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1. 发明申请

WO2014158986A1 MEDICAL DEVICE WITH MULTIPLE SENSOR FUSION 审中-公开
标题翻译：具有多个传感器融合的医疗装置
公开(公告)号：WO2014158986A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/021287
申请日：2014-03-06
申请人： CARDIAC PACEMAKERS, INC.
发明人： AN, Qi , MASKARA, Barun , THAKUR, Pramodsingh Hirasingh , THOMPSON, Julie
IPC分类号： A61N1/05 , A61N1/36 , A61N1/365 , A61N1/368 , A61N1/37
CPC分类号： A61N1/36585 , A61N1/056 , A61N1/36139 , A61N1/3625 , A61N1/3627 , A61N1/365 , A61N1/36514 , A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/3704
摘要： Devices and methods for improving device therapy such as cardiac resynchronization therapy (CRT) by determining a desired value for a device parameter are described. An ambulatory medical device can receive one or more physiologic signals and generate multiple signal metrics from the physiologic signals. The ambulatory medical device can determine a desired value for a device parameter, such as a timing parameter used for controlling the delivery of CRT pacing to various heart chambers, using information fusion of signal metrics that are selected based on one or more of a signal metric sensitivity to perturbations to the device parameter in response to a stimulation, a signal metric variability in response to a stimulation, or a covariability between two or more signal metrics in response to a stimulation. The ambulatory medical device can program a stimulation using the desired device parameter value, and deliver the programmed stimulation to one or more target sites to achieve desired therapeutic effects.
摘要翻译：描述了通过确定器件参数的期望值来改善诸如心脏再同步治疗（CRT）的装置疗法的装置和方法。移动医疗设备可以接收一个或多个生理信号并从生理信号产生多个信号度量。移动医疗设备可以使用基于信号度量的信号融合来确定设备参数的期望值，例如用于控制向各种心脏腔室输送CRT起搏的定时参数，所述信号度量基于信号度量响应于刺激对装置参数的扰动的灵敏度，响应于刺激的信号度量可变性或响应于刺激的两个或更多个信号度量之间的协方差。移动医疗设备可以使用期望的设备参数值对刺激进行编程，并将编程的刺激递送到一个或多个目标位点以实现期望的治疗效果。

2. 发明申请

WO2008150363A1 SYSTEMS AND METHODS FOR TACHYARRHYTHMIA DISCRIMINATION 审中-公开
标题翻译： TACHYARRHYTHMIA歧视的系统和方法
公开(公告)号：WO2008150363A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/006393
申请日：2008-05-19
申请人： CARDIAC PACEMAKERS, INC. , THOMPSON, Julie
发明人： THOMPSON, Julie
IPC分类号： A61B5/046 , A61B5/0464 , A61N1/362 , A61N1/39
CPC分类号： A61B5/0464 , A61B5/7264 , A61N1/3622 , A61N1/3702 , A61N1/3925 , A61N1/3962
摘要： Systems, devices, and methods detect or classify tachyarrhythmias or make a therapy decision. A tachyarrhythmia can be classified using a rhythm discrimination parameter having a value. In certain examples, the value of the rhythm discrimination parameter can be adjusted using a relationship between a detected atrial rate and a detected ventricular rate, or the value can be adjusted using information about at least one of the atrial rate or the ventricular rate in addition to using the relationship between the atrial rate and the ventricular rate. These techniques can improve the specificity of arrhythmia detection or classification, allow anti-tachyarrhythmia therapy to be better tailored to the particular tachyarrhythmia, or provide more automatic operation making it easier for a physician to use an implantable device.
摘要翻译：系统，装置和方法检测或分类快速性心律失常或作出治疗决定。可以使用具有值的节律辨别参数来分类快速性心律失常。在某些示例中，可以使用检测到的心房率和检测到的心室率之间的关系来调整节律辨别参数的值，或者可以使用关于至少一个心房率或心室率的信息来调整该值使用心房率与心室率之间的关系。这些技术可以改善心律失常检测或分类的特异性，允许抗特发性心律失常治疗更适合于特定的快速性心律失常，或提供更自动的操作，使得医生更容易使用可植入装置。

