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1. 发明申请

US20130035665A1 Polymer-Based Occlusion Devices, Systems and Methods 审中-公开
标题翻译：基于聚合物的闭塞装置，系统和方法
公开(公告)号：US20130035665A1
公开(公告)日：2013-02-07
申请号：US13565707
申请日：2012-08-02
申请人： Chaokang Chu , Robert L. Cleek , Edward H. Cully , Jeffrey Duncan , Krzysztof R. Pietrzak , Edward Emil Shaw , Michael J. Vonesh , Eric H. Zacharias
发明人： Chaokang Chu , Robert L. Cleek , Edward H. Cully , Jeffrey Duncan , Krzysztof R. Pietrzak , Edward Emil Shaw , Michael J. Vonesh , Eric H. Zacharias
IPC分类号： A61M25/10 , A61B17/12
CPC分类号： A61B17/12181 , A61B17/12118 , A61B17/12145 , A61B17/1215 , A61B17/12163 , A61B17/1219 , A61B2017/00893 , A61B2017/00942 , A61B2017/1205 , A61B2017/12054 , A61B2050/3008 , A61B2090/0807 , A61L31/00 , A61L31/14 , A61L2430/36
摘要： A method of occluding includes imbibing a porous elongate element comprised of ePTFE with a calcium-containing solution. The method also includes delivering, via a delivery catheter, the calcium-imbibed porous elongate element to a target occlusion site. The method further includes administering, after the calcium-imbibed porous elongate element has been completely delivered to the target occlusion site and resides entirely within a volume defined by the target occlusion site, an alginate-containing solution to the target occlusion site.
摘要翻译：封闭的方法包括用含钙溶液吸收由ePTFE组成的多孔细长元件。该方法还包括通过递送导管将钙吸收的多孔细长元件递送到目标闭塞部位。该方法还包括在钙吸收的多孔细长元件已经完全递送到目标闭塞部位之后并且完全位于由目标闭塞部位限定的体积内的情况下，将含藻酸盐的溶液施用于靶闭塞部位。

2. 发明授权

US09005269B2 Bioabsorbable self-expanding endolumenal devices 有权
标题翻译：生物可吸收的自扩张腔内装置
公开(公告)号：US09005269B2
公开(公告)日：2015-04-14
申请号：US12181197
申请日：2008-07-28
申请人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
发明人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
IPC分类号： A61F2/82 , A61F2/01 , A61B17/12 , A61F2/91 , A61F2/915 , A61L31/06 , A61L31/14 , A61F2/30
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/018 , A61F2002/30062 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0069 , A61F2230/008 , A61F2250/003 , A61L31/06 , A61L31/148 , C08L67/04
摘要： Bioabsorbable self-expanding medical devices formed of an integral framework with a multiplicity of fenestrations are provided. The framework is continuous, non-filamentous, non-braided, and non-interlaced. The devices includes a non-blended hydrolysable co-polymeric material comprising an amorphous component with a glass transition temperature that is below ambient body temperature and a crystallizable component that possesses a crystalline melting point in excess of ambient body temperature. The devices radially expand from a compressed first diameter to an uncompressed second diameter equal to or greater than 1.5 times the first diameter within two minutes in an aqueous medium at 37° C. following release of a compressive force placed on the devices. Additionally, the medical device does not change axial length significantly as the radial dimensions of the devices are changed. Further, the medical devices may be constructed of different bioabsorbable polymers, polymer ratios, and/or different geometries and portions may bioabsorb at different rates.
摘要翻译：提供由具有多个开窗的整体框架形成的生物可吸收的自扩张医疗装置。框架是连续的，非丝状的，非编织的和非隔行的。该装置包括非共混的可水解共聚物材料，其包含玻璃化转变温度低于环境体温的非晶组分和具有超过环境体温的结晶熔点的可结晶组分。在放置在装置上的压缩力释放之后，装置在37℃下在含水介质中在两分钟内从压缩的第一直径径向膨胀至等于或大于第一直径的1.5倍的未压缩的第二直径。此外，随着装置的径向尺寸改变，医疗装置不会显着改变轴向长度。此外，医疗装置可以由不同的生物可吸收聚合物，聚合物比率和/或不同的几何形状构成，并且部分可以以不同的速率生物吸收。

