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1. 发明申请

US20080020478A1 Method of Detecting an Analyte Using a Holographic Sensor 审中-公开
标题翻译：使用全息传感器检测分析物的方法
公开(公告)号：US20080020478A1
公开(公告)日：2008-01-24
申请号：US11597983
申请日：2005-06-06
申请人： Christopher Lowe , Satyamoorthy Kabilan , Mei-Ching Lee
发明人： Christopher Lowe , Satyamoorthy Kabilan , Mei-Ching Lee
IPC分类号： G01N33/66 , A61B3/10 , G01N21/00 , G02B5/32 , G01N21/01
CPC分类号： G01N21/4788 , G01N21/75 , G03H1/0005 , G03H1/0011 , G03H1/0248 , G03H2001/0033 , G03H2210/55 , G03H2270/55 , Y10T436/20
摘要： A method for the detection of an analyte in a fluid, which comprises contacting the fluid with a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the variation arises as a result of interaction between the medium and the analyte; and detecting any change of the optical characteristic of the element; wherein (a) the medium comprises a group which is capable of reacting with the analyte, wherein the analyte or the group is capable of existing in a plurality of forms, and the detecting is conducted in the presence of a first catalyst which is capable of catalysing the conversion of a relatively less reactive form of the analyte or group to a relatively more reactive form; or (b) the fluid comprises a component, other than the analyte, which is capable of interacting with the medium, and the detecting is conducted in the presence of a second catalyst capable of catalysing the removal of said component.
摘要翻译：一种用于检测流体中的分析物的方法，其包括使流体与包括介质的全息元件和设置在介质的整个体积中的全息图接触，其中元件的光学特性由于变化而变化在介质的整个体积中发生的物理性质，并且其中由于介质和分析物之间的相互作用而产生变化; 并检测元件的光学特性的任何变化; 其中（a）所述培养基包括能够与分析物反应的基团，其中所述分析物或所述基团能够以多种形式存在，并且所述检测在第一催化剂存在下进行，所述第一催化剂能够催化相对较少反应性形式的分析物或基团转化成相对更具反应性的形式; 或（b）流体包含能够与介质相互作用的分析物以外的成分，并且在能够催化除去所述成分的第二催化剂的存在下进行检测。

2. 发明申请

US20060063038A1 Holographic sensor 失效
标题翻译：全息传感器
公开(公告)号：US20060063038A1
公开(公告)日：2006-03-23
申请号：US10545275
申请日：2004-02-13
申请人： Christopher Lowe , Jeffrey Blyth , Satyamoorthy Kabilan , Abid Hussain , Xiaoping Yang , Felicity Sartain , Mei-Ching Lee
发明人： Christopher Lowe , Jeffrey Blyth , Satyamoorthy Kabilan , Abid Hussain , Xiaoping Yang , Felicity Sartain , Mei-Ching Lee
IPC分类号： B32B27/00 , G02B5/32 , B32B9/04
CPC分类号： G03H1/02 , G02B5/32 , G03H2260/12 , Y10T436/143333 , Y10T436/144444
摘要： A sensor for the detection of an analyte comprising a cis-diol moiety, which comprises a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the medium is a polymer comprising a group of formula (I): wherein n is 0, 1, 2, 3 or 4; each X (if present) is independently is an atom or group which, viaan electronic effect, promotes formation of a tetrahedral geometry about the boron atom; and Y is a spacer which, when n is 0 or otherwise optionally, is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom. Such a sensor may be used for the detection of glucose.
摘要翻译：一种用于检测包含顺式二醇部分的分析物的传感器，其包括全息元件，该全息元件包括介质和设置在介质的整个体积中的全息图，其中该元件的光学特性由于介质是包含式（I）的基团的聚合物：其中n为0,1,2,3或4; 每个X（如果存在）独立地是通过电子效应促进围绕硼原子形成四面体几何形状的原子或基团; 并且Y是间隔基，当n为0或以其它方式任选时，其是通过电子效应促进围绕硼原子形成四面体几何形状的原子或基团。这种传感器可用于检测葡萄糖。

