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1. 发明授权

US5910444A Plants in which the expression of S-adenosylhomocysteine hydrolase gene is inhibited 失效
标题翻译：其中S-腺苷高半胱氨酸水解酶基因表达被抑制的植物
公开(公告)号：US5910444A
公开(公告)日：1999-06-08
申请号：US669536
申请日：1996-07-12
申请人： Chikara Masuta , Kyoko Uehara , Hideo Tanaka , Shigeru Kuwata
发明人： Chikara Masuta , Kyoko Uehara , Hideo Tanaka , Shigeru Kuwata
IPC分类号： C12N9/14 , C12N15/82 , A01H4/00 , C07H21/00 , C07K14/415 , C12N5/14
CPC分类号： C12N15/8283 , C12N15/8243 , C12N9/14
摘要： The present invention discloses transgenic plants in which the expression of SAHH gene present in their genome is substantially inhibited. Such plants have excellent properties such as resistance to viruses.
摘要翻译： PCT No.PCT / JP95 / 02333 Sec。 371日期：1996年7月12日 102（e）日期1996年7月12日PCT提交1995年11月15日PCT公布。第WO96 / 14734号公报日期1996年5月23日本发明公开了基因组中存在的SAHH基因的表达被基本抑制的转基因植物。这样的植物具有优异的性质，例如抗病毒性。

2. 发明申请

US20120172580A1 ANTI-PLANT-VIRUS AGENT 有权
标题翻译：抗病毒药物
公开(公告)号：US20120172580A1
公开(公告)日：2012-07-05
申请号：US13394395
申请日：2010-09-09
申请人： Chikara Masuta , Hanako Shimura , Shinsuke Sano , Takako Fukagawa
发明人： Chikara Masuta , Hanako Shimura , Shinsuke Sano , Takako Fukagawa
IPC分类号： C07D307/62 , C07H17/04 , C07F9/655
CPC分类号： A01N43/08 , A01N43/16 , A01N57/16
摘要： The present invention provides an anti-plant virus agent which exhibits preventative and therapeutic effects on plant virus diseases. The anti-plant virus agent of the present invention is characterized by containing at least one compound selected from the group consisting of ascorbic acid derivatives represented by Formula (I) (wherein, R1 to R4 each independently represents a hydrogen atom, —SO3H, —PO3H2, a glycosyl group, or —COR11, wherein R11 represents an unsubstituted or substituted C1-30 alkyl group, or an unsubstituted or substituted C2-30 alkenyl group, with the proviso that R1 to R4 may not all be hydrogen atoms at the same time), and salts thereof.
摘要翻译：本发明提供对植物病毒病具有预防和治疗作用的抗植物病毒剂。本发明的抗植物病毒剂的特征在于含有至少一种选自由式（I）表示的抗坏血酸衍生物的化合物（其中，R 1至R 4各自独立地表示氢原子，-SO 3 H， - PO 3 H 2，糖基或-COR 11，其中R 11表示未取代或取代的C 1-30烷基，或未取代或取代的C 2-30烯基，条件是R 1至R 4可不全部为相同的氢原子时间）及其盐。