3. 发明申请

WO2008088897A2 HEART ATTACK DETECTOR 审中-公开
标题翻译：心脏攻击检测器
公开(公告)号：WO2008088897A2
公开(公告)日：2008-07-24
申请号：PCT/US2008/000720
申请日：2008-01-18
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , FOGOROS, Richard , THOMPSON, Julie , KENKNIGHT, Bruce H. , PEDERSON, Michael J. , PATANGAY, Abhilash , BAYNHAM, Tamara C. , MANICKA, Yatheendhar D. , MAZAR, Scott T.
发明人： ZHANG, Yi , FOGOROS, Richard , THOMPSON, Julie , KENKNIGHT, Bruce H. , PEDERSON, Michael J. , PATANGAY, Abhilash , BAYNHAM, Tamara C. , MANICKA, Yatheendhar D. , MAZAR, Scott T.
CPC分类号： A61N1/365 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0452 , A61B5/053 , A61B5/7203 , A61B7/023 , A61N1/36521 , A61N1/36542 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36585
摘要： A system including an implantable trigger event detector and an implantable ischemia detector. The implantable trigger event detector is adapted to detect at least one first condition and to output a responsive trigger signal including information about whether the first condition has been detected. The implantable ischemia detector is adapted to detect a second condition indicative of one or more physiologic cardiovascular events in a subject that are indicative of ischemia. The ischemia detector is coupled to the trigger event detector to receive the trigger signal, and the ischemia detector is enabled upon the trigger signal indicating that the first condition has been detected.
摘要翻译：一种包括可植入触发事件检测器和可植入缺血检测器的系统。可植入触发事件检测器适合于检测至少一个第一状态并输出包括关于是否检测到第一条件的信息的响应触发信号。可植入缺血检测器适于检测指示受试者中指示缺血的一种或多种生理性心血管事件的第二状态。缺血检测器耦合到触发事件检测器以接收触发信号，并且在触发信号指示已经检测到第一条件的情况下启用缺血检测器。

4. 发明申请

WO2006049767A1 ARRHYTHMIA DETECTION AND CLASSIFICATION USING WIRELESS ECG 审中-公开
标题翻译：使用无线心电图进行ARRHYTHMIA检测和分类
公开(公告)号：WO2006049767A1
公开(公告)日：2006-05-11
申请号：PCT/US2005/035057
申请日：2005-09-29
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , MCCABE, Aaron , YONCE, David, J. , THOMPSON, Julie
发明人： ZHANG, Yi , MCCABE, Aaron , YONCE, David, J. , THOMPSON, Julie
IPC分类号： A61N1/362 , A61N1/39 , A61N1/37
CPC分类号： A61N1/3956 , A61B5/0422 , A61B5/0452 , A61B5/686 , A61N1/3622 , A61N1/3706 , A61N1/3712 , A61N1/3756 , A61N1/3925 , A61N2001/083
摘要： A CRM system enhances intracardiac electrogram-based arrhythmia detection using a wireless electrocardiogram (ECG), which is a signal sensed with implantable electrodes and approximating a surface ECG. In one embodiment, an intracardiac electrogram allows for detection of an arrhythmia, and the wireless ECG allows for classification of the detected arrhythmia by locating its origin. In another embodiment, the wireless ECG is sensed as a substitute signal for the intracardiac electrogram when the sensing of the intracardiac electrogram becomes unreliable. In another embodiment, a cardiac signal needed for a particular purpose is selected from one or more intracardiac electrograms and one or more wireless ECGs based on a desirable signal quality. In another embodiment, intracardiac electrogram-based arrhythmia detection and wireless ECG-based arrhythmia detection confirm with each other before indicating a detection of arrhythmia of a certain type.
摘要翻译： CRM系统使用无线心电图（ECG）来增强基于心脏电图的心律失常检测，该无线心电图（ECG）是用可植入电极感测并近似表面ECG的信号。在一个实施例中，心内电描记图允许检测心律失常，并且无线ECG允许通过定位其起点来分类检测到的心律失常。在另一个实施例中，当心脏电图的感测变得不可靠时，无线ECG被感测为心内电描记图的替代信号。在另一个实施例中，基于期望的信号质量，从一个或多个心内电描记图和一个或多个无线ECG选择特定目的所需的心脏信号。在另一个实施例中，基于心脏电图的心律失常检测和基于无线ECG的心律失常检测在指示某种类型的心律失常的检测之前相互确认。

