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1. 发明授权

US10794914B2 Assay apparatuses, methods and reagents 有权
公开(公告)号：US10794914B2
公开(公告)日：2020-10-06
申请号：US13290059
申请日：2011-11-05
申请人： Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Sandor L. Kovacs , Sudeep M. Kumar , George Sigal , Carl Stevens , Michael Vock
发明人： Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Sandor L. Kovacs , Sudeep M. Kumar , George Sigal , Carl Stevens , Michael Vock
IPC分类号： G01N35/10 , B67B7/00 , G01N33/58 , G01N21/64 , G01N21/66 , G01N33/53 , G01N35/02 , G01N35/04
摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

2. 发明授权

US10302649B2 Assay apparatuses, methods and reagents 有权
公开(公告)号：US10302649B2
公开(公告)日：2019-05-28
申请号：US11642968
申请日：2006-12-21
申请人： Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Sandor L. Kovacs , Sudeep M. Kumar , George Sigal , Carl Stevens , Michael Vock
发明人： Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Sandor L. Kovacs , Sudeep M. Kumar , George Sigal , Carl Stevens , Michael Vock
IPC分类号： G01N35/10 , B67B7/00 , G01N33/58 , G01N21/64 , G01N21/66 , G01N33/53 , G01N35/02 , G01N35/04
摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

3. 发明申请

US20120195800A1 ASSAY APPARATUSES, METHODS AND REAGENTS 审中-公开
标题翻译：测定装置，方法和试剂
公开(公告)号：US20120195800A1
公开(公告)日：2012-08-02
申请号：US13290059
申请日：2011-11-05
申请人： Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Sandor L. Kovacs , Sudeep M. Kumar , George Sigal , Carl Stevens , Michael Vock
发明人： Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Sandor L. Kovacs , Sudeep M. Kumar , George Sigal , Carl Stevens , Michael Vock
IPC分类号： G01N21/75
摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
摘要翻译：我们描述用于进行测定的装置，系统，方法，试剂和试剂盒以及其制备方法。它们特别适合进行多孔板测定格式的自动采样，样品制备和分析。例如，它们可用于在环境监测中对其中衍生的空气和/或液体样品中的颗粒进行自动分析。

4. 发明授权

US07807448B2 Assay modules having assay reagents and methods of making and using same 有权
标题翻译：具有测定试剂的测定模块及其制备和使用方法
公开(公告)号：US07807448B2
公开(公告)日：2010-10-05
申请号：US11642970
申请日：2006-12-21
申请人： Eli N. Glezer , Bandele Jeffrey-Coker , Jeff D. Debad , Sudeep M. Kumar , George Sigal , Gisbert Spieles , Michael Tsionsky , Michael Warnock
发明人： Eli N. Glezer , Bandele Jeffrey-Coker , Jeff D. Debad , Sudeep M. Kumar , George Sigal , Gisbert Spieles , Michael Tsionsky , Michael Warnock
IPC分类号： C12M1/34
CPC分类号： B01L3/5025 , B01L3/5085 , B01L2200/12 , B01L2200/16 , B01L2300/0636 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858 , B01L2300/105 , G01N33/54366 , G01N33/54393 , Y10S436/809
摘要： We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.
摘要翻译：我们描述测定模块（例如，测定板，盒，多孔测定板，反应容器等），其制备方法及其用于进行测定的方法。试剂可以以游离形式存在或在固相上负载，包括测定模块或胶体，珠粒或其它颗粒载体表面的隔室（例如，室，通道，流动池，孔等）的表面。特别地，干试剂可以并入到这些测定模块的隔室中，并根据测定方法在使用之前重构。干燥剂材料可用于在干燥状态下维持和稳定这些试剂。

5. 发明授权

US08298834B2 Assay modules having assay reagents and methods of making and using same 有权
标题翻译：具有测定试剂的测定模块及其制备和使用方法
公开(公告)号：US08298834B2
公开(公告)日：2012-10-30
申请号：US12871946
申请日：2010-08-31
申请人： Eli N. Glezer , Bandele Jeffrey-Coker , Jeff D. Debad , Sudeep M. Kumar , George Sigal , Gisbert Spieles , Michael Tsionsky , Michael Warnock
发明人： Eli N. Glezer , Bandele Jeffrey-Coker , Jeff D. Debad , Sudeep M. Kumar , George Sigal , Gisbert Spieles , Michael Tsionsky , Michael Warnock
IPC分类号： G01N33/543
CPC分类号： B01L3/5025 , B01L3/5085 , B01L2200/12 , B01L2200/16 , B01L2300/0636 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858 , B01L2300/105 , G01N33/54366 , G01N33/54393 , Y10S436/809
摘要： We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.
摘要翻译：我们描述测定模块（例如，测定板，盒，多孔测定板，反应容器等），其制备方法及其用于进行测定的方法。试剂可以以游离形式存在或在固相上负载，包括测定模块或胶体，珠粒或其它颗粒载体表面的隔室（例如，室，通道，流动池，孔等）的表面。特别地，干试剂可以并入到这些测定模块的隔室中，并根据测定方法在使用之前重构。干燥剂材料可用于在干燥状态下维持和稳定这些试剂。

