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1. 发明申请

US20070292869A1 Compositions and Methods for Analyzing Renal Cancer 审中-公开
标题翻译：用于分析肾癌的组合物和方法
公开(公告)号：US20070292869A1
公开(公告)日：2007-12-20
申请号：US11681305
申请日：2007-03-02
申请人： Christopher Becker , Peter Clark , Theodore Jones , Shanhua Lin , Thomas Shaler , Frank Torti
发明人： Christopher Becker , Peter Clark , Theodore Jones , Shanhua Lin , Thomas Shaler , Frank Torti
IPC分类号： G01N33/574 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/57438 , G01N2800/52
摘要： Compositions, methods and kits useful for the diagnosis, prognosis, and treatment of renal cell cancer are provided.
摘要翻译：提供了可用于诊断，预后和治疗肾细胞癌的组合物，方法和试剂盒。

2. 发明申请

US20050215883A1 Non-invasive imaging for determination of global tissue characteristics 有权
标题翻译：用于确定全局组织特征的非侵入性成像
公开(公告)号：US20050215883A1
公开(公告)日：2005-09-29
申请号：US11051304
申请日：2005-02-04
申请人： William Hundley , Craig Hamilton , Kimberly Lane , Tim Morgan , Frank Torti
发明人： William Hundley , Craig Hamilton , Kimberly Lane , Tim Morgan , Frank Torti
IPC分类号： A61B5/05 , A61B5/055 , A61B6/03 , G01R33/28 , G01R33/56 , G06T7/00
CPC分类号： A61B5/0033 , A61B5/055 , A61B5/42 , A61B5/4519 , A61B6/032 , A61B6/503 , A61B6/504 , A61B6/506 , G01R33/281 , G01R33/56 , G06T7/0014 , G06T7/41 , G06T2200/24 , G06T2207/10088 , G06T2207/30048
摘要： Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administration of a contrast agent to the patient, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition, for example, after administration of a contrast agent to the patient. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. The region of interest may include heart, blood, muscle, brain, nerve, skeletal, skeletal muscle, liver, kidney, lung, pancreas, endocrine, gastrointestinal and/or genitourinary tissue. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic of the first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
摘要翻译：评估组织特征，包括识别损伤的组织或改变天然组织成分的比例，例如改变心脏中正常心肌细胞和纤维组织的量，鉴定细胞外组分或液体量的增加（如水肿或细胞外基质蛋白）或通过例如在给药后从第一次采集获得包括感兴趣区域的组织的第一图像来提供肿瘤细胞或炎症介质的浸润到患者（例如人）中的感兴趣组织中的造影剂，并且在第二次后续获取期间，例如在向患者施用造影剂之后，获得包括感兴趣区域的组织的第二图像。随后的收购可能会在一段时间后获得，以确定在此期间是否发生损伤。感兴趣的区域可以包括心脏，血液，肌肉，脑，神经，骨骼，骨骼肌，肝，肾，肺，胰腺，内分泌，胃肠和/或泌尿生殖组织。确定第一图像和第二图像的感兴趣区域的全局特征，以允许比较第一图像和第二图像的全局特征，以确定全局组织特征变化的可能性。这种比较可以包括平均值，平均特征，直方图形状（例如偏斜和峰度）或直方图内的强度分布的比较。

