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1. 发明申请

US20050202519A1 Mutated abl kinase domains 审中-公开
标题翻译：突变的abl激酶结构域
公开(公告)号：US20050202519A1
公开(公告)日：2005-09-15
申请号：US10491603
申请日：2002-10-04
申请人： Christophe Barthe , Susan Branford , Amie Corbin , Brian Druker , Justus Duyster , Andreas Hochhaus , Timothy Hughes , Sebastian Kreil , Thibaut Leguay , Francois-Xavier Mahon , Gerald Marit , Martin Muller , Chriatian Peschel , Claude Preudhomme , Catherine Roche Lestienne , Zbigniew Rudzki
发明人： Christophe Barthe , Susan Branford , Amie Corbin , Brian Druker , Justus Duyster , Andreas Hochhaus , Timothy Hughes , Sebastian Kreil , Thibaut Leguay , Francois-Xavier Mahon , Gerald Marit , Martin Muller , Chriatian Peschel , Claude Preudhomme , Catherine Roche Lestienne , Zbigniew Rudzki
IPC分类号： C12N15/09 , C07H21/04 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12Q1/48
CPC分类号： C12N9/1205
摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要翻译：本发明涉及分离的多肽，其包含功能性激酶结构域，所述功能性激酶结构域包含天然人Abl激酶结构域的氨基酸序列或其基本相似的序列，其中至少一种选自Met244，Leu248，Gly250，Glu252，Tyr253， Val256，Glu258，Phe311，Ile313，Phe317，Met318，Met351，Glu355，Glu359，Ile360，His361，Leu370，Asp381，Phe382，His396，Ser417，Glu459和Phe486被另一个氨基酸取代，所述突变的功能性激酶结构域对通过N- [4-甲基-3-（4-吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基甲基） - 苯甲酰胺抑制其酪氨酸激酶活性或其盐使用这样的多肽筛选抑制这种多肽的酪氨酸激酶活性的化合物，编码这种多肽的核酸分子，重组载体和包含此类核酸分子的宿主细胞，以及使用其核酸分子生产这样的多肽用于筛选抑制这些多肽的酪氨酸激酶活性的化合物。

2. 发明申请

US20100021921A1 MUTATED ABL KINASE DOMAINS 审中-公开
标题翻译： MUTATED ABL激酶域
公开(公告)号：US20100021921A1
公开(公告)日：2010-01-28
申请号：US12545133
申请日：2009-08-21
申请人： Christophe Barthe , Susan Branford , Amie Corbin , Brian Jay Druker , Justus Duyster , Andreas Hochhaus , Timothy Hughes , Sebastian Kreil , Thibaut Leguay , Francois-Xavier Mahon , Gerald Marit , Martin Muller , Christian Peschel , Claude Preudhomme , Catherine Roche Lestienne , Zbigniew Rudzki
发明人： Christophe Barthe , Susan Branford , Amie Corbin , Brian Jay Druker , Justus Duyster , Andreas Hochhaus , Timothy Hughes , Sebastian Kreil , Thibaut Leguay , Francois-Xavier Mahon , Gerald Marit , Martin Muller , Christian Peschel , Claude Preudhomme , Catherine Roche Lestienne , Zbigniew Rudzki
IPC分类号： C12Q1/68 , C12N9/12 , C07H21/00 , C12N15/63 , C12N1/00
CPC分类号： C12N9/1205
摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要翻译：本发明涉及分离的多肽，其包含功能性激酶结构域，所述功能性激酶结构域包含天然人Abl激酶结构域的氨基酸序列或其基本相似的序列，其中至少一种选自Met244，Leu248，Gly250，Glu252，Tyr253， Val256，Glu258，Phe311，Ile313，Phe317，Met318，Met351，Glu355，Glu359，Ile360，His361，Leu370，Asp381，Phe382，His396，Ser417，Glu459和Phe486被另一个氨基酸取代，所述突变的功能性激酶结构域对通过N- [4-甲基-3-（4-吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基甲基） - 苯甲酰胺抑制其酪氨酸激酶活性或其盐使用这样的多肽筛选抑制这种多肽的酪氨酸激酶活性的化合物，编码这种多肽的核酸分子，重组载体和包含此类核酸分子的宿主细胞，以及使用其核酸分子生产这样的多肽用于筛选抑制这些多肽的酪氨酸激酶活性的化合物。