6. 发明申请

US20100316992A1 DIAGNOSTIC TEST 审中-公开
标题翻译：诊断测试
公开(公告)号：US20100316992A1
公开(公告)日：2010-12-16
申请号：US12818093
申请日：2010-06-17
申请人： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
发明人： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
IPC分类号： C12Q1/70 , C40B30/04 , G01N33/566
CPC分类号： G01N33/6893 , G01N33/6863 , G01N2333/523 , G01N2333/525 , G01N2333/70578 , G01N2800/065 , G01N2800/52
摘要： Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
摘要翻译：公开了用于进行诸如克罗恩病和溃疡性结肠炎的炎症性肠病的检测的诊断测试的方法。还描述了通过管理本发明的测试来监测患者的方法。还描述了通过管理本发明的测试来监测患者治疗的方法。还描述了通过将本发明的试验施用于用药物或候选药物治疗的患者，动物模型和细胞培养物的样品来评价药物或药物候选物的有效性的方法。还公开了用于确定分析物的有用性的方法，例如，用作本发明各种方法中用于炎性肠病的诊断和监测标志物的细胞因子。

7. 发明申请

US20130172431A1 DIAGNOSTIC TEST 审中-公开
标题翻译：诊断测试
公开(公告)号：US20130172431A1
公开(公告)日：2013-07-04
申请号：US13775952
申请日：2013-02-25
申请人： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
发明人： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/6863 , G01N2333/523 , G01N2333/525 , G01N2333/70578 , G01N2800/065 , G01N2800/52
摘要： Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
摘要翻译：公开了用于进行诸如克罗恩病和溃疡性结肠炎的炎症性肠病的检测的诊断测试的方法。还描述了通过管理本发明的测试来监测患者的方法。还描述了通过管理本发明的测试来监测患者治疗的方法。还描述了通过将本发明的试验施用于用药物或候选药物治疗的患者，动物模型和细胞培养物的样品来评价药物或药物候选物的有效性的方法。还公开了用于确定分析物的有用性的方法，例如，用作本发明各种方法中用于炎性肠病的诊断和监测标志物的细胞因子。

8. 发明授权

US07553448B2 Electrochemiluminescence flow cell and flow cell components 失效
标题翻译：电化学发光流通池和流通池组件
公开(公告)号：US07553448B2
公开(公告)日：2009-06-30
申请号：US10600164
申请日：2003-06-19
申请人： Sudeep M. Kumar , Josephus Marinus Otten , Charles Quentin Davis , Hans Biebuyck
发明人： Sudeep M. Kumar , Josephus Marinus Otten , Charles Quentin Davis , Hans Biebuyck
IPC分类号： G01N21/76 , C12M3/00 , G01N21/64 , G01N33/00
CPC分类号： G01N33/5438 , G01N21/69 , G01N21/76 , G01N33/582 , G01N2021/0389
摘要： An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium, iridium or an alloy of platinum, rhodium or iridium alloyed with an alloy material comprising a transition element. The electrode may be used as counter electrode and/or as a working electrode in the electrochemiluminescence cell. The cell preferably includes a counter electrode and a support attached to the counter electrode. The support comprises a transparent portion in optical registration with the working electrode. The counter electrode may include one or more field extending elements interposed between the transparent portion and the working electrode. The field extending element is preferably a ladder or a grid.
摘要翻译：一种电化学发光电池，其包括能够将电化学发光活性物质引入电化学发光的电极。电极优选由铑，铱或与包含过渡元素的合金材料合金化的铂，铑或铱的合金制成。电极可以用作电化学发光单元中的对电极和/或作为工作电极。电池优选包括反电极和附接到对电极的支撑体。支撑件包括与工作电极对准的透明部分。对电极可以包括插入在透明部分和工作电极之间的一个或多个场延伸元件。场延伸元件优选地是梯子或栅格。

9. 发明申请

US20090246076A1 ELECTROCHEMILUMINESCENCE FLOW CELL AND FLOW CELL COMPONENTS 审中-公开
标题翻译：电致发光细胞和流动细胞组分
公开(公告)号：US20090246076A1
公开(公告)日：2009-10-01
申请号：US12477063
申请日：2009-06-02
申请人： Sudeep M. Kumar , Josephus Marinus Otten , Charles Quentin Davis , Hans Biebuyck
发明人： Sudeep M. Kumar , Josephus Marinus Otten , Charles Quentin Davis , Hans Biebuyck
IPC分类号： G01N21/76
CPC分类号： G01N33/5438 , G01N21/69 , G01N21/76 , G01N33/582 , G01N2021/0389
摘要： An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium, iridium or an alloy of platinum, rhodium or iridium alloyed with an alloy material comprising a transition element. The electrode may be used as counter electrode and/or as a working electrode in the electrochemiluminescence cell. The cell preferably includes a counter electrode and a support attached to the counter electrode. The support comprises a transparent portion in optical registration with the working electrode. The counter electrode may include one or more field extending elements interposed between the transparent portion and the working electrode. The field extending element is preferably a ladder or a grid.
摘要翻译：一种电化学发光电池，其包括能够将电化学发光活性物质引入电化学发光的电极。电极优选由铑，铱或与包含过渡元素的合金材料合金化的铂，铑或铱的合金制成。电极可以用作电化学发光单元中的对电极和/或作为工作电极。电池优选包括反电极和附接到对电极的支撑体。支撑件包括与工作电极对准的透明部分。对电极可以包括插入在透明部分和工作电极之间的一个或多个场延伸元件。场延伸元件优选地是梯子或栅格。

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