3. 发明授权

US07747308B2 Non-invasive systems and methods for the determination of cardiac injury using a characterizing portion of a voxel histogram 有权
标题翻译：使用体素直方图的特征部分来确定心脏损伤的非侵入性系统和方法
公开(公告)号：US07747308B2
公开(公告)日：2010-06-29
申请号：US11346527
申请日：2006-02-02
申请人： William Gregory Hundley , Craig A. Hamilton , Kimberly Lane , Tim Morgan , Frank Torti , Ralph B. D'Agostino
发明人： William Gregory Hundley , Craig A. Hamilton , Kimberly Lane , Tim Morgan , Frank Torti , Ralph B. D'Agostino
IPC分类号： A61B5/05 , G06K9/00
CPC分类号： A61B5/055 , A61B6/506 , G06K9/6212 , G06K2209/05 , G06T7/0012 , G06T2207/10088 , G06T2207/10096 , G06T2207/30048
摘要： Methods, systems and circuits predict cardiotoxicity induced cardiac injury prior to an irreversible state by electronically generating at least one histogram of mean intensities of voxels/pixels in an MRI image of a left ventricle myocardium and electronically determining a likelihood of cardiac injury due to cardiotoxicity based on data from the at least one histogram.
摘要翻译：方法，系统和电路通过电子地生成左心室心肌的MRI图像中的体素/像素的平均强度的至少一个直方图，在不可逆状态之前预测心脏毒性引起的心脏损伤，并且电子地确定由于心脏毒性引起的心脏损伤的可能性来自至少一个直方图的数据。

4. 发明授权

US08532739B2 Non-invasive imaging for determination of global tissue characteristics 有权
标题翻译：用于确定全局组织特征的非侵入性成像
公开(公告)号：US08532739B2
公开(公告)日：2013-09-10
申请号：US12019457
申请日：2008-01-24
申请人： William Gregory Hundley , Craig A. Hamilton , Kimberly Lane , Tim Morgan , Frank Torti
发明人： William Gregory Hundley , Craig A. Hamilton , Kimberly Lane , Tim Morgan , Frank Torti
IPC分类号： A61B5/05
CPC分类号： A61B5/0033 , A61B5/055 , A61B5/42 , A61B5/4519 , A61B6/032 , A61B6/503 , A61B6/504 , A61B6/506 , G01R33/281 , G01R33/56 , G06T7/0014 , G06T7/41 , G06T2200/24 , G06T2207/10088 , G06T2207/30048
摘要： Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
摘要翻译：评估组织特征，包括识别损伤的组织或改变天然组织成分的比例，例如改变心脏中正常心肌细胞和纤维组织的量，鉴定细胞外组分或液体量的增加（如水肿或细胞外基质蛋白），或者通过从第一次获取获得包括感兴趣区域的组织的第一图像，或通过从第一次获取获得包含感兴趣区域的组织的第一图像，来检测肿瘤细胞或炎症介质的浸润到患者（例如人）中的感兴趣组织中，并获得第二图像包括在第二次后续采集期间的感兴趣区域的组织。随后的收购可能会在一段时间后获得，以确定在此期间是否发生损伤。这种比较可以包括平均值，平均特征，直方图形状（例如偏斜和峰度）或直方图内的强度分布的比较。

5. 发明授权

US07333845B2 Non-invasive imaging for determination of global tissue characteristics 有权
标题翻译：用于确定全局组织特征的非侵入性成像
公开(公告)号：US07333845B2
公开(公告)日：2008-02-19
申请号：US11051304
申请日：2005-02-04
申请人： William Gregory Hundley , Craig A. Hamilton , Kimberly Lane , Tim Morgan , Frank Torti
发明人： William Gregory Hundley , Craig A. Hamilton , Kimberly Lane , Tim Morgan , Frank Torti
IPC分类号： A61B5/05
CPC分类号： A61B5/0033 , A61B5/055 , A61B5/42 , A61B5/4519 , A61B6/032 , A61B6/503 , A61B6/504 , A61B6/506 , G01R33/281 , G01R33/56 , G06T7/0014 , G06T7/41 , G06T2200/24 , G06T2207/10088 , G06T2207/30048
摘要： Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administration of a contrast agent to the patient, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition, for example, after administration of a contrast agent to the patient. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. The region of interest may include heart, blood, muscle, brain, nerve, skeletal, skeletal muscle, liver, kidney, lung, pancreas, endocrine, gastrointestinal and/or genitourinary tissue. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic of the first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
摘要翻译：评估组织特征，包括识别损伤的组织或改变天然组织成分的比例，例如改变心脏中正常心肌细胞和纤维组织的量，鉴定细胞外组分或液体量的增加（如水肿或细胞外基质蛋白）或通过例如在给药后从第一次采集获得包括感兴趣区域的组织的第一图像来提供肿瘤细胞或炎症介质的浸润到患者（例如人）中的感兴趣组织中的造影剂，并且在第二次后续获取期间，例如在向患者施用造影剂之后，获得包括感兴趣区域的组织的第二图像。随后的收购可能会在一段时间后获得，以确定在此期间是否发生损伤。感兴趣的区域可以包括心脏，血液，肌肉，脑，神经，骨骼，骨骼肌，肝，肾，肺，胰腺，内分泌，胃肠和/或泌尿生殖组织。确定第一图像和第二图像的感兴趣区域的全局特征，以允许比较第一图像和第二图像的全局特征，以确定全局组织特征变化的可能性。这种比较可以包括平均值，平均特征，直方图形状（例如偏斜和峰度）或直方图内的强度分布的比较。

