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1. 发明授权

US06593570B2 Ion optic components for mass spectrometers 失效
标题翻译：离子光学元件用于质谱仪
公开(公告)号：US06593570B2
公开(公告)日：2003-07-15
申请号：US09747242
申请日：2000-12-22
申请人： Gangqiang Li , Charles W. Russ, IV
发明人： Gangqiang Li , Charles W. Russ, IV
IPC分类号： H01J4900
CPC分类号： H01J49/062
摘要： Apparatus and methods are disclosed for manipulating charged particles. The charged particles are directed from a source thereof into a zone. A first electrical potential is generated in the zone. Simultaneously, a second electrical potential is generated outside the zone. The second electrical potential penetrates into the zone and combines with the first electrical potential to form an oscillating electric potential field having predetermined characteristics sufficient to manipulate the charged particles. The manipulating of the charged particles includes, e.g., transporting, collisional cooling, collisional induced dissociating and collisional focusing. In one embodiment an apparatus comprises a hollow first element and a hollow second element. The second element is disposed within the first element. The second element has at least two openings in a wall thereof. The openings are elongated and radially disposed with respect to the axis of the second element. The length of the openings is at least about 20% of the length of the second element The first element and the second element each are adapted independently to receive a voltage to generate within the second element an electric potential having predetermined characteristics. The apparatus and methods of the invention have particular application to the field of mass spectrometry.
摘要翻译：公开了用于操纵带电粒子的装置和方法。带电粒子从其来源导入区域。在该区域中产生第一电位。同时，在区域外产生第二电位。第二电位渗入该区并与第一电位组合以形成具有足以操纵带电粒子的预定特性的振荡电势场。带电粒子的操纵包括例如运输，碰撞冷却，碰撞诱导的解离和碰撞聚焦。在一个实施例中，一种装置包括中空的第一元件和中空的第二元件。第二元件设置在第一元件内。第二元件在其壁中具有至少两个开口。开口是细长的并且相对于第二元件的轴线径向设置。开口的长度为第二元件的长度的至少约20％。第一元件和第二元件各自独立地适应于接收在第二元件内产生具有预定特征的电位的电压。本发明的装置和方法特别适用于质谱领域。

2. 发明授权

US07385190B2 Reference mass introduction via a capillary 有权
标题翻译：通过毛细管参考质量引入
公开(公告)号：US07385190B2
公开(公告)日：2008-06-10
申请号：US11280710
申请日：2005-11-16
申请人： Steven Fischer , Charles W. Russ, IV , William Barry
发明人： Steven Fischer , Charles W. Russ, IV , William Barry
IPC分类号： H01J49/10
CPC分类号： H01J49/0404 , H01J49/0009
摘要： A mass calibration apparatus for a mass spectrometer includes a capillary, an analyte ion source coupled to the capillary at a first point, a reference mass ion source coupled to the capillary at a second point, downstream from the first point and a mass analyzer coupled to the capillary at a third point downstream from the first and second points. The reference mass ion source may be coupled to the capillary via a tee junction. The reference mass ion source includes a chamber, an ionization device situated within the chamber and one or more reference mass sources that are situated internally within the chamber or are situated external to and coupled to the chamber.
摘要翻译：用于质谱仪的质量校准装置包括毛细管，在第一点处耦合到毛细管的分析物离子源，在第一点处的第二点处耦合到毛细管的参考质量离子源，以及耦合到毛细管在第一和第二点下游的第三点处。参考质量离子源可以经由三通接头耦合到毛细管。参考质量离子源包括室，位于室内的电离装置和位于室内部或位于腔室外部并耦合到室的一个或多个参考质量源。