3. 发明申请

US20090117641A1 Mutated Abl Kinase Domains 审中-公开
标题翻译：突变的Abl激酶结构域
公开(公告)号：US20090117641A1
公开(公告)日：2009-05-07
申请号：US12165217
申请日：2008-06-30
申请人： Christophe Barthe , Susan Bradford , Amie Corbin , Brian Jay Druker , Justus Duyster , Andreas Hochhaus , Timothy Hughes , Sebastian Kreil , Thibaut Leguay , Francios-Xavier Mahon , Gerald Marit , Martin Muller , Christian Peschel , Claude Preudhomme , Catherine Roche Lestienne , Zbigniew Rudzki
发明人： Christophe Barthe , Susan Bradford , Amie Corbin , Brian Jay Druker , Justus Duyster , Andreas Hochhaus , Timothy Hughes , Sebastian Kreil , Thibaut Leguay , Francios-Xavier Mahon , Gerald Marit , Martin Muller , Christian Peschel , Claude Preudhomme , Catherine Roche Lestienne , Zbigniew Rudzki
IPC分类号： C12N9/12
CPC分类号： C12N9/1205
摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要翻译：本发明涉及分离的多肽，其包含功能性激酶结构域，所述功能性激酶结构域包含天然人Abl激酶结构域的氨基酸序列或其基本相似的序列，其中至少一种选自Met244，Leu248，Gly250，Glu252，Tyr253， Val256，Glu258，Phe311，Ile313，Phe317，Met318，Met351，Glu355，Glu359，Ile360，His361，Leu370，Asp381，Phe382，His396，Ser417，Glu459和Phe486被另一个氨基酸取代，所述突变的功能性激酶结构域对通过N- [4-甲基-3-（4-吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基甲基） - 苯甲酰胺抑制其酪氨酸激酶活性或其盐使用这样的多肽筛选抑制这种多肽的酪氨酸激酶活性的化合物，编码这种多肽的核酸分子，重组载体和包含此类核酸分子的宿主细胞，以及使用其核酸分子生产这样的多肽用于筛选抑制这些多肽的酪氨酸激酶活性的化合物。

4. 发明申请

US20060148058A1 Organic compounds 审中-公开
标题翻译：有机化合物
公开(公告)号：US20060148058A1
公开(公告)日：2006-07-06
申请号：US11343891
申请日：2006-01-31
申请人： Christophe Barthe , Pascale Cony-Makhoul , Amie Corbin , Sven De Vos , Brian Druker , Harald Gschaidmeier , Michael Hallek , Andreas Hochhaus , Dieter Hoelzer , Wolf-Karsten Hofmann , Phillip Koeffler , Sebastian Kreil , Francois-Xavier Mahon , Martin Muller , Oliver Ottmann , Markus Warmuth
发明人： Christophe Barthe , Pascale Cony-Makhoul , Amie Corbin , Sven De Vos , Brian Druker , Harald Gschaidmeier , Michael Hallek , Andreas Hochhaus , Dieter Hoelzer , Wolf-Karsten Hofmann , Phillip Koeffler , Sebastian Kreil , Francois-Xavier Mahon , Martin Muller , Oliver Ottmann , Markus Warmuth
IPC分类号： C12N9/12
CPC分类号： C12Q1/6886 , C07K14/82 , C12N9/12 , C12Q1/485 , C12Q2600/106 , G01N33/57426 , G01N2333/82
摘要： The tides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit they tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要翻译：包含由突变的功能性Ab1激酶结构域组成的氨基酸序列的所述突变体，所述突变的功能性激酶结构域对N- [4-甲基-3-（4-吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基甲基） - 苯甲酰胺或其盐，用于筛选抑制这些多肽的酪氨酸激酶活性的化合物，涉及编码这种多肽的核酸分子，重组载体和包含此类核酸分子的宿主细胞，以及这些核酸分子在产生此类多肽中的用途，用于筛选抑制这些多肽的酪氨酸激酶活性的化合物。

5. 发明申请

US20090191606A1 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：US20090191606A1
公开(公告)日：2009-07-30
申请号：US12337322
申请日：2008-12-17
申请人： Christophe Barthe , Pascale Cony-Makhoul , Amie Corbin , Sven De Vos , Brian Jay Druker , Harald Gschaidmeier , Michael Hallek , Andreas Hochhaus , Dieter Hoelzer , Wolf-Karsten Hofmann , Phillip Koeffler , Sebastian Kreil , Francois-Xavier Mahon , Martin Muller , Oliver Gerhard Ottmann , Markus Warmuth
发明人： Christophe Barthe , Pascale Cony-Makhoul , Amie Corbin , Sven De Vos , Brian Jay Druker , Harald Gschaidmeier , Michael Hallek , Andreas Hochhaus , Dieter Hoelzer , Wolf-Karsten Hofmann , Phillip Koeffler , Sebastian Kreil , Francois-Xavier Mahon , Martin Muller , Oliver Gerhard Ottmann , Markus Warmuth
IPC分类号： C12N9/12 , C07H21/00 , C12N15/63 , C12N5/10
CPC分类号： C12Q1/6886 , C07K14/82 , C12N9/12 , C12Q1/485 , C12Q2600/106 , G01N33/57426 , G01N2333/82
摘要： The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1 -ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要翻译：本发明涉及分离的多肽，其包含由突变的功能性Ab1激酶结构域组成的氨基酸序列，所述突变的功能性激酶结构域对N- [4-甲基-3-（4-吡啶基）吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基甲基） - 苯甲酰胺或其盐，用于筛选抑制酪氨酸激酶的化合物这种多肽的活性，编码这种多肽的核酸分子，重组载体和包含此类核酸分子的宿主细胞，以及这种核酸分子在制备这些多肽中的用途，用于筛选抑制酪氨酸激酶的化合物这些多肽的活性。

