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1. 发明申请

US20090280487A1 METHODS FOR PRODUCING OLFACTORY GPCRS 审中-公开
标题翻译：生产OLFACTOR GPCRS的方法
公开(公告)号：US20090280487A1
公开(公告)日：2009-11-12
申请号：US12256311
申请日：2008-10-22
申请人： GENE HUNG , Daniel Ortuno , David J. Unett , Joel Gatlin
发明人： GENE HUNG , Daniel Ortuno , David J. Unett , Joel Gatlin
IPC分类号： C12Q1/68 , C12P21/02 , C12Q1/02 , G01N33/567 , C12N5/10
CPC分类号： C07K14/723
摘要： The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.
摘要翻译：本发明提供了一种在细胞中产生嗅觉GPCR的方法。通常，所述方法包括将含有可操作地连接到编码嗅觉PCR的核酸的启动子的表达盒引入大胶质细胞例如施旺或少突胶质细胞，并将细胞维持在适于产生嗅觉GPCR的条件下。还提供了含有编码嗅觉GPCR的重组核酸的大胶质细胞，筛选嗅GPCR活性的调节剂的方法，以及用于在大胶质细胞中产生嗅觉GPCR的试剂盒。本发明最适用于香料和香料的研究，因此具有多种研究和工业应用。

2. 发明申请

US20100331238A1 Human G protein-coupled receptor and modulators thereof for the treatment of atherosclerosis and atherosclerotic disease and for the treatment of conditions related to MCP-1 expression 失效
标题翻译：人G蛋白偶联受体及其调节剂用于治疗动脉粥样硬化和动脉粥样硬化疾病以及治疗与MCP-1表达相关的病症
公开(公告)号：US20100331238A1
公开(公告)日：2010-12-30
申请号：US11991232
申请日：2006-08-29
申请人： Yaron Hakak , David J. Unett , Joel Gatlin , Chen W. Liaw
发明人： Yaron Hakak , David J. Unett , Joel Gatlin , Chen W. Liaw
IPC分类号： A61K38/17 , C12Q1/02 , C07K14/435 , A61P29/00 , A61P9/10
CPC分类号： G01N33/5041 , A61K38/1709 , A61K49/0008 , C07K14/47 , C07K14/723 , G01N33/6893 , G01N33/74 , G01N2333/726 , G01N2500/00 , G01N2800/32 , G01N2800/323
摘要： The present invention relates to methods of using a G protein-coupled receptor (GPCR) to identify whether a candidate compound is a modulator of atherogenesis. In certain embodiments, the GPCR couples to Gi. In certain embodiments, the GPCR is human. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of atherosclerosis and atherosclerotic disease, including coronary artery disease, myocardial infarction, peripheral arterial disease, and ischemic stroke. Agonists of the invention are additionally useful as therapeutic agents for the prevention or treatment of conditions related to MCP-1 expression, including but not limited to rheumatoid arthritis, Crohn's disease, and multiple sclerosis.
摘要翻译：本发明涉及使用G蛋白偶联受体（GPCR）鉴定候选化合物是否是动脉粥样硬化形成调节剂的方法。在某些实施方案中，GPCR与Gi相连。在某些实施方案中，GPCR是人。本发明的激动剂可用作预防或治疗动脉粥样硬化和动脉粥样硬化疾病（包括冠状动脉疾病，心肌梗塞，外周动脉疾病和缺血性中风）的治疗剂。本发明的激动剂另外可用作预防或治疗与MCP-1表达相关的病症的治疗剂，包括但不限于类风湿性关节炎，克罗恩病和多发性硬化症。

3. 发明申请

US20070231263A1 Human G protein-coupled receptor and modulators thereof for the treatment of hyperglycemia and related disorders 审中-公开
标题翻译：人G蛋白偶联受体及其调节剂用于治疗高血糖症和相关疾病
公开(公告)号：US20070231263A1
公开(公告)日：2007-10-04
申请号：US11604178
申请日：2006-11-22
申请人： Jun Qiu , Robert Webb , David Unett , Joel Gatlin , Daniel Connolly
发明人： Jun Qiu , Robert Webb , David Unett , Joel Gatlin , Daniel Connolly
IPC分类号： A61K48/00 , A61K31/44 , A61K49/00 , C07D417/00 , C07K14/00 , C12N5/06
CPC分类号： C07D417/04 , G01N2333/726 , G01N2500/04 , G01N2800/042
摘要： The present invention relates to methods of identifying whether one or more candidate compounds is a modulator of a G protein-coupled receptor (GPCR) or a modulator of blood glucose concentration. In certain embodiments, the GPCR is human. The present invention also relates to methods of using a modulator of the GPCR. A preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for lowering blood glucose concentration, for preventing or treating certain metabolic disorders, such as insulin resistance, impaired glucose tolerance, and diabetes, and for preventing or treating a complication of an elevated blood glucose concentration, such as atherosclerosis, heart disease, stroke, hypertension and peripheral vascular disease.
摘要翻译：本发明涉及鉴定一种或多种候选化合物是G蛋白偶联受体（GPCR）或血糖浓度调节剂的调节剂的方法。在某些实施方案中，GPCR是人。本发明还涉及使用GPCR的调制器的方法。优选的调节剂是激动剂。本发明的激动剂可用作降低血糖浓度的治疗剂，用于预防或治疗某些代谢紊乱，例如胰岛素抵抗，葡萄糖耐量异常和糖尿病，以及用于预防或治疗血糖浓度升高的并发症，作为动脉粥样硬化，心脏病，中风，高血压和外周血管疾病。

