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1. 发明申请

US20100268072A1 METHOD AND APPARATUS FOR POSITIONAL TRACKING OF THERAPEUTIC ULTRASOUND TRANSDUCER 审中-公开
标题翻译：用于治疗超声波传感器的位置跟踪的方法和装置
公开(公告)号：US20100268072A1
公开(公告)日：2010-10-21
申请号：US12741831
申请日：2008-11-13
申请人： Christopher Stephen Hall , Chien Ting Chin , Balasundara I. Raju , William Tao Shi , Guy Shechter
发明人： Christopher Stephen Hall , Chien Ting Chin , Balasundara I. Raju , William Tao Shi , Guy Shechter
IPC分类号： A61B5/05 , A61N7/00
CPC分类号： A61N7/02 , A61B34/20 , A61B34/25 , A61B2017/00123 , A61B2090/372 , A61M37/0092 , A61N2007/0008
摘要： A therapeutic ultrasound tracking system (10) includes a first and second plurality of tracking elements ((14, 16, 18),(20,22,24)), a tracking generator (26), and a system controller (28). The first plurality of tracking elements (14, 16, 18) is disposed in a first position and orientation with respect to each another and with respect to an energy emission surface (30) of a therapeutic ultrasound probe (12). The second plurality of tracking elements (20,22,24) is adapted to be coupled to a patient (42) in a second position and orientation with respect to each other and with respect to a target region of the patient which is to receive a therapeutic treatment. The tracking generator (26) emits tracking energy for use in connection with the first and second plurality of tracking elements. The system controller (28) detects whether the probe (12) is positioned within an allowable position and orientation with respect to the target region, and (i) responsive to detecting the probe being within the allowable position and orientation, the system controller enables an energization of the probe to perform one of (i)(a) commence the therapeutic treatment and (i)(b) continue the therapeutic treatment, and (ii) responsive to not detecting the probe being within the allowable position and orientation, the system controller disables the energization of the probe for the therapeutic treatment.
摘要翻译：治疗性超声跟踪系统（10）包括第一和第二多个跟踪元件（（14,16,18），（20,22,24）），跟踪发生器（26）和系统控制器（28）。第一组多个跟踪元件（14,16,18）相对于彼此并且相对于治疗性超声波探头（12）的能量发射表面（30）设置在第一位置和方向上。第二组多个跟踪元件（20,22,24）适于以相对于彼此并且相对于要接收患者的目标区域的第二位置和取向联接到患者（42）治疗方法。跟踪发生器（26）发射用于与第一和第二多个跟踪元件结合使用的跟踪能量。系统控制器（28）检测探头（12）是否位于相对于目标区域的允许位置和方位之内，以及（i）响应于探测器在允许的位置和方向上的检测，系统控制器（i）（a）中的一个的通电开始治疗处理，（i）（b）继续治疗，以及（ii）响应于不检测探针在允许的位置和方向内，系统控制器禁用用于治疗治疗的探针通电。

2. 发明申请

US20120029397A1 TUMOR TREATMENT USING ULTRASOUND CAVITATION 审中-公开
标题翻译：使用超声波治疗肿瘤治疗
公开(公告)号：US20120029397A1
公开(公告)日：2012-02-02
申请号：US13262924
申请日：2010-04-02
申请人： Chien Ting Chin , Christopher Stephen Hall , Alexander L. Klibanov
发明人： Chien Ting Chin , Christopher Stephen Hall , Alexander L. Klibanov
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/481 , A61B2017/22008 , A61N2007/0039
摘要： Growth in body tissue is slowed, arrested or reversed. In one aspect, this is accomplished by providing bubbles (S315), and delivering, to cause temporary change in physiology that at least one of retards, arrests and reverses said growth, a series of one or more pulses (206) of energy to respective focal points (213) at the site of the growth. In another aspect, temporary change in physiology, such as transient vasospasm (216) in vasculature of a neoplasm, is induced via the mechanical, non-thermal effects of fluid cavitation caused by the pulses. The bubbles, for facilitating the cavitation, in some embodiments, are afforded by administration of a microbubble agent to the host.
摘要翻译：身体组织的增长减慢，被阻止或逆转。在一个方面，这是通过提供气泡（S315）和递送，以引起生理学的暂时改变，使至少一个延迟，阻止和逆转所述生长，将一系列一个或多个能量脉冲（206）分配到相应的联络点（213）在现场的增长。另一方面，通过由脉冲引起的流体空化的机械非热效应来诱导生理学的暂时性变化，例如肿瘤脉管系统中的瞬时血管痉挛（216）。在一些实施方案中，用于促进气蚀的气泡通过向主体施用微泡剂来提供。