3. 发明申请

US20120065721A1 THERMOPLASTIC FLUOROPOLYMER-COATED MEDICAL DEVICES 有权
标题翻译：热塑性氟聚合物涂层医疗器械
公开(公告)号：US20120065721A1
公开(公告)日：2012-03-15
申请号：US13282892
申请日：2011-10-27
申请人： James W. Chang , Robert L. Cleek , Edward H. Cully , Michael J. Vonesh
发明人： James W. Chang , Robert L. Cleek , Edward H. Cully , Michael J. Vonesh
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61L27/34 , C08L101/04
摘要： A medical device provided with at least a partial surface coating of a thermoplastic copolymer of tetrafluoroethylene and perfluoroalkylvinylether that is free of cross-linking monomers and curing agents. The fluoropolymer coating is preferably an amorphous thermoplastic, is highly inert and biocompatible, has elastomeric characteristics that provide desirable mechanical properties such as good flexibility and durability. These characteristics allow the coating to be considered “functionally transparent” because it withstands mechanical deformations required for the assembly, deployment, expansion, and placement of medical devices, without any adverse effect on the mechanical and biological functionality of the coated device. Further, its inertness, derived from the perfluorocarbon structure, contributes to its functionally transparent nature. The coating can be provided with various liquid or solid additives, can be loaded with large quantities of additives including a wide range of therapeutic agents, and has excellent drug elution characteristics when elutable additives are used.
摘要翻译：一种医疗装置，其具有不含交联单体和固化剂的四氟乙烯和全氟烷基乙烯基醚的热塑性共聚物的至少部分表面涂层。含氟聚合物涂层优选为无定形热塑性塑料，具有高度惰性和生物相容性，具有提供所需机械性能（例如良好的柔韧性和耐久性）的弹性体特性。这些特性使得涂层被认为是“功能上透明的”，因为它可以承受医疗装置的组装，展开，膨胀和放置所需的机械变形，而不会对涂覆装置的机械和生物功能产生任何不利影响。此外，其衍生自全氟化碳结构的惰性有助于其功能上的透明性。该涂层可以提供各种液体或固体添加剂，可以加载大量的添加剂，包括广泛的治疗剂，并且当使用可洗脱添加剂时具有优异的药物洗脱特性。

4. 发明授权

US08048440B2 Thermoplastic fluoropolymer-coated medical devices 有权
标题翻译：热塑性含氟聚合物涂层医疗器械
公开(公告)号：US08048440B2
公开(公告)日：2011-11-01
申请号：US11378401
申请日：2006-03-16
申请人： James W. Chang , Robert L. Cleek , Edward H. Cully , Michael J. Vonesh
发明人： James W. Chang , Robert L. Cleek , Edward H. Cully , Michael J. Vonesh
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61L27/34 , C08L101/04
摘要： A medical device provided with at least a partial surface coating of a thermoplastic copolymer of tetrafluoroethylene and perfluoroalkylvinylether that is free of cross-linking monomers and curing agents. The fluoropolymer coating is preferably an amorphous thermoplastic, is highly inert and biocompatible, has elastomeric characteristics that provide desirable mechanical properties such as good flexibility and durability. These characteristics allow the coating to be considered “functionally transparent” because it withstands mechanical deformations required for the assembly, deployment, expansion, and placement of medical devices, without any adverse effect on the mechanical and biological functionality of the coated device. Further, its inertness, derived from the perfluorocarbon structure, contributes to its functionally transparent nature. The coating can be provided with various liquid or solid additives, can be loaded with large quantities of additives including a wide range of therapeutic agents, and has excellent drug elution characteristics when elutable additives are used. The desirable mechanical characteristics are surprising given the absence of cross-linking monomers and curing agents that would otherwise render such materials inadequately biocompatible. The perfluoroalkylvinylether may be perfluoromethylvinylether, perfluoroethylvinylether or perfluoropropylvinylether.
摘要翻译：一种医疗装置，其具有不含交联单体和固化剂的四氟乙烯和全氟烷基乙烯基醚的热塑性共聚物的至少部分表面涂层。含氟聚合物涂层优选为无定形热塑性塑料，具有高度惰性和生物相容性，具有提供所需机械性能（例如良好的柔韧性和耐久性）的弹性体特性。这些特性使得涂层被认为是“功能上透明的”，因为它可以承受医疗装置的组装，展开，膨胀和放置所需的机械变形，而不会对涂覆装置的机械和生物功能产生任何不利影响。此外，其衍生自全氟化碳结构的惰性有助于其功能上的透明性。该涂层可以提供各种液体或固体添加剂，可以加载大量的添加剂，包括广泛的治疗剂，并且当使用可洗脱添加剂时具有优异的药物洗脱特性。鉴于不存在交联单体和固化剂，否则将使得这些材料生物相容性不足，理想的机械特性令人惊奇。全氟烷基乙烯基醚可以是全氟甲基乙烯基醚，全氟乙基乙烯基醚或全氟丙基乙烯基醚。

