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1. 发明授权

US6096319A Recombinant antigen from the NS3 region of the hepatitis C virus 失效
标题翻译：来自丙型肝炎病毒NS3区域的重组抗原
公开(公告)号：US6096319A
公开(公告)日：2000-08-01
申请号：US511759
申请日：1995-08-07
申请人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
发明人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
IPC分类号： G01N33/53 , A61K38/00 , A61K39/29 , A61P1/16 , A61P31/12 , A61P31/14 , C07H21/04 , C07K14/02 , C07K14/10 , C07K14/18 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/40 , C12N15/51 , C12P21/02 , C12P21/04 , C12R1/19 , G01N33/532 , G01N33/537 , G01N33/569 , G01N33/576 , G01N33/68 , C12Q1/70
CPC分类号： C07K14/005 , G01N33/56983 , G01N33/5767 , A61K38/00 , C12N2770/24222 , Y10S436/82
摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207.+-.10 to 1488.+-.10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.
摘要翻译：本发明涉及由丙型肝炎病毒的氨基酸1207 +/- 10〜1488 +/- 10和少于20种外来氨基酸组成的多肽，以及在免疫学试验中使用该多肽作为抗原。

2. 发明授权

US07122302B2 Method for determining early HCV seroconversion 失效
公开(公告)号：US07122302B2
公开(公告)日：2006-10-17
申请号：US09896032
申请日：2001-06-29
申请人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
发明人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222 , G01N33/56983 , G01N33/5767 , Y10S436/82
摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.

3. 发明申请

US20050095584A1 Method for determining early HCV seroconversion 审中-公开
标题翻译：确定早期HCV血清学转换的方法
公开(公告)号：US20050095584A1
公开(公告)日：2005-05-05
申请号：US10802891
申请日：2004-03-17
申请人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
发明人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
IPC分类号： G01N33/53 , A61K38/00 , A61K39/29 , A61P1/16 , A61P31/12 , A61P31/14 , C07H21/04 , C07K14/02 , C07K14/10 , C07K14/18 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/40 , C12N15/51 , C12P21/02 , C12P21/04 , C12R1/19 , G01N33/532 , G01N33/537 , G01N33/569 , G01N33/576 , G01N33/68 , C12Q1/70 , C12N15/86 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222 , G01N33/56983 , G01N33/5767 , Y10S436/82
摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.
摘要翻译：本发明涉及由免疫学试验中由丙型肝炎病毒的氨基酸1207±10至1488±10和小于20个外来氨基酸组成的多肽和该多肽作为抗原的用途。

4. 发明授权

US06306579B1 Recombinant antigen from the NS3 region of the hepatitis C virus 失效
标题翻译：来自丙型肝炎病毒NS3区域的重组抗原
公开(公告)号：US06306579B1
公开(公告)日：2001-10-23
申请号：US08892704
申请日：1997-07-15
申请人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
发明人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222 , G01N33/56983 , G01N33/5767 , Y10S436/82
摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.
摘要翻译：本发明涉及一种多肽，其由丙型肝炎病毒的氨基酸1207 10至1488 10和少于20个外来氨基酸组成，并且在免疫测试中使用该多肽作为抗原

5. 发明授权

US06270960B1 Recombinant antigen from the NS3 region of the hepatitis C virus 有权
公开(公告)号：US06270960B1
公开(公告)日：2001-08-07
申请号：US09592197
申请日：2000-06-12
申请人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
发明人： Christoph Seidel , Ursula-Henrike Wienhues , Urban Schmitt , Manfred Motz , Michael Wiedmann , Barbara Upmeier , Erwin Soutschek
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222 , G01N33/56983 , G01N33/5767 , Y10S436/82
摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.

6. 发明申请

US20060057563A1 Peptides derived from capsid antigens of the Epstein-Barr virus and the use thereof 有权
公开(公告)号：US20060057563A1
公开(公告)日：2006-03-16
申请号：US11192070
申请日：2005-07-29
申请人： Manfred Motz , Georg Bauer , Erwin Soutschek
发明人： Manfred Motz , Georg Bauer , Erwin Soutschek
IPC分类号： C12Q1/70 , C07H21/04 , C07K14/05
CPC分类号： G01N33/56994
摘要： In the area of virus diagnosis, in particular Epstein-Barr virus (EBV) diagnosis, methods for the detection of EBV and agents suitable for this purpose are provided, including peptides which are derived from p18-VCA and permit discrimination between acute and past EBV infection.