3. 发明授权

US08764665B2 Methods and apparatuses of microbeamforming with adjustable fluid lenses 失效
标题翻译：具有可调节流体透镜的微波成像的方法和装置
公开(公告)号：US08764665B2
公开(公告)日：2014-07-01
申请号：US12596841
申请日：2008-04-30
申请人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： A61B8/00
CPC分类号： G10K11/30
摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

4. 发明申请

US20100087735A1 METHODS AND APPARATUSES OF MICROBEAMFORMING WITH ADJUSTABLE FLUID LENSES 失效
标题翻译：具有可调节流体镜片的微球的方法和装置
公开(公告)号：US20100087735A1
公开(公告)日：2010-04-08
申请号：US12596841
申请日：2008-04-30
申请人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： A61B8/00 , G03B42/06
CPC分类号： G10K11/30
摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

5. 发明授权

US09757034B2 Flexible tether with integrated sensors for dynamic instrument tracking 有权
公开(公告)号：US09757034B2
公开(公告)日：2017-09-12
申请号：US13877343
申请日：2011-10-06
申请人： Adrien Emmanuel Desjardins , Gert Wim 'T Hooft , Raymond Chan , Robert Manzke , Guy Shechter , Christopher Stephen Hall
发明人： Adrien Emmanuel Desjardins , Gert Wim 'T Hooft , Raymond Chan , Robert Manzke , Guy Shechter , Christopher Stephen Hall
IPC分类号： A61B6/00 , A61B5/00 , A61B34/20 , A61B90/98 , A61B17/34 , A61B90/00
CPC分类号： A61B5/0033 , A61B6/4494 , A61B17/3478 , A61B34/20 , A61B90/98 , A61B2034/2061 , A61B2090/3764
摘要： A system and method are provided for tracking a functional part of an instrument during an interventional procedure and displaying dynamic imaging corresponding to a functional part of the instrument. The system comprises: at least one instrument; a system for acquiring anatomical images relevant to guiding the instrument; a tether connected to the imaging system at a fixed end and connected to the instrument at a distal end, the tether comprising at least one longitudinal optical fiber with a plurality of optical shape sensors; an optical console that interrogates the sensors and detects reflected light; and a processor that calculates local curvature at each sensor location to determine the three-dimensional shape of the tether and determines the location and orientation of the instrument relative to the images using the local curvatures of the tether and the location of the fixed end of the tether.

6. 发明申请

US20110020236A1 METHOD FOR THE SYNTHESIS OF HOLLOW SPHERES 审中-公开
标题翻译：中空球藻合成方法
公开(公告)号：US20110020236A1
公开(公告)日：2011-01-27
申请号：US12933126
申请日：2009-03-13
申请人： Marcel Rene Bohmer , Caecilia Hendrina Theodora Chlon , William Tao Shi , Christopher Stephen Hall
发明人： Marcel Rene Bohmer , Caecilia Hendrina Theodora Chlon , William Tao Shi , Christopher Stephen Hall
IPC分类号： A61K49/18 , C08J9/00 , A61K9/50 , A61K49/04 , A61K49/00 , A61B8/00
CPC分类号： A61K49/223 , A61K9/5153 , A61K9/5192 , A61K41/0028 , A61K49/0002 , B01J13/125
摘要： The present invention relates to a method of synthesizing acoustically active biodegradable hollow spheres with a size below 1 micron. By using water soluble organic solvents and pegylated polymers, direct precipitation of these spheres is facilitated leading to a fast and convenient preparation route.
摘要翻译：本发明涉及一种合成尺寸低于1微米的声学活性生物可降解中空球的方法。通过使用水溶性有机溶剂和聚乙二醇化聚合物，促进这些球体的直接沉淀，从而导致快速和方便的制备途径。

