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    • 1. 发明申请
    • Patient-specific hemodynamics of the cardio vascular system
    • 心血管系统的患者特异性血液动力学
    • US20100241404A1
    • 2010-09-23
    • US12661491
    • 2010-03-17
    • Charles A. TaylorHyun Jin KimJessica S. Coogan
    • Charles A. TaylorHyun Jin KimJessica S. Coogan
    • G06G7/60G06F19/00G06F17/50G06G7/57
    • G06F19/3437G06F19/00G06F19/321G16H10/60G16H50/50
    • A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.
    • 提供非侵入性患者特异性方法来帮助分析,诊断,预测或治疗患者心血管系统的血液动力学。 可以使用与至少一部分剩余心血管系统的模型隐含耦合的基于3-D患者图像的模型来预测冠状动脉血流和压力。 3-D患者基于图像的模型包括患者的胸主动脉和心外膜冠状动脉的至少一部分。 模型界面处的一个或多个速度分布的形状被强制以控制循环或逆行流的复杂流动特征,从而最小化模型不稳定性,并导致患者对冠状动脉血流速率和压力的预测。 本发明允许患者特异性预测冠状动脉介入治疗,经皮冠状动脉介入治疗和手术治疗的不同或不同生理状态和血液动力学益处的影响。
    • 5. 发明授权
    • Method for predictive modeling for planning medical interventions and simulating physiological conditions
    • 用于规划医疗干预和模拟生理条件的预测建模方法
    • US06236878B1
    • 2001-05-22
    • US09083857
    • 1998-05-22
    • Charles A. TaylorChristopher K. ZarinsThomas J. R. Hughes
    • Charles A. TaylorChristopher K. ZarinsThomas J. R. Hughes
    • A61B505
    • G16H50/50G06F19/00Y10S128/92
    • A method for predictive modeling of human anatomy and physiologic function for planning medical interventions on at least one portion of a body with the goals of improving the outcome of the medical intervention and reducing the risks associated with medical intervention. The method comprising the steps of generation of multi-dimensional continuous geometric models of human anatomy, the generation of models of physiologic functions, the integration of the multi-dimensional continuous geometric human anatomy models with the physiologic functional models, and the use of the integrated models to predict the outcome of medical interventions. Also a method for the integration of multi-dimensional continuous geometric models of human anatomy and models of physiologic function to evaluate and predict changes in physiologic functions in various functional states, stresses and environments and a method for generating data for disease research.
    • 一种人体解剖学和生理功能的预测模拟方法,用于在身体的至少一部分上规划医疗干预,目标是改善医疗干预的结果并降低与医疗干预相关的风险。 该方法包括以下步骤:产生人体解剖学的多维连续几何模型,生成生理功能模型,将多维连续几何人体解剖模型与生理功能模型的集成以及集成 模型预测医疗干预措施的结果。 整合人体解剖学多维连续几何模型和生理功能模型的方法,用于评估和预测各种功能状态,应力和环境中生理功能的变化以及生成疾病研究数据的方法。
    • 7. 发明授权
    • Method and system for patient-specific modeling of blood flow
    • 血流特异性建模方法与系统
    • US08157742B2
    • 2012-04-17
    • US13290476
    • 2011-11-07
    • Charles A. Taylor
    • Charles A. Taylor
    • A61B5/02
    • A61B5/026A61B5/02007G06F19/00G16H50/50
    • Embodiments include a system for planning treatment for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of an anatomical structure of the patient, create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, and determine a first fractional flow reserve within the anatomical structure of the patient based on the three-dimensional model and a physics-based model relating to the anatomical structure of the patient. The at least one computer system may be further configured to modify the three-dimensional model, and determine a second fractional flow reserve within the anatomical structure of the patient based on the modified three-dimensional model.
    • 实施例包括用于规划患者治疗的系统。 该系统可以包括被配置为接收关于患者的解剖结构的几何形状的患者特定数据的至少一个计算机系统,基于患者的身份创建表示患者的解剖结构的至少一部分的三维模型, 并且基于三维模型和与患者的解剖结构相关的基于物理的模型来确定患者的解剖结构内的第一分数流量储备。 所述至少一个计算机系统还可被配置为修改三维模型,并且基于修改的三维模型确定患者的解剖结构内的第二分数流量储备。