/44 , C07D333/12 , C07D409/06
CPC分类号： C07D409/06 , C07C17/00 , C07C17/14 , C07C17/16 , C07C17/2635 , C07C17/38 , C07C22/04 , C07C22/08 , C07C25/02 , C07C25/24 , C07C45/44 , C07C45/565 , C07D237/32 , C07D333/12
摘要： Novel 3,4-dihydro-4-oxo-3(prop-2-enyl)-1-phtalazineacetic acids and derivatives of formula (I) ##STR1## in which R.sub.1 R.sub.2 and R.sub.3 are the same or different and stand for H, a halogen or a linear or branched aliphatic, saturated or unsaturated radical, substituted or not by at least one halogen or R.sub.4 residue such as defined below, except when R.sub.4 is H; R.sub.4 and R.sub.5 are the same or different and stand for H, a linear or branched aliphatic radical, saturated or unsaturated, an aryl or heteroaryl radical, said radicals being substituted or not by at least one grouping such as fluorine, chlorine, bromine, methyl or trifluoromethyl, where R.sub.4 and R.sub.5 do not simultaneously denote H; R.sub.6 stands for hydroxy or alkoxy radical; R.sub.7 stands for H, a halogen, a linear or branched aliphatic saturated or unsaturated radical, an alkoxy radical, said radicals being substituted or not by analiphatic or halogenated radical, a nitro group, a substituted or unsubstituted amino group, S(O)n R.sub.8 or a cyano group; n is equal to 0,1 or 2; R.sub.8 is an aliphatic, linear or branched radical, an aryl or heteroaryl radical, an amino radical, said radicals being substituted or not by an aliphatic or halogenated radical. This invention also relates to the optional tautomeric forms of said acids and their pharmaceutically acceptable base addition salts. Also described is a process for preparing said compounds and the drugs containing same.
摘要翻译： PCT No.PCT / FR92 / 00920 Sec。 371日期：1994年6月20日 102（e）日期1994年6月20日PCT提交1992年10月2日PCT公布。公开号WO93 / 07109 日期1994年4月15日。新型3,4-二氢-4-氧代-3（丙-2-烯基）-1-对乙酰乙酸及式（I）的衍生物其中R1R2和R3相同或不同的，代表H，卤素或直链或支链的脂肪族，饱和或不饱和基团，除非是R4是H，而是被至少一个卤素或R4残基取代或不被定义如下。 R 4和R 5相同或不同，代表H，直链或支链脂族基团，饱和或不饱和的芳基或杂芳基，所述基团被至少一个基团取代，例如氟，氯，溴，甲基或三氟甲基，其中R 4和R 5不同时表示H; R6代表羟基或烷氧基; R7代表H，卤素，直链或支链脂族饱和或不饱和基团，烷氧基，所述基团被脂肪族或卤代基团取代，或不被取代或未取代的氨基取代或未取代的氨基S（O）n R8或氰基; n等于0,1或2; R 8是脂族，直链或支链基团，芳基或杂芳基，氨基，所述基团被脂肪族或卤代基取代。本发明还涉及所述酸及其药学上可接受的碱加成盐的任选互变异构形式。还描述了制备所述化合物和含有它们的药物的方法。

5. 发明授权

US5387709A Substituted sulfonamides, process of preparation and medicines containing same 失效
标题翻译：取代磺酰胺，制备方法和含有其的药物
公开(公告)号：US5387709A
公开(公告)日：1995-02-07
申请号：US134731
申请日：1993-10-12
申请人： Claude Lardy , Daniel Guerrier , Gilles Chavernac , Francois Collonges
发明人： Claude Lardy , Daniel Guerrier , Gilles Chavernac , Francois Collonges
IPC分类号： A61K31/18 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61K31/396 , A61K31/397 , A61K31/415 , A61K31/47 , A61K31/66 , A61K31/665 , A61K31/675 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/08 , A61P43/00 , C07C211/17 , C07C211/35 , C07C215/38 , C07C217/52 , C07C229/34 , C07C255/46 , C07C303/36 , C07C303/38 , C07C311/16 , C07C311/17 , C07C311/19 , C07C311/20 , C07C311/29 , C07C317/14 , C07C323/67 , C07D203/26 , C07D205/04 , C07D215/36 , C07D233/54 , C07D233/84 , C07D237/04 , C07D257/04 , C07D307/14 , C07D307/64 , C07D309/04 , C07D333/34 , C07F9/38 , C07C255/00
CPC分类号： C07D257/04 , C07C211/17 , C07C211/35 , C07C255/46 , C07C311/16 , C07C311/19 , C07C311/20 , C07C311/29 , C07C317/14 , C07C323/67 , C07D215/36 , C07D233/84 , C07D237/04 , C07D307/64 , C07D309/04 , C07D333/34 , C07F9/3882 , C40B50/14 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： The present invention concerns new substituted sulfonamides, and the physiologically acceptable salts possibly in the form of complexes, esters and amides thereof, represented by the formula: ##STR1##
摘要翻译：本发明涉及新的取代磺酰胺和可能以其复合物，酯和酰胺形式的生理上可接受的盐，由下式表示：

