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1. 发明授权

US06322593B1 Method for treating cross-linked biological tissues 有权
标题翻译：交联生物组织的处理方法
公开(公告)号：US06322593B1
公开(公告)日：2001-11-27
申请号：US09289262
申请日：1999-04-09
申请人： Chandrashekhar P. Pathak , Mark A. Moore , Richard E. Philips, Jr.
发明人： Chandrashekhar P. Pathak , Mark A. Moore , Richard E. Philips, Jr.
IPC分类号： A61F236
CPC分类号： A61L27/3687 , A61L27/3604 , A61L27/3625
摘要： A method for treating biological tissue is provided in which a cross-linked biological tissue containing free aldehyde groups is reacted with a suitable neutralization agent in order to chemically block the aldehyde groups from reactivity toward cellular proteins. Also provided is the cross-linked biological tissue so produced which is substantially free of reactive aldehyde groups and, as a result, exhibits reduced toxicity and improved biocompatibility.
摘要翻译：提供了一种治疗生物组织的方法，其中含有游离醛基的交联生物组织与合适的中和剂反应，以便将醛基从化学方式阻止反应性向细胞蛋白。还提供了如此生产的交联生物组织，其基本上不含活性醛基，结果显示出降低的毒性和改善的生物相容性。

2. 发明授权

US06177514B1 Blocked functional reagants for cross-linking biological tissues 有权
标题翻译：用于交联生物组织的阻断的功能性反应物
公开(公告)号：US06177514B1
公开(公告)日：2001-01-23
申请号：US09289426
申请日：1999-04-09
申请人： Chandrashekhar P. Pathak , Mark A. Moore , Richard E. Philips, Jr.
发明人： Chandrashekhar P. Pathak , Mark A. Moore , Richard E. Philips, Jr.
IPC分类号： A61F202
CPC分类号： A61L27/3687 , A61L27/3604 , A61L27/3625 , Y10S623/915
摘要： A method for cross-linking biological tissue is provided which uses as a cross-linking agent a low molecular weight, substantially monomeric polyfunctional aldehyde formed in situ or just prior to cross-linking. The polyfunctional aldehyde is essentially free of the undesirable heterogeneous polymeric species that result from polyfunctional aldehyde self-reactivity. Also provided is biological tissue that is cross-linked with a substantially monomeric glutaraldehyde.
摘要翻译：提供了一种用于交联生物组织的方法，其使用在原位或刚好在交联之前形成的低分子量，基本上单体的多官能醛作为交联剂。多官能醛基本上不含由多官能醛自反应性产生的不期望的非均相聚合物。还提供了与基本上单体戊二醛交联的生物组织。

3. 发明授权

US06596471B2 Method of cross-linking tissue with a bis-maleimide compound 失效
标题翻译：用双马来酰亚胺化合物交联组织的方法
公开(公告)号：US06596471B2
公开(公告)日：2003-07-22
申请号：US09747023
申请日：2000-12-21
申请人： Chandrashekhar P. Pathak , Mark A. Moore , Richard E. Phillips, Jr.
发明人： Chandrashekhar P. Pathak , Mark A. Moore , Richard E. Phillips, Jr.
IPC分类号： G01N130
CPC分类号： A61L27/3687 , A61L2430/40
摘要： Herein is disclosed a method of cross-linking a tissue, comprising treating the tissue under effective cross-linking conditions with a diunsaturated organic compound comprising structure I: wherein R, R′, and R″ are each independently an organic moiety having from 1 to 20 carbon atoms. Also disclosed is a cross-linked biological tissue produced by treating the tissue according to the above method.
摘要翻译：本文公开了一种交联组织的方法，包括在有效交联条件下用包含结构I的二不饱和有机化合物处理组织：其中R，R'和R“各自独立地为具有1个至20个碳原子。还公开了根据上述方法处理组织而产生的交联生物组织。