3. 发明授权

US08334140B2 Boronate complex and its use in a glucose sensor 失效
标题翻译：硼酸复合物及其在葡萄糖传感器中的应用
公开(公告)号：US08334140B2
公开(公告)日：2012-12-18
申请号：US12093038
申请日：2006-11-08
申请人： Satyamoorthy Kabilan , Mei-Ching Lee , Adrian Martin Horgan , Kathryn Elizabeth Sorrell Medlock , Christopher Robin Lowe , Jeffrey Blyth
发明人： Satyamoorthy Kabilan , Mei-Ching Lee , Adrian Martin Horgan , Kathryn Elizabeth Sorrell Medlock , Christopher Robin Lowe , Jeffrey Blyth
IPC分类号： G01N33/00
CPC分类号： G01N21/4788 , G01N21/453 , G01N33/66 , G02B5/32 , Y10T436/144444
摘要： A sensor comprises respective acceptor and donor compounds immobilised in or on a matrix including a glucose-binding boronate and a cationic species, whereby the spacing between the acceptor and donor compounds is reduced in the presence of glucose. For example a holographic sensor comprises a glucose-binding boronate and a cationic species held within the sensor.
摘要翻译：传感器包括固定在包含葡萄糖结合硼酸盐和阳离子种类的基质中或基质中的相应受体和供体化合物，由此在葡萄糖存在下，受体和供体化合物之间的间距减小。例如，全息传感器包括葡萄糖结合硼酸盐和保持在传感器内的阳离子物质。

4. 发明申请

US20120107944A1 Holographic Sensor 审中-公开
标题翻译：全息传感器
公开(公告)号：US20120107944A1
公开(公告)日：2012-05-03
申请号：US13284094
申请日：2011-10-28
申请人： Christopher Robin Lowe , Jeffrey Blyth , Satyamoorthy Kabilan , Abid Hussain , Xiaoping Yang , Felicity Kate Sartain , Mei-Ching Lee
发明人： Christopher Robin Lowe , Jeffrey Blyth , Satyamoorthy Kabilan , Abid Hussain , Xiaoping Yang , Felicity Kate Sartain , Mei-Ching Lee
IPC分类号： G01N33/66
CPC分类号： G03H1/02 , G02B5/32 , G03H2260/12 , Y10T436/143333 , Y10T436/144444
摘要： A sensor for the detection of an analyte comprising a cis-diol moiety, which comprises a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the medium is a polymer comprising a group of formula (i) wherein n is 0, 1, 2, 3 or 4; each X (if present) is independently is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom; and Y is a spacer which, when n is 0 or otherwise optionally, is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom. Such a sensor may be used for the detection of glucose.
摘要翻译：一种用于检测包含顺式二醇部分的分析物的传感器，其包括全息元件，该全息元件包括介质和设置在介质的整个体积中的全息图，其中该元件的光学特性由于介质是包含其中n为0,1,2,3或4的式（ⅰ）基团的聚合物; 每个X（如果存在）独立地是通过电子效应促进形成围绕硼原子的四面体几何形状的原子或基团; 并且Y是间隔基，当n为0或以其它方式任选时，其是通过电子效应促进围绕硼原子形成四面体几何形状的原子或基团。这种传感器可用于检测葡萄糖。

5. 发明授权

US08048680B2 Holographic sensor 失效
标题翻译：全息传感器
公开(公告)号：US08048680B2
公开(公告)日：2011-11-01
申请号：US10545275
申请日：2004-02-13
申请人： Christopher Robin Lowe , Jeffrey Blyth , Satyamoorthy Kabilan , Abid Hussain , Xiaoping Yang , Felicity Kate Sartain , Mei-Ching Lee
发明人： Christopher Robin Lowe , Jeffrey Blyth , Satyamoorthy Kabilan , Abid Hussain , Xiaoping Yang , Felicity Kate Sartain , Mei-Ching Lee
IPC分类号： C12P19/22
CPC分类号： G03H1/02 , G02B5/32 , G03H2260/12 , Y10T436/143333 , Y10T436/144444
摘要： A sensor for the detection of an analyte comprising a cis-diol moiety, which comprises a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the medium is a polymer comprising a group of formula (I): wherein n is 0, 1, 2, 3 or 4; each X (if present) is independently is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom; and Y is a spacer which, when n is 0 or otherwise optionally, is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom. Such a sensor may be used for the detection of glucose.
摘要翻译：一种用于检测包含顺式二醇部分的分析物的传感器，其包括全息元件，该全息元件包括介质和设置在介质的整个体积中的全息图，其中该元件的光学特性由于介质是包含式（I）的基团的聚合物：其中n为0,1,2,3或4; 每个X（如果存在）独立地是通过电子效应促进形成围绕硼原子的四面体几何形状的原子或基团; 并且Y是间隔基，当n为0或以其它方式任选时，其是通过电子效应促进围绕硼原子形成四面体几何形状的原子或基团。这种传感器可用于检测葡萄糖。

