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1. 发明申请

US20120040925A1 ARYL UREA COMPOUNDS IN COMBINATION WITH OTHER CYTOSTATIC OR CYTOTOXIC AGENTS FOR TREATING HUMAN CANCERS 审中-公开
标题翻译：与治疗人类癌症的其他细胞毒性或细胞毒素组合的ARYL UREA化合物
公开(公告)号：US20120040925A1
公开(公告)日：2012-02-16
申请号：US13189945
申请日：2011-07-25
申请人： Christopher A. Carter , Neil Gibson , Barbara Hibner , Rachel W. Humphrey , Pamela Trail , Patrick W. Wincent , Yifan Zhai
发明人： Christopher A. Carter , Neil Gibson , Barbara Hibner , Rachel W. Humphrey , Pamela Trail , Patrick W. Wincent , Yifan Zhai
IPC分类号： A61K31/7068 , A61P35/00
CPC分类号： C07D213/81 , A61K31/337 , A61K31/435 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/535 , A61K31/65 , A61K31/704 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： This invention relates to aryl urea compounds in combination with cytotoxic or cytostatic agents for use in treating raf kinase mediated diseases such as cancer.
摘要翻译：本发明涉及芳基脲化合物与用于治疗raf激酶介导的疾病如癌症的细胞毒性或细胞抑制剂的组合。

2. 发明申请

US20060247186A1 Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers 审中-公开
公开(公告)号：US20060247186A1
公开(公告)日：2006-11-02
申请号：US11480360
申请日：2006-07-05
申请人： Christopher Carter , Neil Gibson , Barbara Hibner , Rachel Humphrey , Pamela Trail , Patrick Vincent , Yifan Zhai
发明人： Christopher Carter , Neil Gibson , Barbara Hibner , Rachel Humphrey , Pamela Trail , Patrick Vincent , Yifan Zhai
IPC分类号： A61K31/4412 , A61K31/7072 , A61K31/704 , A61K31/337 , A61K31/4745
CPC分类号： C07D213/81 , A61K31/337 , A61K31/435 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/535 , A61K31/65 , A61K31/704 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： This invention relates to aryl urea compounds in combination with cytotoxic or cytostatic agents for use in treating raf kinase mediated diseases such as cancer.

3. 发明申请

US20070236188A1 SELF-OSCILLATING DC-DC BUCK CONVERTER WITH ZERO HYSTERESIS 有权
标题翻译：自振振荡DC-DC转矩转换器
公开(公告)号：US20070236188A1
公开(公告)日：2007-10-11
申请号：US11695876
申请日：2007-04-03
申请人： Neil Gibson , Kevin Scoones , Erich Bayer
发明人： Neil Gibson , Kevin Scoones , Erich Bayer
IPC分类号： G05F1/613
CPC分类号： H02M3/1563
摘要： A self-oscillating DC-DC buck converter with zero hysteresis is described. The converter comprises a comparator with a supply input, a non-inverting input to which a reference voltage is applied, an inverting input to which a feedback signal is applied, and an output to which a filter network is connected. The feedback signal is derived from the filter network and the output voltage of the converter is determined by the reference voltage. Connecting a filter network with an inductor and a capacitor to the output of the comparator and deriving the feedback signal from the filter network, results in an output of the comparator which is a DC output with a superimposed ripple. The level of the DC output is controlled by the reference voltage applied to the non-inverting input of the comparator, and the inductor current develops the ripple in the equivalent series resistance of the load circuit connected to the comparator output. The ripple can be regarded as the ramp signal in a conventional DC-DC converter. Accordingly, the output voltage is regulated to follow the reference voltage, and the proposed topology is equivalent to a DC-DC buck converter.
摘要翻译：描述了具有零滞后的自谐振DC-DC降压转换器。该转换器包括具有电源输入的比较器，施加参考电压的非反相输入端，施加反馈信号的反相输入端和连接有滤波器网络的输出端。反馈信号来自滤波器网络，转换器的输出电压由参考电压决定。将滤波器网络与电感器和电容器连接到比较器的输出端，并从滤波器网络导出反馈信号，从而产生比较器的输出，该输出是具有叠加纹波的直流输出。直流输出的电平由施加到比较器的非反相输入的参考电压控制，电感电流产生与比较器输出相连的负载电路的等效串联电阻的纹波。在常规DC-DC转换器中，纹波可以被看作是斜坡信号。因此，输出电压被调节为跟随参考电压，并且所提出的拓扑等效于DC-DC降压转换器。

