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1. 发明授权

US6013084A Stretch resistant vaso-occlusive coils (II) 失效
标题翻译：抗拉性血管闭塞线圈（II）
公开(公告)号：US6013084A
公开(公告)日：2000-01-11
申请号：US879408
申请日：1997-06-20
申请人： Christopher G. M. Ken , Joseph C. Eder , Clifford Teoh
发明人： Christopher G. M. Ken , Joseph C. Eder , Clifford Teoh
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/00 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00867 , A61B2017/1205 , A61B2017/12063 , A61B2090/3937 , A61F2002/30093 , A61F2210/0019
摘要： This is an implantable vaso-occlusive device. It is typically a vaso-occlusive coil comprising a primary helically wound coil which may then be wound into a secondary shape. Central to the invention is the use of a stretch-resisting member extending through the lumen formed, which stretch-resisting member is fixedly attached, directly or indirectly, to the coil in at least two locations. The stretch-resisting member is preferably somewhat loose within the interior of the lumen so to prevent the coil from collapsing, binding, and therefore stiffening during passage of turns through the human body. The coil should bend easily. In some variations of the invention, the stretch-resisting member may be formed into coil tips at the ends of the coil using simple equipment such as soldering irons or the like. The tips are typically of the same diameter as is the coil body itself. This stretch-resisting member is for the primary purpose of preventing stretching of the coil during movement of that coil, e.g., by retrieval or repositioning after deployment. The device may have a self-forming secondary shape made from a pre-formed primary linear helically wound coil, although it need not have the secondary form. Desirably, the coil is extremely flexible and is controllaby released using a severable or mechanical joint such as an electrolytically detachable joint. External fibers may be attached to the device and affixed to the pre-formed linear member to increase thrombogenicity. The extremely flexible variation of the invention may be hydraulically delivered through the lumen of a catheter and is so flexible that it may be retrievably delivered therethrough a flow-directed catheter. The vaso-occlusive member may be also be covered with a fibrous braid. The device is typically introduced into the body through a catheter. The device is passed axially through the catheter sheath and assumes its secondary form upon exiting the catheter.
摘要翻译：这是一种植入式血管闭塞装置。它通常是包括初级螺旋缠绕线圈的血管闭塞线圈，然后可以将其缠绕成次级形状。本发明的中心在于在至少两个位置上使用延伸穿过形成的内腔的拉伸抵抗构件，该拉伸抵抗构件直接地或间接地固定到线圈上。拉伸阻力构件优选在内腔的内部稍微松动，从而防止线圈在匝穿过人体期间塌陷，结合并因此加强。线圈应弯曲容易。在本发明的一些变型中，可以使用诸如烙铁等的简单设备在线圈的端部处形成线圈尖端。尖端通常具有与线圈体本身相同的直径。该抗拉伸构件的主要目的是防止在线圈移动过程中线圈的拉伸，例如通过在展开后的取回或重新定位。该装置可以具有由预先形成的初级线性螺旋缠绕线圈制成的自成形次级形状，尽管它不需要具有二次形式。理想地，线圈非常柔软，并且使用可分离或机械接头（例如电解可拆卸接头）进行控制释放。外部纤维可以附着到装置上并固定到预先形成的线性构件上以增加血栓形成。本发明的极其灵活的变化可以通过导管的内腔液压输送，并且是如此柔性的，使得其可被可逆地递送通过其中的导向导管。血管闭塞性构件也可以用纤维编织物覆盖。该装置通常通过导管引入身体。该装置轴向穿过导管护套，并在离开导管时呈现其次级形式。