6. 发明申请

US20100167416A1 Novel Boronate Complex and Its Use in a Glucose Sensor 失效
标题翻译：新型硼酸盐络合物及其在葡萄糖传感器中的应用
公开(公告)号：US20100167416A1
公开(公告)日：2010-07-01
申请号：US12093038
申请日：2006-11-08
申请人： Satyamoorthy Kabilan , Mei-Ching Lee , Adrian Martin Horgan , Kathryn Elizabeth Sorrell Medlock , Christopher Robin Lowe , Jeffrey Blyth
发明人： Satyamoorthy Kabilan , Mei-Ching Lee , Adrian Martin Horgan , Kathryn Elizabeth Sorrell Medlock , Christopher Robin Lowe , Jeffrey Blyth
IPC分类号： G01N33/53 , G01N30/00 , A61B5/145
CPC分类号： G01N21/4788 , G01N21/453 , G01N33/66 , G02B5/32 , Y10T436/144444
摘要： A sensor comprises respective acceptor and donor compounds immobilised in or on a matrix including a glucose-binding boronate and a cationic species, whereby the spacing between the acceptor and donor compounds is reduced in the presence of glucose. For example a holographic sensor comprises a glucose-binding boronate and a cationic species held within the sensor.
摘要翻译：传感器包括固定在包含葡萄糖结合硼酸盐和阳离子种类的基质中或基质中的相应受体和供体化合物，由此在葡萄糖存在下，受体和供体化合物之间的间距减小。例如，全息传感器包括葡萄糖结合硼酸盐和保持在传感器内的阳离子物质。

7. 发明申请

US20090106004A1 Systems and methods for evaluating interventions 审中-公开
标题翻译：用于评估干预措施的系统和方法
公开(公告)号：US20090106004A1
公开(公告)日：2009-04-23
申请号：US12285920
申请日：2008-10-16
申请人： Rogers A. Edwards , Alan Karl Graham , Michael Martin Amati , Melissa Kiriaki Williams , Caroline Rachael Wright , Mei-Ching Lee , Daniel Frederick Walsh, JR. , Nick Hughes
发明人： Rogers A. Edwards , Alan Karl Graham , Michael Martin Amati , Melissa Kiriaki Williams , Caroline Rachael Wright , Mei-Ching Lee , Daniel Frederick Walsh, JR. , Nick Hughes
IPC分类号： G06G7/60
CPC分类号： G16H50/80 , G16H50/30 , G16H50/50
摘要： A system and method for evaluating one or more interventions having a direct or indirect impact on a disease identification or a disease progression incorporating a causal framework to establish relationships among the disease, complications, and comorbidities. The system and method determines population groups and risk factors for the disease, complications, and comorbidities. The system and method structures and calibrates a simulation model of the relationships, population groups, and risk factors and characterizes interventions. The system and method analyzes the characterized interventions to determine the direct or indirect impact of the interventions on the disease identification or progression using the simulation model. An indication of the impact of the interventions is provided on an electronic display or to a memory device.
摘要翻译：一种用于评估一种或多种干预措施的系统和方法，所述干预措施对疾病识别或疾病进展具有直接或间接影响，其包括因果框架以建立疾病，并发症和合并症之间的关系。该系统和方法确定了疾病，并发症和合并症的人群和危险因素。系统和方法结构和校准关系，人口群体和风险因素的模拟模型，并描述干预措施。该系统和方法分析了特征性干预措施，以使用模拟模型确定干预措施对疾病识别或进展的直接或间接影响。在电子显示器或存储器件上提供干预的影响的指示。

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