3. 发明申请

US20070143877A1 Plant virus vector 有权
标题翻译：植物病毒载体
公开(公告)号：US20070143877A1
公开(公告)日：2007-06-21
申请号：US10562227
申请日：2004-06-25
申请人： Chikara Masuta , Takeshi Matsumura , Noriko Itchoda
发明人： Chikara Masuta , Takeshi Matsumura , Noriko Itchoda
IPC分类号： A01H1/00 , C12N7/00
CPC分类号： C12N15/8203
摘要： A novel plant virus vector and a method of gene expression into plants are provided, and the present invention relates to a plant virus vector characterized in that a part of the sequence of the 2b region of the RNA2 molecule of the Cucumber mosaic virus (CMV) is deleted; the aforementioned plant virus vector characterized in that the region from the StuI site to the stop codon of the 2b ORF of pCY2, which is an infectious clone of CMV-Y RNA2, is deleted; and a method of gene expression in plants characterized in that a foreign gene is introduced so as to be stably expressed in a plant using the genetic recombinant. This vector is useful as a plant RNA vector for causing stable expression of foreign genes.
摘要翻译：提供了一种新型植物病毒载体和植物基因表达方法，本发明涉及植物病毒载体，其特征在于黄瓜花叶病毒（CMV）的RNA2分子的2b区的一部分序列，被删除上述植物病毒载体的特征在于缺失了作为CMV-Y RNA2的感染性克隆的pCY2的2b ORF的StuI位点至终止密码子的区域; 以及植物中的基因表达方法，其特征在于引入外源基因，以便使用遗传重组体在植物中稳定表达。该载体可用作引起外源基因稳定表达的植物RNA载体。

4. 发明授权

US5304731A Vector 失效
标题翻译：向量
公开(公告)号：US5304731A
公开(公告)日：1994-04-19
申请号：US944710
申请日：1992-09-11
申请人： Chikara Masuta , Yoichi Takanami , Akira Koiwai
发明人： Chikara Masuta , Yoichi Takanami , Akira Koiwai
IPC分类号： C12N15/09 , C12N15/82 , C12N15/83 , C12P21/00 , A01H1/04 , C12N7/00 , C12N15/00 , C12P19/34
CPC分类号： C12N15/8203
摘要： This invention relates to a novel vector constructed by inserting an exogenous RNA fragment into a vector comprising a satellite RNA of a plant virus in a way wherein the replication ability of the satellite is retained as much as possible to convert it to a chimeric RNA molecule. Those novel vectors satisfactorily have conditions necessary as a vector and may effectively be used for transformation of plants, synthesis of proteins and the like.
摘要翻译：本发明涉及一种通过将外源RNA片段插入到包含植物病毒的卫星RNA的载体中而构建的新载体，其中尽可能保留卫星的复制能力以将其转化为嵌合RNA分子。这些新型载体令人满意地具有作为载体必需的条件，并且可以有效地用于植物的转化，蛋白质的合成等。

5. 发明申请

US20120041072A1 Antiviral agent 失效
标题翻译：抗病毒剂
公开(公告)号：US20120041072A1
公开(公告)日：2012-02-16
申请号：US13067623
申请日：2011-06-15
申请人： Shinsuke Sano , Takako Fukagawa , Hirokazu Yamada , Chikara Masuta , Hanako Shimura
发明人： Shinsuke Sano , Takako Fukagawa , Hirokazu Yamada , Chikara Masuta , Hanako Shimura
IPC分类号： A61K31/122 , A61P31/12
CPC分类号： A61K31/122 , A61K31/7088 , A61K31/7105
摘要： A compound having inhibitory activity on the binding of a substance α to a PTGS suppressor protein, wherein the substance α has a property of inducing PTGS and a property of binding to the PTGS suppressor protein and shows a decrease in the property of inducing PTGS upon binding to the PTGS suppressor protein.
摘要翻译：对物质α与PTGS抑制蛋白的结合具有抑制活性的化合物，其中物质α具有诱导PTGS的性质和与PTGS抑制蛋白结合的性质，并且在结合时表现出诱导PTGS的性质的降低到PTGS抑制蛋白。

