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1. 发明申请

US20050009206A1 Peptide and protein arrays and direct-write lithographic printing of peptides and proteins 有权
标题翻译：肽和蛋白质阵列和肽和蛋白质的直写平版印刷
公开(公告)号：US20050009206A1
公开(公告)日：2005-01-13
申请号：US10788414
申请日：2004-03-01
申请人： Chad Mirkin , Jung-Hyurk Lim , David Ginger , Jwa-Min Nam , Ki-Bum Lee , Linette Demers , Albena Ivanisevic
发明人： Chad Mirkin , Jung-Hyurk Lim , David Ginger , Jwa-Min Nam , Ki-Bum Lee , Linette Demers , Albena Ivanisevic
IPC分类号： G01Q70/12 , G01Q60/00 , G01Q70/18 , G01Q80/00 , G03B27/42 , G01N33/543
CPC分类号： G03B27/42 , Y10S977/857 , Y10S977/884 , Y10S977/885 , Y10S977/886
摘要： The present invention relates to the use of direct-write lithographic printing of proteins and peptides onto surfaces. In particular, the present invention relates to methods for creating protein and peptide arrays and compositions derived therefrom. Nanoscopic tips can be used to deposit the peptide or protein onto the surface to produce a pattern. The pattern can be dots or lines having dot diameter and line width of less than 1,000 nm. The tips and the substrate surfaces can be adapted for the peptide and protein lithography.
摘要翻译：本发明涉及将蛋白质和肽直接写入平版印刷在表面上的用途。特别地，本发明涉及用于产生蛋白质和肽阵列的方法和由其衍生的组合物。可以使用纳米尖端将肽或蛋白质沉积到表面上以产生图案。图案可以是点直径和线宽小于1,000nm的点或线。尖端和底物表面可适用于肽和蛋白质光刻。

2. 发明申请

US20060051798A1 Bio-barcodes based on oligonucleotide-modified particles 有权
标题翻译：基于寡核苷酸修饰颗粒的生物条形码
公开(公告)号：US20060051798A1
公开(公告)日：2006-03-09
申请号：US11217106
申请日：2005-08-31
申请人： Chad Mirkin , So-Jung Park , Jwa-Min Nam
发明人： Chad Mirkin , So-Jung Park , Jwa-Min Nam
IPC分类号： C12Q1/68
CPC分类号： B82Y30/00 , B01J2219/00274 , C07B2200/11 , C07H21/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C40B40/00 , Y10S977/924 , C12Q2563/155 , C12Q2525/197 , C12Q2563/185
摘要： The present invention relates to a screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. proteins such as antibodies, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in one solution.
摘要翻译：本发明涉及用于检测一种或多种目标分析物的存在或不存在的筛选方法，组合物和试剂盒，例如，蛋白质如抗体，在样品中。特别地，本发明涉及利用报道寡核苷酸作为生化条形码来检测一种溶液中多种蛋白质结构或其他目标分析物的方法。

3. 发明申请

US20060040286A1 Bio-barcode based detection of target analytes 审中-公开
标题翻译：基于生物条形码的目标分析物检测
公开(公告)号：US20060040286A1
公开(公告)日：2006-02-23
申请号：US11127808
申请日：2005-05-12
申请人： Chad Mirkin , Jwa-Min Nam , Byung-Keun Oh , C. Shad Thaxton , Dimitra Georganopoulou
发明人： Chad Mirkin , Jwa-Min Nam , Byung-Keun Oh , C. Shad Thaxton , Dimitra Georganopoulou
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , G01N33/54333 , C12Q2565/501 , C12Q2565/113 , C12Q2563/179 , C12Q2563/143 , C12Q2563/149 , C12Q2563/155
摘要： The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in a solution.
摘要翻译：本发明涉及用于检测一种或多种目标分析物的存在或不存在的筛选方法，组合物和试剂盒，例如，生物分子。特别地，本发明涉及利用报告寡核苷酸作为检测多种蛋白质结构或溶液中其它目标分析物的生化条形码的方法。