7. 发明授权

US07476498B2 Peptides derived from capsid antigens of the Epstein-Barr virus and the use thereof 有权
标题翻译：衍生自爱泼斯坦 - 巴尔病毒衣壳抗原的肽及其用途
公开(公告)号：US07476498B2
公开(公告)日：2009-01-13
申请号：US11192070
申请日：2005-07-29
申请人： Manfred Motz , Georg Bauer , Erwin Soutschek
发明人： Manfred Motz , Georg Bauer , Erwin Soutschek
IPC分类号： C12Q1/70
CPC分类号： G01N33/56994
摘要： In the area of virus diagnosis, in particular Epstein-Barr virus (EBV) diagnosis, methods for the detection of EBV and agents suitable for this purpose are provided, including peptides which are derived from p18-VCA and permit discrimination between acute and past EBV infection.
摘要翻译：在病毒诊断领域，特别是EB病毒（EBV）诊断中，提供了用于检测EBV的方法和适合于此目的的试剂，包括衍生自p18-VCA的肽，并允许区分急性和过去的EBV 感染。

8. 发明授权

US06808711B2 Immunologically active proteins from Borrelia burgdorferi, nucleic acids which encode them, and their use in test kits and as vaccines 有权
标题翻译：来自博氏疏螺旋体的免疫活性蛋白质，编码它们的核酸及其在测试试剂盒和疫苗中的应用
公开(公告)号：US06808711B2
公开(公告)日：2004-10-26
申请号：US10403220
申请日：2003-03-26
申请人： Manfred Motz , Erwin Soutschek
发明人： Manfred Motz , Erwin Soutschek
IPC分类号： A61K3902
CPC分类号： C07K14/20 , A61K39/00 , A61K2039/51 , Y02A50/401
摘要： The present invention relates to immunologically active proteins from Borrelia burgdorferi which are present in a form which is free of other proteins derived from Borrelia burgdorferi and which exhibit the sequence of the protein 1829-22A, which has the amino acid sequence (SEQ. ID NO:1) MKKFNLIIEALFAILLTACNFGLMEETKIALESSSKDVKNKILQIKKDAE DKGVNFAAFTSSETGSKVTNGGLALREAKIQAINEVEKFLKRIEEEALKL KEHGNSGQFLELFDLLLEVLESLEPIGIKGLKDFISEEAKCNPISTSER LIEVKVQIENKMEEVKRKQNLNKERKSNKGKKKK or a part sequence therefor having at least 10 consecutive amino acids, or exhibit the sequence of the protein 1829-22B, which has the amino acid sequence (SEQ. ID NO:2) MIKYNKIILTLTLLASLLAACSLTGKARLESSVKDITNEIEKAIKEAEDA GVKTDAFTETQTGGKVAGPKIRAAKIRVADLTIKFLEATEEETITFKENG AGEDEFSGIYDLILNAAKAVEKIGMKDMTKTVEEAAKENPKTTANGIIEI VKVMKAKVENIKEKQTKNQK or part sequence thereof having at least 10 consecutive amino acids.

