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1. 发明授权

US08716218B2 Extracellular histones as biomarkers for prognosis and molecular targets for therapy 有权
标题翻译：细胞外组蛋白作为预后的生物标志物和治疗的分子靶标
公开(公告)号：US08716218B2
公开(公告)日：2014-05-06
申请号：US12266336
申请日：2008-11-06
申请人： Charles T. Esmon , Jun Xu , Xiaomei Zhang
发明人： Charles T. Esmon , Jun Xu , Xiaomei Zhang
IPC分类号： A61K38/10
CPC分类号： A61K38/10 , A61K31/727 , A61K38/1709 , A61K38/36 , A61K38/4833 , A61K38/4846 , A61K38/4866 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/08 , C07K16/18 , C07K16/40 , C07K2317/76 , C12Y304/21005 , C12Y304/21006 , C12Y304/21069 , G01N33/6875 , A61K2300/00
摘要： Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.
摘要翻译：高发炎反应可导致多种疾病，包括败血症。现在显示出响应于炎性攻击而释放的细胞外组蛋白是介导脓毒血症的内皮功能障碍，器官衰竭和死亡的介质。因此，它们可以通过抑制剂药理靶向，并且用作脓毒症和其他疾病的预后的生物标志物。

2. 发明申请

US20090117099A1 EXTRACELLULAR HISTONES AS BIOMARKERS FOR PROGNOSIS AND MOLECULAR TARGETS FOR THERAPY 有权
标题翻译：作为预防和分子靶向治疗的生物标志物的细胞结合蛋白
公开(公告)号：US20090117099A1
公开(公告)日：2009-05-07
申请号：US12266336
申请日：2008-11-06
申请人： Charles T. Esmon , Jun Xu , Xiaomei Zhang
发明人： Charles T. Esmon , Jun Xu , Xiaomei Zhang
IPC分类号： A61K39/395 , A61K38/16 , A61K38/48 , A61K31/727 , C12Q1/00
CPC分类号： A61K38/10 , A61K31/727 , A61K38/1709 , A61K38/36 , A61K38/4833 , A61K38/4846 , A61K38/4866 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/08 , C07K16/18 , C07K16/40 , C07K2317/76 , C12Y304/21005 , C12Y304/21006 , C12Y304/21069 , G01N33/6875 , A61K2300/00
摘要： Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.
摘要翻译：高发炎反应可导致多种疾病，包括败血症。现在显示出响应于炎性攻击而释放的细胞外组蛋白是介导脓毒血症的内皮功能障碍，器官衰竭和死亡的介质。因此，它们可以通过抑制剂药理靶向，并且用作脓毒症和其他疾病的预后的生物标志物。

3. 发明申请

US20150006082A1 METHOD AND APPARATUS FOR MICROSEISMIC ATTRIBUTE MAPPING FOR STIMULATED RESERVOIR VOLUME EVALUATION 审中-公开
标题翻译：用于刺激储层体积评估的微观特征映射的方法和装置
公开(公告)号：US20150006082A1
公开(公告)日：2015-01-01
申请号：US13927883
申请日：2013-06-26
申请人： Xiaomei Zhang , Marc Holland , Wouter van der Zee
发明人： Xiaomei Zhang , Marc Holland , Wouter van der Zee
IPC分类号： G01V1/30
CPC分类号： G01V1/306 , G01V1/288
摘要： A method for estimating a volume of a stimulated reservoir includes receiving a seismic signal from each microseismic event in a plurality of microseismic events in an earth formation by an array of seismic receivers. The method further includes representing each microseismic event by a plurality of markers in the three-dimensional space. A spatial distribution of the markers represents a volume of rock influenced by a microseismic event, wherein the volume and a location of each event are derived from the seismic signal. The method further includes calculating a scalar attribute for each marker in the plurality of markers, dividing the three-dimensional space into a plurality of three-dimensional grid cells, and summing the scalar attributes for all the markers in each grid cell to provide a total scalar attribute for each grid cell.
摘要翻译：用于估计受刺激储层的体积的方法包括：通过地震接收器阵列在地层中的多个微震事件中从每个微震事件接收地震信号。该方法还包括通过三维空间中的多个标记表示每个微震事件。标记的空间分布表示受微震事件影响的岩石体积，其中每个事件的体积和位置是从地震信号导出的。该方法还包括计算多个标记中每个标记的标量属性，将三维空间划分为多个三维网格单元，并对每个网格单元中所有标记的标量属性求和，以提供总数每个网格单元的标量属性。