2. 发明授权

US06193728B1 Stretch resistant vaso-occlusive coils (II) 有权
标题翻译：抗拉性血管闭塞线圈（II）
公开(公告)号：US06193728B1
公开(公告)日：2001-02-27
申请号：US09433766
申请日：1999-11-04
申请人： Christopher G. M. Ken , Joseph C. Eder , Clifford Teoh
发明人： Christopher G. M. Ken , Joseph C. Eder , Clifford Teoh
IPC分类号： A61M2900
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00867 , A61B2017/1205 , A61B2017/12063 , A61B2090/3937 , A61F2002/30093 , A61F2210/0019
摘要： This is an implantable vaso-occlusive device. It is typically a vaso-occlusive coil comprising a primary helically wound coil which may then be wound into a secondary shape. Central to the invention is the use of a stretch-resisting member extending through the lumen formed, which stretch-resisting member is fixedly attached, directly or indirectly, to the coil in at least two locations. The stretch-resisting member is preferably somewhat loose within the interior of the lumen so to prevent the coil from collapsing, binding, and therefore stiffening during passage of turns through the human body. The coil should bend easily. In some variations of the invention, the stretch-resisting member may be formed into coil tips at the ends of the coil using simple equipment such as soldering irons or the like. The tips are typically of the same diameter as is the coil body itself. This stretch-resisting member is for the primary purpose of preventing stretching of the coil during movement of that coil, e.g., by retrieval or repositioning after deployment. The device may have a self-forming secondary shape made from a pre-formed primary linear helically wound coil, although it need not have the secondary form. Desirably, the coil is extremely flexible and is controllaby released using a severable or mechanical joint such as an electrolytically detachable joint. External fibers may be attached to the device and affixed to the pre-formed linear member to increase thrombogenicity. The extremely flexible variation of the invention may be hydraulically delivered through the lumen of a catheter and is so flexible that it may be retrievably delivered therethrough a flow-directed catheter. The vaso-occlusive member may be also be covered with a fibrous braid. The device is typically introduced into the body through a catheter. The device is passed axially through the catheter sheath and assumes its secondary form upon exiting the catheter.
摘要翻译：这是一种植入式血管闭塞装置。它通常是包括初级螺旋缠绕线圈的血管闭塞线圈，然后可以将其缠绕成次级形状。本发明的中心在于在至少两个位置上使用延伸穿过形成的内腔的拉伸抵抗构件，该拉伸抵抗构件直接地或间接地固定到线圈上。拉伸阻力构件优选在内腔的内部稍微松动，从而防止线圈在匝穿过人体期间塌陷，结合并因此加强。线圈应弯曲容易。在本发明的一些变型中，可以使用诸如烙铁等的简单设备在线圈的端部处形成线圈尖端。尖端通常具有与线圈体本身相同的直径。该抗拉伸构件的主要目的是防止在线圈移动过程中线圈的拉伸，例如通过在展开后的取回或重新定位。该装置可以具有由预先形成的初级线性螺旋缠绕线圈制成的自成形次级形状，尽管它不需要具有二次形式。理想地，线圈非常柔软，并且使用可分离或机械接头（例如电解可拆卸接头）进行控制释放。外部纤维可以附着到装置上并固定到预先形成的线性构件上以增加血栓形成。本发明的极其灵活的变化可以通过导管的内腔液压输送，并且是如此柔性的，使得其可被可逆地递送通过其中的导向导管。血管闭塞性构件也可以用纤维编织物覆盖。该装置通常通过导管引入身体。该装置轴向穿过导管护套，并在离开导管时呈现其次级形式。

3. 发明授权

US08172871B2 Closure medical device 有权
标题翻译：关闭医疗器械
公开(公告)号：US08172871B2
公开(公告)日：2012-05-08
申请号：US11849244
申请日：2007-08-31
申请人： Christopher G. M. Ken
发明人： Christopher G. M. Ken
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/0496 , A61B2017/2939
摘要： A closure device for closing a puncture wound has a distal section that can be placed against the interior wall of a vessel and a proximal section that bunches in the tissue tract to close the wound.
摘要翻译：用于封闭穿刺伤口的闭合装置具有远端部分，该远端部分可以抵靠容器的内壁放置，并且近端部分在组织道中聚束以封闭伤口。

