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1. 发明申请

US20090131798A1 METHOD AND APPARATUS FOR INTRAVASCULAR IMAGING AND OCCLUSION CROSSING 审中-公开
标题翻译：方法和装置用于血管成像和闭塞穿刺
公开(公告)号：US20090131798A1
公开(公告)日：2009-05-21
申请号：US12273593
申请日：2008-11-19
申请人： Christopher D. Minar , Peter Skujins , Raju R. Viswanathan , Guy Besson , Gareth T. Munger
发明人： Christopher D. Minar , Peter Skujins , Raju R. Viswanathan , Guy Besson , Gareth T. Munger
IPC分类号： A61B8/14 , A61B18/14 , A61M25/01
CPC分类号： A61B8/4461 , A61B5/02007 , A61B8/0833 , A61B8/12 , A61B8/445 , A61B18/1492 , A61B2017/22042 , A61B2018/00083 , A61B2018/00214 , A61B2018/144 , A61M25/0068 , A61M25/0082 , A61M25/0127 , A61M25/09 , A61M2025/0166 , A61M2025/09175 , A61M2025/09183 , A61M2205/054 , A61M2205/103 , A61M2205/3515
摘要： This invention describes an occlusion crossing apparatus for creating an opening in occluded tissue at a target location in interventional and surgical applications with simultaneous or nearly simultaneous intravascular imaging. In particular, the present invention is concerned with a magnetically guidable occlusion crossing apparatus and methods of using same together with intravascular ultrasound imaging, said occlusion crossing apparatus being usable in combination with a magnetic field and comprising an ultrasound imaging catheter with at least one ultrasound transducer at its distal tip; the catheter including a lumen through which a magnetically steered guidewire is passed and extends beyond the distal end of the catheter; the guidewire possibly comprising an electrode at its distal end for delivery of ablative electrical energy at a target location in a body lumen; and at least one magnetic guiding element mounted to the guidewire for orienting the portion of the guidewire that extends from the distal tip of the imaging catheter and placing the tip of the guidewire at the desired target location.
摘要翻译：本发明描述了一种闭塞交叉装置，用于在具有同时或几乎同时的血管内成像的介入和外科应用中在目标位置处的闭塞组织中形成开口。特别地，本发明涉及磁导引阻塞交叉装置及其与血管内超声成像一起使用的方法，所述闭塞交叉装置可与磁场组合使用，并且包括具有至少一个超声换能器的超声成像导管在其远端; 所述导管包括内腔，磁导杆引导线穿过所述内腔延伸超过所述导管的远端; 所述导丝可能包括在其远端处的电极，用于在体腔内的目标位置处输送消融电能; 以及安装到所述导丝的至少一个磁性引导元件，用于使所述导丝的从所述成像导管的远侧末端延伸的部分定向，并将所述导丝的末端放置在期望的目标位置。

2. 发明申请

US20080312673A1 Method and apparatus for CTO crossing 审中-公开
标题翻译： CTO穿越的方法和装置
公开(公告)号：US20080312673A1
公开(公告)日：2008-12-18
申请号：US12134150
申请日：2008-06-05
申请人： Raju R. Viswanathan , Gareth T. Munger , Heather Drury , Christopher D. Minar
发明人： Raju R. Viswanathan , Gareth T. Munger , Heather Drury , Christopher D. Minar
IPC分类号： A61B17/22
CPC分类号： A61B90/36 , A61B18/1492 , A61B34/20 , A61B34/25 , A61B34/73 , A61B2017/00022 , A61B2017/00061 , A61B2017/00106 , A61B2017/22001 , A61B2017/22038 , A61B2034/2051 , A61B2090/3784
摘要： A method of treating vessel occlusions including chronic total occlusions (CTO) of the coronary arteries is presented that relies on remote navigation of a remotely steered medical device to the occlusion and controlled application of ablative energy or mechanical push together with real-time local imaging of the vasculature or real-time vessel wall sensing. The combinative use of remote navigation methods and real-time imaging or real-time sensing enables crossing of elongated lesions and CTOs, calcified lesions and CTOs and lesions and CTOs located at vessel branches.
摘要翻译：提出了一种治疗血管闭塞的方法，包括冠状动脉的慢性完全闭塞（CTO），其依赖于远程导航的医疗装置的远程导航，以阻塞和控制消融能量或机械推动的应用，以及实时局部成像脉管系统或实时血管壁感知。组合使用远程导航方法和实时成像或实时检测可以使位于血管分支处的细长病变和CTO，钙化病变和CTO以及病变和CTO交叉。

