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    • 2. 发明授权
    • Pipette tip rack and refill pack containing large maximized volume
freely nestable pipette tips
    • 移液器支架和充填包,其中包含大的最大体积可自由嵌套的移液器吸头
    • US5779984A
    • 1998-07-14
    • US759409
    • 1996-12-04
    • Christopher KellyDavid J. LemieuxHaakon T. Magnussen, Jr.James S. PetrekKenneth Rainin
    • Christopher KellyDavid J. LemieuxHaakon T. Magnussen, Jr.James S. PetrekKenneth Rainin
    • B01L9/00B65D25/10B01L3/02B65D85/00
    • B01L9/543B65D25/108
    • A plurality of large maximized internal volume freely nestable pipette tips for mounting in a standard pipette tip rack or refill pack including a horizontally extending pipette tip support having a plurality of through holes arranged in an array, each hole having a center which is spaced a distance "s" from centers of immediately adjacent through holes, each pipette tip having a substantially cylindrical proximal portion and an elongated generally conical distal portion coaxial with and joined to its proximal portion adjacent a downward facing outwardly extending shoulder and including at a distal end of the tip a relatively small orifice for receiving and dispensing fluid into and from the pipette tip upon operation of a pipette to which the pipette tip is mounted, the proximal portion of each pipette tip having an outer diameter equal to or slightly less than "s" and a slightly conical inner surface for tightly receiving and releasably attaching to a pipette tip mounting shaft of a large volume pipette and the distal portion of each pipette tip in a first array of tips being vertically oriented in a different one of the through holes in the support with its shoulder on a top of the support.
    • 多个大的最大化的内部体积可自由嵌套的移液管尖端,用于安装在标准移液管末端架或补充包中,其包括具有排列成阵列的多个通孔的水平延伸的移液管末梢支撑件,每个孔具有间隔一定距离的中心 “s”从紧邻的通孔的中心,每个移液管尖端具有基本上圆柱形的近端部分和细长的大致圆锥形的远端部分,该近端部分与其近端部分同轴并连接到邻近向下的向外延伸的肩部并且包括在远端 在操作移液管尖端安装移液管的操作时,将一个相当小的孔用于接收和分配流体和/或从移液管尖端分配流体,每个移液管尖端的近端部分具有等于或略小于“s”的外径, 一个稍微锥形的内表面,用于紧密地接收和可释放地附接到a的移液管尖端安装轴 大体积移液管,并且第一阵列尖端中的每个移液管尖端的远端部分垂直地定向在支撑件中的不同的一个通孔中,其肩部位于支撑件的顶部上。
    • 4. 发明授权
    • Volume adjustable manual pipette with quick set volume adjustment
    • 体积可调式手动移液器,可快速设定音量调节
    • US06428750B1
    • 2002-08-06
    • US09548439
    • 2000-04-13
    • Kenneth RaininHaakon T. Magnussen, Jr.Phillip YeeWilliam D. HombergJames S. Petrek
    • Kenneth RaininHaakon T. Magnussen, Jr.Phillip YeeWilliam D. HombergJames S. Petrek
    • B01L302
    • B01L3/0224Y10T436/2575
    • A volume adjustable manual pipette having a hand-holdable housing supporting (i) an electronic digital display and associated position sensing and control circuitry, (ii) a plunger unit and (iii) a quick set volume adjustment mechanism for simultaneously controlling the volume setting of the pipette and the electronic display, the quick set volume adjustment mechanism comprising a pipette volume setting member for limiting upward movement of the plunger unit within the housing to define the volume setting for the pipette and the volume setting member being supported for axial movement on the plunger unit and releasably secured relative to the housing by a pipette user operable locking mechanism. When released from the housing, the volume setting member is axially moveable on and with the plunger unit to quickly set the volume for the pipette. When secured to the housing, the plunger unit is axially moveable relative to the volume setting unit to aspirate and dispense the selected volume of liquid into and from a pipette tip extending from a lower end of the housing. The volume setting of the pipette is monitored by the sensing and control circuitry to provide a real time display of the volume setting of the pipette.
