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1. 发明授权

US08160389B2 Method for overlapping visual slices 有权
标题翻译：视觉切片重叠的方法
公开(公告)号：US08160389B2
公开(公告)日：2012-04-17
申请号：US12179575
申请日：2008-07-24
申请人： Charles Bissonnette , Charles Parker , Daniel Cook , Douglas Charles Shimonek , William Hsu , Yin Li
发明人： Charles Bissonnette , Charles Parker , Daniel Cook , Douglas Charles Shimonek , William Hsu , Yin Li
IPC分类号： G06K9/20 , G06K9/34
CPC分类号： G06T11/00
摘要： Image editing tools are commonly used to assist with manipulating and saving visual compositions. Many image editing tools provide slicing functionality to create images slices (sub-images) of the visual composition. As provided herein, a slice representation of a visual composition is defined by an arbitrarily chosen set of coordinates within the visual composition. This slice region may be defined independent of other slice regions (e.g. the slice region may or may not overlap, abut, etc. other slice regions). The slice representation comprises the slice region and one or more objects or portions thereof within the slice region. Slice representations may also comprise overlapping objects and/or slice region coordinates. Objects may be manipulated within a slice representation without affecting that object within other slice representations.
摘要翻译：图像编辑工具通常用于帮助操纵和保存视觉作品。许多图像编辑工具提供切片功能来创建视觉构图的图像切片（子图像）。如本文所提供的，视觉合成的切片表示由视觉合成中的任意选择的坐标系定义。该切片区域可以独立于其它切片区域（例如切片区域可以重叠，邻接等等等切片区域）而被定义。切片表示包括切片区域和切片区域内的一个或多个对象或其部分。切片表示还可以包括重叠对象和/或切片区域坐标。可以在切片表示内操纵对象，而不会影响其他切片表示中的对象。

2. 发明申请

US20100021060A1 METHOD FOR OVERLAPPING VISUAL SLICES 有权
标题翻译：用于重写视觉幻灯片的方法
公开(公告)号：US20100021060A1
公开(公告)日：2010-01-28
申请号：US12179575
申请日：2008-07-24
申请人： Charles Bissonnette , Charles Parker , Daniel Cook , Douglas Charles Shimonek , William Hsu , Yin Li
发明人： Charles Bissonnette , Charles Parker , Daniel Cook , Douglas Charles Shimonek , William Hsu , Yin Li
IPC分类号： G06K9/46
CPC分类号： G06T11/00
摘要： Image editing tools are commonly used to assist with manipulating and saving visual compositions. Many image editing tools provide slicing functionality to create images slices (sub-images) of the visual composition. As provided herein, a slice representation of a visual composition is defined by an arbitrarily chosen set of coordinates within the visual composition. This slice region may be defined independent of other slice regions (e.g. the slice region may or may not overlap, abut, etc. other slice regions). The slice representation comprises the slice region and one or more objects or portions thereof within the slice region. Slice representations may also comprise overlapping objects and/or slice region coordinates. Objects may be manipulated within a slice representation without affecting that object within other slice representations.
摘要翻译：图像编辑工具通常用于帮助操纵和保存视觉作品。许多图像编辑工具提供切片功能来创建视觉构图的图像切片（子图像）。如本文所提供的，视觉合成的切片表示由视觉合成中的任意选择的坐标系定义。该切片区域可以独立于其它切片区域（例如切片区域可以重叠，邻接等等等切片区域）而被定义。切片表示包括切片区域和切片区域内的一个或多个对象或其部分。切片表示还可以包括重叠对象和/或切片区域坐标。可以在切片表示内操纵对象，而不影响其他切片表示内的该对象。