6. 发明申请

US20110070456A1 Method for Producing an Organic Electronic Component, and Organic Electronic Component 审中-公开
标题翻译：有机电子元件的制造方法和有机电子元件
公开(公告)号：US20110070456A1
公开(公告)日：2011-03-24
申请号：US12922833
申请日：2009-06-17
申请人： Marc Philippens , Richard Scheicher , Andreas Lovich , Ansgar Fischer , Martin Muller , Karsten Heuser , Ralph Paetzold
发明人： Marc Philippens , Richard Scheicher , Andreas Lovich , Ansgar Fischer , Martin Muller , Karsten Heuser , Ralph Paetzold
IPC分类号： B32B37/14 , B32B27/32
CPC分类号： H01L51/0097 , H01L51/524 , H01L51/5268 , H01L2251/5338 , H01L2251/5361 , H01L2251/566 , Y02E10/549 , Y02P70/521 , Y10T428/31938
摘要： A method for producing an organic electronic component comprises, in particular, the following steps: A) producing at least one functional layer stack (10) with the following substeps: A1) providing a flexible first substrate (1), A2) applying at least one organic layer (2) in large-area fashion on the first substrate (1) by means of a coil coating plant (90), and A3) singulating the first substrate (1) with the at least one organic layer (2) into a plurality of functional layer stacks (10); B) providing a second substrate (5), which has a lower flexibility and a higher impermeability with respect to moisture and oxygen than the first substrate (1); and C) applying the at least one of the plurality of the functional layer stacks (10) with a surface (11) of the first substrate (1) remote from the organic layer (2) on the second substrate (5).
摘要翻译：一种制造有机电子部件的方法特别包括以下步骤：A）产生具有以下子步骤的至少一个功能层堆叠（10）：A1）提供柔性第一基板（1），A2）至少施加一个有机层（2）以大面积方式通过线圈涂覆设备（90）在第一基底（1）上，以及A3）将具有至少一个有机层（2）的第一基底（1）分成多个功能层堆叠（10）; B）提供第二衬底（5），其具有比第一衬底（1）更低的柔性和相对于水分和氧气的更高的不渗透性; 以及C）将所述多个所述功能层堆叠（10）中的所述至少一个与所述第一基板（1）的远离所述有机层（2）的表面（11）施加在所述第二基板（5）上。

7. 发明授权

US07884177B2 Method and device for the continuous polycondensation of polyester material in the solid phase 有权
标题翻译：聚酯材料在固相中连续缩聚的方法和装置
公开(公告)号：US07884177B2
公开(公告)日：2011-02-08
申请号：US10470988
申请日：2001-02-26
申请人： Camille Borer , Martin Muller , Brent Allan Culbert
发明人： Camille Borer , Martin Muller , Brent Allan Culbert
IPC分类号： C08G63/80 , C08G63/88 , C08F6/26
CPC分类号： C08G63/88 , C08G63/785 , C08G63/80
摘要： The invention relates to a method and device for the continuous polycondensation of polyester material in the solid phase, in particular in the form of partially crystalline granulate. The aim of the invention is to achieve a high product throughput on recrystallising and recondensation of polyester material with a low initial IV. Said aim is achieved, whereby on recrystallisation, a low residence time of 1-10 minutes is achieved, by means of a rapid heating of a thin product layer, followed by an SSP treatment.
摘要翻译：本发明涉及一种在固相中聚酯材料的连续缩聚，特别是部分结晶颗粒形式的方法和装置。本发明的目的是在初始IV低的聚酯材料的重结晶和再缩合中实现高产品生产量。实现所述目的，由此在再结晶时，通过快速加热薄的产物层，随后进行SSP处理，实现1-10分钟的低停留时间。