6. 发明申请

US20070054939A1 Thiazolypiperidine derivatives as mtp inhibitors 失效
标题翻译：噻唑基哌啶衍生物作为mtp抑制剂
公开(公告)号：US20070054939A1
公开(公告)日：2007-03-08
申请号：US10561989
申请日：2004-06-02
申请人： Philippe Guedat , Francois Collonges , Herve Dumas , Jean-Yves Ortholand , Jacques Decerprit , Jaxques Barbanton , Robert Foster , Peter Kane , Bernd Went
发明人： Philippe Guedat , Francois Collonges , Herve Dumas , Jean-Yves Ortholand , Jacques Decerprit , Jaxques Barbanton , Robert Foster , Peter Kane , Bernd Went
IPC分类号： A61K31/4545 , A61K31/454 , C07D417/14
CPC分类号： C07D417/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/10 , C07D495/04
摘要： The present invention relates to thiazolylpiperidine derivatives of the general formula (I): in which: A represents a radical chosen from the radicals a1 and a2 below: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3 below: and R1, R2, R2′, R3, R4, R5, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
摘要翻译：本发明涉及通式（I）的噻唑基哌啶衍生物：其中：A表示选自以下基团a1和a2的基团：G表示选自以下基团g1，g2和g3的键或二价基团：和R 1，R 2，R 2，R 3，R 4，R 4， >，R 5，Y和Z如说明书中所定义。式（I）化合物用于治疗高甘油三酯血症，高胆固醇血症和血脂异常。

7. 发明申请

US20070254919A1 Aroyl-O-Piperidine Derivatives for the Treatment of Diabetes-Related Problems 有权
标题翻译：用于治疗糖尿病相关问题的芳酰基-O-哌啶衍生物
公开(公告)号：US20070254919A1
公开(公告)日：2007-11-01
申请号：US11629176
申请日：2005-05-19
申请人： Philippe Guedat , Francois Collonges , Olivier Chevreuil , Herve Dumas , Marie Denault , Stephane Yvon , Peter Kane , Julia Lainton , Avril Robertson , Bernd Wendt
发明人： Philippe Guedat , Francois Collonges , Olivier Chevreuil , Herve Dumas , Marie Denault , Stephane Yvon , Peter Kane , Julia Lainton , Avril Robertson , Bernd Wendt
IPC分类号： A61K31/445 , A61P3/10 , C07D211/06
CPC分类号： C07D211/46 , C07D211/96 , C07D213/12 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12
摘要： The present invention relates to derivatives of aroyl-O-piperidine structure of the general formula (I): in which R1, R2, R3 and R4 are as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper-triglyceridaemia, hypercholesterolaemia and dyslipidaemia, and to the prevention or treatment of obesity.
摘要翻译：本发明涉及通式（I）的芳酰基-O-哌啶结构的衍生物：其中R 1，R 2，R 3， SUP>和R 4'如说明书中所定义。式（I）化合物用于治疗高甘油三酯血症，高胆固醇血症和血脂异常，以及预防或治疗肥胖症的应用。

8. 发明申请

US20060058372A1 N-Benzodioxolyl, n-benzodioxanyl and n-benzodioxepinyl arylcarboxamide derivatives and pharmaceutical compositions comprising them 审中-公开
标题翻译： N-苯并二恶唑基，正苯并二氧杂环己烷基和正苯并二氧杂环丙基芳基甲酰胺衍生物和包含它们的药物组合物
公开(公告)号：US20060058372A1
公开(公告)日：2006-03-16
申请号：US10532587
申请日：2003-10-01
申请人： Herve Dumas , Jacques Barbanton , Francois Collonges , Jacques Decerprit , Jean-Yves Ortholand , David Benzies , Stuart Cameron , Richard Foster , Stefan Guessregen , Peter Kane , Julia Lainton , Avril Robertson , Bernd Wendt , Mark Warne
发明人： Herve Dumas , Jacques Barbanton , Francois Collonges , Jacques Decerprit , Jean-Yves Ortholand , David Benzies , Stuart Cameron , Richard Foster , Stefan Guessregen , Peter Kane , Julia Lainton , Avril Robertson , Bernd Wendt , Mark Warne
IPC分类号： A61K31/335 , C07D321/10
CPC分类号： C07D405/12 , C07C65/24 , C07C65/34 , C07C69/007 , C07C69/616 , C07C271/12 , C07D317/46 , C07D319/18 , C07D319/20 , C07D321/10 , C07F7/1804
摘要： The present invention relates to a compound of the formula (I): in which T, A, R, B Xi, Yi and n are as defined in Claim 1, and to the pharmaceutically usable derivatives, solvates and stereoisomers thereof, comprising a mixture thereof in all proportions, which can be used in the treatment of dyslipidaemia, and to pharmaceutical compositions comprising them.
摘要翻译：本发明涉及式（I）化合物：其中T，A，R，B Xi，Yi和n如权利要求1中所定义，以及其药学上可用的衍生物，溶剂合物和立体异构体，其包含混合物其可以用于治疗血脂异常的各种比例，以及包含该脂质体的药物组合物