5. 发明申请

US20080281393A1 Bioabsorbable Self-Expanding Endolumenal Devices 有权
标题翻译：生物可吸收的自扩张腔内装置
公开(公告)号：US20080281393A1
公开(公告)日：2008-11-13
申请号：US12181197
申请日：2008-07-28
申请人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
发明人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
IPC分类号： A61F2/92
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/018 , A61F2002/30062 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0069 , A61F2230/008 , A61F2250/003 , A61L31/06 , A61L31/148 , C08L67/04
摘要： The present invention is directed to bioabsorbable self-expanding medical devices for use inside or outside body conduits that self-expand at, or below, normal human body temperature without requisite for a polymeric thermal transition.
摘要翻译：本发明涉及用于在正常人体温度下或在正常人体温度下自膨胀而不在聚合物热转变条件下自身膨胀的身体导管内部或外部的生物可吸收自膨胀医疗装置。

6. 发明授权

US08609125B2 Thermoplastic fluoropolymer-coated medical devices 有权
标题翻译：热塑性含氟聚合物涂层医疗器械
公开(公告)号：US08609125B2
公开(公告)日：2013-12-17
申请号：US13282892
申请日：2011-10-27
申请人： James W. Chang , Robert L. Cleek , Edward H. Cully , Michael J. Vonesh
发明人： James W. Chang , Robert L. Cleek , Edward H. Cully , Michael J. Vonesh
IPC分类号： A61F2/02
CPC分类号： A61L31/10 , A61L27/34 , C08L101/04
摘要： A medical device provided with at least a partial surface coating of a thermoplastic copolymer of tetrafluoroethylene and perfluoroalkylvinylether that is free of cross-linking monomers and curing agents. The fluoropolymer coating is preferably an amorphous thermoplastic, is highly inert and biocompatible, has elastomeric characteristics that provide desirable mechanical properties such as good flexibility and durability. These characteristics allow the coating to be considered “functionally transparent” because it withstands mechanical deformations required for the assembly, deployment, expansion, and placement of medical devices, without any adverse effect on the mechanical and biological functionality of the coated device. Further, its inertness, derived from the perfluorocarbon structure, contributes to its functionally transparent nature. The coating can be provided with various liquid or solid additives, can be loaded with large quantities of additives including a wide range of therapeutic agents, and has excellent drug elution characteristics when elutable additives are used.
摘要翻译：一种医疗装置，其具有不含交联单体和固化剂的四氟乙烯和全氟烷基乙烯基醚的热塑性共聚物的至少部分表面涂层。含氟聚合物涂层优选为无定形热塑性塑料，具有高度惰性和生物相容性，具有提供所需机械性能（例如良好的柔韧性和耐久性）的弹性体特性。这些特性使得涂层被认为是“功能上透明的”，因为它可以承受医疗装置的组装，展开，膨胀和放置所需的机械变形，而不会对涂覆装置的机械和生物功能产生任何不利影响。此外，其衍生自全氟化碳结构的惰性有助于其功能上的透明性。该涂层可以提供各种液体或固体添加剂，可以加载大量的添加剂，包括广泛的治疗剂，并且当使用可洗脱添加剂时具有优异的药物洗脱特性。

