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1. 发明授权

US08024024B2 Remote control of medical devices using real time location data 有权
标题翻译：使用实时位置数据远程控制医疗设备
公开(公告)号：US08024024B2
公开(公告)日：2011-09-20
申请号：US12163693
申请日：2008-06-27
申请人： Raju R. Viswanathan , Walter M. Blume , Ilker Tunay , Charidimos E. Gasparakis , Gareth T. Munger
发明人： Raju R. Viswanathan , Walter M. Blume , Ilker Tunay , Charidimos E. Gasparakis , Gareth T. Munger
IPC分类号： A61B5/05 , A61B1/00
CPC分类号： A61M25/0105 , A61B5/024 , A61B5/062 , A61B5/0816 , A61B18/1492 , A61B34/70 , A61B34/73 , A61B2034/2051 , A61B2090/065
摘要： A method of determining the quality of contact between a remotely navigated medical device and a cyclically moving anatomical structure includes measuring movement of the device, and processing the measured movement of the device to determine the contact between the device and the moving anatomical structure.
摘要翻译：确定远程导航的医疗设备和循环移动的解剖结构之间的接触质量的方法包括测量设备的移动，以及处理所测量的设备的移动以确定设备与移动的解剖结构之间的接触。

2. 发明授权

US07961926B2 Registration of three-dimensional image data to 2D-image-derived data 失效
标题翻译：将三维图像数据注册到2D图像派生数据
公开(公告)号：US07961926B2
公开(公告)日：2011-06-14
申请号：US12835211
申请日：2010-07-13
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： G06K9/00
CPC分类号： G06K9/00208 , G06T7/33 , G06T7/38 , G06T2207/10072 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method for obtaining registration of a three-dimensional image data set of an anatomical vessel with corresponding two-dimensional image data of the vessel in an X-ray imaging system, where the method comprise the user identifying two points on an anatomical vessel on at least two X-ray image planes, the user identifying two similar points on the surface of the corresponding three-dimensional anatomical image data, determining the orientation direction of the vessel from the two user identified image data surface points, determining the orientation direction of the vessel from the two points obtained from the X-ray image planes, and calculating a transformation of the three-dimensional image data to obtain a best fit registration of the direction derived from the image surface points with the direction derived from the X-ray image data points.
摘要翻译：一种用于在X射线成像系统中获得具有血管的相应二维图像数据的解剖血管的三维图像数据集的注册的方法，其中所述方法包括用户识别解剖血管上的两个点至少两个X射线图像平面，用户识别相应三维解剖图像数据的表面上的两个相似点，从两个用户识别的图像数据表面点确定血管的取向方向，确定血管的取向方向从X射线图像平面获得的两点获取血管，并计算三维图像数据的变换，以获得从图像表面点导出的方向与从X射线图像导出的方向的最佳拟合配准数据点。

3. 发明授权

US07961924B2 Method of three-dimensional device localization using single-plane imaging 失效
标题翻译：使用单平面成像进行三维设备定位的方法
公开(公告)号：US07961924B2
公开(公告)日：2011-06-14
申请号：US11842402
申请日：2007-08-21
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： A61B5/06 , A61B1/00158 , A61B1/01 , A61B5/062 , A61B6/12 , A61B6/503
摘要： A method and system for determining the three-dimensional location and orientation of a medical device distal end using a single-plane imaging system, using a computational model of the medical device and a transfer function for the medical device describing local device shape and orientation in response to user or computer determined inputs. The method allows guidance of an interventional medical system to a set of target points within the patient using a single-projection imaging system.
摘要翻译：一种用于使用单平面成像系统来确定医疗装置远端的三维位置和取向的方法和系统，使用医疗装置的计算模型和用于描述局部装置形状和取向的医疗装置的传递函数响应用户或计算机确定的输入。该方法允许使用单投影成像系统将介入医疗系统引导到患者体内的一组目标点。

4. 发明授权

US07831294B2 System and method of surgical imagining with anatomical overlay for navigation of surgical devices 有权
标题翻译：手术设想的系统和方法与解剖学覆盖物用于外科手术装置的导航
公开(公告)号：US07831294B2
公开(公告)日：2010-11-09
申请号：US10962174
申请日：2004-10-07
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： A61B5/05
CPC分类号： A61B5/062 , A61B6/12 , A61B6/4441 , A61B6/463 , A61B6/547 , A61B34/10 , A61B34/20 , A61B34/25 , A61B90/36 , A61B2017/00243 , A61B2017/00703 , A61B2034/101 , A61B2034/105 , A61B2034/107 , A61B2034/2051 , A61B2090/363 , A61B2090/364 , A61B2090/365 , A61B2090/376
摘要： A system and method are provided for control of a navigation system for deploying a medical device within a subject, and for enhancement of a display image of anatomical features for viewing the projected location and movement of medical devices, and projected locations of a variety of anatomical features and other spatial markers in the operating region. The display of the X-ray imaging system information is augmented in a manner such that a physician can more easily become oriented in three dimensions with the use of a single-plane X-ray display. The projection of points and geometrical shapes within the subject body onto a known imaging plane can be obtained using associated imaging parameters and projective geometry.
摘要翻译：提供了一种系统和方法，用于控制用于在受试者内部署医疗装置的导航系统，并且用于增强用于观察医疗装置的投影位置和运动的解剖特征的显示图像，以及各种解剖学的投影位置特征和其他空间标记。 X射线成像系统信息的显示以这样的方式被增强，使得医生可以通过使用单平面X射线显示器更容易地在三维方向上定向。可以使用相关的成像参数和投影几何来获得主体内的点和几何形状到已知成像平面上的投影。