4. 发明申请

US20080125491A1 Human G Protein-Coupled Receptor and Modulators Thereof for the Treatment of Cell Death-Related Disorders 有权
标题翻译：人类G蛋白偶联受体及其调节剂用于治疗细胞死亡相关性疾病
公开(公告)号：US20080125491A1
公开(公告)日：2008-05-29
申请号：US10549228
申请日：2004-03-15
申请人： Sonia Villegas , Gregory S. Kelner , David J. Unett , Joel Gatlin
发明人： Sonia Villegas , Gregory S. Kelner , David J. Unett , Joel Gatlin
IPC分类号： A61K31/165 , C12Q1/02 , C07C233/00 , A61P25/00 , A61P21/00 , A61K47/00 , C12N5/06
CPC分类号： G01N33/6887 , C07C233/58 , C07C235/40 , C07C235/82 , C07C237/24 , C07C255/58 , C07C311/16 , C07C311/21 , C07C317/44 , C07C323/62 , C07C2603/26 , G01N33/6896 , G01N33/74 , G01N2333/726 , G01N2500/04
摘要： The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In certain embodiments, the GPCR is human. In certain embodiments, the GPCR is expressed endogenously by neuronal cells or muscle cells. In certain embodiments, the GPCR is neuroprotective or myoprotective. In certain embodiments, the GPCR is a Humanin receptor. The present invention also relates to methods of using a modulator of said GPCR. A preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of neurodegenerative diseases in general, including Alzheimer's disease, Parkinson's disease, prion-associated disease, stroke and motor-neuron disease in particular, peripheral neuropathy, cerebral amyloid beta-protein angiopathy, and ischemic heart disease, including myocardial infarction and congestive heart failure.
摘要翻译：本发明涉及鉴定候选化合物是G蛋白偶联受体（GPCR）的调节剂的方法。在某些实施方案中，GPCR是人。在某些实施方案中，GPCR由神经元细胞或肌肉细胞内源性表达。在某些实施方案中，GPCR是神经保护的或保护性的。在某些实施方案中，GPCR是人受体。本发明还涉及使用所述GPCR的调节剂的方法。优选的调节剂是激动剂。本发明的激动剂可用作预防或治疗一般的神经变性疾病的治疗剂，包括阿尔茨海默氏病，帕金森病，朊病毒相关疾病，中风和运动神经元疾病，特别是周围神经病，脑淀粉样蛋白β-蛋白血管病和缺血性心脏病，包括心肌梗死和充血性心力衰竭。

5. 发明授权

US08691498B2 Methods of screening for a compound that reduces atherogenesis 失效
标题翻译：筛选减少动脉粥样化形成的化合物的方法
公开(公告)号：US08691498B2
公开(公告)日：2014-04-08
申请号：US11991232
申请日：2006-08-29
申请人： Yaron Hakak , David J. Unett , Joel Gatlin , Chen W. Liaw
发明人： Yaron Hakak , David J. Unett , Joel Gatlin , Chen W. Liaw
IPC分类号： C12Q1/00 , C12Q1/68 , C07K14/705
CPC分类号： G01N33/5041 , A61K38/1709 , A61K49/0008 , C07K14/47 , C07K14/723 , G01N33/6893 , G01N33/74 , G01N2333/726 , G01N2500/00 , G01N2800/32 , G01N2800/323
摘要： The present invention relates to methods of using a G protein-coupled receptor (GPCR) to identify whether a candidate compound is a modulator of atherogenesis. In certain embodiments, the GPCR couples to Gi. In certain embodiments, the GPCR is human. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of atherosclerosis and atherosclerotic disease, including coronary artery disease, myocardial infarction, peripheral arterial disease, and ischemic stroke. Agonists of the invention are additionally useful as therapeutic agents for the prevention or treatment of conditions related to MCP-1 expression, including but not limited to rheumatoid arthritis, Crohn's disease, and multiple sclerosis.
摘要翻译：本发明涉及使用G蛋白偶联受体（GPCR）鉴定候选化合物是否是动脉粥样硬化形成调节剂的方法。在某些实施方案中，GPCR与Gi相连。在某些实施方案中，GPCR是人。本发明的激动剂可用作预防或治疗动脉粥样硬化和动脉粥样硬化疾病（包括冠状动脉疾病，心肌梗塞，外周动脉疾病和缺血性中风）的治疗剂。本发明的激动剂另外可用作预防或治疗与MCP-1表达相关的病症的治疗剂，包括但不限于类风湿性关节炎，克罗恩病和多发性硬化症。