4. 发明申请

US20050248378A1 Method of generating a pulsed output signal from a periodic ramp signal and a reference voltage, and a switch mode power converter 有权
标题翻译：从周期性斜坡信号和参考电压产生脉冲输出信号的方法，以及开关模式功率转换器
公开(公告)号：US20050248378A1
公开(公告)日：2005-11-10
申请号：US11080882
申请日：2005-03-15
申请人： Neil Gibson , Kevin Scoones
发明人： Neil Gibson , Kevin Scoones
IPC分类号： H02M1/08 , H03F3/217 , H03K4/08 , H03K5/06 , H03K5/12 , H03K7/08
CPC分类号： H03K7/08 , H03F3/217 , H03K5/06
摘要： In the proposed method of generating a pulsed output signal from a periodic ramp signal and a reference voltage, the linear range of duty cycles of the pulsed output signal is significantly extended to minimum values. The ramp signal and the reference voltage are applied to inputs of a comparator and the output signal is taken from an output of the comparator. The ramp signal has a ramp that extends between a minimum voltage level and a maximum voltage level. The duty cycle of the pulse signal is controlled by varying the reference voltage between the minimum and maximum voltage levels. The ramp has an initial start section extending from the minimum voltage level and a main section extending between the initial section and the maximum voltage level. The ramp slope has a constant value over the main ramp section and a value greater than the constant value over the initial section. In the initial section of the ramp the slope is varied in a manner to compensate for non-linearity of the comparator in an operating range where the reference voltage is close to the minimum voltage level of the ramp signal. It is also preferred to insert a short blanking period before the actual ramp of the waveform. The method can be used in switched mode power converters and in class-d amplifiers.
摘要翻译：在从周期性斜坡信号和参考电压产生脉冲输出信号的所提出的方法中，脉冲输出信号的占空比的线性范围显着地扩展到最小值。斜坡信号和参考电压被施加到比较器的输入，并且输出信号取自比较器的输出。斜坡信号具有在最小电压电平和最大电压电平之间延伸的斜坡。通过改变最小和最大电压电平之间的参考电压来控制脉冲信号的占空比。斜坡具有从最小电压电平延伸的初始起始部分和在初始部分和最大电压电平之间延伸的主部分。斜坡斜率在主斜坡段上具有恒定值，并且大于初始段上的常数值。在斜坡的初始部分中，斜率以在参考电压接近斜坡信号的最小电压电平的操作范围内补偿比较器的非线性的方式变化。还需要在波形的实际斜坡之前插入短的消隐期。该方法可用于开关电源转换器和D类放大器。

