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    • 10. 发明授权
    • Stabilized aqueous amide antimicrobial composition
    • 稳定的含水酰胺抗菌组合物
    • US4163797A
    • 1979-08-07
    • US860541
    • 1977-12-14
    • George A. BurkCharles E. Reineke
    • George A. BurkCharles E. Reineke
    • A01N25/22A01N37/30A01N37/34A01N9/20
    • A01N37/30A01N25/22A01N37/34
    • Aqueous antimicrobial compositions which comprise a halogenated amide antimicrobial, such as 2,2-dibromonitrilopropionamide, a water miscible organic solvent such as a straight chain polyalkylene glycol (e.g., polyethylene glycol 200) or an ether thereof (e.g., a mono- or di-lower alkyl and/or phenyl ether) and water are stabilized against decomposition of the halogenated amide antimicrobial by the addition of a carbamoyl or sulfamoyl stabilizer, such as dimethyl formamide, sulfamide, urea, oxamide, biuret, caprolactam, succinimide, etc. The compositions, so stabilized, exhibit reduced rates of decomposition of the halogenated amide antimicrobial relative to the corresponding non-stabilized aqueous compositions.
    • 包含卤代酰胺抗微生物剂如2,2-二溴三氟丙酰胺,水混溶性有机溶剂如直链聚亚烷基二醇(例如聚乙二醇200)或其醚(例如,单 - 或二 - 低级烷基和/或苯基醚)和水通过加入氨基甲酰基或氨磺酰基稳定剂如二甲基甲酰胺,磺酰胺,脲,草酰胺,缩二脲,己内酰胺,琥珀酰亚胺等来稳定,防止卤代酰胺抗微生物分解。组合物 如此稳定,表现出相对于相应的非稳定水性组合物的卤化酰胺抗微生物分解速率降低。