4. 发明授权

US06528107B2 Method for producing antimicrobial antithrombogenic medical devices 失效
标题翻译：生产抗微生物抗血栓形成的医疗器械的方法
公开(公告)号：US06528107B2
公开(公告)日：2003-03-04
申请号：US09359235
申请日：1999-07-22
申请人： Joseph A. Chinn , Richard E. Phillips, Jr. , Joseph A. Sauter , R. Michael Casanova , Chandrashekhar P. Pathak , Mark A. Moore , L. Diane Bruce
发明人： Joseph A. Chinn , Richard E. Phillips, Jr. , Joseph A. Sauter , R. Michael Casanova , Chandrashekhar P. Pathak , Mark A. Moore , L. Diane Bruce
IPC分类号： A61L1500
CPC分类号： A61L31/16 , A61F2/2409 , A61L27/16 , A61L27/54 , A61L2300/404 , A61L2300/42
摘要： A method is provided for producing antimicrobial, antithrombogenic medical devices. The method employs an antimicrobial treatment process wherein an antimicrobial agent is dissolved in an appropriate solvent and the resulting solution is contacted with a portion of a medical device of interest. The antimicrobial treatment process is advantageously performed without the need for additional compounds to facilitate antimicrobial agent uptake into the device. The method further comprises an antithrombogenic treatment process wherein antithrombogenic agents or materials are applied or otherwise associated with at least some portion of the medical device.
摘要翻译：提供了用于生产抗微生物，抗血栓形成的医疗装置的方法。该方法采用抗微生物处理方法，其中将抗微生物剂溶解在合适的溶剂中，并将所得溶液与感兴趣的医疗装置的一部分接触。抗微生物处理方法有利地进行，而不需要额外的化合物以促进抗微生物剂吸收到装置中。该方法还包括抗血栓形成治疗方法，其中抗血栓形成剂或材料被施用或以其它方式与医疗装置的至少一部分相关联。

5. 发明授权

US06479079B1 Anticalcification treatments for fixed biomaterials 有权
标题翻译：固定生物材料的抗碱化治疗
公开(公告)号：US06479079B1
公开(公告)日：2002-11-12
申请号：US09459429
申请日：1999-12-13
申请人： Chandrashenkhar P. Pathak , Mark A. Moore , Richard E. Phillips
发明人： Chandrashenkhar P. Pathak , Mark A. Moore , Richard E. Phillips
IPC分类号： A61K3500
CPC分类号： A61L27/3687 , A61L27/3604 , A61L27/50 , A61L2400/02
摘要： A method for treating biomaterial is provided in which a biological tissue, typically after being cross-linked, is contacted with an anticalcification treatment solution under condition effective to render the biomaterial resistant to in vivo calcification upon implantation in a host animal. The anticalcification treatment solutions comprise higher alcohol solutions, a polyol solutions and/or a polar aprotic organic solvent solutions.
摘要翻译：提供了一种治疗生物材料的方法，其中通常在交联后的生物组织在有效使得生物材料在植入宿主动物体内抵抗体内钙化的条件下与抗细胞治疗溶液接触。抗化学处理溶液包含高级醇溶液，多元醇溶液和/或极性非质子有机溶剂溶液。

6. 发明申请

US20120006220A1 PROJECTILES FOR MARKING TARGETS, METHODS OF MANUFACTURING THE SAME, AND METHODS OF UTILIZING THE SAME 有权
标题翻译：用于标记目标的项目，其制造方法及其使用方法
公开(公告)号：US20120006220A1
公开(公告)日：2012-01-12
申请号：US13234963
申请日：2011-09-16
申请人： David W. Endicott, JR. , Daniel W. Doll , R. Brad Cragun , Jared K. Olson , Michael T. Rose , Mark A. Moore , James D. Rozanski , Russell J. George
发明人： David W. Endicott, JR. , Daniel W. Doll , R. Brad Cragun , Jared K. Olson , Michael T. Rose , Mark A. Moore , James D. Rozanski , Russell J. George
IPC分类号： F42B12/38 , B21K21/06 , F42B12/40
CPC分类号： F42B12/40
摘要： Projectiles containing a fluorophore composition comprising a fluorophore compound and an activator composition comprising an activator compound for marking targets are disclosed. Some embodiments include a nose structure with a cavity radially segmented into a plurality of radially isolated compartments by at least one laterally and radially extending internal wall. Additional embodiments include a fore compartment and an aft compartment sealed by a septum. Yet additional embodiments include at least one pressurized cavity and may further include a plunger positioned and configured to pierce each pressurized cavity. Methods of manufacturing target marking projectiles and methods of marking targets are also disclosed.
摘要翻译：公开了包含含有荧光团化合物的荧光团组合物和包含用于标记靶标的活化剂化合物的活化剂组合物的射弹。一些实施例包括具有通过至少一个横向和径向延伸的内壁径向分割成多个径向隔离的隔室的空腔的鼻部结构。另外的实施例包括由隔膜密封的前隔室和后舱。另外的实施例包括至少一个加压空腔，并且还可以包括定位和构造成刺穿每个加压空腔的柱塞。还公开了制造目标标记射弹的方法和标记目标的方法。