7. 发明授权

US09381018B2 Device for rapid repair of body conduits 有权
公开(公告)号：US09381018B2
公开(公告)日：2016-07-05
申请号：US13149696
申请日：2011-05-31
申请人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
发明人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
IPC分类号： A61F2/84 , A61B17/11 , A61F2/07 , A61F2/97 , A61B17/06 , A61F2/06 , A61F2/30 , A61F2/89
CPC分类号： A61F2/07 , A61B17/06166 , A61B17/11 , A61B2017/1107 , A61F2/064 , A61F2/844 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2/958 , A61F2/97 , A61F2002/075 , A61F2002/30713 , A61F2220/0075 , A61F2220/0091 , A61F2250/0087
摘要： A self-expanding stent-graft provided in a diametrically compacted state for implantation and retained preferably by a constraining sheath, useful for the temporary or permanent repair of injured, partially or entirely transected body conduits including blood vessels. It may be used under direct visualization to quickly stop or substantially reduce loss of blood from such damaged vessels and to quickly re-establish perfusion distal to the injury site. The device would typically be implanted under emergency room conditions but also be used in field situations by trained medical technicians. After an end of the device is inserted into a blood vessel through the injury access, deployment preferably initiates from the device end in a direction moving toward the middle of the length of the device by directionally releasing the constraining sheath. In a preferred embodiment, the two opposing ends of the device are individually deployable from the compacted, small diameter intended for insertion into a vessel, to the larger diameter at which they fit interferably into a portion of the vessel.

8. 发明申请

US20120289997A1 Embolic Filter Frame Having Looped Support Strut Elements 有权
标题翻译：具有环形支撑支柱元件的栓塞过滤器框架
公开(公告)号：US20120289997A1
公开(公告)日：2012-11-15
申请号：US13555543
申请日：2012-07-23
申请人： Edward H. Cully , Michael J. Vonesh
发明人： Edward H. Cully , Michael J. Vonesh
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , B23P11/00 , Y10T29/49826
摘要： An embolic frame having looped support struts. The frame configuration provides enhanced longitudinal compliance, improved sealing against a vessel wall, low profile delivery, and a short deployed length. The looped support struts have a high degree of “radial” stiffness with a low degree of “longitudinal” stiffness. In the deployed state, the frame exerts a relatively high stress onto a vessel wall to maintain an effective seal, yet remains compliant in the longitudinal direction. The looped support struts elongate when tensioned and assume a compressed and essentially linear form. While constrained in this linear state by a delivery catheter, the support struts exert minimal stress onto the delivery system. The overall delivery profile and stiffness are therefore reduced. When the delivery catheter constraint is removed during deployment, the struts “snap open” and assume a looped configuration which exert a high degree of force onto the vessel wall.
摘要翻译：具有环状支撑支柱的栓塞框架。框架结构提供增强的纵向顺应性，改进的针对血管壁的密封，薄型输送和短部署长度。环形支撑支柱具有高度的径向刚度，并且具有低程度的纵向刚度。在展开状态下，框架在容器壁上施加相当高的应力以保持有效的密封，但在长度方向保持柔顺。环形支撑件在张紧时伸长并呈现压缩且基本线性的形式。虽然通过输送导管在这种线性状态下被约束，但是支撑支柱对输送系统施加最小的压力。因此，总体输送轮廓和刚度降低。当在展开期间移除输送导管约束时，支柱卡扣打开并且呈现向血管壁施加高度力的环形构造。

