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1. 发明申请

US20100261985A1 METHOD AND APPARATUS FOR DETERMINING HYDRATION LEVELS FROM SKIN TURGOR 审中-公开
标题翻译：用于确定皮肤水分的水平水平的方法和装置
公开(公告)号：US20100261985A1
公开(公告)日：2010-10-14
申请号：US12294640
申请日：2007-03-29
申请人： Eric Cohen-Solal , Yan S. Shi , Balasundara I. Raju
发明人： Eric Cohen-Solal , Yan S. Shi , Balasundara I. Raju
IPC分类号： A61B5/00
CPC分类号： A61B5/4875 , A61B5/0055 , A61B5/442 , A61B8/0858
摘要： A method and apparatus for determining patient hydration levels is disclosed. The method includes measuring a skin turgor. Suction measurements are performed, wherein the distance between an ultrasound transducer and the skin surface is measured over time.
摘要翻译：公开了一种用于确定患者水合水平的方法和装置。该方法包括测量皮肤膨胀。进行抽吸测量，其中测量超声换能器和皮肤表面之间的距离随时间变化。

2. 发明申请

US20100016765A1 INTEGRATED SPECT IMAGING AND ULTRASOUND THERAPY SYSTEM 审中-公开
标题翻译：一体化SPECT成像和超声治疗系统
公开(公告)号：US20100016765A1
公开(公告)日：2010-01-21
申请号：US12520432
申请日：2007-12-19
申请人： Christopher S. Hall , Shunmugavelu Sokka , Balasundara I. Raju
发明人： Christopher S. Hall , Shunmugavelu Sokka , Balasundara I. Raju
IPC分类号： A61N7/00 , A61M5/00 , G01T1/164 , G01T1/20
CPC分类号： A61N7/02 , A61B6/037
摘要： A method and apparatus for the integration of an ultrasound transducer with a SPECT imaging system is disclosed. The ultrasound transducer allows the delivery of particle-born drug therapies or thermally active therapies at the same site detected with SPECT imaging. The system includes a SPECT imaging subsystem; an ultrasound transducer for producing a signal representative of applied ultrasound and signally coupled to the SPECT imaging subsystem; and co-registering means for co-registering the signal representative of applied ultrasound in a coordinate system of SPECT imaging subsystem. The SPECT subsystem may be replaced with a SPECT/CT combined system to provide morphology that allows for treatment planning. In another embodiment, the ultrasound transducer can be used intermittently with the sequential gathering of SPECT images for tracking time-varying properties of the binding of specific SPECT contrast agents to biomarkers of disease. In this way, the ultrasound and SPECT imaging devices form a novel combination to improve patient care through improved spatial registration, therapy planning, and workflow.
摘要翻译：公开了一种用于将超声换能器与SPECT成像系统集成的方法和装置。超声换能器允许在用SPECT成像检测的相同部位输送粒子出生的药物治疗或热活性治疗。该系统包括一个SPECT成像子系统; 超声换能器，用于产生代表施加的超声波并且信号耦合到SPECT成像子系统的信号; 以及用于在SPECT成像子系统的坐标系中共同对应表示应用的超声波的信号的共同配准装置。可以用SPECT / CT组合系统替换SPECT子系统，以提供允许治疗计划的形态。在另一个实施例中，可以间歇地使用超声换能器与SPECT图像的顺序收集，以跟踪特定SPECT造影剂与疾病生物标志物的结合的时变特性。以这种方式，超声和SPECT成像装置形成了一种新颖的组合，通过改进空间注册，治疗计划和工作流程来改善患者的护理。