9. 发明授权

US06610301B1 Immunologically active proteins from Borrelia burgdorferi, nucleic acids which encode them, and their use in test kits and as vaccines 有权
标题翻译：来自博氏疏螺旋体的免疫活性蛋白，编码它们的核酸及其在测试试剂盒和疫苗中的应用
公开(公告)号：US06610301B1
公开(公告)日：2003-08-26
申请号：US09242299
申请日：1999-02-12
申请人： Manfred Motz , Erwin Soutschek
发明人： Manfred Motz , Erwin Soutschek
IPC分类号： A61K3902
CPC分类号： C07K14/20 , A61K39/00 , A61K2039/51 , Y02A50/401
摘要： The present invention relates to immunologically active proteins from Borrelia burgdorferi which are present in a form which is free of other proteins derived from Borrelia burgdorferi and which exhibit the sequence of the protein 1829-22A, which has the amino acid sequence MKKFNLIIEALFAILLTACNFGLMEETKIALESSSKDVKNKILQIKKDAEDKGVNFAAFTSSETG SKVTNGGLALREAKIQAINEVEKFLKRIEEEALKLKEHGNSGQFLELFDLLLEVLESLEPIGIKG LKDFISEEAKCNPISTSERLIEVKVQIENKMEEVKRKQNLNKERKSNKGKKKK SEQ. ID NO.: 1 or a part sequence thereof having at least 10 consecutive amino acids, or exhibit the sequence of the protein 1829-22B, which has the amino acid sequence MIKYNKIILTLTLLASLLAACSLTGKARLESSVKDITNEIEKAIKEAEDAGVKTDAFTETQTGGK VAGPKIRAAKIRVADLTIKFLEATEEETITFKENGAGEDEFSGIYDLILNAAKAVEKIGMKDMTK TVEEAAKENPKTTANGIIEIVKVMKAKVENIKEKQTKNQK SEQ. ID NO.: 2 or a part sequence thereof having at least 10 consecutive amino acids.
摘要翻译：本发明涉及由莱姆病螺旋体免疫活性的蛋白质，其存在于一种形式，其不含来自伯氏疏螺旋和其表现出的蛋白1829-22A，其具有氨基酸sequenceMKKFNLIIEALFAILLTACNFGLMEETKIALESSSKDVKNKILQIKKDAEDKGVNFAAFTSSETG SKVTNGGLALREAKIQAINEVEKFLKRIEEEALKLKEHGNSGQFLELFDLLLEVLESLEPIGIKG LKDFISEEAKCNPISTSERLIEVKVQIENKMEEVKRKQNLNKERKSNKGKKKK SEQ的序列衍生其它蛋白质。或具有至少10个连续氨基酸的部分序列，或表现出具有氨基酸序列的蛋白质1829-22B的序列，其具有以下氨基酸序列：MIKYNKIILTLTLLASLLAACSLTGKARLESSVKDITNEIEKAIKEAEDAGVKTDAFTETQTGGK VAGPKIRAAKIRVADLTIKFLEATEEETITFKENGAGEDEFSGIYDLILNAAKAVEKIGMKDMTK TVEEAAKENPKTTANGIIEIVKVMKAKVENIKEKQTKNQK SEQ ID NO： ID号：2或其具有至少10个连续氨基酸的部分序列。

10. 发明授权

US06274307B1 Immunologically active peptides or polypeptides from the parvovirus B19 失效
标题翻译：来自细小病毒B19的免疫活性肽或多肽
公开(公告)号：US06274307B1
公开(公告)日：2001-08-14
申请号：US08856841
申请日：1997-05-15
申请人： Erwin Soutschek , Manfred Motz
发明人： Erwin Soutschek , Manfred Motz
IPC分类号： C12Q170
CPC分类号： C07K14/005 , C12N2750/14222 , Y10S435/975
摘要： Immunologically active peptides or polypeptides with a partial amino-acid sequence of the capsid proteins VP1 and VP2 of parvovirus B19 which permit tests to be carried out at low cost, sensitively and specifically for the determination of antibodies against human parvovirus B19 are made available. Short peptide sequences which, employed as antigen, serve to identify anti-B19 IgG-positive sera are identified. Furthermore, the production of these peptides using genetic engineering measures is disclosed. Other antigens which are produced by genetic engineering and which can be stably produced in a high yield in E.coli and subsequently purified therefrom are used as additional antigens for IgG detection. Finally, a set of antigens permits tests to be carried out to determine IgM antibodies against the virus. In addition, the components, produced by genetic engineering, of the surface proteins represent substances which can be used for prophylactic immunisation.
摘要翻译：提供具有细小病毒B19的衣壳蛋白VP1和VP2的部分氨基酸序列的免疫活性肽或多肽，其允许以低成本进行测试，敏感地且专门用于测定抗人细小病毒B19的抗体。鉴定用作抗原的短肽序列，用于鉴定抗B19 IgG阳性血清。此外，公开了使用遗传工程措施生产这些肽。通过遗传工程产生并且可以在大肠杆菌中以高产量稳定产生并随后从其中纯化的其他抗原用作IgG检测的额外抗原。最后，一组抗原允许进行测试来确定针对病毒的IgM抗体。此外，通过遗传工程生产的表面蛋白质的组分代表可用于预防性免疫的物质。

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