3. 发明授权

US09002450B2 Systems and methods for assessing the sphericity and dimensional extent of heart chambers for use with an implantable medical device 有权
标题翻译：用于评估与可植入医疗装置一起使用的心室的球形度和尺寸范围的系统和方法
公开(公告)号：US09002450B2
公开(公告)日：2015-04-07
申请号：US12975085
申请日：2010-12-21
申请人： Stuart Rosenberg , Yelena Nabutovsky , Cecilia Qin Xi , Jong Gill , Kyungmoo Ryu , Brian Jeffrey Wenzel , William Hsu
发明人： Stuart Rosenberg , Yelena Nabutovsky , Cecilia Qin Xi , Jong Gill , Kyungmoo Ryu , Brian Jeffrey Wenzel , William Hsu
IPC分类号： A61N1/00 , A61N1/362 , A61N1/365 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684 , A61N1/3686 , A61N1/3962
摘要： Techniques are provided for use with an implantable medical device for assessing left ventricular (LV) sphericity and atrial dimensional extent based on impedance measurements for the purposes of detecting and tracking heart failure and related conditions such as volume overload or mitral regurgitation. In some examples described herein, various short-axis and long-axis impedance vectors are exploited that pass through portions of the LV for the purposes of assessing LV sphericity. In other examples, impedance measurements taken along a vector between a right atrial (RA) ring electrode and an LV electrode implanted near the atrioventricular (AV) groove are exploited to assess LA extent, biatrial extent or mitral annular diameter. The assessment techniques can be employed alone or in conjunction with other heart failure detection techniques, such as those based on left atrial pressure (LAP.)
摘要翻译：提供技术用于可植入医疗装置，用于基于阻抗测量来评估左心室（LV）球形度和心房尺寸范围，以便检测和跟踪心力衰竭和相关状况（例如体积过载或二尖瓣反流）。在本文描述的一些示例中，为了评估LV球形度的目的，利用穿过LV的部分的各种短轴和长轴阻抗矢量。在其他示例中，利用沿右心房（RA）环电极和植入在房室（AV）槽附近的LV电极之间的载体进行的阻抗测量来评估LA范围，生物学程度或二尖瓣环直径。评估技术可以单独使用或与其他心力衰竭检测技术结合使用，例如基于左心房压力（LAP）的那些。

4. 发明授权

US08315697B2 Classification of supraventricular and ventricular cardiac rhythms using cross channel timing algorithm 有权
标题翻译：使用交叉通道定时算法对室上和心室心律的分类
公开(公告)号：US08315697B2
公开(公告)日：2012-11-20
申请号：US13285483
申请日：2011-10-31
申请人： William Hsu
发明人： William Hsu
IPC分类号： A61B5/0464
CPC分类号： A61B5/0464 , A61B5/7264
摘要： A system and method for classifying cardiac complexes sensed during a tachycardia episode. A first cardiac signal and a second cardiac signal are sensed, where the first cardiac signal has a voltage. A first cardiac complex and a second cardiac complex of a cardiac cycle are detected in the first and second cardiac signal, respectively. A predetermined alignment feature is identified in the second cardiac complex. A datum is defined, or positioned, at a specified interval from the predetermined alignment feature of the second cardiac complex. Voltage values are then measured from the first cardiac complex at each of two or more measurement intervals from the datum. The voltage values are then compared voltage values measured from NSR cardiac complexes to classify the first cardiac complex is either a ventricular tachycardia complex or a supraventricular tachycardiac complex.
摘要翻译：在心动过速发作期间感测到的心脏复合物的分类系统和方法。感测第一心脏信号和第二心脏信号，其中第一心脏信号具有电压。分别在第一和第二心脏信号中检测心脏周期的第一心脏复合体和第二心脏复合体。在第二心脏复合物中识别预定的对准特征。以与第二心脏复合体的预定对准特征相对的规定间隔定义或定位基准。然后从基准的两个或更多个测量间隔中的每一个处测量来自第一心脏复合物的电压值。然后将电压值比较从NSR心脏复合物测量的电压值，以分类第一心脏复合物是室性心动过速复合物或室上性心动过速复合物。

5. 发明申请

US20120221066A1 Systems and Methods for Activating and Controlling Impedance-Based Detection Systems of Implantable Medical Devices 有权
标题翻译：用于激活和控制可植入医疗器械的基于阻抗的检测系统的系统和方法
公开(公告)号：US20120221066A1
公开(公告)日：2012-08-30
申请号：US13035773
申请日：2011-02-25
申请人： Stuart Rosenberg , Cecilia Qin Xi , Yelena Nabutovsky , Brian Jeffrey Wenzel , Jong Gill , William Hsu
发明人： Stuart Rosenberg , Cecilia Qin Xi , Yelena Nabutovsky , Brian Jeffrey Wenzel , Jong Gill , William Hsu
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/3702 , A61N1/372
摘要： Techniques are provided for use with implantable medical devices for addressing encapsulation effects, particularly in the detection of cardiac decompensation events such as heart failure (HF) or cardiogenic pulmonary edema (PE.) In one example, during an acute interval following device implant, cardiac decompensation is detected using heart rate variability (HRV), ventricular evoked response (ER) or various other non-impedance-based parameters that are insensitive to component encapsulation effects. During the subsequent chronic interval, decompensation is detected using intracardiac or transthoracic impedance signals. In another example, the degree of maturation of encapsulation of implanted components is assessed using impedance frequency-response measurements or based on the frequency bandwidth of heart sounds or other physiological signals. In this manner, impedance-based HF/PE detection systems can be activated as soon as component encapsulation has matured, without necessarily waiting until completion of a preset post-implant maturation interval, often set to forty-five days or more.
摘要翻译：提供技术用于可植入医疗装置，用于解决封装效应，特别是在心脏代偿失调事件如心力衰竭（HF）或心源性肺水肿（PE）的检测中。在一个实例中，在装置植入后的急性期间，心脏使用心率变异性（HRV），心室诱发反应（ER）或对组件封装效应不敏感的各种其他基于非阻抗的参数来检测代偿失调。在随后的慢性间隔期间，使用心内或经胸阻抗信号检测代偿失调。在另一示例中，使用阻抗频率响应测量值或基于心脏声音或其他生理信号的频率带宽来评估植入部件的封装的成熟程度。以这种方式，一旦组件封装已经成熟，就可以激活基于阻抗的HF / PE检测系统，而不必等待直到完成植入后成熟间隔的预设，通常设置为四十五天或更长时间。