5. 发明申请

US20050164219A1 Methods and primers for detecting target nucleic acid sequences 有权
标题翻译：用于检测靶核酸序列的方法和引物
公开(公告)号：US20050164219A1
公开(公告)日：2005-07-28
申请号：US10862580
申请日：2004-06-08
申请人： David Whitcombe , Jane Theaker , Neil Gibson , Stephen Little
发明人： David Whitcombe , Jane Theaker , Neil Gibson , Stephen Little
IPC分类号： G01N33/50 , C12N15/09 , C12Q1/68 , G01N33/58 , C12Q1/70 , C07H21/04
CPC分类号： C12Q1/6853 , C12Q1/6818 , C12Q1/6823 , C12Q2531/113 , C12Q2525/186 , C12Q2525/161 , C12Q2565/1025 , C12Q2561/119 , C12Q2525/301
摘要： A method for the detection of a target nucleic acid, which method comprises contacting template nucleic acid from a sample with (i) a signalling system and (ii) a tailed nucleic acid primer having a template binding region and the tail comprising a linker and a target binding region, in the presence of appropriate nucleoside triphosphates and an agent for polymerisation thereof, under conditions such that the template binding region of the primer will hybridise to a complementary sequence in the template nucleic acid and be extended to form a primer extension product, separating any such product from the template whereupon the target binding region in the tail of the primer will hybridise to a sequence in the primer extension product corresponding to the target nucleic acid, and wherein any such target specific hybridisation causes a detectable change in the signalling system, such that the presence or absence of the target nucleic acid in the sample is detected by reference to the presence or absence of a detectable change in the signalling system.
摘要翻译：一种用于检测靶核酸的方法，所述方法包括使来自样品的模板核酸与（i）信号系统和（ii）具有模板结合区的尾部核酸引物接触，并且所述尾部包含接头和在适当的核苷三磷酸和其聚合剂的存在下，在引物的模板结合区域将与模板核酸中的互补序列杂交并延伸以形成引物延伸产物的条件下，将任何这样的产物与模板分离，由此引物尾部中的靶结合区域将与对应于靶核酸的引物延伸产物中的序列杂交，并且其中任何这样的靶特异性杂交引起信号系统中可检测的变化，使得通过参考前文检测样品中靶核酸的存在或不存在信号系统中存在或不存在可检测的变化。

6. 发明授权

US06535063B1 Drive method for a cross-connected class AB output stage with shared base current in pre-driver 有权
标题翻译：交流连接AB类输出级的驱动方法，具有预驱动器中的共享基极电流
公开(公告)号：US06535063B1
公开(公告)日：2003-03-18
申请号：US10005112
申请日：2001-12-03
申请人： Neil Gibson , Marco Corsi , Tobin Hagan
发明人： Neil Gibson , Marco Corsi , Tobin Hagan
IPC分类号： H03F318
CPC分类号： H03F1/307 , H03F3/3076
摘要： The present invention provides technical advantages as a class AB output driver (400) with minimal cross-over distortion. If the differential input to the driver is I+&dgr;I/2 and I−&dgr;I/2, then the current gain is the average of &bgr;n and &bgr;p, more specifically, (&bgr;n−&bgr;p)*I+((&bgr;n+&bgr;p)/2)* &dgr;I. The offset current (&bgr;n−&bgr;p)*I is taken out with a feedback loop.
摘要翻译：本发明提供了具有最小交叉失真的AB类输出驱动器（400）的技术优点。如果驱动器的差分输入为I +δI/ 2和I-δI/ 2，则当前增益是betan和betap的平均值，更具体地说，（betan-betap）* I +（（betan + betap）/ 2 ）* deltaI。偏移电流（betan-betap）* I用反馈回路取出。

7. 发明授权

US06420933B1 Low distortion current-to-current converter 有权
标题翻译：低失真电流 - 电流转换器
公开(公告)号：US06420933B1
公开(公告)日：2002-07-16
申请号：US09716597
申请日：2000-11-20
申请人： Neil Gibson , Leland S. Swanson , Marco Corsi
发明人： Neil Gibson , Leland S. Swanson , Marco Corsi
IPC分类号： H03F318
CPC分类号： H03F3/3432 , H03F3/3067 , H03F2203/30006
摘要： A current-to-current impedance converter re-circulates the driver transistor collector current back into the output current path to generate an error current that has two portions including a DC offset portion and a second order in 1/&bgr; portion. Since the error current has no first order in 1/&bgr; portion, the current-to-current ronverter exhbits very low distortion.
摘要翻译：电流 - 电流阻抗转换器将驱动晶体管集电极电流重新循环回输出电流路径，以产生具有两个部分的误差电流，该部分包括1 /β部分中的DC偏移部分和第二阶数。由于误差电流在1 /β部分中没有一级，所以电流到电流转换器出现非常低的失真。