4. 发明授权

US6113629A Hydrogel for the therapeutic treatment of aneurysms 失效
公开(公告)号：US6113629A
公开(公告)日：2000-09-05
申请号：US71250
申请日：1998-05-01
申请人： Christopher G. M. Ken
发明人： Christopher G. M. Ken
IPC分类号： A61K47/30 , A61K33/24 , A61K38/00 , A61K38/18 , A61K45/00 , A61K47/02 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61P9/00 , A61P43/00 , C07K16/22 , A61F2/06
CPC分类号： A61K47/38 , A61K38/18 , A61K47/02 , A61K47/32 , A61K47/34 , A61K47/36 , C07K16/22
摘要： The hydrogel for the treatment of aneurysms acts as a carrier for both a radiopaque agent allowing the hydrogel to be visualized under fluoroscopy and a therapeutic agent such as one or more human growth factors. The hydrogel is delivered through a catheter into the aneurysm, where the hydrogel becomes more viscous upon reaching body temperature, or upon exposure to bodily fluids, to block blood flow into the aneurysm. In addition to stopping blood flow into the aneurysm, the delivery of human growth factors to the aneurysm site promotes the growth of a cellular layer across the neck of the aneurysm. The hydrogel may be of a type that dissolves over time or one which remains as a permanent occlusive agent within the aneurysm.

5. 发明授权

US5833705A Stretch resistant vaso-occlusive coils 失效
标题翻译：抗拉伸血管闭塞线圈
公开(公告)号：US5833705A
公开(公告)日：1998-11-10
申请号：US717285
申请日：1996-09-20
申请人： Christopher G. M. Ken , Son M. Gia , Erik T. Engelson
发明人： Christopher G. M. Ken , Son M. Gia , Erik T. Engelson
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/00 , A61F2/84 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00867 , A61B2017/12063 , A61B2090/3937 , A61F2002/30093 , A61F2210/0019
摘要： This is an implantable vaso-occlusive device. It is typically a vaso-occlusive coil comprised of a primary helically wound coil which may then be wound into a secondary shape. Central to the invention is the use of a stretch-resisting member fixedly attached within at least a portion of the primary coil. The stretch-resisting member may be formed into coil tips at the ends of the coil by melting the polymeric fibers or alloys or by attaching the fibers with a glue. This stretch-resisting member is for the primary purpose of preventing stretching of the coil during movement of that coil, e.g., by retrieval or repositioning after deployment. The device typically has a self-forming secondary shape made from a pre-formed primary linear helically wound coil, although it need not have the secondary form. External fibers may be attached to the device and affixed to the pre-formed linear member to increase. The vaso-occlusive member may be also be covered with a fibrous braid. The device is typically introduced into the body through a catheter. The device is passed axially through the catheter sheath and assumes its secondary form upon exiting the catheter.
摘要翻译：这是一种植入式血管闭塞装置。通常是由初级螺旋缠绕线圈组成的血管闭塞线圈，然后可以将其卷绕成次级形状。本发明的中心是使用固定地附接在初级线圈的至少一部分中的拉伸抵抗构件。拉伸阻力构件可以通过熔化聚合物纤维或合金或通过用胶粘附纤维而在线圈的端部形成线圈尖端。该抗拉伸构件的主要目的是防止在线圈移动过程中线圈的拉伸，例如通过在展开后的取回或重新定位。该装置通常具有由预先形成的初级线性螺旋缠绕线圈制成的自成形次级形状，尽管它不需要具有二次形式。外部纤维可以附接到装置并固定到预先形成的线性构件上以增加。血管闭塞性构件也可以用纤维编织物覆盖。该装置通常通过导管引入身体。该装置轴向穿过导管护套，并在离开导管时呈现其次级形式。

