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    • 3. 发明申请
    • 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof
    • 1-芳基-5-烷基吡唑衍生物化合物,其制备方法和使用方法
    • US20080031902A1
    • 2008-02-07
    • US11825050
    • 2007-07-03
    • Hyoung LeeLoïc de FalloisPhilip TimmonsWilliam CawthorneAdalberto de Leon
    • Hyoung LeeLoïc de FalloisPhilip TimmonsWilliam CawthorneAdalberto de Leon
    • A01N25/00A01N43/56A01P15/00C07D231/10C07D231/16
    • A01N43/56A01N25/02A01N47/02A61K31/415A61K31/4439A61K45/06C07D231/18C07D401/04
    • Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): wherein: R1 is hydrogen, cyano, halogen, R8, formyl, —C(O)R8, —C(O)OR8, —C(O)NR9R10, or —C(S)NH2; R2 is R2 or —S(O)mR11; R3 is methyl, ethyl or C1-C4 haloalkyl; R4, R5 and R7 are independently hydrogen, halogen, alkyl, haloalkyl, cyano or nitro; R6 is halogen, alkyl, haloalkyl, alkoxy, haloalkyloxy, cyano, nitro, —C(O)R12, —S(O)nR12 or SF5; Z is a nitrogen atom or C—R13; R8 is alkyl, haloalkyl, cycloalkyl or halocycloalkyl; R9 is hydrogen, alkyl, haloalkyl or alkoxy; R10 is hydrogen, alkyl, haloalkyl or alkoxy; R11 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl or cycloalkyl; R12 is alkyl or haloalkyl; R13 is hydrogen, halogen, cyano, nitro, alkyl, haloalkyl, alkoxy or haloalkoxy; m is 0, 1 or 2; and n is 0, 1 or 2; or a salt thereof, the method of making compounds of formula (I) and the use of these compounds against ectoparasites, endoparasites and pests.
    • 提供式(I)的1-芳基-5-烷基吡唑化合物:其中:R 1是氢,氰基,卤素,R 8,甲酰基,-C (O)R 8,-C(O)OR 8,-C(O)NR 9 R 10 >或-C(S)NH 2; R 2是R 2或-S(O)m R 11; R 3是甲基,乙基或C 1 -C 4卤代烷基; R 4,R 5和R 7独立地是氢,卤素,烷基,卤代烷基,氰基或硝基; R 6是卤素,烷基,卤代烷基,烷氧基,卤代烷氧基,氰基,硝基,-C(O)R 12,-S(O) R 12或SF 5; Z是氮原子或C-R 13; R 8是烷基,卤代烷基,环烷基或卤代环烷基; R 9是氢,烷基,卤代烷基或烷氧基; R 10是氢,烷基,卤代烷基或烷氧基; R 11是烷基,卤代烷基,烯基,卤代烯基,炔基,卤代炔基或环烷基; R 12是烷基或卤代烷基; R 13是氢,卤素,氰基,硝基,烷基,卤代烷基,烷氧基或卤代烷氧基; m为0,1或2; 且n为0,1或2; 或其盐,制备式(I)化合物的方法以及这些化合物对外寄生虫,内寄生虫和害虫的用途。