6. 发明申请

US20120190957A1 SYSTEM AND METHOD FOR MONITORING CARDIAC DISEASE 审中-公开
标题翻译：监测心脏病的系统和方法
公开(公告)号：US20120190957A1
公开(公告)日：2012-07-26
申请号：US13010535
申请日：2011-01-20
申请人： Jong Gill , Cecilia Qin Xi , Stuart Rosenberg , Yelena Nabutovsky , Brian Jeffrey Wenzel , William Hsu
发明人： Jong Gill , Cecilia Qin Xi , Stuart Rosenberg , Yelena Nabutovsky , Brian Jeffrey Wenzel , William Hsu
IPC分类号： A61B5/042 , A61B5/0408 , A61B5/0402
CPC分类号： A61B5/0452 , A61B5/4842 , A61N1/3627 , A61N1/36507
摘要： A method of monitoring progression of cardiac disease includes applying stimulus pulses to the heart and sensing electrophysiological responses of the heart at a plurality of different monitoring locations of the heart. The method also includes comparing a previously and subsequently sensed electrophysiological responses that are sensed near a first location of the monitoring locations and comparing previously and subsequently sensed electrophysiological responses that are sensed near a second location of the monitoring locations. The method further includes identifying a change in progression of cardiac disease of the heart based on a difference between the previously and subsequently sensed electrophysiological responses at the first location and based on a difference between the previously and subsequently sensed electrophysiological responses at the second location.
摘要翻译：监测心脏疾病进展的方法包括向心脏施加刺激脉冲并感测在心脏的多个不同监测位置的心脏的电生理反应。该方法还包括比较在监测位置的第一位置附近感测的先前和随后感测到的电生理反应，并比较先前和随后感测到的在监测位置的第二位置附近感测到的电生理反应。该方法还包括基于在第一位置处的先前感测和随后感测的电生理反应之间的差异，并且基于在第二位置处的先前感知和随后感测到的电生理反应之间的差异来识别心脏的心脏疾病进展的变化。

7. 发明授权

US08019408B2 System for verifying the integrity of cardiac complex templates 有权
标题翻译：用于验证心脏复合物模板完整性的系统
公开(公告)号：US08019408B2
公开(公告)日：2011-09-13
申请号：US12685281
申请日：2010-01-11
申请人： Alan F. Marcovecchio , William Hsu
发明人： Alan F. Marcovecchio , William Hsu
IPC分类号： A61B5/04
CPC分类号： A61B5/04525
摘要： A method and system for verifying the integrity of normal sinus rhythm (NSR) templates and updating the NSR template after selected time intervals. At selected time intervals after establishing a NSR template, cardiac complexes are sensed and values for one or more cardiac parameters are measured. The values of the cardiac parameters are compared to predetermined value ranges for NSR cardiac complexes. When the values of the cardiac parameters fall within the predetermined value ranges, values for the differences between the values of the cardiac parameters for the cardiac complexes and the values for the cardiac parameters of the NSR cardiac complexes are calculated. When the values of the differences are greater than one or more threshold values, the NSR template is updated as a function of the sensed cardiac complexes.
摘要翻译：一种用于验证正常窦性心律（NSR）模板的完整性并在选定的时间间隔后更新NSR模板的方法和系统。在建立NSR模板之后的选定的时间间隔，感测心脏复合物并测量一个或多个心脏参数的值。将心脏参数的值与NSR心脏复合物的预定值范围进行比较。当心脏参数的值落在预定值范围内时，计算心脏复合物心脏参数值与NSR心脏复合物心脏参数值之差的值。当差异的值大于一个或多个阈值时，NSR模板被更新为感测的心脏复合物的函数。