6. 发明授权

US08853172B2 Anti-plant-virus agent 有权
标题翻译：抗病毒剂
公开(公告)号：US08853172B2
公开(公告)日：2014-10-07
申请号：US13394395
申请日：2010-09-09
申请人： Chikara Masuta , Hanako Shimura , Shinsuke Sano , Takako Fukagawa
发明人： Chikara Masuta , Hanako Shimura , Shinsuke Sano , Takako Fukagawa
IPC分类号： A61K31/34 , A61K31/70 , A01N57/16 , A01N43/08 , A01N43/16
CPC分类号： A01N43/08 , A01N43/16 , A01N57/16
摘要： The present invention provides an anti-plant virus agent which exhibits preventative and therapeutic effects on plant virus diseases. The anti-plant virus agent of the present invention is characterized by containing at least one compound selected from the group consisting of ascorbic acid derivatives represented by Formula (I) (wherein, R1 to R4 each independently represents a hydrogen atom, —SO3H, —PO3H2, a glycosyl group, or —COR11, wherein R11 represents an unsubstituted or substituted C1-30 alkyl group, or an unsubstituted or substituted C2-30 alkenyl group, with the proviso that R1 to R4 may not all be hydrogen atoms at the same time), and salts thereof.
摘要翻译：本发明提供对植物病毒病具有预防和治疗作用的抗植物病毒剂。本发明的抗植物病毒剂的特征在于含有至少一种选自由式（I）表示的抗坏血酸衍生物的化合物（其中，R 1至R 4各自独立地表示氢原子，-SO 3 H， - PO 3 H 2，糖基或-COR 11，其中R 11表示未取代或取代的C 1-30烷基，或未取代或取代的C 2-30烯基，条件是R 1至R 4可不全部为相同的氢原子时间）及其盐。

7. 发明授权

US08680158B2 Antiviral agent 失效
标题翻译：抗病毒剂
公开(公告)号：US08680158B2
公开(公告)日：2014-03-25
申请号：US13067623
申请日：2011-06-15
申请人： Shinsuke Sano , Takako Fukagawa , Hirokazu Yamada , Chikara Masuta , Hanako Shimura
发明人： Shinsuke Sano , Takako Fukagawa , Hirokazu Yamada , Chikara Masuta , Hanako Shimura
IPC分类号： A01N35/00 , A61K31/12
CPC分类号： A61K31/122 , A61K31/7088 , A61K31/7105
摘要： A compound having inhibitory activity on the binding of a substance α to a PTGS suppressor protein, wherein the substance α has a property of inducing PTGS and a property of binding to the PTGS suppressor protein and shows a decrease in the property of inducing PTGS upon binding to the PTGS suppressor protein.
摘要翻译：对物质α与PTGS抑制蛋白的结合具有抑制活性的化合物，其中物质α具有诱导PTGS的性质和与PTGS抑制蛋白结合的性质，并且在结合时显示诱导PTGS的性质的降低到PTGS抑制蛋白。

8. 发明申请

US20100216981A1 ANTIVIRAL AGENT 审中-公开
标题翻译：抗病毒剂
公开(公告)号：US20100216981A1
公开(公告)日：2010-08-26
申请号：US12450150
申请日：2008-03-19
申请人： Shinsuke Sano , Takako Fukagawa , Hirokazu Yamada , Chikara Masuta , Hanako Shimura
发明人： Shinsuke Sano , Takako Fukagawa , Hirokazu Yamada , Chikara Masuta , Hanako Shimura
IPC分类号： C07H21/04 , C07C49/553 , C07C49/543 , C07C49/537
CPC分类号： A61K31/122 , A61K31/7088 , A61K31/7105
摘要： An object of the present invention is to provide a viral disease control agent which has a mechanism of action different from conventional one as a substitute for existing viral disease control methods and is used in more practical and safer manners. The present invention utilizes a compound having inhibitory activity on the binding of a substance α to a PTGS suppressor protein, wherein the substance α has a property of inducing PTGS and a property of binding to the PTGS suppressor protein and shows a decrease in the property of inducing PTGS upon binding to the PTGS suppressor protein.
摘要翻译：本发明的目的是提供一种病毒性疾病控制剂，其具有与常规作用不同的作用机理，作为现有病毒性疾病控制方法的替代物，并以更实际和更安全的方式使用。本发明利用对物质α与PTGS抑制蛋白的结合具有抑制活性的化合物，其中物质α具有诱导PTGS的性质和与PTGS抑制蛋白结合的性质，并且表现出降低在结合PTGS抑制蛋白时诱导PTGS。