9. 发明授权

US5476846A Substituted sulfonamides, process of preparation and medicines containing same 失效
标题翻译：取代磺酰胺，制备方法和含有其的药物
公开(公告)号：US5476846A
公开(公告)日：1995-12-19
申请号：US341101
申请日：1994-11-17
申请人： Claude Lardy , Daniel Guerrier , Gilles Chavernac , Francois Collonges
发明人： Claude Lardy , Daniel Guerrier , Gilles Chavernac , Francois Collonges
IPC分类号： A61K31/18 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61K31/396 , A61K31/397 , A61K31/415 , A61K31/47 , A61K31/66 , A61K31/665 , A61K31/675 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/08 , A61P43/00 , C07C211/17 , C07C211/35 , C07C215/38 , C07C217/52 , C07C229/34 , C07C255/46 , C07C303/36 , C07C303/38 , C07C311/16 , C07C311/17 , C07C311/19 , C07C311/20 , C07C311/29 , C07C317/14 , C07C323/67 , C07D203/26 , C07D205/04 , C07D215/36 , C07D233/54 , C07D233/84 , C07D237/04 , C07D257/04 , C07D307/14 , C07D307/64 , C07D309/04 , C07D333/34 , C07F9/38 , A01N37/12 , A01N37/44
CPC分类号： C07D257/04 , C07C211/17 , C07C211/35 , C07C255/46 , C07C311/16 , C07C311/19 , C07C311/20 , C07C311/29 , C07C317/14 , C07C323/67 , C07D215/36 , C07D233/84 , C07D237/04 , C07D307/64 , C07D309/04 , C07D333/34 , C07F9/3882 , C40B50/14 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： The present invention concerns new substituted sulfonamides, and the physiologically acceptable salts, complexes, esters and amides thereof, represented by the formula ##STR1## which is defined herein. Said compounds find application as anti-thrombotic and anti-asthmatic medicines.
摘要翻译：本发明涉及新的取代磺酰胺及其生理学上可接受的盐，络合物，酯和酰胺，由本文定义的式（IMAGE）表示。所述化合物可用作抗血栓形成和抗哮喘药物。

10. 发明授权

US4602034A (Oxo-4-4H-(1)-benzopyran-8-yl) alkanoic acids, salts and derivatives, their manufacture and medicines containing them 失效
标题翻译：（氧代-4-4H-（1） - 苯并吡喃-8-基）链烷酸，盐和衍生物，其制备和含有它们的药物
公开(公告)号：US4602034A
公开(公告)日：1986-07-22
申请号：US669037
申请日：1984-11-06
申请人： Philippe Briet , Jean-Jacques Berthelon , Francois Collonges
发明人： Philippe Briet , Jean-Jacques Berthelon , Francois Collonges
IPC分类号： A61K31/35 , A61K31/352 , A61K31/38 , A61K31/535 , A61P35/00 , C07D311/22 , C07D311/30 , C07D311/36 , C07D407/04 , C07D409/04 , C07D409/06 , C07D311/26
CPC分类号： C07D407/04 , C07D311/22 , C07D311/30 , C07D311/36 , C07D409/04
摘要： The invention concerns: (oxo-4-4H-(1)-benzopyran-8-yl) alkanoic acids and their derivatives, their manufacture, represented by the formula: ##STR1## where Ar is hydrogen, a phenyl radical which may or may not be substituted, thenyl, furyl, naphthyl, a lower alkyl, cycloalkyl, aralkyl radical; B is a linear or branched lower alkyl radical, either saturated or ethylinically unsaturated; R.sub.1 is hydrogen or a phenyl radical; X is hydrogen or a lower alkyl or alkoxy radical and n=1, as well as salts, esters, aminoesters and amides.Compounds and their derivatives may be used as medicines, in particular in the control of tumors.
摘要翻译：本发明涉及：（氧代-4-4H-（1） - 苯并吡喃-8-基）链烷酸及其衍生物，它们的制备由下式表示：其中Ar是氢，苯基可以或可以未取代的噻吩基，呋喃基，萘基，低级烷基，环烷基，芳烷基; B是直链或支链的低级烷基，饱和或亚乙基不饱和的; R1是氢或苯基; X是氢或低级烷基或烷氧基，n = 1，以及盐，酯，氨基酯和酰胺。化合物及其衍生物可用作药物，特别是用于控制肿瘤。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式