5. 发明申请

WO2006020198A2 TACHYARRHYTHMIA DISCRIMINATION OR THERAPY DECISIONS 审中-公开
标题翻译： TACHYARRHYTHMIA歧视或治疗决定
公开(公告)号：WO2006020198A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/025397
申请日：2005-07-18
申请人： CARDIAC PACEMAKERS, INC. , SMITH, Valerie , DUJMOVIC, Richard, Milon, Jr. , THOMPSON, Julie
发明人： SMITH, Valerie , DUJMOVIC, Richard, Milon, Jr. , THOMPSON, Julie
IPC分类号： A61N1/362
CPC分类号： A61B5/7264 , A61B5/0464 , A61N1/3622 , A61N1/3962
摘要： This document discusses, among other things, systems, devices, and methods for detecting or classifying tachyarrhythmias or making a therapy decision. In one example, a rate-dependent threshold is used for comparing atrial and ventricular rates for classifying a tachyarrhythmia as a ventricular tachyarrhythmia (VT) or a supraventricular tachyarrhythmia (SVT). In another example, the classification uses an atrial rate cutoff value, a ventricular rate cutoff value, or both. In another example, a tachyarrhythmia detection is tested over a time window with a duration that is automatically adjusted as a substantially continuously monotonically decreasing function of duration vs. rate. These techniques improve the specificity of arrhythmia detection or classification, allow anti-tachyarrhythmia therapy to be better tailored to the particular tachyarrhythmia, or provide more automatic operation making it easier for a physician to use an implantable device.
摘要翻译：本文件还讨论了用于检测或分类快速性心律失常或作出治疗决定的系统，设备和方法。在一个示例中，速率依赖阈值用于比较心房和心室率，用于将快速性心律失常分类为室性快速性心律失常（VT）或室上性快速性心律失常（SVT）。在另一个例子中，分类使用心房率截止值，心室率截止值或两者。在另一个示例中，在时间窗口上测试快速心律失常检测，其持续时间被自动调整为持续时间与速率的基本上连续单调递减的功能。这些技术改进了心律失常检测或分类的特异性，允许抗特发性心律失常治疗更适合特定的快速性心律失常，或提供更自动的操作，使得医生更容易使用可植入装置。

6. 发明申请

WO2014158800A1 HEART FAILURE MANAGEMENT TO AVOID REHOSPITALIZATION 审中-公开
标题翻译：心脏失败管理以避免复发
公开(公告)号：WO2014158800A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/020232
申请日：2014-03-04
申请人： CARDIAC PACEMAKERS, INC.
发明人： THAKUR, Pramodsingh Hirasingh , AN, Qi , MASKARA, Barun , THOMPSON, Julie
IPC分类号： A61B5/00 , A61B5/0205
CPC分类号： A61B5/7275 , A61B5/02 , A61B5/0205 , A61B5/091 , A61B5/4848 , A61B5/686 , A61B5/7282 , A61B5/746 , A61B7/04 , A61N1/36114 , A61N1/36139 , A61N1/3627 , A61N1/36585 , A61N1/3682 , G06F19/00
摘要： Systems and methods are described for subject rehospitalization management. In an example, multiple physiologic signals can be obtained from a subject using multiple sensors. In response to a hospitalization event, pre-hospitalization characteristics of the multiple physiologic signals can be identified. Post-hospitalization characteristics of the multiple physiologic signals can be identified, including characteristics that differ from their corresponding pre-hospitalization characteristics. Later subsequent physiologic signals can be further monitored after the hospitalization event, such as using the same multiple sensors, and subsequent physiologic signal characteristics can be identified. In an example, a heart failure diagnostic indication can be determined using information about the pre-hospitalization characteristics, the post-hospitalization characteristics, and the subsequent characteristics. Information about relative changes in signal characteristics from multiple sensors can be used to identify particular subject physiologic signals to monitor during subsequent periods.
摘要翻译：系统和方法被描述为主体再住院管理。在一个例子中，可以使用多个传感器从受试者获得多个生理信号。针对住院治疗事件，可以确定多发生生理信号的住院前特征。可以确定多种生理信号的住院后特征，包括与其相应的住院前特征不同的特征。后来的生理信号可以在住院事件之后进一步监测，例如使用相同的多个传感器，并且可以识别随后的生理信号特征。在一个示例中，可以使用关于住院前特征，住院后特征和随后特征的信息来确定心力衰竭诊断指示。可以使用关于来自多个传感器的信号特性的相对变化的信息来识别特定的受试者生理信号以在随后的时间段内监测。