5. 发明授权

US07761133B2 Navigation of remotely actuable medical device using control variable and length 有权
标题翻译：使用控制变量和长度导航遥控医疗设备
公开(公告)号：US07761133B2
公开(公告)日：2010-07-20
申请号：US11236772
申请日：2005-09-27
申请人： Raju R. Viswanathan , Walter M. Blume
发明人： Raju R. Viswanathan , Walter M. Blume
IPC分类号： A61B5/05
CPC分类号： A61B5/06 , A61B5/061 , A61B5/062
摘要： A method of navigating a medical device includes determining the location of a medical device at a point in an operating region in a subject's body, the medical device being responsive to at least one control variable to assume a desired configuration includes storing information representative of the at least one control variable being applied to the medical device at the point, and more preferably storing information representative of the at least one control variable and the device length.
摘要翻译：一种导航医疗设备的方法包括：确定医疗设备在受试者身体的操作区域中的某一点处的位置，所述医疗设备响应于至少一个控制变量来采取所需的配置，包括存储代表在至少一个控制变量在该点被应用于医疗设备，更优选地存储表示至少一个控制变量和设备长度的信息。

6. 发明授权

US07756308B2 Registration of three dimensional image data to 2D-image-derived data 有权
标题翻译：将三维图像数据注册到2D图像派生数据
公开(公告)号：US07756308B2
公开(公告)日：2010-07-13
申请号：US11349548
申请日：2006-02-07
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： G06K9/00
CPC分类号： G06K9/00208 , G06T7/33 , G06T7/38 , G06T2207/10072 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method for obtaining registration of a three-dimensional image data set of an anatomical vessel with corresponding two-dimensional image data of the vessel in an X-ray imaging system, where the method comprise the user identifying two points on an anatomical vessel on at least two X-ray image planes, the user identifying two similar points on the surface of the corresponding three-dimensional anatomical image data, determining the orientation direction of the vessel from the two user identified image data surface points, determining the orientation direction of the vessel from the two points obtained from the X-ray image planes, and calculating a transformation of the three-dimensional image data to obtain a best fit registration of the direction derived from the image surface points with the direction derived from the X-ray image data points.
摘要翻译：一种用于在X射线成像系统中获得具有血管的相应二维图像数据的解剖血管的三维图像数据集的注册的方法，其中所述方法包括用户识别解剖血管上的两个点至少两个X射线图像平面，用户识别相应三维解剖图像数据的表面上的两个相似点，从两个用户识别的图像数据表面点确定血管的取向方向，确定血管的取向方向从X射线图像平面获得的两点获取血管，并计算三维图像数据的变换，以获得从图像表面点导出的方向与从X射线图像导出的方向的最佳拟合配准数据点。

7. 发明授权

US07714577B2 Method and apparatus for high-gain magnetic resonance imaging 失效
公开(公告)号：US07714577B2
公开(公告)日：2010-05-11
申请号：US11582094
申请日：2006-10-17
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： G01V3/00
CPC分类号： G01R33/34061 , B82Y10/00 , B82Y25/00 , G01R33/34053 , G01R33/3415 , G01R33/3808
摘要： A method and apparatus for Magnetic Resonance Imaging with specialized imaging coils possessing high Signal-to-Noise-Ratio (SNR). Imaging and/or Radio Frequency receiving coils include a ballistic electrical conductor such as carbon nanotubes, the ballistic electrical conductor having a resistance that does not increase significantly with length. Due to their enhanced SNR properties, system designs with smaller static magnetic field strength can be constructed for the same quality of imaging, leading to substantial reductions in system size and cost, as well as to enhanced imaging with existing MRI systems.

8. 发明授权

US07540866B2 User interface for remote control of medical devices 有权
公开(公告)号：US07540866B2
公开(公告)日：2009-06-02
申请号：US11146412
申请日：2005-06-06
申请人： Raju R. Viswanathan , Walter M. Blume , Jeffrey M. Garibaldi , John Rauch
发明人： Raju R. Viswanathan , Walter M. Blume , Jeffrey M. Garibaldi , John Rauch
IPC分类号： A61B17/00
CPC分类号： A61B6/548 , A61B6/12 , A61B8/0833 , A61B34/20 , A61B34/25 , A61B34/70 , A61B34/73 , A61B90/37 , A61B2034/105 , A61B2034/107 , A61B2034/2051 , A61B2034/2074 , A61B2090/364 , A61B2090/376 , A61B2090/3958
摘要： An interface for remotely controlling a medical device in a patient's body provides a two dimensional display of a three dimensional rendering of the operating region, and allows the user to select the orientation or location of the distal end of the medical device on the display and then operate a navigation system to cause the distal end of the medical device to approximately assume the selected orientation or location.