4. 发明申请

US20050037397A1 Bio-barcode based detection of target analytes 审中-公开
标题翻译：基于生物条形码的目标分析物检测
公开(公告)号：US20050037397A1
公开(公告)日：2005-02-17
申请号：US10877750
申请日：2004-06-25
申请人： Chad Mirkin , Jwa-Min Nam , C. Thaxton
发明人： Chad Mirkin , Jwa-Min Nam , C. Thaxton
IPC分类号： C07B61/00 , C07H21/00 , C12Q1/68 , C12P19/34
CPC分类号： B82Y30/00 , B01J2219/005 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00734 , B01J2219/00743 , C07B2200/11 , C07H21/00 , C12Q1/6804 , C12Q1/6816 , C12Q1/6834 , C40B40/00 , C12Q2565/113 , C12Q2563/179
摘要： The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in a solution.
摘要翻译：本发明涉及用于检测一种或多种目标分析物的存在或不存在的筛选方法，组合物和试剂盒，例如，生物分子。特别地，本发明涉及利用报告寡核苷酸作为检测多种蛋白质结构或溶液中其它目标分析物的生化条形码的方法。

5. 发明申请

US20050277205A1 Multicomponent magnetic nanorods for biomolecular separations 审中-公开
标题翻译：用于生物分子分离的多组分磁性纳米棒
公开(公告)号：US20050277205A1
公开(公告)日：2005-12-15
申请号：US11062983
申请日：2005-02-22
申请人： Ki-Bum Lee , Sungho Park , Chad Mirkin , Byung-Keun Oh
发明人： Ki-Bum Lee , Sungho Park , Chad Mirkin , Byung-Keun Oh
IPC分类号： C12Q1/68 , G01N33/531 , G01N33/553
CPC分类号： G01N33/531 , B82Y5/00
摘要： The present invention relates to methods and compositions for separation of proteins. In particular, the present invention provides multicomponent nanorods for biomolecular separations of proteins.
摘要翻译：本发明涉及分离蛋白质的方法和组合物。特别地，本发明提供了用于蛋白质的生物分子分离的多组分纳米棒。

6. 发明申请

US20070129321A1 Nanoarrays of single virus particles, methods and instrumentation for the fabrication and use thereof 有权
标题翻译：单一病毒颗粒的纳米阵列，其制造和使用的方法和仪器
公开(公告)号：US20070129321A1
公开(公告)日：2007-06-07
申请号：US11506200
申请日：2006-08-18
申请人： Chad Mirkin , Rafael Vega , Daniel Maspoch , Khalid Salaita
发明人： Chad Mirkin , Rafael Vega , Daniel Maspoch , Khalid Salaita
IPC分类号： A61K31/70 , A01N43/04
CPC分类号： A61K31/70 , B82Y5/00 , B82Y30/00 , C12N7/00 , C12N2770/00011 , G01N33/56983 , Y10S977/802
摘要： A novel coordination chemistry or metal ion binding approach to controlling the site-isolation and orientation of virus particles, such as TMV, on a nanoarray template generated by lithography including Dip Pen Nanolithography. By using the surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry was used to immobilize individual virus particles without the need for their genetic modification. Single particle control will enable a wide variety of studies involving viruses that are not possible with microarrays because of the size mismatch between the architecture of the virus and the features that make up such arrays. These include: single particle, single cell infectivity studies, the exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation can influence their bioactivity. This is a pioneering example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.
摘要翻译：一种新颖的配位化学或金属离子结合方法，用于通过包括Dip Pen Nanoithography在内的光刻技术生成的纳米阵列模板上控制病毒颗粒（如TMV）的位点分离和取向。通过使用许多病毒中固有的表面化学，使用金属离子或无机配位化学来固定个体病毒颗粒，而不需要进行遗传修饰。由于病毒架构与组成这些阵列的特征之间的大小不匹配，单粒子控制将能够进行涉及病毒的各种研究，这些病毒是微不足道的。这些包括：单粒子，单细胞感染性研究，材料合成和分子电子学模板等结构的探索，以及旨在了解表面呈现如何影响其生物活性的研究。这是在单粒子水平上的这种控制的开创性例子，因此在生物系统中商业使用纳米阵列。