7. 发明授权

US07836454B1 Information appliance architecture 有权
标题翻译：信息家电架构
公开(公告)号：US07836454B1
公开(公告)日：2010-11-16
申请号：US11341275
申请日：1999-03-19
申请人： Patrick J. Coleman , Thomas E. Whittaker , David C. W. Yip , Mark A. Moore
发明人： Patrick J. Coleman , Thomas E. Whittaker , David C. W. Yip , Mark A. Moore
IPC分类号： G06F13/00
CPC分类号： G06F8/20 , G06F9/45537
摘要： An architecture for an information appliance adapted for a specific application supports a variety of appliance personalities, relying on a single core technology. The information appliance comprises an application-optimized hardware platform, including a processor, a display coupled to the processor, an input/output device coupled to an information source and to the processor, a user input device, and working memory coupled to the processor. Non-volatile memory is coupled to the processor and stores appliance operating software and application software. The appliance operating software includes logic executed by the processor, which manages information flow from the information source through the working memory to the display, and the application software includes logic executed by the processor and responsive to the user input to manage selection of information from the information source. The appliance operating software includes an operating system kernel that is adapted for the processor, and a system library that includes logic providing an interface to the application software. An operating system service layer provides an abstraction function between the system library and the appliance operating system kernel and hardware, so that the logic in the system library and above, such as in the application itself, is executable with a development platform operating system which is completely different from the operating system of the appliance.
摘要翻译：适用于特定应用的信息设备架构支持各种设备个性，依靠单核技术。信息设备包括应用优化的硬件平台，包括处理器，耦合到处理器的显示器，耦合到信息源和处理器的输入/输出设备，用户输入设备以及耦合到处理器的工作存储器。非易失性存储器耦合到处理器并存储设备操作软件和应用软件。设备操作软件包括由处理器执行的逻辑，其处理从信息源通过工作存储器到显示器的信息流，并且应用软件包括由处理器执行并响应于用户输入的逻辑，以管理来自信息来源。设备操作软件包括适于处理器的操作系统内核，以及包括向应用软件提供接口的逻辑的系统库。操作系统服务层提供系统库与设备操作系统内核和硬件之间的抽象功能，使得系统库及其以上的逻辑（如应用程序本身）可以使用开发平台操作系统完全不同于设备的操作系统。

8. 发明授权

US06251579B1 Oxidative stabilization of collagen containing materials 失效
标题翻译：含胶原蛋白的氧化稳定性
公开(公告)号：US06251579B1
公开(公告)日：2001-06-26
申请号：US09023549
申请日：1998-02-13
申请人： Mark A. Moore , Richard E. Phillips , Melanie D. Robinson
发明人： Mark A. Moore , Richard E. Phillips , Melanie D. Robinson
IPC分类号： A01N102
CPC分类号： A61L27/24 , A01N1/02 , A01N1/0221 , C08H1/06
摘要： This invention relates, in general, to a process for cross-linking and stabilizing proteinaceous material, and in particular, to a process for oxidizing collagenous material, by oxidizing the tissue. The invention also relates to the resulting cross-linked product. The method comprises immersing the material to be cross-linked in a solution comprising compounds designed to generate the radical species singlet oxygen or other oxidizing intermediates without the addition of an external energy source. Immersing collagen containing tissue in a solution comprising an oxidizing agent and sufficient dissolved oxygen, under controlled conditions of pH and temperature, provides a cross-linked and stabilized collagen containing tissue that resists chemical and enzymatic degradation.
摘要翻译：本发明一般涉及通过氧化组织来交联和稳定蛋白质材料的方法，特别是涉及氧化胶原材料的方法。本发明还涉及所得到的交联产物。该方法包括将待交联的材料浸入包含设计成产生自由基物质单线态氧或其它氧化中间体的化合物的溶液中而不添加外部能量源。在pH和温度的控制条件下，将含有胶原蛋白的组织浸入包含氧化剂和足够的溶解氧的溶液中，提供了抗化学和酶降解的交联和稳定的含胶原蛋白的组织。