3. 发明授权

US06486469B1 Dielectric capillary high pass ion filter 失效
标题翻译：电介质毛细管高通离子过滤器
公开(公告)号：US06486469B1
公开(公告)日：2002-11-26
申请号：US09429063
申请日：1999-10-29
申请人： Steven M. Fischer , Robert K. Crawford , Charles W. Russ, IV
发明人： Steven M. Fischer , Robert K. Crawford , Charles W. Russ, IV
IPC分类号： B01D5944
CPC分类号： H01J49/04
摘要： For delivery of ions from a higher pressure ion source to a mass analyzer operating at high vacuum, high pass ion filtration is effected within a dielectric capillary interface between the higher pressure ionization chamber and the lower pressure environment of a mass analyzer, by application of electrical potentials to end electrodes and to at least one electrode associated with the dielectric capillary between the ends, to create an end-to-end electric field generally opposing gas flow-assisted movement of ions from the upstream end to the downstream end, and to create a steeper voltage gradient along an upstream portion than along a downstream portion of the capillary. The voltage gradient along the steeper upstream portion of the capillary is sufficiently steep to cause ions having drift velocities below a lower limit to stall within the capillary. The respective potentials may be adjusted to increase the steepness of the upstream voltage gradient to increase the drift velocity lower limit.
摘要翻译：为了将离子从较高压力的离子源输送到在高真空下操作的质量分析仪，在高压离子化室和质量分析仪的较低压力环境之间的介电毛细管界面内，通过施加电将端电极和与末端之间的介电毛细管相关联的至少一个电极的电位产生一个端对端电场，通常相对于从上游端到下游端的离子的气流辅助运动，并产生沿着上游部分比沿着毛细管的下游部分更陡峭的电压梯度。沿着毛细管的较陡的上游部分的电压梯度足够陡峭，导致具有低于下限的漂移速度的离子在毛细管内停止。可以调节各个电位以增加上游电压梯度的陡度以增加漂移速度下限。

4. 发明授权

US6037587A Chemical ionization source for mass spectrometry 失效
标题翻译：用于质谱的化学电离源
公开(公告)号：US6037587A
公开(公告)日：2000-03-14
申请号：US951951
申请日：1997-10-17
申请人： Jerry T. Dowell , Jeffery S. Hollis , Charles W. Russ, IV
发明人： Jerry T. Dowell , Jeffery S. Hollis , Charles W. Russ, IV
IPC分类号： G01N27/62 , H01J27/02 , H01J37/08 , H01J49/04 , H01J49/10 , B01D59/44 , H01J49/00
CPC分类号： H01J49/145
摘要： A mass spectrometer having an ionization source containing a chemical ionization chamber, wherein the inner surfaces of the chamber are formed from molybdenum to reduce adsorption, degradation and decomposition of an analyte and to reduce adverse ion/surface reactions is disclosed. A method of reducing adsorption, degradation and decomposition of an analyte and reducing adverse ion/surface reactions in an ionization source containing a chemical ionization chamber of a mass spectrometer including the step of forming the inner surfaces of the chamber from molybdenum is also disclosed. The inner surfaces may formed from molybdenum by constructing the entire chamber or the inner surfaces of the chamber from molybdenum; by depositing, plating or coating molybdenum on the inner surfaces of the chamber; or by a combination thereof. Suitable forms of molybdenum include solid molybdenum, mixtures containing at least 10% by weight molybdenum, and reaction products containing molybdenum.
摘要翻译：一种具有含有化学电离室的电离源的质谱仪，其中室的内表面由钼形成，以减少分析物的吸附，降解和分解并减少不利的离子/表面反应。还公开了一种减少分析物的吸附，降解和分解并减少含有质谱仪的化学电离室的电离源中的不利的离子/表面反应的方法，包括从钼形成室的内表面的步骤。通过从钼构成整个室或室的内表面，内表面可以由钼形成; 通过在室的内表面上沉积，镀覆或涂覆钼; 或通过其组合。钼的合适形式包括固体钼，含有至少10重量％钼的混合物和含有钼的反应产物。