8. 发明授权

US08970199B2 Electronic device and method for DC-DC conversion with variable bias current 有权
标题翻译：具有可变偏置电流的DC-DC转换的电子设备和方法
公开(公告)号：US08970199B2
公开(公告)日：2015-03-03
申请号：US12792919
申请日：2010-06-03
申请人： Kevin Scoones , Gerhard Thiele , Neil Gibson
发明人： Kevin Scoones , Gerhard Thiele , Neil Gibson
IPC分类号： H02M3/157 , H02M1/32 , H02M3/158 , H02M1/00
CPC分类号： H02M3/157 , H02M1/32 , H02M3/1588 , H02M2001/0032 , Y02B70/1466
摘要： The invention relates to an electronic device and a method for DC-DC conversion using a comparator for generating an output signal for driving a power switch of a switch mode DC-DC converter. The electronic device is configured to reduce a bias current of the comparator with a first slope in response to a decreasing load and to increase the bias current of the comparator with a second slope in response to an increasing load, wherein the second slope is steeper than the first slope.
摘要翻译：本发明涉及使用比较器产生用于驱动开关模式DC-DC转换器的电源开关的输出信号的DC-DC转换的电子装置和方法。电子设备被配置为响应于负载的减小而以比第一斜率减小比较器的偏置电流，并且响应于增加的负载而以比第二斜率增加比较器的偏置电流，其中第二斜率比第一个斜坡

9. 发明授权

US08829874B2 Electronic device and method for DC-DC conversion with low power mode 有权
标题翻译：具有低功耗模式的DC-DC转换的电子设备和方法
公开(公告)号：US08829874B2
公开(公告)日：2014-09-09
申请号：US13597107
申请日：2012-08-28
申请人： Neil Gibson
发明人： Neil Gibson
IPC分类号： G05F1/40 , H02M3/158 , H02M1/00 , H02M3/156
CPC分类号： H02M3/1588 , H02M3/156 , H02M2001/0032 , Y02B70/1466 , Y02B70/16
摘要： The invention relates to an electronic device and a method for DC-DC-conversion. The electronic device includes energizing switch and a commutating switch coupled at a switching node. The switching node is configured to be coupled to an inductor. The electronic device is configured to repeatedly suspend the regular synchronous switching of the commutating switch during a load detection period, to sense the voltage at the output node during the load detection period and to determine a high-load condition or a light-load condition of the DC-DC-conversion based on the sensed voltage at the output node.
摘要翻译：本发明涉及一种用于DC-DC转换的电子设备和方法。电子设备包括通电开关和耦合在开关节点处的换向开关。开关节点被配置为耦合到电感器。电子设备被配置为在负载检测周期期间重复地中止整流开关的正常同步切换，以在负载检测期间感测输出节点处的电压，并且确定负载状态或轻负载状态基于输出节点处感测到的电压的DC-DC转换。

10. 发明申请

US20130063104A1 ELECTRONIC DEVICE AND METHOD FOR DC-DC CONVERSION WITH LOW POWER MODE 有权
标题翻译：具有低功率模式的DC-DC转换的电子设备和方法
公开(公告)号：US20130063104A1
公开(公告)日：2013-03-14
申请号：US13597107
申请日：2012-08-28
申请人： Neil Gibson
发明人： Neil Gibson
IPC分类号： G05F1/46
CPC分类号： H02M3/1588 , H02M3/156 , H02M2001/0032 , Y02B70/1466 , Y02B70/16
摘要： The invention relates to an electronic device and a method for DC-DC-conversion. The electronic device includes energizing switch and a commutating switch coupled at a switching node. The switching node is configured to be coupled to an inductor. The electronic device is configured to repeatedly suspend the regular synchronous switching of the commutating switch during a load detection period, to sense the voltage at the output node during the load detection period and to determine a high-load condition or a light-load condition of the DC-DC-conversion based on the sensed voltage at the output node.
摘要翻译：本发明涉及一种用于DC-DC转换的电子设备和方法。电子设备包括通电开关和耦合在开关节点处的换向开关。开关节点被配置为耦合到电感器。电子设备被配置为在负载检测周期期间重复地中止整流开关的正常同步切换，以在负载检测期间感测输出节点处的电压，并且确定负载状态或轻负载状态基于输出节点处感测到的电压的DC-DC转换。

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