6. 发明授权

US08252772B2 Hyperthermic technologies and therapeutic uses thereof 有权
标题翻译：高热技术及其治疗用途
公开(公告)号：US08252772B2
公开(公告)日：2012-08-28
申请号：US12302382
申请日：2007-05-25
申请人： Suzy Torti , Frank Torti , David Loren Carroll , Steven Akman , Omkaram Nalamasu , Pulickel Ajayan
发明人： Suzy Torti , Frank Torti , David Loren Carroll , Steven Akman , Omkaram Nalamasu , Pulickel Ajayan
IPC分类号： A61K31/69 , A61K31/13
CPC分类号： A61K33/44 , A61K9/0009 , A61K9/0092 , A61K33/00 , A61K33/22 , A61K41/0052 , A61K45/06 , A61K49/06 , A61K49/1884 , A61K2300/00 , B82Y5/00
摘要： The present invention provides nanoscale and microscale compositions useful for a variety of purposes, including the diagnosis and treatment of diseases. In one embodiment, the present invention provides a disease treatment system comprising a thermal induction agent and a radiation source, wherein the thermal induction agent comprises at least one carbon nanotube, at least one carbon microtube, or a mixture thereof.
摘要翻译：本发明提供了可用于各种目的的纳米尺度和微量组合物，包括疾病的诊断和治疗。在一个实施方案中，本发明提供包含热诱导剂和辐射源的疾病治疗系统，其中所述热诱导剂包含至少一种碳纳米管，至少一种碳微管或其混合物。

7. 发明申请

US20100075925A1 Hyperthermic Technologies And Therapeutic Uses Thereof 有权
标题翻译：高温技术及其治疗用途
公开(公告)号：US20100075925A1
公开(公告)日：2010-03-25
申请号：US12302382
申请日：2007-05-25
申请人： Suzy Torti , Frank Torti , David Loren Carroll , Steven Akman , Pulicked Ajayan
发明人： Suzy Torti , Frank Torti , David Loren Carroll , Steven Akman , Pulicked Ajayan
IPC分类号： A61K31/69 , A61K31/13 , A61P35/00
CPC分类号： A61K33/44 , A61K9/0009 , A61K9/0092 , A61K33/00 , A61K33/22 , A61K41/0052 , A61K45/06 , A61K49/06 , A61K49/1884 , A61K2300/00 , B82Y5/00
摘要： The present invention provides nanoscale and microscale compositions useful for a variety of purposes, including the diagnosis and treatment of diseases. In one embodiment, the present invention provides a disease treatment system comprising a thermal induction agent and a radiation source, wherein the thermal induction agent comprises at least one carbon nanotube, at least one carbon microtube, or a mixture thereof.
摘要翻译：本发明提供了可用于各种目的的纳米尺度和微量组合物，包括疾病的诊断和治疗。在一个实施方案中，本发明提供包含热诱导剂和辐射源的疾病治疗系统，其中所述热诱导剂包含至少一种碳纳米管，至少一种碳微管或其混合物。