4. 发明申请

US20140372094A1 GENERATION OF FRACTURE NETWORKS USING SEISMIC DATA 有权
标题翻译：使用地震数据生成破碎网络
公开(公告)号：US20140372094A1
公开(公告)日：2014-12-18
申请号：US13916143
申请日：2013-06-12
申请人： Marc Holland , Wouter E. Van Der Zee , Xiaomei Zhang
发明人： Marc Holland , Wouter E. Van Der Zee , Xiaomei Zhang
IPC分类号： G01V11/00
CPC分类号： G01V11/00 , E21B43/26 , E21B47/02208 , G01V1/288
摘要： An embodiment of a method for constructing a fracture network includes: receiving seismic data collected from a stimulation operation in an earth formation, the seismic data including seismic event data including a first seismic event associated with a first time increment and a second seismic event associated with a subsequent second time increment; and constructing a fracture network model. The model is constructed by: constructing an initial portion of the model based on the first seismic event; and subsequently updating the initial portion of the model based on the second seismic event.
摘要翻译：用于构造断裂网络的方法的实施例包括：接收从地层中的刺激操作收集的地震数据，所述地震数据包括地震事件数据，包括与第一时间增量相关联的第一地震事件和与随后的第二次增量; 并构建骨折网络模型。该模型通过以下方式构建：基于第一次地震事件构建模型的初始部分; 并且随后基于第二地震事件更新模型的初始部分。

5. 发明申请

US20120185821A1 PATTERN-BASED CONSTRUCTION AND EXTENSION OF ENTERPRISE APPLICATIONS IN A CLOUD COMPUTING ENVIRONMENT 有权
标题翻译：云计算环境中基于模式的构建与扩展企业应用
公开(公告)号：US20120185821A1
公开(公告)日：2012-07-19
申请号：US13236022
申请日：2011-09-19
申请人： Rahim Mohamed Yaseen , John Liang , Yunhee Choi , Xiaomei Zhang
发明人： Rahim Mohamed Yaseen , John Liang , Yunhee Choi , Xiaomei Zhang
IPC分类号： G06F9/44
CPC分类号： G06F8/10 , G06F8/316 , G06F8/35
摘要： Methods, software programs and systems for extending and modifying software functionality, and, more particularly, for using one or more patterns for an enterprise software object to express desired functionality and configuration, and to generate the enterprise software object using the patterns, in an enterprise environment are disclosed. A method according to certain of these embodiments includes selecting one or more patterns from a number of patterns, where the one or more patterns are for an enterprise software object. The enterprise software object can then be generated. The enterprise software object is generated using the one or more patterns. Each of the patterns is configured to describe a solution within a corresponding one of a number of problem domains.
摘要翻译：用于扩展和修改软件功能的方法，软件程序和系统，更具体地，用于使用企业软件对象中的一个或多个模式来表达期望的功能和配置，以及在企业中使用模式生成企业软件对象环境被披露。根据这些实施例中的某些的方法包括从多个模式中选择一个或多个模式，其中一个或多个模式用于企业软件对象。然后可以生成企业软件对象。使用一个或多个模式生成企业软件对象。每个模式被配置为描述在多个问题域中的对应的一个中的解决方案。

