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1. 发明授权

US5367162A Integrating transient recorder apparatus for time array detection in time-of-flight mass spectrometry 失效
标题翻译：在飞行时间质谱中集成瞬时记录仪用于时间阵列检测
公开(公告)号：US5367162A
公开(公告)日：1994-11-22
申请号：US81731
申请日：1993-06-23
申请人： John F. Holland , Christie G. Enke , Michael R. Davenport , Lawrence W. Janow
发明人： John F. Holland , Christie G. Enke , Michael R. Davenport , Lawrence W. Janow
IPC分类号： H01J49/02 , H01J49/40 , B01D59/04 , H01J49/00
CPC分类号： H01J49/025 , H01J49/40
摘要： An integrating transient recorder for time array detection of ions within an ion source extraction. The arrival times of all ions having various mass-to-charge ratios are calculated and integrating or peak detecting circuitry is activated just prior to the calculated time of arrival of each ion, and then only for a time duration in accordance with a predetermined data collection time window sufficient to enable each ion mass value to be completely measured. An analog-to-digital converter converts the area or peak analog signal for each ion into a corresponding digital signal and outputs the digital signals to a plurality of FIFO buffers. The FIFO buffers are read out for each successive transient by a digital signal processor and summed over a predetermined number of sequential transients in a mass locked registry creating a file of ion intensities versus mass-to-charge ratio of all ions detected. In a preferred embodiment the apparatus includes a mass defect detector which compares the actual arrival time of the ions with the calculated anticipated time of arrival and applies appropriate time delays from a selected one of a plurality of delta-mass tables. This causes the area or peak detection circuity to be turned on either slightly prior to or subsequent to the calculated times of arrival of each of the ions to thus cause each of the ions to be received clearly and completely within each data collection window. Preferred embodiments include combinations of analog or digital peak or area capture and analog or digital successive summations.
摘要翻译：用于时间阵列检测离子源提取中离子的积分瞬态记录仪。计算具有各种质荷比的所有离子的到达时间，并且在计算的每个离子的到达时间之前激活积分或峰值检测电路，然后仅根据预定数据收集的持续时间足以使每个离子质量值完全测量的时间窗。模数转换器将每个离子的面积或峰值模拟信号转换成相应的数字信号，并将数字信号输出到多个FIFO缓冲器。通过数字信号处理器对每个连续的瞬态读出FIFO缓冲器，并在质量锁定的注册表中的预定数量的顺序瞬变相加，从而产生离子强度的文件与检测到的所有离子的质荷比。在优选实施例中，装置包括质量缺陷检测器，其将离子的实际到达时间与计算的预计到达时间进行比较，并从多个delta质量表中选择的一个施加适当的时间延迟。这导致区域或峰值检测电路在计算出的每个离子的到达时间之前或之后稍微打开，从而使每个离子在每个数据收集窗口内被清楚和完全地接收。优选实施例包括模拟或数字峰值或区域捕获以及模拟或数字连续求和的组合。

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