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1. 发明授权

US06486469B1 Dielectric capillary high pass ion filter 失效
标题翻译：电介质毛细管高通离子过滤器
公开(公告)号：US06486469B1
公开(公告)日：2002-11-26
申请号：US09429063
申请日：1999-10-29
申请人： Steven M. Fischer , Robert K. Crawford , Charles W. Russ, IV
发明人： Steven M. Fischer , Robert K. Crawford , Charles W. Russ, IV
IPC分类号： B01D5944
CPC分类号： H01J49/04
摘要： For delivery of ions from a higher pressure ion source to a mass analyzer operating at high vacuum, high pass ion filtration is effected within a dielectric capillary interface between the higher pressure ionization chamber and the lower pressure environment of a mass analyzer, by application of electrical potentials to end electrodes and to at least one electrode associated with the dielectric capillary between the ends, to create an end-to-end electric field generally opposing gas flow-assisted movement of ions from the upstream end to the downstream end, and to create a steeper voltage gradient along an upstream portion than along a downstream portion of the capillary. The voltage gradient along the steeper upstream portion of the capillary is sufficiently steep to cause ions having drift velocities below a lower limit to stall within the capillary. The respective potentials may be adjusted to increase the steepness of the upstream voltage gradient to increase the drift velocity lower limit.
摘要翻译：为了将离子从较高压力的离子源输送到在高真空下操作的质量分析仪，在高压离子化室和质量分析仪的较低压力环境之间的介电毛细管界面内，通过施加电将端电极和与末端之间的介电毛细管相关联的至少一个电极的电位产生一个端对端电场，通常相对于从上游端到下游端的离子的气流辅助运动，并产生沿着上游部分比沿着毛细管的下游部分更陡峭的电压梯度。沿着毛细管的较陡的上游部分的电压梯度足够陡峭，导致具有低于下限的漂移速度的离子在毛细管内停止。可以调节各个电位以增加上游电压梯度的陡度以增加漂移速度下限。

2. 发明授权

US07332715B2 Atmospheric pressure ion source high pass ion filter 失效
标题翻译：大气压离子源高通离子过滤器
公开(公告)号：US07332715B2
公开(公告)日：2008-02-19
申请号：US11505089
申请日：2006-08-16
申请人： Charles W. Russ, IV , Steven M. Fischer , Robert K. Crawford
发明人： Charles W. Russ, IV , Steven M. Fischer , Robert K. Crawford
IPC分类号： B01D59/44
CPC分类号： H01J49/061 , H01J49/04 , H01J49/10
摘要： For generation and delivery of ions from an ionization chamber through an ion entrance orifice to a mass analyzer operating at high vacuum, high pass ion filtration is effected within the ionization chamber by application of electrical potentials to an electrode associated with the ion entrance orifice and to an electrode between the ionization region and the ion entrance orifice to create a retarding electric field upstream from the ion entrance orifice. The retarding electric field hinders the movement to the ion entrance orifice of ions having drift velocities below a lower limit, and as the retarding voltage gradient is made steeper, the lower limit increases.
摘要翻译：为了将离子从离子入口通过离子入口孔传送到在高真空下操作的质量分析器，通过将电位施加到与离子入口孔相关联的电极，在离子化室内进行高通离子过滤，并且电离区域和离子入口孔之间的电极，以产生离子入口孔上游的延迟电场。延迟电场阻碍了离子入口孔的移动，其离子入射孔的漂移速度低于下限，随着延迟电压梯度变得更陡峭，下限增加。

3. 发明授权

US07112786B2 Atmospheric pressure ion source high pass ion filter 有权
公开(公告)号：US07112786B2
公开(公告)日：2006-09-26
申请号：US11168756
申请日：2005-06-27
申请人： Charles W. Russ, IV , Steven M. Fischer , Robert K. Crawford
发明人： Charles W. Russ, IV , Steven M. Fischer , Robert K. Crawford
IPC分类号： H01J49/04
CPC分类号： H01J49/061 , H01J49/04 , H01J49/10
摘要： For generation and delivery of ions from an ionization chamber through an ion entrance orifice to a mass analyzer operating at high vacuum, high pass ion filtration is effected within the ionization chamber by application of electrical potentials to an electrode associated with the ion entrance orifice and to an electrode between the ionization region and the ion entrance orifice to create a retarding electric field upstream from the ion entrance orifice. The retarding electric field hinders the movement to the ion entrance orifice of ions having drift velocities below a lower limit, and as the retarding voltage gradient is made steeper, the lower limit increases.