7. 发明申请

WO2011005376A1 RESPIRATION RATE TRENDING FOR DETECTING EARLY ONSET WORSENING HEART FAILURE 审中-公开
标题翻译：用于检测早期心跳加重心脏衰竭的呼吸频率变化
公开(公告)号：WO2011005376A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/036386
申请日：2010-05-27
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , AVERINA, Viktoria, A. , THOMPSON, Julie
发明人： ZHANG, Yi , AVERINA, Viktoria, A. , THOMPSON, Julie
IPC分类号： A61B5/08 , A61N1/362
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/0809 , A61B5/113 , A61B5/7275 , A61N1/36521 , G06F19/00
摘要： Patient respiration is sensed from which respiration measurements are made, including a median respiration rate (MedRR) and a maximum respiration rate (MaxRR). Determinations are made as to whether an abnormality exists in MedRR and in MaxRR. An output indicative of the patient's tachypnea status is generated in response to determining the abnormality in MedRR and MaxRR.
摘要翻译：从呼吸测量中检出患者呼吸，包括呼吸中值（MedRR）和最大呼吸频率（MaxRR）。确定MedRR和MaxRR中是否存在异常。响应于确定MedRR和MaxRR中的异常而产生指示患者呼吸暂停状态的输出。

8. 发明公开

EP2451350A1 RESPIRATION RATE TRENDING FOR DETECTING EARLY ONSET WORSENING HEART FAILURE 审中-公开
标题翻译：呼吸频率开发控制心力衰竭恶化的早期检测
公开(公告)号：EP2451350A1
公开(公告)日：2012-05-16
申请号：EP10721084.1
申请日：2010-05-27
申请人： Cardiac Pacemakers, Inc.
发明人： ZHANG, Yi , AVERINA, Viktoria, A. , THOMPSON, Julie
IPC分类号： A61B5/08 , A61N1/362
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/0809 , A61B5/113 , A61B5/7275 , A61N1/36521 , G06F19/00
摘要： Patient respiration is sensed from which respiration measurements are made, including a median respiration rate (MedRR) and a maximum respiration rate (MaxRR). Determinations are made as to whether an abnormality exists in MedRR and in MaxRR. An output indicative of the patient's tachypnea status is generated in response to determining the abnormality in MedRR and MaxRR.

9. 发明公开

EP2968916A1 MEDICAL DEVICE WITH MULTIPLE SENSOR FUSION 有权
标题翻译：在Fusion的多传感器医疗器械
公开(公告)号：EP2968916A1
公开(公告)日：2016-01-20
申请号：EP14712509.0
申请日：2014-03-06
申请人： Cardiac Pacemakers, Inc.
发明人： AN, Qi , MASKARA, Barun , THAKUR, Pramodsingh Hirasingh , THOMPSON, Julie
IPC分类号： A61N1/05 , A61N1/36 , A61N1/365 , A61N1/368 , A61N1/37
CPC分类号： A61N1/36585 , A61N1/056 , A61N1/36139 , A61N1/3625 , A61N1/3627 , A61N1/365 , A61N1/36514 , A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/3704
摘要： Devices and methods for improving device therapy such as cardiac resynchronization therapy (CRT) by determining a desired value for a device parameter are described. An ambulatory medical device can receive one or more physiologic signals and generate multiple signal metrics from the physiologic signals. The ambulatory medical device can determine a desired value for a device parameter, such as a timing parameter used for controlling the delivery of CRT pacing to various heart chambers, using information fusion of signal metrics that are selected based on one or more of a signal metric sensitivity to perturbations to the device parameter in response to a stimulation, a signal metric variability in response to a stimulation, or a covariability between two or more signal metrics in response to a stimulation. The ambulatory medical device can program a stimulation using the desired device parameter value, and deliver the programmed stimulation to one or more target sites to achieve desired therapeutic effects.

10. 发明授权

EP1778344B1 DISCRIMINATION BETWEEN ATRIAL AND VENTRICULAR TACHYARRHYTHMIA 有权
标题翻译：之间的区分心房和心室快速性心律失常
公开(公告)号：EP1778344B1
公开(公告)日：2014-01-08
申请号：EP05772968.3
申请日：2005-07-18
申请人： CARDIAC PACEMAKERS, INC.
发明人： SMITH, Valerie , DUJMOVIC, Richard, Milon, Jr. , THOMPSON, Julie
IPC分类号： A61N1/362 , A61N1/39 , A61B5/0464
CPC分类号： A61B5/7264 , A61B5/0464 , A61N1/3622 , A61N1/3962

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