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1. 发明专利

JP2007020590A Material for aneurysm curing 审中-公开
标题翻译：抗氧化物质
公开(公告)号：JP2007020590A
公开(公告)日：2007-02-01
申请号：JP2003207850
申请日：2003-08-19
申请人： Chemo Sero Therapeut Res Inst , Institute Of Physical & Chemical Research , Hiroshi Ujiie , 弘氏家 , 独立行政法人理化学研究所 , 財団法人化学及血清療法研究所
发明人： UJIIE HIROSHI , SUZUKI YOSHIAKI , IWAKI MASAYA , UCHIDA TAKANORI
IPC分类号： A61L31/00 , A61F2/06 , A61K31/00
CPC分类号： A61L31/04 , A61K31/00 , A61L2400/18 , A61L2430/36
摘要： PROBLEM TO BE SOLVED: To provide a polymeric material with the tissue compatibility improved by the ion beam irradiation for preventing rupture of an aneurysm with a risk of rupture.
SOLUTION: The material for aneurysm curing is made of the polymeric material comprising carbon as a constituent element. At least part of the surface is reformed by the ion impact.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供具有通过离子束照射改善的组织相容性的聚合物材料，以防止具有破裂风险的动脉瘤破裂。解决方案：用于动脉瘤固化的材料由包含碳作为构成元素的聚合材料制成。至少部分表面被离子冲击所改变。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2004248984A Coating material for treating aneurysm 有权
标题翻译：用于治疗神经病的涂层材料
公开(公告)号：JP2004248984A
公开(公告)日：2004-09-09
申请号：JP2003044734
申请日：2003-02-21
申请人： Chemo Sero Therapeut Res Inst , 財団法人化学及血清療法研究所
发明人： IWASAKI YOSHINOBU , KURODA SATOSHI , UCHIDA TAKANORI , SHINYA KIKO
IPC分类号： A61L31/00
摘要： PROBLEM TO BE SOLVED: To provide a safe and effective coating material for treating aneurysm. SOLUTION: This coating material for treating aneurysm is constituted of a fibrinogen component and a thrombin component contained as effective components and a bioabsorbable synthetic fiber contained as a base material. The base material is formed in a bioabsorbable synthetic nonwoven fabric composed of polyglycolic acid. Consequently, the flexibility and contraction and expansion properties of this coating material are excellent and the material can be stuck closely to the wall of a blood vessel. In addition, this material can prevent the enlargement, rupture, and relapse of an aneurysm by urging the growth of connective tissue in the surroundings of an applied part by covering the aneurysm. In addition, this material does not cause any excessive inflammatory reaction in nerves and blood vessel tissues in the surroundings of the applied part and can be made to absorb the aneurysm with time. Consequently, the coating material can replace the conventional coating material with higher effectiveness and safety. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：要解决的问题：提供用于治疗动脉瘤的安全有效的涂层材料。
解决方案：用于治疗动脉瘤的涂层材料由作为有效成分含有的纤维蛋白原成分和凝血酶成分以及作为基材含有的生物体吸收性合成纤维构成。基材由聚乙醇酸组成的生物可吸收性合成无纺布形成。因此，该涂料的柔软性，收缩膨胀特性优异，能够紧贴于血管壁。此外，该材料通过覆盖动脉瘤来促进施用部位周围的结缔组织的生长，可以防止动脉瘤的扩大，破裂和复发。此外，该材料在施加部位的周围的神经和血管组织中不会引起过度的炎症反应，并且可以随时间吸收动脉瘤。因此，涂层材料可以以更高的有效性和安全性代替常规的涂层材料。版权所有（C）2004，JPO＆NCIPI