6. 发明申请

US20110195110A1 UREA COMPOUNDS USEFUL IN THE TREATMENT OF CANCER 审中-公开
标题翻译： UREA化合物可用于治疗癌症
公开(公告)号：US20110195110A1
公开(公告)日：2011-08-11
申请号：US12095611
申请日：2006-12-01
申请人： Roger Smith , Holia N. Hatoum-Mokdad , Louis David Cantin , Donald E. Bierer , Wenlang Fu , Dhanapalan Nagarathnam , Gaetan Ladouceur , Yamin Wang , Herbert Ogutu , Scot Wilhelm , Ian Taylor , Sanjeeva Reddy , Richard Gedrich , Christopher Carter , Aaron Schmitt , Xiaomei Zhang
发明人： Roger Smith , Holia N. Hatoum-Mokdad , Louis David Cantin , Donald E. Bierer , Wenlang Fu , Dhanapalan Nagarathnam , Gaetan Ladouceur , Yamin Wang , Herbert Ogutu , Scot Wilhelm , Ian Taylor , Sanjeeva Reddy , Richard Gedrich , Christopher Carter , Aaron Schmitt , Xiaomei Zhang
IPC分类号： A61K9/127 , C07D401/12 , C07D401/14 , A61K31/4439 , A61K31/506 , A61K31/444 , A61K31/4375 , A61K31/4535 , A61K38/20 , A61K33/24 , A61K38/21 , A61K33/36 , A61K39/395 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： C07D401/12 , C07D401/14
摘要： Pyrazole urea compounds, pharmaceutical compositions which contain them and methods for treating cancer using them.
摘要翻译：吡唑脲化合物，含有它们的药物组合物和使用它们治疗癌症的方法。

7. 发明授权

US10197704B2 Corrective scaling of interpreted fractures based on the microseismic detection range bias correction 有权
$Corrective scaling of interpreted fractures based on the microseismic detection range bias correction$
公开(公告)号：US10197704B2
公开(公告)日：2019-02-05
申请号：US14577751
申请日：2014-12-19
申请人： Marc Holland , Xiaomei Zhang
发明人： Marc Holland , Xiaomei Zhang
IPC分类号： E21B47/00 , G01V99/00 , E21B43/26 , G01V1/48 , G06F17/10 , G01V1/28 , G01V1/30 , G01V1/38 , G01V1/42 , G01V1/50
摘要： A method for correcting a fracture model of a reservoir includes receiving a seismic signal from seismic events due to a plurality of stimulated reservoir stages to provide detected seismic event information and estimating a number of undetected seismic events and a magnitude for each of the undetected seismic events to provide undetected seismic event information for each stage. The detected seismic event information and the undetected seismic event information provide corrected seismic event information for each stage. The method further includes calculating a scaling factor for each stage using a scalar property of the corresponding stage and a reference stage scalar property, applying the scaling factor for each stage to the corrected seismic event information to provide scaled seismic event information for each stage, and correcting the fracture model with the scaled seismic event information for each stage to provide a corrected fracture model.