8. 外观设计

USD593271S1 Trash can 有权
公开(公告)号：USD593271S1
公开(公告)日：2009-05-26
申请号：US29301775
申请日：2008-03-14
申请人： Frank Yang , Tzu-Hao Wei , William Hsu
设计人： Frank Yang , Tzu-Hao Wei , William Hsu

9. 发明授权

US07473227B2 Apparatus for the treatment of sleep apnea 有权
标题翻译：用于治疗睡眠呼吸暂停的装置
公开(公告)号：US07473227B2
公开(公告)日：2009-01-06
申请号：US10932923
申请日：2004-09-02
申请人： William Hsu , Mark Johnson , Gerlad Czygan
发明人： William Hsu , Mark Johnson , Gerlad Czygan
IPC分类号： A61B5/02
CPC分类号： A61B5/0538 , A61B5/0031 , A61B5/02028 , A61B5/0205 , A61B5/0245 , A61B5/029 , A61B5/0464 , A61B5/07 , A61B5/1112 , A61B5/1118 , A61B5/1123 , A61B5/1126 , A61B5/4818 , A61B5/686 , A61B2562/0219 , A61N1/36514
摘要： The invention concerns a medical device for implantation in a body, comprising a stimulation unit, a sleep detector unit having at least one signal input which is adapted to detect a sleep condition of the body and to produce a sleep signal, an apnea detector unit which is adapted to detect sleep apnea in dependence on at least one body signal caused by the body and to produce an apnea signal, a therapy unit which is at least indirectly connected to the stimulation unit! the sleep detector unit and to the apnea detector unit and which is adapted to produce, in dependence on the apnea signal and the sleep signal, at least one apnea therapy signal which represents therapy information for preventing and/or for the treatment of sleep apnea, and to send same to the stimulation unit. The medical device has a position sensor, which is operatively connected to the signal input of the sleep detector unit and adapted in dependence on its inclination about at least one spatial axis extending through the position sensor in relation to the horizontal to alter at least one of its electrical properties.
摘要翻译：本发明涉及用于植入体内的医疗装置，包括刺激单元，具有至少一个信号输入的睡眠检测器单元，适于检测身体的睡眠状况并产生睡眠信号，呼吸暂停检测器单元适于根据由身体引起的至少一个身体信号并产生呼吸暂停信号来检测睡眠呼吸暂停，治疗单元至少间接地连接到刺激单元！睡眠检测器单元和呼吸暂停检测器单元，其适于根据呼吸暂停信号和睡眠信号产生代表用于预防和/或治疗睡眠呼吸暂停的治疗信息的至少一种呼吸暂停治疗信号，并将其发送到刺激单元。该医疗装置具有位置传感器，该位置传感器可操作地连接到睡眠检测器单元的信号输入端，并根据其相对于水平面延伸穿过位置传感器的至少一个空间轴线的倾斜度进行调节，以改变至少一个其电性能。

10. 发明授权

US07354404B2 Cardiac rhythm template generation system and method 有权
标题翻译：心律模板生成系统及方法
公开(公告)号：US07354404B2
公开(公告)日：2008-04-08
申请号：US10802001
申请日：2004-03-16
申请人： Jaeho Kim , William Hsu , Joseph Bocek , Harley White
发明人： Jaeho Kim , William Hsu , Joseph Bocek , Harley White
IPC分类号： A61B5/0452
CPC分类号： A61B5/04525
摘要： A method and system provides for generating a snapshot representative of one beat of a patient's normal cardiac rhythm. Cardiac rate channel signals and shock channel signals are sensed. A fiducial point is determined for a predefined number of the cardiac rate channel signals. A predefined number of the shock channel signals are aligned using the fiducial point. A template is generated using the aligned shock channel signals, whereby the template is representative of one of the patient's normal supra-ventricular conducted cardiac beats. The template is updated on a periodic basis.
摘要翻译：一种方法和系统提供用于产生代表患者正常心律的一次搏动的快照。检测心率通道信号和冲击通道信号。为预定数量的心率通道信号确定基准点。使用基准点对预定数量的冲击通道信号进行对准。使用对准的冲击通道信号产生模板，由此模板代表患者的正常心室心脏传出心跳中的一个。模板定期更新。

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