8. 发明申请

US20080119718A1 NON-INVASIVE IMAGING FOR DETERMINATION OF GLOBAL TISSUE CHARACTERISTICS 有权
标题翻译：非侵入式成像确定全球组织特征
公开(公告)号：US20080119718A1
公开(公告)日：2008-05-22
申请号：US12019457
申请日：2008-01-24
申请人： William Hundley , Craig Hamilton , Kimberly Lane , Tim Morgan , Frank Torti
发明人： William Hundley , Craig Hamilton , Kimberly Lane , Tim Morgan , Frank Torti
IPC分类号： A61B5/00
CPC分类号： A61B5/0033 , A61B5/055 , A61B5/42 , A61B5/4519 , A61B6/032 , A61B6/503 , A61B6/504 , A61B6/506 , G01R33/281 , G01R33/56 , G06T7/0014 , G06T7/41 , G06T2200/24 , G06T2207/10088 , G06T2207/30048
摘要： Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administration of a contrast agent to the patient, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition, for example, after administration of a contrast agent to the patient. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. The region of interest may include heart, blood, muscle, brain, nerve, skeletal, skeletal muscle, liver, kidney, lung, pancreas, endocrine, gastrointestinal and/or genitourinary tissue. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic of the first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
摘要翻译：评估组织特征，包括识别损伤的组织或改变天然组织成分的比例，例如改变心脏中正常心肌细胞和纤维组织的量，鉴定细胞外组分或液体量的增加（如水肿或细胞外基质蛋白）或通过例如在给药后从第一次采集获得包括感兴趣区域的组织的第一图像来提供肿瘤细胞或炎症介质的浸润到患者（例如人）中的感兴趣组织中的造影剂，并且在第二次后续获取期间，例如在向患者施用造影剂之后，获得包括感兴趣区域的组织的第二图像。随后的收购可能会在一段时间后获得，以确定在此期间是否发生损伤。感兴趣的区域可以包括心脏，血液，肌肉，脑，神经，骨骼，骨骼肌，肝，肾，肺，胰腺，内分泌，胃肠和/或泌尿生殖组织。确定第一图像和第二图像的感兴趣区域的全局特征，以允许比较第一图像和第二图像的全局特征，以确定全局组织特征变化的可能性。这种比较可以包括平均值，平均特征，直方图形状（例如偏斜和峰度）或直方图内的强度分布的比较。

9. 发明申请

US20080004521A1 Non-invasive systems and methods for the determination of cardiac injury using a characterizing portion of a voxel histogram 有权
标题翻译：使用体素直方图的特征部分来确定心脏损伤的非侵入性系统和方法
公开(公告)号：US20080004521A1
公开(公告)日：2008-01-03
申请号：US11346527
申请日：2006-02-02
申请人： William Hundley , Craig Hamilton , Kimberly Lane , Tim Morgan , Frank Torti , Ralph D'Agostino
发明人： William Hundley , Craig Hamilton , Kimberly Lane , Tim Morgan , Frank Torti , Ralph D'Agostino
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B6/506 , G06K9/6212 , G06K2209/05 , G06T7/0012 , G06T2207/10088 , G06T2207/10096 , G06T2207/30048
摘要： Methods, systems and circuits predict cardiotoxicity induced cardiac injury prior to an irreversible state by electronically generating at least one histogram of mean intensities of voxels/pixels in an MRI image of a left ventricle myocardium and electronically determining a likelihood of cardiac injury due to cardiotoxicity based on data from the at least one histogram.
摘要翻译：方法，系统和电路通过电子地生成左心室心肌的MRI图像中的体素/像素的平均强度的至少一个直方图，在不可逆状态之前预测心脏毒性引起的心脏损伤，并且电子地确定由于心脏毒性引起的心脏损伤的可能性来自至少一个直方图的数据。

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