8. 发明申请

US20160178798A1 CORRECTIVE SCALING OF INTERPRETED FRACTURES BASED ON THE MICROSEISMIC DETECTION RANGE BIAS CORRECTION 审中-公开
标题翻译：基于微观检测范围偏差校正的解释性断裂的校正
公开(公告)号：US20160178798A1
公开(公告)日：2016-06-23
申请号：US14577751
申请日：2014-12-19
申请人： Marc Holland , Xiaomei Zhang
发明人： Marc Holland , Xiaomei Zhang
IPC分类号： G01V99/00 , G06F17/10 , E21B47/00 , G01V1/48 , E21B43/26
CPC分类号： G01V99/005 , E21B43/26 , E21B47/00 , G01V1/282 , G01V1/288 , G01V1/301 , G01V1/3808 , G01V1/42 , G01V1/48 , G01V1/50 , G01V2210/1234 , G01V2210/1429 , G01V2210/163 , G01V2210/169 , G01V2210/646 , G01V2210/663 , G06F17/10
摘要： A method for correcting a fracture model of a reservoir includes receiving a seismic signal from seismic events due to a plurality of stimulated reservoir stages to provide detected seismic event information and estimating a number of undetected seismic events and a magnitude for each of the undetected seismic events to provide undetected seismic event information for each stage. The detected seismic event information and the undetected seismic event information provide corrected seismic event information for each stage. The method further includes calculating a scaling factor for each stage using a scalar property of the corresponding stage and a reference stage scalar property, applying the scaling factor for each stage to the corrected seismic event information to provide scaled seismic event information for each stage, and correcting the fracture model with the scaled seismic event information for each stage to provide a corrected fracture model.
摘要翻译：用于校正储层的断裂模型的方法包括：由于多个受刺激的储层阶段而从地震事件接收地震信号，以提供检测到的地震事件信息并且估计未检测到的地震事件的数量以及未检测到的地震事件的大小为每个阶段提供未检测到的地震事件信息。检测到的地震事件信息和未检测到的地震事件信息为每个阶段提供校正的地震事件信息。该方法还包括使用相应级的标量属性和参考级标量特性来计算每个级的缩放因子，将每个级的缩放因子应用于校正的地震事件信息，以为每个级提供缩放的地震事件信息，以及利用每个阶段的缩放地震事件信息来校正断裂模型，以提供校正的断裂模型。

9. 发明授权

US09612359B2 Generation of fracture networks using seismic data 有权
$Generation of fracture networks using seismic data$
公开(公告)号：US09612359B2
公开(公告)日：2017-04-04
申请号：US13916143
申请日：2013-06-12
申请人： Marc Holland , Wouter E. Van Der Zee , Xiaomei Zhang
发明人： Marc Holland , Wouter E. Van Der Zee , Xiaomei Zhang
IPC分类号： G06G7/48 , G01V11/00 , E21B43/26 , E21B47/022 , G01V1/28
CPC分类号： G01V11/00 , E21B43/26 , E21B47/02208 , G01V1/288
摘要： An embodiment of a method for constructing a fracture network includes: receiving seismic data collected from a stimulation operation in an earth formation, the seismic data including seismic event data including a first seismic event associated with a first time increment and a second seismic event associated with a subsequent second time increment; and constructing a fracture network model. The model is constructed by: constructing an initial portion of the model based on the first seismic event; and subsequently updating the initial portion of the model based on the second seismic event.

10. 发明授权

US09535663B2 Pattern-based construction and extension of enterprise applications in a cloud computing environment 有权
标题翻译：在云计算环境下，基于模式的企业应用的构建和扩展
公开(公告)号：US09535663B2
公开(公告)日：2017-01-03
申请号：US13236022
申请日：2011-09-19
申请人： Rahim Mohamed Yaseen , John Liang , Yunhee Choi , Xiaomei Zhang
发明人： Rahim Mohamed Yaseen , John Liang , Yunhee Choi , Xiaomei Zhang
IPC分类号： G06F9/44
CPC分类号： G06F8/10 , G06F8/316 , G06F8/35
摘要： Methods, software programs and systems for extending and modifying software functionality, and, more particularly, for using one or more patterns for an enterprise software object to express desired functionality and configuration, and to generate the enterprise software object using the patterns, in an enterprise environment are disclosed. A method according to certain of these embodiments includes selecting one or more patterns from a number of patterns, where the one or more patterns are for an enterprise software object. The enterprise software object can then be generated. The enterprise software object is generated using the one or more patterns. Each of the patterns is configured to describe a solution within a corresponding one of a number of problem domains.
摘要翻译：用于扩展和修改软件功能的方法，软件程序和系统，更具体地，用于使企业软件对象中使用一个或多个模式来表达期望的功能和配置，以及在企业中使用模式生成企业软件对象环境被披露。根据这些实施例中的某些的方法包括从多个模式中选择一个或多个模式，其中一个或多个模式用于企业软件对象。然后可以生成企业软件对象。使用一个或多个模式生成企业软件对象。每个模式被配置为描述在多个问题域中的对应的一个中的解决方案。

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