3. 发明申请

US20090018449A1 Ultrasonic Method and Apparatus for Measuring or Detecting Flow Behavior of a Non-Sinusoidal Periodicity 审中-公开
标题翻译：用于测量或检测非正弦周期的流动行为的超声波方法和装置
公开(公告)号：US20090018449A1
公开(公告)日：2009-01-15
申请号：US12161983
申请日：2007-01-29
申请人： Balasundara I. Raju
发明人： Balasundara I. Raju
IPC分类号： A61B8/06
CPC分类号： A61B8/06 , A61B5/021 , A61B5/0402 , A61B5/7207 , A61B8/08 , A61B8/488 , A61B8/5269 , A61B8/543 , A61N1/3925
摘要： A method and apparatus for automated detection of a general, non-sinusoidal type of periodicity in ultrasound Doppler signals from pulsatile blood flow is described. The method computes a pulsation index, which is a sum of the normalized powers of the fundamental and several harmonic components in the frequency spectrum of the banded Doppler signal. A weighting function may be applied to the power from each harmonic component in order to suppress contributions due to spurious peaks, as in the case when pulsatile flow is absent.
摘要翻译：描述了用于自动检测来自脉动血流的超声多普勒信号中的一般非正弦型周期性的方法和装置。该方法计算脉动指数，其是带状多普勒信号的频谱中的基波和多个谐波分量的归一化功率之和。加权函数可以应用于来自每个谐波分量的功率，以便抑制由于假峰造成的贡献，如在不存在脉动流的情况下。

4. 发明授权

US10058718B2 Transurethral ultrasound probe for treatment of prostate 有权
公开(公告)号：US10058718B2
公开(公告)日：2018-08-28
申请号：US13202602
申请日：2010-02-05
申请人： Shriram Sethuraman , Gosta Ehnholm , Balasundara I. Raju
发明人： Shriram Sethuraman , Gosta Ehnholm , Balasundara I. Raju
IPC分类号： A61H1/00 , A61N7/02 , A61B17/00 , A61B18/00 , A61B90/00
CPC分类号： A61N7/022 , A61B2017/00911 , A61B2018/00023 , A61B2090/0472 , A61B2090/374
摘要： A probe including a shaft on which an ultrasound element is mounted, an outer sheath and an acoustic membrane surrounding the shaft and the ultrasound element such that the shaft and ultrasound element are rotatable therein. Passages may supply a cooling and acoustic coupling fluid to an inlet and outlet adjacent the acoustic element to cool the acoustic element and fill a volume between the acoustic element and the acoustic sheath with the fluid. A balloon may be mounted on the probe to be selectively inflated to fix a position of the probe. A drain for urine and other bodily fluids may be provided through the probe.

5. 发明申请

US20110301508A1 TRANSURETHRAL ULTRASOUND PROBE FOR TREATMENT OF PROSTATE 审中-公开
标题翻译：用于治疗前列腺的超声超声探头
公开(公告)号：US20110301508A1
公开(公告)日：2011-12-08
申请号：US13202602
申请日：2010-02-05
申请人： Shriram Sethuraman , Gosta Ehnholm , Balasundara I. Raju
发明人： Shriram Sethuraman , Gosta Ehnholm , Balasundara I. Raju
IPC分类号： A61N7/00
CPC分类号： A61N7/022 , A61B2017/00911 , A61B2018/00023 , A61B2090/0472 , A61B2090/374
摘要： A probe (40) includes a shaft (52) on which an ultrasound element (42) is mounted. An outer sheath (64) and an acoustic membrane (66) surround the shaft and the ultrasound element such that the shaft and ultrasound element are rotatable therein. Passages (56) supply a cooling and acoustic coupling fluid to an inlet and outlet (48) adjacent the acoustic element to cool the acoustic element and fill a volume between the acoustic element and the acoustic sheath with the fluid. A balloon (90) mounted on the probe is selectively inflated in order to fix a position of the probe. A drain (94, 98) drains urine and other bodily fluids through the probe.
摘要翻译：探针（40）包括其上安装有超声波元件（42）的轴（52）。围绕轴和超声波元件的外护套（64）和声膜（66）使得轴和超声元件能够在其中旋转。通道（56）将冷却和声耦合流体提供给邻近声学元件的入口和出口（48），以冷却声学元件并用流体填充声学元件和声学护套之间的体积。安装在探针上的球囊（90）选择性地膨胀以固定探针的位置。排水口（94,98）通过探头排出尿液和其他体液。