3. 发明专利

JP2012100851A Biological tissue adhesive applicator 有权
标题翻译：生物组织粘合剂应用
公开(公告)号：JP2012100851A
公开(公告)日：2012-05-31
申请号：JP2010251515
申请日：2010-11-10
申请人： Chemo-Sero-Therapeutic Research Inst , Sumitomo Bakelite Co Ltd , 一般財団法人化学及血清療法研究所 , 住友ベークライト株式会社
发明人： SUZUKI ZENETSU , IKEDA MASAO , UCHIDA TAKANORI , ICHIKI OSAMU , OKA SHIRO
IPC分类号： A61B17/00 , A61B17/11 , A61M35/00 , B05B7/08
CPC分类号： A61B17/00491 , A61B2017/00495 , B05B7/0475 , B05B7/0491 , B05B7/0876 , B05B7/2429 , B05B7/2472 , B05B11/02
摘要： PROBLEM TO BE SOLVED: To provide a biological tissue adhesive applicator that can satisfactorily prevent its tip from being solidified under intermittent use.SOLUTION: The biological tissue adhesive applicator 100 includes: a nozzle body 1; a gas injection port 2; chemical solution injection ports 3a, 3b; chemical solution discharge ports 4a, 4b; chemical solution circulation tubes 5a, 5b serving for communication between the chemical solution injection ports 3a, 3b and chemical solution discharge ports 4a, 4b respectively; a gas jet port 6; two communicating ports 8a, 8b provided at the chemical solution circulation tube 5b to introduce gas inside the nozzle body 1 toward the chemical solution discharge port 4b; and check valves 7a, 7b provided at the chemical solution circulation tubes 5a, 5b to allow a chemical solution to flow into the chemical solution circulation tubes 5a, 5b from the chemical solution injection ports 3a, 3b and to regulate the outflow of the chemical solution toward the chemical solution discharge ports 4a, 4b from the inside of the chemical solution circulation tubes 5a, 5b.
摘要翻译：要解决的问题：提供可以令人满意地防止其尖端在间歇使用下固化的生物组织粘合剂施加器。解决方案：生物组织粘合剂涂布器100包括：喷嘴体1; 气体注入口2; 化学溶液注入口3a，3b; 化学溶液排出口4a，4b; 分别用于化学溶液注入口3a，3b和化学溶液排出口4a，4b之间的连通的化学溶液循环管5a，5b; 气体喷射口6; 设置在化学溶液循环管5b处的两个连通口8a，8b，以将喷嘴体1内的气体引向化学溶液排出口4b; 以及设置在化学溶液循环管5a，5b处的止回阀7a，7b，以使化学溶液从化学溶液注入口3a，3b流入化学溶液循环管5a，5b，并调节化学溶液的流出从化学溶液循环管5a，5b的内部向化学溶液排出口4a，4b排出。版权所有（C）2012，JPO＆INPIT

4. 发明公开

EP1588722A4 HEMOSTATIC MATERIALS 审中-公开
标题翻译：止血材料
公开(公告)号：EP1588722A4
公开(公告)日：2011-03-02
申请号：EP04702784
申请日：2004-01-16
申请人： CHEMO SERO THERAPEUT RES INST
发明人： UCHIDA TAKANORI , SHINYA NORIKO , KAETSU HIROSHI
IPC分类号： A61L15/32 , A61F13/00 , A61F13/36 , A61L15/26
CPC分类号： A61L15/32 , A61F13/36 , A61F2013/00472 , A61L15/26 , A61L2400/04 , Y10T442/2508 , Y10T442/2525 , Y10T442/2861 , Y10T442/696 , C08L65/04

5. 发明公开

EP2944330A4 ARTIFICIAL BLOOD VESSEL USING DECELLULARIZED BLOOD VESSEL SHEET 审中-公开
标题翻译： KÜNSTLICHESBLUTGEFÄSSUNTER VERWENDUNG EINER DEZELLULARISIERTENBLUTGEFÄSSFOLIE
公开(公告)号：EP2944330A4
公开(公告)日：2016-09-07
申请号：EP13871129
申请日：2013-12-17
申请人： CHEMO SERO THERAPEUT RES INST
发明人： SHINYA NORIKO , UCHIDA TAKANORI , KISHIDA AKIO , HIGAMI TETSUYA
IPC分类号： A61L27/36 , A61F2/06
CPC分类号： A61F2/82 , A61F2/06 , A61F2/062 , A61F2230/0069 , A61F2240/002 , A61L27/3625 , A61L27/3683 , A61L27/507 , A61L27/54 , A61L2300/252 , Y10T156/1038 , A61L27/34 , C08L89/00
摘要： An artificial blood vessel that can be transplanted to blood vessels with a small diameter, can be adjusted to an arbitrary size of a diameter, improves in invasiveness when a graft is taken, and overcomes the problem on the provision of a graft is provided. An artificial blood vessel prepared from a decellularized tubular structure, which is prepared by processing a decellularized, sheet-like blood vessel (decellularized blood vessel sheet) into a roll structure, and a tissue adhesive, wherein a portion which is contacted with blood that flows within the artificial blood vessel consists of the tissue of the tunica intima lined with the tissue of the tunica media whereas a portion of the sheet that overlaps when the sheet is processed into a roll structure (overlap width) consists of the tissue of the tunica media and wherein a tissue adhesive is applied to the overlap width.
摘要翻译：可以移植到具有小直径的血管的人造血管可以调节到任意尺寸的直径，提高移植物时的侵入性，并且克服了提供移植物的问题。由脱细胞化的管状结构制备的人造血管，其通过将脱细胞化的片状血管（脱细胞血管片）加工成辊结构而制备，以及组织粘合剂，其中与血液接触的部分在人造血管内部由内膜内膜与中膜的组织组成，而当片材加工成辊结构（重叠宽度）时与片材重叠的部分片材由中膜的组织组成并且其中将组织粘合剂施加到所述重叠宽度。