7. 发明申请

US20050172704A1 Methods utilizing scanning probe microscope tips and products thereof or produced thereby 有权
标题翻译：使用扫描探针显微镜尖端及其产品或由其制造的方法
公开(公告)号：US20050172704A1
公开(公告)日：2005-08-11
申请号：US10951031
申请日：2004-09-28
申请人： Chad Mirkin , Richard Piner , Seunghun Hong
发明人： Chad Mirkin , Richard Piner , Seunghun Hong
IPC分类号： B05D1/00 , B05D1/18 , B05D1/26 , B82B3/00 , G01Q10/00 , G01Q60/00 , G01Q70/06 , G01Q70/16 , G01Q80/00 , G03F7/00 , G03F7/16 , G03F7/20 , H01L21/027 , G01B5/28
CPC分类号： B82B3/00 , B05D1/007 , B05D1/185 , B05D1/26 , G01Q80/00 , G03F7/0002 , G03F7/165 , Y10S977/849 , Y10S977/853 , Y10S977/854 , Y10S977/855 , Y10S977/856 , Y10S977/857 , Y10S977/86 , Y10S977/88 , Y10S977/884 , Y10S977/885 , Y10S977/886 , Y10S977/895 , Y10T428/24802
摘要： The invention provides a lithographic method referred to as “dip pen” nanolithography (DPN). DPN utilizes a scanning probe microscope (SPM) tip (e.g., an atomic force microscope (AFM) tip) as a “pen,” a solid-state substrate (e.g., gold) as “paper,” and molecules with a chemical affinity for the solid-state substrate as “ink.” Capillary transport of molecules from the SPM tip to the solid substrate is used in DPN to directly write patterns consisting of a relatively small collection of molecules in submicrometer dimensions, making DPN useful in the fabrication of a variety of microscale and nanoscale devices. The invention also provides substrates patterned by DPN, including submicrometer combinatorial arrays, and kits, devices and software for performing DPN. The invention further provides a method of performing AFM imaging in air. The method comprises coating an AFM tip with a hydrophobic compound, the hydrophobic compound being selected so that AFM imaging performed using the coated AFM tip is improved compared to AFM imaging performed using an uncoated AFM tip. Finally, the invention provides AFM tips coated with the hydrophobic compounds.
摘要翻译：本发明提供了称为“浸笔”纳米光刻（DPN）的光刻方法。 DPN使用扫描探针显微镜（SPM）尖端（例如，原子力显微镜（AFM）尖端）作为“笔”，固态基底（例如，金）作为“纸”，并且具有化学亲和力的分子固态基板为“墨水”。在DPN中使用分子从SPM尖端到固体基质的毛细管传输，以直接写入由亚微米尺寸的相对小的分子集合组成的图案，使得DPN可用于制造各种微尺寸和纳米尺寸的器件。本发明还提供由DPN图案化的衬底，包括亚微米组合阵列，以及用于执行DPN的试剂盒，装置和软件。本发明还提供了一种在空气中进行AFM成像的方法。该方法包括用疏水性化合物涂覆AFM尖端，选择疏水性化合物，使得与使用未涂覆的AFM尖端进行的AFM成像相比，使用涂覆的AFM尖端进行的AFM成像得到改善。最后，本发明提供涂覆有疏水化合物的AFM尖端。

8. 发明申请

US20080044575A1 PATTERNING OF SOLID STATE FEATURES BY DIRECT WRITE NANOLITHOGRAPHIC PRINTING 有权
标题翻译：通过直写写纳印刷印刷固体状态特征
公开(公告)号：US20080044575A1
公开(公告)日：2008-02-21
申请号：US11847263
申请日：2007-08-29
申请人： Chad Mirkin , Vinayak Dravid , Ming Su , Xiaogang Liu
发明人： Chad Mirkin , Vinayak Dravid , Ming Su , Xiaogang Liu
IPC分类号： B05D5/00
CPC分类号： B82B3/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F7/0002 , Y10S977/855 , Y10S977/857 , Y10T428/24802 , Y10T428/24926 , Y10T428/265
摘要： The present invention includes a method of fabricating organic/inorganic composite nanostructures on a substrate comprising depositing a solution having a block copolymer and an inorganic precursor on the substrate using dip pen nanolithography. The nanostructures comprises arrays of lines and/or dots having widths/diameters less than 1 micron. The present invention also includes a device comprising an organic/inorganic composite nanoscale region chemically bonded to a substrate, wherein the nanoscale region, wherein the nanoscale region has a nanometer scale dimension other than height.
摘要翻译：本发明包括在衬底上制造有机/无机复合纳米结构的方法，其包括使用浸渍笔纳米光刻法在衬底上沉积具有嵌段共聚物和无机前体的溶液。纳米结构包括具有小于1微米的宽度/直径的线和/或点的阵列。本发明还包括一种包括化学键合到基底上的有机/无机复合纳米尺度区域的器件，其中所述纳米尺度区域，其中所述纳米尺度区域具有除了高度之外的纳米尺度尺寸。