4. 发明授权

US06661003B2 Dielectric capillary high pass ion filter 失效
公开(公告)号：US06661003B2
公开(公告)日：2003-12-09
申请号：US10224637
申请日：2002-08-20
申请人： Steven M. Fischer , Robert K. Crawford , Charles W. Russ, IV
发明人： Steven M. Fischer , Robert K. Crawford , Charles W. Russ, IV
IPC分类号： B01D5944
CPC分类号： H01J49/04
摘要： For delivery of ions from a higher pressure ion source to a mass analyzer operating at high vacuum, high pass ion filtration is effected within a dielectric capillary interface between the higher pressure ionization chamber and the lower pressure environment of a mass analyzer, by application of electrical potentials to end electrodes and to at least one electrode associated with the dielectric capillary between the ends, to create an end-to-end electric field generally opposing gas flow-assisted movement of ions from the upstream end to the downstream end, and to create a steeper voltage gradient along an upstream portion than along a downstream portion of the capillary. The voltage gradient along the steeper upstream portion of the capillary is sufficiently steep to cause ions having drift velocities below a lower limit to stall within the capillary. The respective potentials may be adjusted to increase the steepness of the upstream voltage gradient to increase the drift velocity lower limit.

5. 发明授权

US06797947B2 Internal introduction of lock masses in mass spectrometer systems 有权
标题翻译：在质谱仪系统内部引入锁定质量
公开(公告)号：US06797947B2
公开(公告)日：2004-09-28
申请号：US10664512
申请日：2003-09-16
申请人： Charles W. Russ, IV , Steven M. Fischer
发明人： Charles W. Russ, IV , Steven M. Fischer
IPC分类号： H01J4910
CPC分类号： H01J49/0009 , H01J49/004
摘要： An apparatus and method for calibrating a mass spectrometer by internally introducing calibration masses at a post-source stage of the mass spectrometer is provided. A source of lock mass ions adjacent the ion optics creates lock mass ions within the ion optics. Lock mass ions mix with the analyte ions in the ion optics prior to mass analysis. The source of lock mass ions may include various means for ionizing lock mass molecules including but not limited to photoionization, field desorption-ionization, electron ionization, and thermal ionization means. An apparatus and method of mass calibrating a tandem mass spectrometer is also provided. The mass calibration apparatus includes a collision cell for fragmenting analyte ions and a source of lock mass ions adjacent said collision cell for creating lock mass ions in the collision cell.
摘要翻译：提供了通过在质谱仪的后源阶段内部引入校准质量来校准质谱仪的装置和方法。与离子光学器件相邻的锁定质量离子源产生离子光学器件内的锁定质子离子。在质量分析之前，将质子离子与离子光学中的分析物离子混合。锁定质量离子的来源可以包括用于电离锁定质量分子的各种装置，包括但不限于光电离，场解吸电离，电子离子化和热电离装置。还提供了质量校准串联质谱仪的装置和方法。质量校准装置包括用于碎裂分析物离子的碰撞单元和邻近所述碰撞室的锁定质量离子源，用于在碰撞室中产生锁定质量离子。