    • 一种体积可调节的手动移液器,其具有可手持的壳体,其支撑(i)电子数字显示器和相关联的位置感测和控制电路,(ii)柱塞单元和(iii)快速设定体积调节机构,用于同时控制 移液管和电子显示器,快速设定的体积调节机构包括用于限制柱塞单元在壳体内的向上运动的移液管体积调节构件,以限定用于移液管的体积设置,并且容积设定构件被支撑以在 柱塞单元,并通过移液管用户可操作的锁定机构相对于壳体可释放地固定。 当从壳体释放时,体积调节构件可以在柱塞单元上和与柱塞单元一起轴向移动以快速设定移液管的体积。 当固定到壳体时,柱塞单元相对于体积设定单元轴向移动,以将选定体积的液体吸入并分配到从壳体的下端延伸的移液管尖端和从其移出。 移液器的体积设置由感测和控制电路监控,以提供移液器的体积设置的实时显示。
    • 6. 发明授权
    • Pipette mechanism
    • 移液器机构
    • US4763535A
    • 1988-08-16
    • US004864
    • 1987-01-20
    • Kenneth RaininHaakon T. Magnussen, Jr.Roy P. Moeller
    • Kenneth RaininHaakon T. Magnussen, Jr.Roy P. Moeller
    • B01L3/02G01N1/14
    • B01L3/0224
    • A dashpot piston mounted in a closed chamber is coupled by an axially movable shaft to a pipette piston to regulate return movement of the pipette piston within a pipette cylinder to draw fluid into the cylinder. The dashpot shaft is movable within limits relative to the dashpot piston to accommodate a blow-out of residual fluid from the pipette by the shaft driving the pipette piston beyond a home position to blow residual fluid from the pipette cylinder. An air inlet port in the bottom of the chamber allows air to be drawn into the chamber with upward movement of the dashpot piston while a valve adjacent to the air inlet port opens in response to downward movement of the dashpot piston to exit air from the chamber. Control of the relative sizes of the air inlet port and valve outlet regulates the relative rates of upward and downward piston movement in the cylinder. The dashpot piston carries a movable plate of a variable capacitor transducer for monitoring the position of the pipette piston within the pipette cylinder.
    • 安装在封闭室中的缓冲器活塞通过可轴向移动的轴联接到移液管活塞,以调节移液管活塞在移液管气缸内的返回运动,以将流体吸入气缸。 缓冲器轴可相对于缓冲器活塞在极限内移动,以通过驱动移液管活塞的轴超过原始位置来容纳来自移液管的剩余流体的吹出,以吹送来自移液管的残余流体。 在室的底部的空气入口允许空气随着缓冲器活塞的向上运动而被吸入室中,同时与空气入口相邻的阀响应于缓冲器活塞向下移动以从腔室排出空气而打开 。 控制进气口和阀门出口的相对尺寸可调节气缸中上下活塞运动的相对速率。 缓冲器活塞承载可变电容换能器的可移动板,用于监测移液管活塞在移液管内的位置。
    • 8. 发明授权
    • Portable automated pipette for accurately pipetting and/or titrating
liquids
    • 便携式自动移液器,用于精确移液和/或滴定液体
    • US4905526A
    • 1990-03-06
    • US59644
    • 1987-06-08
    • Haakon T. Magnussen, Jr.Gary L. SmithStephen J. RuskewiczAnthony K. Wingo
    • Haakon T. Magnussen, Jr.Gary L. SmithStephen J. RuskewiczAnthony K. Wingo
    • B01L3/02G01N1/00
    • B01L3/0227B01L2300/027Y10T436/116664Y10T436/25625Y10T436/2575
    • A hand held self-contained automated pipette for portable operation having an electrically operated digital linear actuator. The actuator preferably includes a stepper motor driving a rotor. A threaded screw is coaxially positioned within the rotor and is connected to an actuator shaft having elongate grooves slidable in a guide for preventing shaft rotation so that precise linear motion is imparted to the shaft. A pipetting displacement assembly having one of various sizes is removably attached for actuation by a common actuator including programmed movement of a displacing piston in a displacement cylinder to optimize air interface volume, neutralize variations in vacuum pipette effects, and provide an accommodated stroke and readout for improved accuracy while pipetting and/or titrating different ranges of volumes. Upon calibration the piston undertakes immediate excursion to an end of travel limit and after motor slippage is retracted to a home position. This home position is chosen for optimum preservation of an air interface volume between drawn liquid and the piston tailored with particularity to the displacement assembly being used. Multiple precision modes, including pipetting, multiple dispensing, titration, dilution, and measurement, are provided. Other features are also disclosed.
    • 手持式独立自动移液器,用于便携式操作,具有电动数字线性致动器。 致动器优选地包括驱动转子的步进马达。 螺纹螺杆同轴地定位在转子内并且连接到致动器轴,致动器轴具有可在引导件中滑动的细长槽,用于防止轴旋转,从而将准确的线性运动施加到轴上。 具有各种尺寸之一的移液装置可移除地附接以用于通过公共致动器进行致动,该执行器包括位移缸中的置换活塞的编程移动,以优化空气界面体积,中和真空吸管效应的变化,并提供容纳的行程和读数 在吸取和/或滴定不同体积范围时提高准确度。 在校准后,活塞立即偏移到行程极限结束,并且电机滑动回缩到原始位置。 选择该起始位置是为了最佳地保持拉伸液体和活塞之间的空气界面体积,特别适用于所使用的位移组件。 提供了多种精确模式,包括移液,多次分配,滴定,稀释和测量。 还公开了其他特征。