6. 发明授权

US5649949A Variable cross-section conical vasoocclusive coils 失效
标题翻译：可变截面圆锥形血管收缩线圈
公开(公告)号：US5649949A
公开(公告)日：1997-07-22
申请号：US625805
申请日：1996-03-28
申请人： Michael P. Wallace , Francisco S. Villar , Christopher G. M. Ken , David A. Gyorke , Timothy S. Winkle
发明人： Michael P. Wallace , Francisco S. Villar , Christopher G. M. Ken , David A. Gyorke , Timothy S. Winkle
IPC分类号： A61B17/12
CPC分类号： A61B17/1215 , A61B17/12022 , A61B17/12109 , A61B17/12145
摘要： This is an implantable vasoocclusive device. It is constructed of a primary helically wound coil, which primary coil is further wound into secondary shapes which are at least partially substantially conical. Other portions of the secondary shape may have sections of constant diameter or of other conical shapes. The primary coil may be made in such a way that it has regions of differing flexibility. Fibrous materials may be placed on the coils in tufted, streamer, or woven configurations so to increase the thrombogenicity of the overall assembled device.
摘要翻译：这是一种植入式血管收缩装置。它由主螺旋卷绕线圈构成，初级线圈进一步卷绕成至少部分基本上为圆锥形的次级形状。二次形状的其他部分可以具有恒定直径或其它圆锥形状的部分。初级线圈可以制成具有不同柔性的区域。纤维材料可以以簇状，拖缆或编织构型放置在线圈上，以增加整个装配的装置的血栓形成。

7. 发明授权

US06193708B1 Detachable aneurysm neck bridge (I) 有权
标题翻译：可拆卸动脉瘤颈桥（I）
公开(公告)号：US06193708B1
公开(公告)日：2001-02-27
申请号：US09276132
申请日：1999-03-24
申请人： Christopher G. M. Ken , Thuzar K. Han , Matthew Yingwing Hui , Liem Ho
发明人： Christopher G. M. Ken , Thuzar K. Han , Matthew Yingwing Hui , Liem Ho
IPC分类号： A61B1700
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/1214 , A61B17/12172 , A61B2017/12063
摘要： This is a device for bridging the neck of either a wide-necked or narrow-necked aneurysm in the vasculature. In general, it is a device used to stabilize the presence of vaso-occlusive devices (such as helically wound coils) in the aneurysm. The device preferably is delivered by a core wire which terminates in an electrolytically severable joint. The core wire will often be insulated. The retainer assembly itself is also attached to the electrolytic joint and typically has a number of array elements which are intended to be resident within the aneurysm after the device is deployed from the distal end of a catheter. After deployment of this retainer, the aneurysm is at least partially filled with a vaso-occlusive device such as helically wound coils.
摘要翻译：这是用于桥接脉管系统中的宽颈或窄颈动脉瘤的颈部的装置。通常，它是用于稳定动脉瘤中血管闭塞装置（例如螺旋缠绕线圈）的存在的装置。该装置优选地通过终止于电解可分割接头的芯线输送。芯线通常是绝缘的。保持器组件本身也附接到电解接头，并且通常具有许多阵列元件，其在器械从导管的远端部署之后旨在驻留在动脉瘤内。在部署该保持器之后，动脉瘤至少部分地填充有血管闭塞装置，例如螺旋缠绕的线圈。

8. 发明授权

US6033423A Multiple layered vaso-occlusive coils 失效
标题翻译：多层血管闭塞线圈
公开(公告)号：US6033423A
公开(公告)日：2000-03-07
申请号：US974275
申请日：1997-11-19
申请人： Christopher G. M. Ken , Erik T. Engelson
发明人： Christopher G. M. Ken , Erik T. Engelson
IPC分类号： A61F2/82 , A61B17/12 , A61B17/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00526
摘要： This is an implantable vaso-occlusive device. It is a complex, helically wound coil having multiple secondary layers of primary windings. The final shape is often chunky in nature and may be used in the approximate shape of an anatomical cavity. It may be deployed in the approximate shape of a sphere, an ovoid, or other distorted spherical shape. The device is a self-forming shape made from a pre-formed linear vaso-occlusion member. Fibers may be introduced onto the device and affixed to the pre-formed linear member. The constituent member may be also be covered with a fibrous braid. The device is typically introduced through a catheter. The device is passed axially through the catheter sheath and assumes its form upon exiting the catheter without further action. The invention also includes methods of winding the anatomically shaped vaso-occlusive device into appropriately shaped forms and annealing them to form various devices.
摘要翻译：这是一种植入式血管闭塞装置。它是具有多个初级绕组次级层的复杂的螺旋卷绕线圈。最终形状本质上通常是块状的，并且可以以解剖腔的近似形状使用。它可以以球体，卵球形或其他变形的球形的近似形状部署。该装置是由预先形成的线性血管闭塞构件制成的自形成形状。纤维可以引入到装置上并固定到预成形的线性构件上。构成部件也可以用纤维编织物覆盖。该装置通常通过导管引入。该装置轴向穿过导管护套，并且在离开导管时采取其形式，而无需进一步的动作。本发明还包括将解剖形状的血管闭塞装置卷绕成适当形状的形状并将其退火以形成各种装置的方法。