6. 发明授权

US06583407B1 Method and apparatus for selective ion delivery using ion polarity independent control 失效
标题翻译：使用离子极性独立控制的选择性离子传递的方法和装置
公开(公告)号：US06583407B1
公开(公告)日：2003-06-24
申请号：US09645050
申请日：2000-08-23
申请人： Steven M. Fischer , Charles W. Russ, IV
发明人： Steven M. Fischer , Charles W. Russ, IV
IPC分类号： B01D5944
CPC分类号： H01J49/04
摘要： The present invention relates to a method for selectively delivering ions to a mass analyzer operating in a vacuum region. The method involves providing a dielectric conduit having an axial bore originating in an inlet opening that communicates with an ion source and terminating in an exit opening disposed within the vacuum region. A gas stream comprising an ion having a polarity and traveling at a drift velocity is flowed through the bore from the inlet opening toward the exit opening. A motion component is altered in a manner that does not substantially depend on the polarity of the ion to effect a change in the drift velocity of the ion. The invention also provides an apparatus to carry out the method.
摘要翻译：本发明涉及一种用于选择性地将离子输送到在真空区域中操作的质量分析器的方法。该方法包括提供具有源自入口开口的轴向孔的电介质导管，其与离子源连通并终止于设置在真空区域内的出口。包含具有极性并以漂移速度行进的离子的气流从入口开口流向出口。改变运动分量的方式基本上不取决于离子的极性来实现离子的漂移速度的变化。本发明还提供一种执行该方法的装置。

7. 发明授权

US07166836B1 Ion beam focusing device 有权
标题翻译：离子束聚焦装置
公开(公告)号：US07166836B1
公开(公告)日：2007-01-23
申请号：US11221491
申请日：2005-09-07
申请人： Charles W. Russ, IV , Steven M. Fischer
发明人： Charles W. Russ, IV , Steven M. Fischer
IPC分类号： H01J49/42 , H01J37/26
CPC分类号： H01J49/42 , H01J49/04
摘要： The invention provides an apparatus for focusing ions exiting a multipole mass filter. In general terms, the ion focusing apparatus comprises: a housing having an ion entrance and an ion exit, and, contained within the housing: a) a multipole ion guide having an open ion entrance end, and b) a neutral gas. The ion focusing apparatus is configured so that an ion beam enters the housing via the ion entrance and is collisionally focused by the multipole ion guide and neutral gas prior to exiting the housing. The apparatus is readily employed to collisionally focus an ion beam exiting a quadrupole mass filter. Also provided is a mass spectrometry system containing the ion focusing apparatus, and methods employing the same.
摘要翻译：本发明提供一种用于聚焦离开多极质量过滤器的离子的装置。一般来说，离子聚焦装置包括：具有离子入口和离子出口的壳体，并且容纳在壳体内：a）具有开放离子入口端的多极离子导向器，以及b）中性气体。离子聚焦装置被配置为使得离子束经由离子入口进入壳体并且在离开壳体之前被多极离子导向器和中性气体碰撞聚焦。该装置容易地用于将离开四极质量过滤器的离子束碰撞地聚焦。还提供了含有离子聚焦装置的质谱系统及其应用方法。

8. 发明授权

US06649909B2 Internal introduction of lock masses in mass spectrometer systems 有权
标题翻译：在质谱仪系统内部引入锁定质量
公开(公告)号：US06649909B2
公开(公告)日：2003-11-18
申请号：US10081780
申请日：2002-02-20
申请人： Charles W. Russ, IV , Steven M. Fischer
发明人： Charles W. Russ, IV , Steven M. Fischer
IPC分类号： H01J4910
CPC分类号： H01J49/0009 , H01J49/004
摘要： An apparatus and method for calibrating a mass spectrometer by internally introducing calibration masses at a post-source stage of the mass spectrometer is provided. A source of lock mass ions adjacent the ion optics creates lock mass ions within the ion optics. Lock mass ions mix with the analyte ions in the ion optics prior to mass analysis. The source of lock mass ions may include various means for ionizing lock mass molecules including but not limited to photoionization, field desorption-ionization, electron ionization, and thermal ionization means. An apparatus and method of mass calibrating a tandem mass spectrometer is also provided. The mass calibration apparatus includes a collision cell for fragmenting analyte ions and a source of lock mass ions adjacent said collision cell for creating lock mass ions in the collision cell.
摘要翻译：提供了通过在质谱仪的后源阶段内部引入校准质量来校准质谱仪的装置和方法。与离子光学器件相邻的锁定质量离子源产生离子光学器件内的锁定质子离子。在质量分析之前，将质子离子与离子光学中的分析物离子混合。锁定质量离子的来源可以包括用于电离锁定质量分子的各种装置，包括但不限于光电离，场解吸电离，电子离子化和热电离装置。还提供了质量校准串联质谱仪的装置和方法。质量校准装置包括用于碎裂分析物离子的碰撞单元和邻近所述碰撞室的锁定质量离子源，用于在碰撞室中产生锁定质量离子。