3. 发明申请

US20090138009A1 MAGNETICALLY GUIDED ENERGY DELIVERY APPARATUS 有权
标题翻译： MAGNETICALLY指导能源交付工具
公开(公告)号：US20090138009A1
公开(公告)日：2009-05-28
申请号：US12265013
申请日：2008-11-05
申请人： Raju R. Viswanathan , Gareth T. Munger , Ashwini K. Pandey , Christopher D. Minar
发明人： Raju R. Viswanathan , Gareth T. Munger , Ashwini K. Pandey , Christopher D. Minar
IPC分类号： A61B18/14
CPC分类号： A61M25/09 , A61B18/1492 , A61B2018/00101 , A61B2034/2051 , A61M2025/09183
摘要： This invention describes an energy delivery apparatus for delivering electrical energy at a target location, said energy delivery apparatus being usable in combination with a magnetic field and comprising an electrical conductor having a substantially elongated configuration; an electrode for delivering electrical energy at the target location, with the electrode being electrically coupled to the electrical conductor and having an exposed surface with at least a portion of the exposed surface having one of its principal radii of curvature smaller than 0.35 mm; an insulating dielectric coating along a substantial portion of the length of the electrical conductor, with the dielectric coating having a dielectric constant smaller than about 3; at least one guiding element mounted to the electrical conductor, with at least one of the guiding elements including a magnetically responsive material. The magnetic field is used to move the guiding element in order to position the electrode substantially adjacent to the target location.
摘要翻译：本发明描述了一种用于在目标位置传送电能的能量输送装置，所述能量输送装置可与磁场结合使用并且包括具有基本细长构型的电导体; 用于在目标位置处传送电能的电极，其中电极电耦合到电导体并且具有暴露表面，其中暴露表面的至少一部分具有小于0.35mm的其主曲率半径之一; 绝缘电介质涂层沿电导体的长度的大部分，电介质涂层的介电常数小于约3; 安装到电导体的至少一个引导元件，其中至少一个引导元件包括磁响应材料。磁场用于移动引导元件，以使电极基本上邻近目标位置。

4. 发明授权

US08231618B2 Magnetically guided energy delivery apparatus 有权
标题翻译：磁导式能量输送装置
公开(公告)号：US08231618B2
公开(公告)日：2012-07-31
申请号：US12265013
申请日：2008-11-05
申请人： Raju R. Viswanathan , Gareth T. Munger , Ashwini K. Pandey , Christopher D. Minar
发明人： Raju R. Viswanathan , Gareth T. Munger , Ashwini K. Pandey , Christopher D. Minar
IPC分类号： A61B18/14
CPC分类号： A61M25/09 , A61B18/1492 , A61B2018/00101 , A61B2034/2051 , A61M2025/09183
摘要： This invention describes an energy delivery apparatus for delivering electrical energy at a target location, said energy delivery apparatus being usable in combination with a magnetic field and comprising an electrical conductor having a substantially elongated configuration; an electrode for delivering electrical energy at the target location, with the electrode being electrically coupled to the electrical conductor and having an exposed surface with at least a portion of the exposed surface having one of its principal radii of curvature smaller than 0.35 mm; an insulating dielectric coating along a substantial portion of the length of the electrical conductor, with the dielectric coating having a dielectric constant smaller than about 3; at least one guiding element mounted to the electrical conductor, with at least one of the guiding elements including a magnetically responsive material. The magnetic field is used to move the guiding element in order to position the electrode substantially adjacent to the target location.
摘要翻译：本发明描述了一种用于在目标位置传送电能的能量输送装置，所述能量输送装置可与磁场结合使用并且包括具有基本细长构型的电导体; 用于在目标位置处传送电能的电极，其中电极电耦合到电导体并且具有暴露表面，其中暴露表面的至少一部分具有小于0.35mm的其主曲率半径之一; 绝缘电介质涂层沿电导体的长度的大部分，电介质涂层的介电常数小于约3; 安装到电导体的至少一个引导元件，其中至少一个引导元件包括磁响应材料。磁场用于移动引导元件，以使电极基本上邻近目标位置。

5. 发明申请

US20090131927A1 METHOD AND APPARATUS FOR REMOTE DETECTION OF RF ABLATION 审中-公开
标题翻译：用于远程检测射频消融的方法和装置
公开(公告)号：US20090131927A1
公开(公告)日：2009-05-21
申请号：US12272185
申请日：2008-11-17
申请人： Nathan Kastelein , Ashwini K. Pandey , Yi-Ren Woo , Raju R. Viswanathan , Gareth T. Munger , Christopher D. Minar , Roger G. Riedel, JR.
发明人： Nathan Kastelein , Ashwini K. Pandey , Yi-Ren Woo , Raju R. Viswanathan , Gareth T. Munger , Christopher D. Minar , Roger G. Riedel, JR.
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00083 , A61B2018/00702 , A61B2018/00779 , A61B2018/144 , A61B2218/002
摘要： Devices for the generation and detection of an ablative plasma discharge in a subject are presented. Methods of use, including navigation and operation of the devices to facilitate minimally invasive therapeutic procedures are disclosed.
摘要翻译：提出了用于产生和检测受试者中烧蚀等离子体放电的装置。公开了使用方法，包括用于促进微创治疗程序的装置的导航和操作。