7. 发明申请

US20130131499A1 APPARATUS, SYSTEM AND METHOD FOR IMAGING AND TREATMENT USING OPTICAL POSITION SENSING 审中-公开
标题翻译：装置，使用光学位置感测成像和处理的系统和方法
公开(公告)号：US20130131499A1
公开(公告)日：2013-05-23
申请号：US13577268
申请日：2011-01-14
申请人： Raymond Chan , Guy Shechter , Adrien Emmanuel Desjardins , Gert 'T Hooft , Christopher Stephen Hall
发明人： Raymond Chan , Guy Shechter , Adrien Emmanuel Desjardins , Gert 'T Hooft , Christopher Stephen Hall
IPC分类号： A61B5/06
CPC分类号： A61B5/065 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4245 , A61B8/4254 , A61B8/4263 , A61B8/4405 , A61B8/4483 , A61B34/20 , A61N7/02
摘要： An apparatus, system and method for determining a position includes a transducer device (102) configured to receive signals from a console (104) and generate images based upon reflected waves. A flexible cable (108) is coupled to the transducer device to provide excitation energy to the transducer device from the console. An optical fiber (110) has a shape and position corresponding to a shape and position of the cable during operation. A plurality of sensors (122) is in optical communication with the optical fiber. The sensors are configured to measure deflections and bending in the optical fiber such that the deflections and bending in the optical fiber are employed to determine positional information about the transducer device.
摘要翻译：用于确定位置的装置，系统和方法包括被配置为从控制台（104）接收信号并基于反射波产生图像的换能器装置（102）。柔性电缆（108）耦合到换能器装置，以从控制台向换能器装置提供激发能量。光纤（110）具有在操作期间对应于电缆的形状和位置的形状和位置。多个传感器（122）与光纤光学通信。传感器被配置为测量光纤中的偏转和弯曲，使得光纤中的偏转和弯曲被用于确定关于换能器装置的位置信息。

8. 发明授权

US10194831B2 Apparatus, system and method for imaging and treatment using optical position sensing 有权
公开(公告)号：US10194831B2
公开(公告)日：2019-02-05
申请号：US13577268
申请日：2011-01-14
申请人： Raymond Chan , Guy Shechter , Adrien Emmanuel Desjardins , Gert 'T Hooft , Christopher Stephen Hall
发明人： Raymond Chan , Guy Shechter , Adrien Emmanuel Desjardins , Gert 'T Hooft , Christopher Stephen Hall
IPC分类号： A61B5/06 , A61B8/12 , A61B8/00 , A61B8/08 , A61N7/02 , A61B34/20
摘要： An apparatus, system and method for determining a position includes a transducer device (102) configured to receive signals from a console (104) and generate images based upon reflected waves. A flexible cable (108) is coupled to the transducer device to provide excitation energy to the transducer device from the console. An optical fiber (110) has a shape and position corresponding to a shape and position of the cable during operation. A plurality of sensors (122) is in optical communication with the optical fiber. The sensors are configured to measure deflections and bending in the optical fiber such that the deflections and bending in the optical fiber are employed to determine positional information about the transducer device.