8. 发明申请

US20090094009A1 SYSTEM AND METHOD FOR MODELING OF TURBO-CHARGED ENGINES AND INDIRECT MEASUREMENT OF TURBINE AND WASTE-GATE FLOW AND TURBINE EFFICIENCY 失效
标题翻译：涡轮增压发动机的建模系统和方法以及涡轮机和废气流量和涡轮机效率的间接测量
公开(公告)号：US20090094009A1
公开(公告)日：2009-04-09
申请号：US11867422
申请日：2007-10-04
申请人： Martin Muller
发明人： Martin Muller
IPC分类号： G06G7/48
CPC分类号： G06F17/5009 , F02D41/0007 , F02D41/1445 , F02D41/1447 , F02D41/145 , F02D2041/1433 , G06F17/5095 , G06F2217/16 , G06F2217/80 , Y02T10/144 , Y02T10/82
摘要： A real-time system for modeling a turbo-charged engine includes a model configured to estimate various exhaust states such as turbine inlet pressure, turbine outlet pressure, turbine outlet temperature, turbine mass flow rate and waste-gate valve mass flow rate. The model is dependent only on the availability of normal operating values available in a conventionally-configured automotive controller and one or more measured intake side parameters such as ambient pressure, boost pressure, ambient temperature and compressor mass flow rate. The model is constructed to reflect a high-level application of energy conservation between the turbine (generated power) and compressor (absorbed power). A method for the indirect measurement of turbine and waste-gate flow uses turbine inlet and outlet pressure, inlet temperature and engine mass air flow rate measurements. A method for the indirect measurement of turbine efficiency avoids the need for manufacturer's turbine data.
摘要翻译：用于对涡轮增压发动机进行建模的实时系统包括被配置为估计各种排气状态的模型，例如涡轮进口压力，涡轮出口压力，涡轮出口温度，涡轮质量流量和废气门阀质量流量。该模型仅取决于常规配置的汽车控制器中可用的正常工作值的可用性以及一个或多个测量的进气侧参数，例如环境压力，增压压力，环境温度和压缩机质量流量。该模型被构造为反映在涡轮（发电）和压缩机（吸收功率）之间的节能的高水平应用。用于间接测量涡轮机和废气门流量的方法使用涡轮机入口和出口压力，入口温度和发动机质量空气流量测量。用于间接测量涡轮机效率的方法避免了制造商的涡轮数据的需要。

9. 发明授权

US07456392B2 Use of ultraphobic surfaces having a multitude of hydrophilic areas for analyzing samples 有权
标题翻译：使用具有大量亲水区域的超疏水表面来分析样品
公开(公告)号：US07456392B2
公开(公告)日：2008-11-25
申请号：US10505616
申请日：2003-02-24
申请人： Joachim Engelking , Karsten Reihs , Eckhard Nordhoff , Martin Muller
发明人： Joachim Engelking , Karsten Reihs , Eckhard Nordhoff , Martin Muller
IPC分类号： B01L3/00
CPC分类号： H01J49/0418 , B01J2219/00527 , B01L3/5085 , B01L3/5088 , B01L2300/0819 , B01L2300/165 , B01L2300/166 , C12Q1/6837 , G01N1/22 , Y10T428/31504 , C12Q2565/627
摘要： The invention relates to the use of surfaces having hydrophilic and/or oleophilic areas, each of which being completely surrounded by the ultraphobic areas, for analyzing samples. The invention also relates to a method for precisely dosing liquids without contaminating them.
摘要翻译：本发明涉及具有亲水和/或亲油性区域的表面的用途，每个区域都被超疏水区域完全包围，用于分析样品。本发明还涉及一种用于精确计量液体而不污染它们的方法。

10. 发明申请

US20080108755A1 Microgel-containing composition 审中-公开
标题翻译：含微凝胶的组合物
公开(公告)号：US20080108755A1
公开(公告)日：2008-05-08
申请号：US12004941
申请日：2007-12-20
申请人： Ludger Heiliger , Thomas Fruh , Volker Muller , Heiko Tebbe , Werner Obrecht , Robert Schuster , Martin Muller
发明人： Ludger Heiliger , Thomas Fruh , Volker Muller , Heiko Tebbe , Werner Obrecht , Robert Schuster , Martin Muller
IPC分类号： C08F8/00
CPC分类号： C08L21/00 , C08L23/10 , C08L2666/02 , C08L2666/08
摘要： The present invention relates to a composition containing thermoplastic materials and crosslinked microgels that have not been crosslinked by high-energy radiation, to a process for its preparation, to its use in the production of thermoplastically processable molded articles, and to molded articles produced from the composition.
摘要翻译：本发明涉及一种含热塑性材料和交联微凝胶的组合物，其未被高能量辐射交联，其制备方法，其在生产热塑性加工成型制品中的应用，以及由组成。

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