6. 发明申请

US20100268072A1 METHOD AND APPARATUS FOR POSITIONAL TRACKING OF THERAPEUTIC ULTRASOUND TRANSDUCER 审中-公开
标题翻译：用于治疗超声波传感器的位置跟踪的方法和装置
公开(公告)号：US20100268072A1
公开(公告)日：2010-10-21
申请号：US12741831
申请日：2008-11-13
申请人： Christopher Stephen Hall , Chien Ting Chin , Balasundara I. Raju , William Tao Shi , Guy Shechter
发明人： Christopher Stephen Hall , Chien Ting Chin , Balasundara I. Raju , William Tao Shi , Guy Shechter
IPC分类号： A61B5/05 , A61N7/00
CPC分类号： A61N7/02 , A61B34/20 , A61B34/25 , A61B2017/00123 , A61B2090/372 , A61M37/0092 , A61N2007/0008
摘要： A therapeutic ultrasound tracking system (10) includes a first and second plurality of tracking elements ((14, 16, 18),(20,22,24)), a tracking generator (26), and a system controller (28). The first plurality of tracking elements (14, 16, 18) is disposed in a first position and orientation with respect to each another and with respect to an energy emission surface (30) of a therapeutic ultrasound probe (12). The second plurality of tracking elements (20,22,24) is adapted to be coupled to a patient (42) in a second position and orientation with respect to each other and with respect to a target region of the patient which is to receive a therapeutic treatment. The tracking generator (26) emits tracking energy for use in connection with the first and second plurality of tracking elements. The system controller (28) detects whether the probe (12) is positioned within an allowable position and orientation with respect to the target region, and (i) responsive to detecting the probe being within the allowable position and orientation, the system controller enables an energization of the probe to perform one of (i)(a) commence the therapeutic treatment and (i)(b) continue the therapeutic treatment, and (ii) responsive to not detecting the probe being within the allowable position and orientation, the system controller disables the energization of the probe for the therapeutic treatment.
摘要翻译：治疗性超声跟踪系统（10）包括第一和第二多个跟踪元件（（14,16,18），（20,22,24）），跟踪发生器（26）和系统控制器（28）。第一组多个跟踪元件（14,16,18）相对于彼此并且相对于治疗性超声波探头（12）的能量发射表面（30）设置在第一位置和方向上。第二组多个跟踪元件（20,22,24）适于以相对于彼此并且相对于要接收患者的目标区域的第二位置和取向联接到患者（42）治疗方法。跟踪发生器（26）发射用于与第一和第二多个跟踪元件结合使用的跟踪能量。系统控制器（28）检测探头（12）是否位于相对于目标区域的允许位置和方位之内，以及（i）响应于探测器在允许的位置和方向上的检测，系统控制器（i）（a）中的一个的通电开始治疗处理，（i）（b）继续治疗，以及（ii）响应于不检测探针在允许的位置和方向内，系统控制器禁用用于治疗治疗的探针通电。

7. 发明申请

US20100076315A1 METHOD AND APPARATUS FOR HANDS-FREE ULTRASOUND 审中-公开
标题翻译：无手术超声的方法和装置
公开(公告)号：US20100076315A1
公开(公告)日：2010-03-25
申请号：US12442710
申请日：2007-09-10
申请人： Ramon Q. Erkamp , Eric V. Cohen-Solal , Balasundara I. Raju , Jose M. I. Azevedo
发明人： Ramon Q. Erkamp , Eric V. Cohen-Solal , Balasundara I. Raju , Jose M. I. Azevedo
IPC分类号： A61B8/14
CPC分类号： A61B8/4236 , A61B6/541 , A61B8/06 , A61B8/4281 , A61B8/4444 , A61B8/565
摘要： A skin-mounted device (10) comprises an acoustic module (24) and an attachment assembly (16). An acoustically coupling layer (34) affixes and acoustically couples the module (24) to a skin (18).
摘要翻译：皮肤安装装置（10）包括声学模块（24）和附接组件（16）。声耦合层（34）将模块（24）附接并声学耦合到皮肤（18）。

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