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1. 发明申请

US20060240523A1 Endogenous and non-endogenous versions of human G protein-coupled receptors 审中-公开
公开(公告)号：US20060240523A1
公开(公告)日：2006-10-26
申请号：US11479174
申请日：2006-06-30
申请人： Chen Liaw , Derek Chalmers , Dominic Behan , Dominique Maciejewski-Lenior , James Leonard , I-Lin Lin , Daniel Ortuno
发明人： Chen Liaw , Derek Chalmers , Dominic Behan , Dominique Maciejewski-Lenior , James Leonard , I-Lin Lin , Daniel Ortuno
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/70571 , C07K14/723 , G01N33/566 , G01N2333/70571 , G01N2333/726
摘要： The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor and to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.

2. 发明申请

US20090280487A1 METHODS FOR PRODUCING OLFACTORY GPCRS 审中-公开
标题翻译：生产OLFACTOR GPCRS的方法
公开(公告)号：US20090280487A1
公开(公告)日：2009-11-12
申请号：US12256311
申请日：2008-10-22
申请人： GENE HUNG , Daniel Ortuno , David J. Unett , Joel Gatlin
发明人： GENE HUNG , Daniel Ortuno , David J. Unett , Joel Gatlin
IPC分类号： C12Q1/68 , C12P21/02 , C12Q1/02 , G01N33/567 , C12N5/10
CPC分类号： C07K14/723
摘要： The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.
摘要翻译：本发明提供了一种在细胞中产生嗅觉GPCR的方法。通常，所述方法包括将含有可操作地连接到编码嗅觉PCR的核酸的启动子的表达盒引入大胶质细胞例如施旺或少突胶质细胞，并将细胞维持在适于产生嗅觉GPCR的条件下。还提供了含有编码嗅觉GPCR的重组核酸的大胶质细胞，筛选嗅GPCR活性的调节剂的方法，以及用于在大胶质细胞中产生嗅觉GPCR的试剂盒。本发明最适用于香料和香料的研究，因此具有多种研究和工业应用。

3. 发明申请

US20080009015A1 Methods for Producing Olfactory Gpcrs 审中-公开
标题翻译：生产嗅觉食物的方法
公开(公告)号：US20080009015A1
公开(公告)日：2008-01-10
申请号：US10579399
申请日：2004-11-15
申请人： Gene Hung , Daniel Ortuno , David Unett , Joel Gatlin
发明人： Gene Hung , Daniel Ortuno , David Unett , Joel Gatlin
IPC分类号： C07K14/705 , G01N33/53 , C12P21/06
CPC分类号： C07K14/723
摘要： The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.
摘要翻译：本发明提供了一种在细胞中产生嗅觉GPCR的方法。通常，所述方法包括将含有可操作地连接到编码嗅觉PCR的核酸的启动子的表达盒引入大胶质细胞例如施旺或少突胶质细胞，并将细胞维持在适于产生嗅觉GPCR的条件下。还提供了含有编码嗅觉GPCR的重组核酸的大胶质细胞，筛选嗅GPCR活性的调节剂的方法，以及用于在大胶质细胞中产生嗅觉GPCR的试剂盒。本发明最适用于香料和香料的研究，因此具有多种研究和工业应用。

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