9. 发明授权

US6004338A Stretch resistant vaso-occlusive coils 有权
标题翻译：抗拉伸血管闭塞线圈
公开(公告)号：US6004338A
公开(公告)日：1999-12-21
申请号：US132117
申请日：1998-08-11
申请人： Christopher G. M. Ken , Son M. Gia , Erik T. Engelson
发明人： Christopher G. M. Ken , Son M. Gia , Erik T. Engelson
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/00 , A61F2/84 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00867 , A61B2017/12063 , A61B2090/3937 , A61F2002/30093 , A61F2210/0019
摘要： This is an implantable vaso-occlusive device. It is typically a vaso-occlusive coil comprised of a primary helically wound coil which may then be wound into a secondary shape. Central to the invention is the use of a stretch-resisting member fixedly attached within at least a portion of the primary coil. The stretch-resisting member may be formed into coil tips at the ends of the coil by melting the polymeric fibers or alloys or by attaching the fibers with a glue. This stretch-resisting member is for the primary purpose of preventing stretching of the coil during movement of that coil, e.g., by retrieval or repositioning after deployment. The device typically has a self-forming secondary shape made from a pre-formed primary linear helically wound coil, although it need not have the secondary form. External fibers may be attached to the device and affixed to the pre-formed linear member to increase . The vaso-occlusive member may be also be covered with a fibrous braid. The device is typically introduced into the body through a catheter. The device is passed axially through the catheter sheath and assumes its secondary form upon exiting the catheter.
摘要翻译：这是一种植入式血管闭塞装置。通常是由初级螺旋缠绕线圈组成的血管闭塞线圈，然后可以将其卷绕成次级形状。本发明的中心是使用固定地附接在初级线圈的至少一部分中的拉伸抵抗构件。拉伸阻力构件可以通过熔化聚合物纤维或合金或通过用胶粘附纤维而在线圈的端部形成线圈尖端。该抗拉伸构件的主要目的是防止在线圈移动过程中线圈的拉伸，例如通过在展开后的取回或重新定位。该装置通常具有由预先形成的初级线性螺旋缠绕线圈制成的自成形次级形状，尽管它不需要具有二次形式。外部纤维可以附接到装置并固定到预先形成的线性构件上以增加。血管闭塞性构件也可以用纤维编织物覆盖。该装置通常通过导管引入身体。该装置轴向穿过导管护套，并在离开导管时呈现其次级形式。

10. 发明授权

US5766160A Variable stiffness coils 失效
标题翻译：可变刚度线圈
公开(公告)号：US5766160A
公开(公告)日：1998-06-16
申请号：US480042
申请日：1995-06-06
申请人： Gene Samson , Ivan Sepetka , U. Hiram Chee , Christopher G. M. Ken , Nga T. Van
发明人： Gene Samson , Ivan Sepetka , U. Hiram Chee , Christopher G. M. Ken , Nga T. Van
IPC分类号： A61M31/00 , A61B17/12 , A61B17/00
CPC分类号： A61B17/1215 , A61B17/12022 , A61B17/12109 , A61B17/12145
摘要： This invention is an implantable vaso-occlusive device. It is a helically wound coil having a central section along its longitudinal axis which is somewhat stiffer than at least one of its end regions.
摘要翻译：本发明是可植入血管闭塞装置。它是螺旋缠绕的线圈，其沿其纵向轴线具有中心部分，该中心部分比其端部区域中的至少一个稍微更硬。

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