6. 发明申请

US20090082722A1 REMOTE NAVIGATION ADVANCER DEVICES AND METHODS OF USE 审中-公开
标题翻译：远程导航高级设备及其使用方法
公开(公告)号：US20090082722A1
公开(公告)日：2009-03-26
申请号：US12196214
申请日：2008-08-21
申请人： Gareth T. Munger , Janet Adair , Ashwini K. Pandey , John B. Kinder, JR. , John C. Knudson , Christopher D. Minar , Roger G. Riedel, JR. , Steven E. Scott , Scott Klimek , Alan D. Eskuri , Amy R. Raatikka , Pete Skujins , Stephen W. Pryor
发明人： Gareth T. Munger , Janet Adair , Ashwini K. Pandey , John B. Kinder, JR. , John C. Knudson , Christopher D. Minar , Roger G. Riedel, JR. , Steven E. Scott , Scott Klimek , Alan D. Eskuri , Amy R. Raatikka , Pete Skujins , Stephen W. Pryor
IPC分类号： A61M25/092
CPC分类号： A61M25/0113 , A61B5/06 , A61B5/064 , A61B6/12 , A61B34/30 , A61B2034/301 , A61M25/09041 , A61M2025/0008
摘要： Various systems for advancing medical devices within a subject's body are provided that configured to engage the outer surface of the medical device at a number of points about the circumference of the medical device, to thereby grip the medical device for enabling advancement of the device. The advancing systems include engaging portions configured to engage the outer surface of a medical device at a number of points about the circumference of the medical device. The engaging portions preferably engage opposing sides of the medical device's outer surface over a predetermined longitudinal length, to clamp against a longitudinal portion of the medical device that provides improved surface contact with the medical device over conventional roller guides. Various methods for performing medical procedures utilizing various medical devices and advancer systems are also provided.
摘要翻译：提供用于推进被检体内的医疗装置的各种系统，其构造为在医疗装置的周围的多个点处接合医疗装置的外表面，从而夹持医疗装置以使装置能够前进。前进系统包括被配置为在医疗装置的圆周周围的多个点处接合医疗装置的外表面的接合部分。接合部优选地将预定的纵向长度的医疗装置的外表面的相对侧接合，以抵靠医疗装置的纵向部分，以与传统的滚子引导件相比提供与医疗装置的改进的表面接触。还提供了使用各种医疗装置和推进器系统执行医疗程序的各种方法。

7. 发明申请

US20110046618A1 METHODS AND SYSTEMS FOR TREATING OCCLUDED BLOOD VESSELS AND OTHER BODY CANNULA 审中-公开
标题翻译：治疗血液血管和其他身体肛门的方法和系统
公开(公告)号：US20110046618A1
公开(公告)日：2011-02-24
申请号：US12847062
申请日：2010-07-30
申请人： Christopher D. Minar , Pete Skujins , Alan D. Eskuri , Hong Cao , Khamla Vongphakdy
发明人： Christopher D. Minar , Pete Skujins , Alan D. Eskuri , Hong Cao , Khamla Vongphakdy
IPC分类号： A61B18/00
CPC分类号： A61B5/053 , A61B18/1206 , A61B18/1492 , A61B2018/00875 , A61B2018/144
摘要： A method of treating an occluded blood vessel includes sensing the impedance at a plurality of locations around the circumference of the blood vessel at least two different frequencies to identify vascular occlusive material, and distinguish vascular occlusive material from the vessel wall.
摘要翻译：一种治疗闭塞血管的方法包括：在血管周围的多个位置处感测至少两个不同频率的阻抗，以识别血管闭塞性材料，并将血管闭塞性材料与血管壁区分开。

8. 发明申请

US20110152712A1 Impedance Measurement Tissue Identification in Blood Vessels 审中-公开
标题翻译：血管阻抗测量组织识别
公开(公告)号：US20110152712A1
公开(公告)日：2011-06-23
申请号：US12973889
申请日：2010-12-20
申请人： Hong Cao , Christopher D. Minar , Pete Skujins , Alan D. Eskuri
发明人： Hong Cao , Christopher D. Minar , Pete Skujins , Alan D. Eskuri
IPC分类号： A61B5/053 , A61B18/14
CPC分类号： A61B5/0537 , A61B5/02007 , A61B5/6852 , A61B18/1477 , A61B18/1492 , A61B34/20 , A61B2017/00026 , A61B2018/00422 , A61B2018/00738 , A61B2018/00875 , A61B2018/1425 , A61B2018/144
摘要： A system for radio frequency (RF) wire guidance during RF occlusion canalization including a RF wire configured to travel through a blood vessel, an impedance measure unit configured to measure an electrical impedance between the RF wire and a reference electrode, a RF power source, an activation controller configured to connect the RF power source to the RF wire when the impedance measure unit indicates that the RF wire is contacting an occlusion material, a RF wire steering system; and a controller configured to activate the steering system to maintain the RF wire within the occlusion material based on impedance measured by the impedance measure unit.
摘要翻译：一种用于射频封堵管道内射频（RF）导线的系统，包括配置成穿过血管的RF线，被配置为测量RF线与参考电极之间的电阻抗的阻抗测量单元，RF电源，激活控制器，被配置为当所述阻抗测量单元指示所述RF线接触闭塞材料，RF线转向系统时将所述RF功率源连接到所述RF线; 以及控制器，其被配置为基于由所述阻抗测量单元测量的阻抗来激活所述转向系统以将所述RF线保持在所述闭塞材料内。

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