5. 发明授权

US5298745A Multilayer multipole 失效
标题翻译：多层多极
公开(公告)号：US5298745A
公开(公告)日：1994-03-29
申请号：US984610
申请日：1992-12-02
申请人： Jeffrey T. Kernan , Donald A. Johnson , Charles W. Russ, IV
发明人： Jeffrey T. Kernan , Donald A. Johnson , Charles W. Russ, IV
IPC分类号： G21K1/087 , H01J49/42
CPC分类号： H01J49/4215 , G21K1/087 , H01J49/068 , H01J49/4255
摘要： Multipole technology is used generally for charged particle optics which includes separating, focusing, or collimating "charged particles" (i.e., ions, electrons, etc.). A primary application of multipole technology is mass filters and particularly quadrupole mass filters. A quadrupole mass filter has a quadrupole substrate having four poles, each having a generally hyperbolic cross section, and interconnected by bridges. The bridges have apertures that facilitate the construction of poles inside the quadrupole substrate and prevent the build-up of unwanted charge. A plating substrate for electroplating is bonded to each pole substrate with a thin-film adhesion layer. Poles are electroplated upon these plating substrates. A diffusion barrier layer prevents the portions of the plating substrates from migrating to the quadrupole substrate where they would undermine the thin-film adhesion layer. Additionally, the diffusion barrier layer prevents portions of the thin-film adhesion layer from migrating away from the quadrupole substrate that could result in adhesion problems and contamination of the poles. Quadrupole mass filters formed with metallization and electroplating techniques have the advantages of consistent and predictable performance, high durability, nearly uniform thickness, and nearly hyperbolic cross-section that results in electric fields with a nearly idealized hyperbolic cross section.
摘要翻译：多极技术通常用于带电粒子光学器件，其包括分离，聚焦或准直“带电粒子”（即离子，电子等）。多极技术的主要应用是质量过滤器，特别是四极杆质量过滤器。四极质量过滤器具有四极基体，其具有四个极，每个极具有大体上双曲线的横截面，并且通过桥互连。桥梁具有有利于在四极基板内构造极的孔，并防止不想要的电荷的积聚。用于电镀的电镀基板用薄膜粘合层结合到各极基板上。在这些电镀基板上电极。扩散阻挡层防止电镀基板的部分迁移到四极基板，在那里它们将破坏薄膜粘合层。此外，扩散阻挡层防止薄膜粘附层的部分从四极基板迁移，这可能导致粘合问题和极的污染。用金属化和电镀技术形成的四极质量过滤器具有一致和可预测的性能，高耐久性，几乎均匀的厚度和几乎双曲线的横截面的优点，导致具有接近理想化的双曲线截面的电场。

6. 发明授权

US07112786B2 Atmospheric pressure ion source high pass ion filter 有权
公开(公告)号：US07112786B2
公开(公告)日：2006-09-26
申请号：US11168756
申请日：2005-06-27
申请人： Charles W. Russ, IV , Steven M. Fischer , Robert K. Crawford
发明人： Charles W. Russ, IV , Steven M. Fischer , Robert K. Crawford
IPC分类号： H01J49/04
CPC分类号： H01J49/061 , H01J49/04 , H01J49/10
摘要： For generation and delivery of ions from an ionization chamber through an ion entrance orifice to a mass analyzer operating at high vacuum, high pass ion filtration is effected within the ionization chamber by application of electrical potentials to an electrode associated with the ion entrance orifice and to an electrode between the ionization region and the ion entrance orifice to create a retarding electric field upstream from the ion entrance orifice. The retarding electric field hinders the movement to the ion entrance orifice of ions having drift velocities below a lower limit, and as the retarding voltage gradient is made steeper, the lower limit increases.

7. 发明授权

US07166836B1 Ion beam focusing device 有权
标题翻译：离子束聚焦装置
公开(公告)号：US07166836B1
公开(公告)日：2007-01-23
申请号：US11221491
申请日：2005-09-07
申请人： Charles W. Russ, IV , Steven M. Fischer
发明人： Charles W. Russ, IV , Steven M. Fischer
IPC分类号： H01J49/42 , H01J37/26
CPC分类号： H01J49/42 , H01J49/04
摘要： The invention provides an apparatus for focusing ions exiting a multipole mass filter. In general terms, the ion focusing apparatus comprises: a housing having an ion entrance and an ion exit, and, contained within the housing: a) a multipole ion guide having an open ion entrance end, and b) a neutral gas. The ion focusing apparatus is configured so that an ion beam enters the housing via the ion entrance and is collisionally focused by the multipole ion guide and neutral gas prior to exiting the housing. The apparatus is readily employed to collisionally focus an ion beam exiting a quadrupole mass filter. Also provided is a mass spectrometry system containing the ion focusing apparatus, and methods employing the same.
摘要翻译：本发明提供一种用于聚焦离开多极质量过滤器的离子的装置。一般来说，离子聚焦装置包括：具有离子入口和离子出口的壳体，并且容纳在壳体内：a）具有开放离子入口端的多极离子导向器，以及b）中性气体。离子聚焦装置被配置为使得离子束经由离子入口进入壳体并且在离开壳体之前被多极离子导向器和中性气体碰撞聚焦。该装置容易地用于将离开四极质量过滤器的离子束碰撞地聚焦。还提供了含有离子聚焦装置的质谱系统及其应用方法。