9. 发明申请

US20090131798A1 METHOD AND APPARATUS FOR INTRAVASCULAR IMAGING AND OCCLUSION CROSSING 审中-公开
标题翻译：方法和装置用于血管成像和闭塞穿刺
公开(公告)号：US20090131798A1
公开(公告)日：2009-05-21
申请号：US12273593
申请日：2008-11-19
申请人： Christopher D. Minar , Peter Skujins , Raju R. Viswanathan , Guy Besson , Gareth T. Munger
发明人： Christopher D. Minar , Peter Skujins , Raju R. Viswanathan , Guy Besson , Gareth T. Munger
IPC分类号： A61B8/14 , A61B18/14 , A61M25/01
CPC分类号： A61B8/4461 , A61B5/02007 , A61B8/0833 , A61B8/12 , A61B8/445 , A61B18/1492 , A61B2017/22042 , A61B2018/00083 , A61B2018/00214 , A61B2018/144 , A61M25/0068 , A61M25/0082 , A61M25/0127 , A61M25/09 , A61M2025/0166 , A61M2025/09175 , A61M2025/09183 , A61M2205/054 , A61M2205/103 , A61M2205/3515
摘要： This invention describes an occlusion crossing apparatus for creating an opening in occluded tissue at a target location in interventional and surgical applications with simultaneous or nearly simultaneous intravascular imaging. In particular, the present invention is concerned with a magnetically guidable occlusion crossing apparatus and methods of using same together with intravascular ultrasound imaging, said occlusion crossing apparatus being usable in combination with a magnetic field and comprising an ultrasound imaging catheter with at least one ultrasound transducer at its distal tip; the catheter including a lumen through which a magnetically steered guidewire is passed and extends beyond the distal end of the catheter; the guidewire possibly comprising an electrode at its distal end for delivery of ablative electrical energy at a target location in a body lumen; and at least one magnetic guiding element mounted to the guidewire for orienting the portion of the guidewire that extends from the distal tip of the imaging catheter and placing the tip of the guidewire at the desired target location.
摘要翻译：本发明描述了一种闭塞交叉装置，用于在具有同时或几乎同时的血管内成像的介入和外科应用中在目标位置处的闭塞组织中形成开口。特别地，本发明涉及磁导引阻塞交叉装置及其与血管内超声成像一起使用的方法，所述闭塞交叉装置可与磁场组合使用，并且包括具有至少一个超声换能器的超声成像导管在其远端; 所述导管包括内腔，磁导杆引导线穿过所述内腔延伸超过所述导管的远端; 所述导丝可能包括在其远端处的电极，用于在体腔内的目标位置处输送消融电能; 以及安装到所述导丝的至少一个磁性引导元件，用于使所述导丝的从所述成像导管的远侧末端延伸的部分定向，并将所述导丝的末端放置在期望的目标位置。

10. 发明申请

US20080294232A1 MAGNETIC CELL DELIVERY 审中-公开
标题翻译：磁性细胞传递
公开(公告)号：US20080294232A1
公开(公告)日：2008-11-27
申请号：US12121774
申请日：2008-05-15
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： A61F2/06 , A61N2/00
CPC分类号： A61F2/90 , A61B5/06 , A61B5/4839 , A61B6/12 , A61F2210/009 , A61K9/0019 , A61K9/5094
摘要： Systems and methods of delivering magnetically loaded cells to target areas within a patient are described. Cells rendered magnetically attractable by being loaded with magnetic microparticles are delivered from a hollow interventional device distal tip and attracted towards a previously placed implant. Implants, such as stents, are magnetized by application of a magnetic field sequence; magnetized cells are attracted by the local magnetic domains and associated field gradients within the implant, and adhere to and are retained by the local tissues, such as tissue protrusions through a stent struts. Application of a magnetic field or field gradient sequence concurrently with the magnetic cell delivery facilitates pulling the cells away from the lumen axis and towards the implant surface and vessel or organ walls.
摘要翻译：描述了将磁负载细胞递送到患者内的目标区域的系统和方法。通过装载磁性微粒而呈磁力吸引的细胞从中空的介入装置远端引出并被吸引到先前放置的植入物上。植入物，如支架，通过施加磁场序列被磁化; 磁化的细胞被植入物内的局部磁畴和相关的场梯度吸引，并且粘附并被局部组织保留，例如通过支架支柱的组织突起。与磁性细胞递送同时施加磁场或场梯度序列有助于将细胞从管腔轴向并且朝向植入物表面和血管或器官壁延伸。

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