6. 发明公开

EP0835667A4 TISSUE ADHESIVE APPLIED WITH SPRAY 无效
标题翻译：通过喷洒磨毛布胶
公开(公告)号：EP0835667A4
公开(公告)日：2002-02-20
申请号：EP97907319
申请日：1997-03-14
申请人： CHEMO SERO THERAPEUT RES INST
发明人： UCHIDA TAKANORI , KAETSU HIROSHI , FUKUNAGA NOBUTO , SHINYA NORIKO , SAKAMOTO TAKAHIRO
IPC分类号： A61B17/00 , A61L24/10 , A61L25/00
CPC分类号： A61L24/106 , A61B17/00491 , A61B2017/00495 , Y10S514/822
摘要： A tissue adhesive capable of forming fibrins uniformly at high density, and exhibiting marked closing effect. This tissue adhesive is mixed with an aseptic gas and the mixture is applied to tissue. The tissue adhesive comprises separated fibrinogen solution and thrombin solution. The volume ratio of the fibrinogen solution to the thrombin solution is 2:1-10:1. This tissue adhesive is used to stick living tissue of a human being or an animal or to close the same.

7. 发明专利

CA2124320C APPLICATOR FOR APPLYING A BIOCOMPATIBLE ADHESIVE 未知
公开(公告)号：CA2124320C
公开(公告)日：2007-02-06
申请号：CA2124320
申请日：1993-09-24
申请人： CHEMO SERO THERAPEUT RES INST
发明人： FUKUNAGA NOBUTO , KAWAKAMI KATSUMI , UCHIDA TAKANORI , ISHIHARA YOSHIMITSU
IPC分类号： A61M11/00 , A61B17/00 , A61L26/00 , A61M11/02
摘要： An applicator for applying a biocompatible adhesive containing human or animal protein as a principal ingredient to a surgical site of a living body includes a housing to which a sterile gas is supplied. A gas supply tube is connected to the housing. Two adjacent nozzles eject the sterile gas in the same direction. Two adapters are connected to respective nozzles of syringe barrels, and there is a pair of solution tubes, each having one end connected to the adapter and the other end protruded outwardly from the sterile gas ejection nozzle through the housing. Respective solutions supplied from the syringes via the barrel adapters are ejected from the outlets of the solution tubes. The sterile gas is ejected from two nozzles in the same direction. Consequently, the solutions are sprayed. and mixed by the sterile gas, and then applied to the surgical site.

8. 发明专利

ES2130412T3 未知
公开(公告)号：ES2130412T3
公开(公告)日：1999-07-01
申请号：ES94911768
申请日：1993-09-24
申请人： CHEMO SERO THERAPEUT RES INST
发明人： FUKUNAGA NOBUTO , KAWAKAMI KATSUMI , UCHIDA TAKANORI , ISHIHARA YOSHIMITSU
IPC分类号： A61B17/00 , A61L26/00 , A61L25/00 , A61M35/00

9. 发明专利

CA2894145A1 ARTIFICIAL BLOOD VESSEL USING DECELLULARIZED BLOOD VESSEL SHEET 未知
公开(公告)号：CA2894145A1
公开(公告)日：2014-07-17
申请号：CA2894145
申请日：2013-12-17
申请人： CHEMO SERO THERAPEUT RES INST
发明人： SHINYA NORIKO , UCHIDA TAKANORI , KISHIDA AKIO , HIGAMI TETSUYA
IPC分类号： A61L27/00 , A61F2/06
摘要： Provided is an artificial blood vessel, which can be transplanted to a blood vessel having a small diameter, the diameter of which can be arbitrarily set, which has improved invasiveness when a graft is harvested and, therefore, which overcomes the problem on graft supply. The artificial blood vessel, which is configured from a decellularized tubular structure, said decellularized tubular structure being prepared by shaping a sheet-shaped decellularized blood vessel (a decellularized blood vessel sheet) into a roll structure, and an adhesive for living tissues, wherein, in the artificial blood vessel, a part to be in contact with blood that flows within the artificial blood vessel is formed of an inner membrane tissue that is lined with a medium membrane tissue, a part (a sticking part) where the sheet overlaps in shaping the sheet into a roll structure is formed of the medium membrane tissue, and the whole sticking part is coated with the adhesive for living tissues.

10. 发明专利

DE69324004T3 未知
公开(公告)号：DE69324004T3
公开(公告)日：2005-09-01
申请号：DE69324004
申请日：1993-09-24
申请人： CHEMO SERO THERAPEUT RES INST
发明人： FUKUNAGA NOBUTO , KAWAKAMI KATSUMI , UCHIDA TAKANORI , ISHIHARA YOSHIMITSU
IPC分类号： A61B17/00 , A61L26/00 , A61M35/00 , A61L25/00

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