6. 发明申请

US20110177522A1 Methods for Producing Olfactory GPCRs 审中-公开
标题翻译：产生嗅觉GPCR的方法
公开(公告)号：US20110177522A1
公开(公告)日：2011-07-21
申请号：US12860621
申请日：2010-08-20
申请人： GENE HUNG , DANIEL ORTUNO , DAVID J. UNETT , JOEL GATLIN
发明人： GENE HUNG , DANIEL ORTUNO , DAVID J. UNETT , JOEL GATLIN
IPC分类号： G01N33/53 , C12P21/06 , C12Q1/02 , C12N5/00
CPC分类号： C07K14/723
摘要： The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.
摘要翻译：本发明提供了一种在细胞中产生嗅觉GPCR的方法。通常，所述方法包括将含有可操作地连接到编码嗅觉PCR的核酸的启动子的表达盒引入大胶质细胞例如施旺或少突胶质细胞，并将细胞维持在适于产生嗅觉GPCR的条件下。还提供了含有编码嗅觉GPCR的重组核酸的大胶质细胞，筛选嗅GPCR活性的调节剂的方法，以及用于在大胶质细胞中产生嗅觉GPCR的试剂盒。本发明最适用于香料和香料的研究，因此具有多种研究和工业应用。

7. 发明授权

US07776558B2 Human G protein-coupled receptor and modulators thereof for the treatment of cell death-related disorders 有权
标题翻译：人G蛋白偶联受体及其调节剂用于治疗细胞死亡相关疾病
公开(公告)号：US07776558B2
公开(公告)日：2010-08-17
申请号：US10549228
申请日：2004-03-15
申请人： Sonia Villegas , Gregory S. Kelner , David J. Unett , Joel Gatlin
发明人： Sonia Villegas , Gregory S. Kelner , David J. Unett , Joel Gatlin
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： G01N33/6887 , C07C233/58 , C07C235/40 , C07C235/82 , C07C237/24 , C07C255/58 , C07C311/16 , C07C311/21 , C07C317/44 , C07C323/62 , C07C2603/26 , G01N33/6896 , G01N33/74 , G01N2333/726 , G01N2500/04
摘要： The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In certain embodiments, the GPCR is human. In certain embodiments, the GPCR is expressed endogenously by neuronal cells or muscle cells. In certain embodiments, the GPCR is neuroprotective or myoprotective. In certain embodiments, the GPCR is a Humanin receptor. The present invention also relates to methods of using a modulator of the GPCR. A preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of neurodegenerative diseases in general, including Alzheimer's disease, Parkinson's disease, prion-associated disease, stroke and motor-neuron disease in particular, peripheral neuropathy, cerebral amyloid beta-protein angiopathy, and ischemic heart disease, including myocardial infarction and congestive heart failure.
摘要翻译：本发明涉及鉴定候选化合物是G蛋白偶联受体（GPCR）的调节剂的方法。在某些实施方案中，GPCR是人。在某些实施方案中，GPCR由神经元细胞或肌肉细胞内源性表达。在某些实施方案中，GPCR是神经保护的或保护性的。在某些实施方案中，GPCR是人受体。本发明还涉及使用GPCR的调制器的方法。优选的调节剂是激动剂。本发明的激动剂可用作预防或治疗一般的神经变性疾病的治疗剂，包括阿尔茨海默氏病，帕金森病，朊病毒相关疾病，中风和运动神经元疾病，特别是周围神经病，脑淀粉样蛋白β-蛋白血管病和缺血性心脏病，包括心肌梗死和充血性心力衰竭。

8. 发明申请

US20080009015A1 Methods for Producing Olfactory Gpcrs 审中-公开
标题翻译：生产嗅觉食物的方法
公开(公告)号：US20080009015A1
公开(公告)日：2008-01-10
申请号：US10579399
申请日：2004-11-15
申请人： Gene Hung , Daniel Ortuno , David Unett , Joel Gatlin
发明人： Gene Hung , Daniel Ortuno , David Unett , Joel Gatlin
IPC分类号： C07K14/705 , G01N33/53 , C12P21/06
CPC分类号： C07K14/723
摘要： The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.
摘要翻译：本发明提供了一种在细胞中产生嗅觉GPCR的方法。通常，所述方法包括将含有可操作地连接到编码嗅觉PCR的核酸的启动子的表达盒引入大胶质细胞例如施旺或少突胶质细胞，并将细胞维持在适于产生嗅觉GPCR的条件下。还提供了含有编码嗅觉GPCR的重组核酸的大胶质细胞，筛选嗅GPCR活性的调节剂的方法，以及用于在大胶质细胞中产生嗅觉GPCR的试剂盒。本发明最适用于香料和香料的研究，因此具有多种研究和工业应用。

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