9. 发明授权

US6156531A Cross-linking tissue with a compound having a C.sub.8 to C.sub.40 aliphatic chain 失效
标题翻译：与具有C8〜C40脂肪族链的化合物交联组织
公开(公告)号：US6156531A
公开(公告)日：2000-12-05
申请号：US119205
申请日：1998-07-20
申请人： C. P. Pathak , Mark A. Moore
发明人： C. P. Pathak , Mark A. Moore
IPC分类号： A61K35/12 , A61L27/38 , A61L27/50 , G01N1/30 , C12N11/06 , A61K38/17 , C07K1/00 , C07K17/06
CPC分类号： A61L27/3687 , A61K35/12 , A61L27/3604 , A61L27/38 , A61L27/50 , Y10S530/816
摘要： Collagen-containing tissue is cross-linked to provide tissue suitable for use in production of bioprosthetic devices. A cross-linking agent is used having an aliphatic component containing about 8 to 40 carbon atoms and two collagen-reactive groups such as isocyanate, epoxy or n-hydroxysuccinimide. The cross-linking agent may be produced by dimerizing fatty acids, and modifying carboxylic acid group of the fatty acids before or after dimerization to contain collagen-reactive groups. The cross-linked tissue has desirable mechanical and biocompatibility features and a reduced susceptibility to calcification.
摘要翻译：含有胶原的组织被交联以提供适合用于生产生物假体装置的组织。使用具有含有约8至40个碳原子的脂族组分和两个胶原反应性基团如异氰酸酯，环氧或正羟基琥珀酰亚胺的交联剂。交联剂可以通过二聚脂肪酸和在二聚化之前或之后修饰脂肪酸的羧酸基团以产生含有胶原反应性基团来制备。交联组织具有期望的机械和生物相容性特征，并且降低了钙化的易感性。

10. 发明授权

US06132986A Tissue crosslinking for bioprostheses using activated difunctional or polyfunctional acids 有权
标题翻译：使用活化的双官能或多官能酸进行生物预处理的组织交联
公开(公告)号：US06132986A
公开(公告)日：2000-10-17
申请号：US298211
申请日：1999-04-23
申请人： C. P. Pathak , Mark A. Moore , Richard E. Phillips
发明人： C. P. Pathak , Mark A. Moore , Richard E. Phillips
IPC分类号： A61L27/36 , G01N1/30 , C12Q1/02
CPC分类号： A61L27/3691 , A61L27/3687 , G01N1/30 , A61L2430/40
摘要： The disclosed invention relates to the process of fixating tissue to obtain tissue for bioprosthetic applications. The fixating process comprises exposing the tissue to a fluid comprising activated difunctional or polyfunctional acids that can react with amino groups in tissue under mild conditions. Activating moieties include disuccinimidyl moieties, n-hydroxy disuccinimidyl moieties, sulfo-disuccinimidyl moieties, and mixtures thereof. The acid is preferably aliphatic difunctional or polyfunctional acids, more preferably a naturally occurring aliphatic difunctional or polyfunctional acids. Even more preferred is an acid consisting of glutaric, suberic acid, sebacic acid, tartaric acid, or mixtures thereof. The activated difunctional or polyfunctional acids are esters comprising the difunctional or polyfunctional acids and the activating moieties.
摘要翻译：所公开的发明涉及固定组织以获得生物假体应用的组织的方法。固定方法包括将组织暴露于包含活性双官能或多官能酸的流体，其可在温和条件下与组织中的氨基发生反应。活化部分包括二琥珀酰亚胺基部分，正羟基二琥珀酰亚胺基部分，磺基二琥珀酰亚胺基部分及其混合物。酸优选是脂族二官能或多官能酸，更优选天然存在的脂族二官能或多官能酸。甚至更优选的是由戊二酸，辛二酸，癸二酸，酒石酸或其混合物组成的酸。活化的双官能或多官能酸是包含双官能或多官能酸和活化部分的酯。

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