9. 发明申请

US20130188855A1 FLEXIBLE TETHER WITH INTEGRATED SENSORS FOR DYNAMIC INSTRUMENT TRACKING 有权
标题翻译：具有集成传感器用于动态仪器跟踪的柔性四面体
公开(公告)号：US20130188855A1
公开(公告)日：2013-07-25
申请号：US13877343
申请日：2011-10-06
申请人： Adrien Emmanuel Desjardins , Gert Wim 'T Hooft , Raymond Chan , Robert Manzke , Guy Shechter , Christopher Stephen Hall
发明人： Adrien Emmanuel Desjardins , Gert Wim 'T Hooft , Raymond Chan , Robert Manzke , Guy Shechter , Christopher Stephen Hall
IPC分类号： A61B5/00
CPC分类号： A61B5/0033 , A61B6/4494 , A61B17/3478 , A61B34/20 , A61B90/98 , A61B2034/2061 , A61B2090/3764
摘要： A system and method are provided for tracking a functional part of an instrument during an interventional procedure and displaying dynamic imaging corresponding to a functional part of the instrument. The system comprises: at least one instrument; a system for acquiring anatomical images relevant to guiding the instrument; a tether connected to the imaging system at a fixed end and connected to the instrument at a distal end, the tether comprising at least one longitudinal optical fiber with a plurality of optical shape sensors; an optical console that interrogates the sensors and detects reflected light; and a processor that calculates local curvature at each sensor location to determine the three-dimensional shape of the tether and determines the location and orientation of the instrument relative to the images using the local curvatures of the tether and the location of the fixed end of the tether.
摘要翻译：提供了一种系统和方法，用于在介入过程期间跟踪仪器的功能部分，并显示对应于仪器的功能部分的动态成像。该系统包括：至少一个仪器; 用于获取与引导仪器相关的解剖图像的系统; 在固定端连接到成像系统并在远端连接到仪器的系绳，所述系绳包括具有多个光学形状传感器的至少一个纵向光纤; 光学控制台，用于询问传感器并检测反射光; 以及处理器，其计算每个传感器位置处的局部曲率以确定系绳的三维形状，并且使用系绳的局部曲率和固定端的位置来确定乐器相对于图像的位置和取向系绳

10. 发明授权

US08475442B2 Ultrasonic assembly with adjustable fluid lens 失效
标题翻译：超声波组件带可调节液晶镜头
公开(公告)号：US08475442B2
公开(公告)日：2013-07-02
申请号：US12663307
申请日：2008-07-07
申请人： Christopher Stephen Hall , Anna Teresa Fernandez , Jan Frederik Suijver
发明人： Christopher Stephen Hall , Anna Teresa Fernandez , Jan Frederik Suijver
IPC分类号： A61B18/04
CPC分类号： A61N7/022 , A61B2017/00243 , A61N2007/0056 , G10K11/30
摘要： An ultrasonic assembly suited for attachment to a catheter, e.g. for medical treatment. The ultrasonic assembly includes an adjustable ultrasonic focus mechanism arranged in connection with the ultrasonic transducer to adjust focus of ultrasonic waves generated by the transducer. The ultrasonic focus mechanism includes a fluid focus lens with at least two fluids separated by an interface such that ultrasonic waves are substantially reflected at the interface. At least two electrodes are arranged in connection with the fluid focus lens so as to allow adjustment of the interface shape, e.g. a curvature of the interface, when a voltage is applied to the electrodes. In preferred embodiments the electrodes are arranged so as to allow adjustment of the fluid focus lens in an elevation direction as well as in a radial direction. In simple embodiments with rotational symmetric geometry with the transducer positioned in the center of the fluid focus lens, ultrasonic waves can be focused in an annular ring. This is e.g. suitable for ablative or coagulative necrotic treatment of human tissue, e.g. for atrial fibrillation treatment. In some embodiments, the assembly has a number of separate individually adjustable fluid focus lens compartments allowing a more detailed control of the ultrasonic focus pattern.
摘要翻译：适于附接到导管的超声波组件，例如用于治疗。超声波组件包括与超声波换能器连接布置的可调超声波聚焦机构，以调节由换能器产生的超声波的焦点。超声波聚焦机构包括流体聚焦透镜，其中至少两个流体被界面分开，使得超声波在界面处被大体上反射。至少两个电极与流体聚焦透镜连接设置，以便允许调节界面形状，例如，当向电极施加电压时，界面的曲率。在优选实施例中，电极被布置成允许在高度方向以及径向方向上调整流体聚焦透镜。在具有旋转对称几何形状的简单实施例中，换能器定位在流体聚焦透镜的中心，超声波可以聚焦在环形环中。这是例如适用于人体组织的消融或凝血坏死治疗，例如用于心房颤动治疗。在一些实施例中，组件具有多个单独可单独调节的流体聚焦透镜隔室，允许对超声波聚焦图案进行更详细的控制。

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