9. 发明授权

US08197529B2 Removable stent-graft 有权
标题翻译：可移植支架移植物
公开(公告)号：US08197529B2
公开(公告)日：2012-06-12
申请号：US12491895
申请日：2009-06-25
申请人： Edward H. Cully , Erin B. Hutchinson , Michael J. Vonesh , Woodrow W. Watson
发明人： Edward H. Cully , Erin B. Hutchinson , Michael J. Vonesh , Woodrow W. Watson
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B2017/22035 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2002/072 , A61F2002/075 , A61F2002/9528 , A61F2220/005 , A61F2250/0071
摘要： A removable device such as a stent-graft, intended for applications where it may be desirable to remove the device at some time following implantation. The stent-graft of the present invention includes a helically-wound stent component provided with a covering of graft material. It is removable by gripping an end of the helically-wound stent component with a retrieval device and applying tension to the stent component in the direction in which it is intended to be withdrawn from the site of implantation. The use of such a retrieval device allows the stent-graft to be removed remotely, such as via a catheter inserted into the body at a different location from the implantation site. The design of the stent-graft is such that the stent component is extended axially while the adjacent portion of the graft separates between windings of the stent component. The axial extension of the stent component, with portions of the graft still joined to the stent component, allows the device to be “unraveled” (or “unwound”) and removed through a catheter of diameter adequately small to be inserted into the body cavity that contained the stent-graft. It is removed atraumatically, without incurring significant trauma to the body conduit in which it had been deployed.
摘要翻译：诸如支架移植物的可移除装置，其用于在植入后的某个时间可能需要移除装置的应用。本发明的支架移植物包括设置有移植材料覆盖物的螺旋缠绕的支架组件。通过用拾取装置抓住螺旋缠绕的支架部件的一端并且沿着其将要从植入部位取出的方向对支架部件施加张力，其可移除。使用这种检索装置允许远程地移除支架移植物，例如通过在与植入部位不同的位置插入体内的导管。支架移植物的设计使得支架部件沿轴向延伸，而移植物的相邻部分在支架部件的绕组之间分离。支架部件的轴向延伸，其中移植物的一部分仍然连接到支架部件，允许装置“解开”（或“展开”）并通过足够小的直径的导管移除以插入体腔包含支架移植物。它无创伤地去除，而不会对其部署的身体导管造成重大创伤。

10. 发明申请

US20110276012A1 PUNCTURABLE CATHETER 有权
标题翻译：可拆卸导管
公开(公告)号：US20110276012A1
公开(公告)日：2011-11-10
申请号：US13186198
申请日：2011-07-19
申请人： JOSEPH R. ARMSTRONG , Edward H. Cully , Keith M. Flury , Michael J. Vonesh
发明人： JOSEPH R. ARMSTRONG , Edward H. Cully , Keith M. Flury , Michael J. Vonesh
IPC分类号： A61M25/00
CPC分类号： A61M25/0043 , A61F2/958 , A61M25/005 , A61M25/0052 , A61M25/10 , A61M2025/0183 , A61M2025/0188 , A61M2025/1056 , A61M2025/1081
摘要： A catheter provided with a guidewire catheter lumen having a thin covering that is easily punctured by a guidewire at virtually any desired point along the catheter length. The thin covering may be integral with the catheter shaft, or may be a separate component that covers only the portion of the catheter shaft immediately adjacent the outer portion of the guidewire lumen, or may be a thin tubular construct that surrounds the entire catheter shaft. The covering is preferably relatively translucent, allowing for good visualization of the location of the end of the guidewire to enable puncturing of the covering at the desired location along the length of the catheter shaft. The covering is also preferably tear resistant at puncture sites. The catheter shaft is preferably made of a material having a color that provides good visibility against an operating field, and more preferably is phosphorescent either entirely or in part. Materials suitable for the catheter shaft are polymeric materials well known in the art; the catheter shaft may optionally be provided with metallic stiffening components such as wires or hypotubes along all or part of the catheter length.
摘要翻译：导管，其具有导线导管管腔，该导管管腔具有薄的覆盖层，其在导管长度的几乎任何所需点处被导丝容易地刺穿。薄的覆盖物可以与导管轴成一体，或者可以是仅覆盖导管轴的紧邻导丝管腔的外部的部分的单独的部件，或者可以是围绕整个导管轴的薄的管状结构。覆盖物优选地是相对半透明的，允许良好地可视化导丝端部的位置，以使得能够沿着导管轴的长度在期望的位置刺穿覆盖物。覆盖物也优选在穿刺部位具有抗撕裂性。导管轴优选由具有对操作场提供良好可见性的颜色的材料制成，更优选地，全部或部分地是磷光。适用于导管轴的材料是本领域公知的聚合材料; 导管轴可以可选地沿着导管长度的全部或部分设置有金属加强部件，例如电线或海波管。

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