8. 发明授权

US06661003B2 Dielectric capillary high pass ion filter 失效
公开(公告)号：US06661003B2
公开(公告)日：2003-12-09
申请号：US10224637
申请日：2002-08-20
申请人： Steven M. Fischer , Robert K. Crawford , Charles W. Russ, IV
发明人： Steven M. Fischer , Robert K. Crawford , Charles W. Russ, IV
IPC分类号： B01D5944
CPC分类号： H01J49/04
摘要： For delivery of ions from a higher pressure ion source to a mass analyzer operating at high vacuum, high pass ion filtration is effected within a dielectric capillary interface between the higher pressure ionization chamber and the lower pressure environment of a mass analyzer, by application of electrical potentials to end electrodes and to at least one electrode associated with the dielectric capillary between the ends, to create an end-to-end electric field generally opposing gas flow-assisted movement of ions from the upstream end to the downstream end, and to create a steeper voltage gradient along an upstream portion than along a downstream portion of the capillary. The voltage gradient along the steeper upstream portion of the capillary is sufficiently steep to cause ions having drift velocities below a lower limit to stall within the capillary. The respective potentials may be adjusted to increase the steepness of the upstream voltage gradient to increase the drift velocity lower limit.

9. 发明授权

US06649909B2 Internal introduction of lock masses in mass spectrometer systems 有权
标题翻译：在质谱仪系统内部引入锁定质量
公开(公告)号：US06649909B2
公开(公告)日：2003-11-18
申请号：US10081780
申请日：2002-02-20
申请人： Charles W. Russ, IV , Steven M. Fischer
发明人： Charles W. Russ, IV , Steven M. Fischer
IPC分类号： H01J4910
CPC分类号： H01J49/0009 , H01J49/004
摘要： An apparatus and method for calibrating a mass spectrometer by internally introducing calibration masses at a post-source stage of the mass spectrometer is provided. A source of lock mass ions adjacent the ion optics creates lock mass ions within the ion optics. Lock mass ions mix with the analyte ions in the ion optics prior to mass analysis. The source of lock mass ions may include various means for ionizing lock mass molecules including but not limited to photoionization, field desorption-ionization, electron ionization, and thermal ionization means. An apparatus and method of mass calibrating a tandem mass spectrometer is also provided. The mass calibration apparatus includes a collision cell for fragmenting analyte ions and a source of lock mass ions adjacent said collision cell for creating lock mass ions in the collision cell.
摘要翻译：提供了通过在质谱仪的后源阶段内部引入校准质量来校准质谱仪的装置和方法。与离子光学器件相邻的锁定质量离子源产生离子光学器件内的锁定质子离子。在质量分析之前，将质子离子与离子光学中的分析物离子混合。锁定质量离子的来源可以包括用于电离锁定质量分子的各种装置，包括但不限于光电离，场解吸电离，电子离子化和热电离装置。还提供了质量校准串联质谱仪的装置和方法。质量校准装置包括用于碎裂分析物离子的碰撞单元和邻近所述碰撞室的锁定质量离子源，用于在碰撞室中产生锁定质量离子。

10. 发明授权

US06417511B1 Ring pole ion guide apparatus, systems and method 有权
标题翻译：环形极离子导向装置，系统及方法
公开(公告)号：US06417511B1
公开(公告)日：2002-07-09
申请号：US09617877
申请日：2000-07-17
申请人： Charles W. Russ, IV , Steven M. Fischer
发明人： Charles W. Russ, IV , Steven M. Fischer
IPC分类号： H01J4900
CPC分类号： H01J49/065 , H01J49/063
摘要： A ring pole ion guide apparatus and method provide the focusing and confinement advantages of conventional multipoles and the axial field of a conventional DC ring guide all in one device. The ring pole apparatus comprises a ring stack portion and a multipole portion, wherein the ring stack portion essentially overlaps the multipole portion inside and outside along a central axis. The ring pole apparatus can be used in a mass spectrometer system to guide ions from the ion source to the mass spectrometer or between mass spectrometer stages, or to dissociate ions into daughter ions in an ion dissociation system. A single ring pole ion guide can span a plurality of pressure transition stages with several of the rings acting as pressure partitions.
摘要翻译：环形离子引导装置和方法提供常规的多极的聚焦和约束优点以及传统的直流环导轨的轴向场。环形杆装置包括环形堆叠部分和多极部分，其中环形堆叠部分沿着中心轴线基本上与多极部分内部和外部重叠。环状电极装置可用于质谱仪系统中以将离子从离子源引导到质谱仪或质谱仪级之间，或者将离子离解成离子离解系统中的子离子。单个环形极离子引导件可以跨越多个压力过渡级，其中几个环用作压力分隔件。

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