9. 发明授权

US09018444B2 Non-diffusing plant virus vector 有权
标题翻译：非扩散植物病毒载体
公开(公告)号：US09018444B2
公开(公告)日：2015-04-28
申请号：US13057818
申请日：2009-08-07
申请人： Noriho Fukuzawa , Takeshi Matsumura , Noriko Itchoda , Takeaki Ishihara , Chikara Masuta
发明人： Noriho Fukuzawa , Takeshi Matsumura , Noriko Itchoda , Takeaki Ishihara , Chikara Masuta
IPC分类号： C12N15/83 , C12N15/33 , C12N15/82 , C12N15/86
CPC分类号： C12N15/8203 , C12N15/86 , C12N2770/14043
摘要： The present invention is to provide a novel non-diffusing plant virus vector wherein virus vector infection and proliferation are possible only in a recombinant plant transformed with a gene necessary for viral proliferation, thereby enabling avoidance of unintended diffusion of a recombinant virus, a selective and specific expression system therefor, and a method of expression thereof which comprises combining a non-diffusing virus vector lacking a gene involved in intercellular movement of a cucumber mosaic virus (CMV) genome and a transgenic plant transformed with the lacked gene involved in intercellular movement for the non-diffusing virus vector to establish infection and proliferation selectively and specifically in the transgenic plant.
摘要翻译：本发明提供一种新的非扩散性植物病毒载体，其中病毒载体的感染和增殖仅在用病毒增殖所必需的基因转化的重组植物中是可能的，从而能够避免重组病毒的非预期扩散，选择性和特异性表达系统及其表达方法，其包括将缺乏参与黄瓜花叶病毒（CMV）基因组的细胞间运动的基因的非扩散病毒载体与转基因植物相结合，转基因植物参与细胞间移动非扩散病毒载体在转基因植物中选择性和特异性地建立感染和增殖。

10. 发明申请

US20110138497A1 Non-Diffusing Plant Virus Vector 有权
标题翻译：非扩散植物病毒载体
公开(公告)号：US20110138497A1
公开(公告)日：2011-06-09
申请号：US13057818
申请日：2009-08-07
申请人： Noriho Fukuzawa , Takeshi Matsumura , Noriko Itchoda , Takeaki Ishihara , Chikara Masuta
发明人： Noriho Fukuzawa , Takeshi Matsumura , Noriko Itchoda , Takeaki Ishihara , Chikara Masuta
IPC分类号： A01H1/06 , C12N15/63 , A01H5/00
CPC分类号： C12N15/8203 , C12N15/86 , C12N2770/14043
摘要： The present invention is to provide a novel non-diffusing plant virus vector wherein virus vector infection and proliferation are possible only in a recombinant plant transfected with a gene necessary for viral proliferation, thereby enabling avoidance of unintended diffusion of a recombinant virus, a selective and specific expression system therefor, and a method of expression thereof which comprises combining a non-diffusing virus vector lacking a gene involved in intercellular movement of a cucumber mosaic virus (CMV) genome and a transgenic plant transfected with the lacked gene involved in intercellular movement for the non-diffusing virus vector to establish infection and proliferation selectively and specifically in the transgenic plant.
摘要翻译：本发明提供一种新的非扩散性植物病毒载体，其中病毒载体的感染和增殖仅在用病毒增殖所必需的基因转染的重组植物中是可能的，从而能够避免重组病毒的非预期扩散，选择性和特异性表达系统及其表达方法，其包括将缺少涉及黄瓜花叶病毒（CMV）基因组的细胞间运动的基因的非扩散病毒载体与转染有参与细胞间移动的缺失基因的转基因植物组合非扩散病毒载体在转基因植物中选择性和特异性地建立感染和增殖。

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