9. 发明授权

US06417511B1 Ring pole ion guide apparatus, systems and method 有权
标题翻译：环形极离子导向装置，系统及方法
公开(公告)号：US06417511B1
公开(公告)日：2002-07-09
申请号：US09617877
申请日：2000-07-17
申请人： Charles W. Russ, IV , Steven M. Fischer
发明人： Charles W. Russ, IV , Steven M. Fischer
IPC分类号： H01J4900
CPC分类号： H01J49/065 , H01J49/063
摘要： A ring pole ion guide apparatus and method provide the focusing and confinement advantages of conventional multipoles and the axial field of a conventional DC ring guide all in one device. The ring pole apparatus comprises a ring stack portion and a multipole portion, wherein the ring stack portion essentially overlaps the multipole portion inside and outside along a central axis. The ring pole apparatus can be used in a mass spectrometer system to guide ions from the ion source to the mass spectrometer or between mass spectrometer stages, or to dissociate ions into daughter ions in an ion dissociation system. A single ring pole ion guide can span a plurality of pressure transition stages with several of the rings acting as pressure partitions.
摘要翻译：环形离子引导装置和方法提供常规的多极的聚焦和约束优点以及传统的直流环导轨的轴向场。环形杆装置包括环形堆叠部分和多极部分，其中环形堆叠部分沿着中心轴线基本上与多极部分内部和外部重叠。环状电极装置可用于质谱仪系统中以将离子从离子源引导到质谱仪或质谱仪级之间，或者将离子离解成离子离解系统中的子离子。单个环形极离子引导件可以跨越多个压力过渡级，其中几个环用作压力分隔件。

10. 发明授权

US07259368B2 Apparatus for delivering ions from a grounded electrospray assembly to a vacuum chamber 有权
标题翻译：用于将离子从接地电喷雾组件输送到真空室的装置
公开(公告)号：US07259368B2
公开(公告)日：2007-08-21
申请号：US11361125
申请日：2006-02-24
申请人： William D. Frazer , Steven M. Fischer , Robert K. Crawford
发明人： William D. Frazer , Steven M. Fischer , Robert K. Crawford
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/165 , H01J49/045
摘要： The present invention relates to an apparatus for delivering ions to a vacuum chamber. The apparatus comprises an ionization chamber, an ionization region within the ionization chamber, a vacuum interface at a vacuum interface voltage and a vacuum chamber, wherein the ionization chamber communicates with the vacuum chamber through the vacuum interface. Sample is introduced into the ionization chamber from an electrospray assembly at approximately ground potential. Two electrodes are provided within the chamber such that three electric fields are generated, a first field extending from the electrospray assembly to the first electrode, a second field extending from the second electrode to the first electrode, and a third field extending from the second electrode to the vacuum interface. Ions are forced to travel through the fields in order before entering the vacuum chamber. In addition, the invention provides a method of delivering ions to a vacuum chamber.
摘要翻译：本发明涉及一种用于将离子输送到真空室的装置。该装置包括电离室，电离室内的电离区域，真空界面电压下的真空界面和真空室，其中电离室通过真空界面与真空室连通。将样品从大约接地电位的电喷雾组件引入电离室。在室内提供两个电极，使得产生三个电场，从电喷雾组件延伸到第一电极的第一场，从第二电极延伸到第一电极的第二场和从第二电极延伸的第三场到真空界面。在进入真空室之前，离子被迫穿过田野。此外，本发明提供了将离子输送到真空室的方法。

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