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1. 发明专利

JP2004248984A Coating material for treating aneurysm 有权
标题翻译：用于治疗神经病的涂层材料
公开(公告)号：JP2004248984A
公开(公告)日：2004-09-09
申请号：JP2003044734
申请日：2003-02-21
申请人： Chemo Sero Therapeut Res Inst , 財団法人化学及血清療法研究所
发明人： IWASAKI YOSHINOBU , KURODA SATOSHI , UCHIDA TAKANORI , SHINYA KIKO
IPC分类号： A61L31/00
摘要： PROBLEM TO BE SOLVED: To provide a safe and effective coating material for treating aneurysm. SOLUTION: This coating material for treating aneurysm is constituted of a fibrinogen component and a thrombin component contained as effective components and a bioabsorbable synthetic fiber contained as a base material. The base material is formed in a bioabsorbable synthetic nonwoven fabric composed of polyglycolic acid. Consequently, the flexibility and contraction and expansion properties of this coating material are excellent and the material can be stuck closely to the wall of a blood vessel. In addition, this material can prevent the enlargement, rupture, and relapse of an aneurysm by urging the growth of connective tissue in the surroundings of an applied part by covering the aneurysm. In addition, this material does not cause any excessive inflammatory reaction in nerves and blood vessel tissues in the surroundings of the applied part and can be made to absorb the aneurysm with time. Consequently, the coating material can replace the conventional coating material with higher effectiveness and safety. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：要解决的问题：提供用于治疗动脉瘤的安全有效的涂层材料。
解决方案：用于治疗动脉瘤的涂层材料由作为有效成分含有的纤维蛋白原成分和凝血酶成分以及作为基材含有的生物体吸收性合成纤维构成。基材由聚乙醇酸组成的生物可吸收性合成无纺布形成。因此，该涂料的柔软性，收缩膨胀特性优异，能够紧贴于血管壁。此外，该材料通过覆盖动脉瘤来促进施用部位周围的结缔组织的生长，可以防止动脉瘤的扩大，破裂和复发。此外，该材料在施加部位的周围的神经和血管组织中不会引起过度的炎症反应，并且可以随时间吸收动脉瘤。因此，涂层材料可以以更高的有效性和安全性代替常规的涂层材料。版权所有（C）2004，JPO＆NCIPI

2. 发明专利

JP2011219879A Fiber composite 有权
标题翻译：纤维复合材料
公开(公告)号：JP2011219879A
公开(公告)日：2011-11-04
申请号：JP2010086812
申请日：2010-04-05
申请人： Chemo-Sero-Therapeutic Research Institute , Teijin Ltd , 一般財団法人化学及血清療法研究所 , 帝人株式会社
发明人： KANEKO HIROAKI , SATAKE MAKOTO , FUKUHIRA YUKAKO , MIYABASHIRA SUMIKA , SHINYA KIKO
IPC分类号： A61L15/64 , A61L27/00 , D01F6/92 , D04H1/435 , D04H1/728 , D06M15/15 , D06M101/32
摘要： PROBLEM TO BE SOLVED: To provide a fiber composite that has excellent adhesiveness with a wound site and a kit for preparing the same.SOLUTION: A fiber composite comprises a fiber structure 2 of a biocompatible polymer having an average fiber diameter of 0.1 to 10 μm, with a thickness of 10 to 200 μm, an average apparent density of 30 to 250 kg/m, and a contact angle of a water droplet on the fiber surface of 30 degrees or more, and a fibrin gel matrix 1. A kit for preparing a fiber composite comprises the fiber structure, fibrinogen, and thrombin. The fiber structure can be manufactured by electrospinning under specific conditions.
摘要翻译：要解决的问题：提供一种与伤口部位的粘合性优异的纤维复合体及其制备用试剂盒。解决方案：纤维复合材料包括平均纤维直径为0.1至10μm，厚度为10至200μm，平均表观密度为30至250kg / m 2的生物相容性聚合物的纤维结构体2 POS =“POST”> 3 ，纤维表面上的水滴的接触角为30度以上，纤维蛋白凝胶基质1.纤维复合材料的制备方法包括纤维结构，纤维蛋白原，和凝血酶。纤维结构可以通过在特定条件下静电纺丝制造。版权所有（C）2012，JPO＆INPIT

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