9. 发明申请

US20070190551A1 Non-alloying core shell nanoparticles 审中-公开
标题翻译：非合金核壳纳米粒子
公开(公告)号：US20070190551A1
公开(公告)日：2007-08-16
申请号：US11636392
申请日：2006-12-08
申请人： Chad Mirkin , Yun-Wei Cao , Rongchao Jin
发明人： Chad Mirkin , Yun-Wei Cao , Rongchao Jin
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： B22F1/0062 , A61K49/0067 , A61K49/0093 , B22F1/0059 , B22F1/025 , B22F9/24 , B22F2998/00 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y25/00 , B82Y30/00 , C01B19/007 , C01G7/00 , C01G11/02 , C01G49/08 , C01P2002/82 , C01P2004/04 , C01P2004/64 , C01P2004/84 , C01P2006/42 , C12Q1/6813 , C12Q1/6816 , C12Q1/6834 , G01N33/543 , G01N33/5434 , G01N33/54393 , G01N33/553 , G01N33/588 , H01F1/0054 , H01L29/127 , Y10T428/12083 , C12Q2563/155 , B22F1/0018
摘要： The present invention relates composite core/shell nanoparticles and a two-step method for their preparation. The present invention further relates to biomolecule-core/shell nanoparticle conjugates and methods for their preparation. The invention also relates to methods of detection of biomolecules comprising the biomolecule-core/shell nanoparticle conjugates.
摘要翻译：本发明涉及复合核/壳纳米颗粒和两步法的制备方法。本发明还涉及生物分子 - 核/壳纳米颗粒缀合物及其制备方法。本发明还涉及检测包含生物分子 - 核/壳纳米颗粒共轭物的生物分子的方法。

10. 发明申请

US20050272885A1 Surface and site-specific polymerization by direct-write lithography 失效
标题翻译：通过直写光刻技术进行表面和位点特异性聚合
公开(公告)号：US20050272885A1
公开(公告)日：2005-12-08
申请号：US10893543
申请日：2004-07-19
申请人： Chad Mirkin , Xiaogang Liu , Shouwu Guo
发明人： Chad Mirkin , Xiaogang Liu , Shouwu Guo
IPC分类号： C08F2/00 , G03F7/00 , G03F7/20 , H01J20060101
CPC分类号： G03F7/0002 , G01Q80/00 , G03F7/2049 , H01J2237/31738 , Y10S977/857 , Y10S977/882 , Y10S977/897
摘要： Polymeric microstructures and nanostructures can be prepared with use of a tip to pattern a surface. A tip can be used to pattern a structure which can initiate polymerization. The structure can be then exposed to monomer to induce polymerization at the structure. Alternatively, a tip can be used to pattern a surface with a monomer in which the surface is treated with polymerization catalyst so that polymerization occurs at the patterning site. Ring-opening metathesis polymerization can be carried out with use of the tip to control the polymerization. The tip can be a sharp tip as used in for example an atomic force microscope tip. Norbornene types of monomers can be used. Biological macromolecules can be also prepared.
摘要翻译：可以使用尖端来制备聚合物微结构和纳米结构以对表面进行图案化。尖端可用于图案化可引发聚合的结构。然后将该结构暴露于单体以在结构处引发聚合。或者，可以使用尖端来用表面用聚合催化剂处理的单体对表面进行图案化，使得在图案化位点发生聚合。可以使用尖端进行开环易位聚合以控制聚合。尖端可以是例如原子力显微镜尖端中使用的尖锐尖端。可以使用降冰片烯类型的单体。还可制备生物大分子。

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