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1. 发明申请

WO2011005376A1 RESPIRATION RATE TRENDING FOR DETECTING EARLY ONSET WORSENING HEART FAILURE 审中-公开
标题翻译：用于检测早期心跳加重心脏衰竭的呼吸频率变化
公开(公告)号：WO2011005376A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/036386
申请日：2010-05-27
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , AVERINA, Viktoria, A. , THOMPSON, Julie
发明人： ZHANG, Yi , AVERINA, Viktoria, A. , THOMPSON, Julie
IPC分类号： A61B5/08 , A61N1/362
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/0809 , A61B5/113 , A61B5/7275 , A61N1/36521 , G06F19/00
摘要： Patient respiration is sensed from which respiration measurements are made, including a median respiration rate (MedRR) and a maximum respiration rate (MaxRR). Determinations are made as to whether an abnormality exists in MedRR and in MaxRR. An output indicative of the patient's tachypnea status is generated in response to determining the abnormality in MedRR and MaxRR.
摘要翻译：从呼吸测量中检出患者呼吸，包括呼吸中值（MedRR）和最大呼吸频率（MaxRR）。确定MedRR和MaxRR中是否存在异常。响应于确定MedRR和MaxRR中的异常而产生指示患者呼吸暂停状态的输出。

2. 发明申请

WO2011017049A1 MEDICAL DEVICE FOR TREATING HEART FAILURE THROUGH BLOOD VOLUME REDISTRIBUTION 审中-公开
标题翻译：用于通过血容量重新分配来治疗心脏失败的医疗装置
公开(公告)号：WO2011017049A1
公开(公告)日：2011-02-10
申请号：PCT/US2010/043228
申请日：2010-07-26
申请人： CARDIAC PACEMAKERS, INC. , AVERINA, Viktoria, A. , HAMANN, Jason, J. , RUBLE, Stephen , SHUROS, Allan, C.
发明人： AVERINA, Viktoria, A. , HAMANN, Jason, J. , RUBLE, Stephen , SHUROS, Allan, C.
IPC分类号： A61B5/08 , A61B5/053
CPC分类号： A61N1/3601 , A61B5/0537 , A61B5/0538 , A61B5/0809 , A61B5/4035 , A61B5/4869 , A61N1/36114 , A61N1/36521 , A61N1/36585
摘要： A first fluid status indicator of a pulmonary fluid status associated with pulmonary edema and a second fluid status indicator of a non-pulmonary fluid status can be used to provide an alert or to control a therapy for pulmonary edema. Additionally, intermittent cardiac blood volume redistribution therapy can be used to provide cardiac conditioning in heart failure patients.
摘要翻译：可以使用与肺水肿相关的肺液体状态和非肺液体状态的第二流体状态指示器的第一流体状态指示器来提供警报或控制肺水肿的治疗。此外，间歇性心脏血容量再分配治疗可用于在心力衰竭患者中提供心脏调节。

3. 发明申请

WO2014126934A1 MEDICAL DEVICE FOR ALGORITHM ADAPTATION TO AN EXTERNAL IMPACT ON THE DATA 审中-公开
标题翻译：适用于数据外部影响的算法的医疗设备
公开(公告)号：WO2014126934A1
公开(公告)日：2014-08-21
申请号：PCT/US2014/015853
申请日：2014-02-11
申请人： CARDIAC PACEMAKERS, INC.
发明人： AVERINA, Viktoria, A. , THAKUR, Pramodsingh Hirasingh , ZHANG, Yi , AN, Qi
IPC分类号： A61N1/362 , A61B5/046
CPC分类号： A61B5/7221 , A61B5/02055 , A61B5/0452 , A61B5/4839 , A61B5/686 , A61B5/7278 , A61B2560/0276 , A61N1/3627
摘要： Devices and methods for detecting a physiological target event such as events indicative of HF decompensation status are described. An ambulatory medical device is configured to determine the presence and timing of a confounding event, segment a sensed physiological signal into at least two data segments, adjust the physiological signal by removing or lessening the impact of the confounding event on the physiological signal. The adjusted data can be presented to the user, and the ambulatory medical device can detect the target events using the adjusted physiologic signal. In some embodiments, the ambulatory medical device can be configured to detect an event indicative of HF decompensation using a physiological signal and the information of the detected confounding event.
摘要翻译：描述用于检测生理目标事件（例如表示HF失代偿状态的事件）的装置和方法。移动医疗装置被配置为确定混杂事件的存在和定时，将感测的生理信号分段成至少两个数据段，通过去除或减轻混淆事件对生理信号的影响来调整生理信号。可以将调整后的数据呈现给用户，并且移动医疗设备可以使用经调整的生理信号来检测目标事件。在一些实施例中，可以将移动医疗装置配置成使用生理信号和所检测的混杂事件的信息来检测指示HF代偿失真的事件。

4. 发明申请

WO2015020980A1 SYSTEM AND METHOD FOR DETECTING WORSENING OF HEART FAILURE BASED ON TIDAL VOLUME 审中-公开
标题翻译：用于检测基于TODAL VOLUME的心脏失败的威胁的系统和方法
公开(公告)号：WO2015020980A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/049644
申请日：2014-08-04
申请人： CARDIAC PACEMAKERS, INC.
发明人： ZHANG, Yi , AVERINA, Viktoria, A. , BECK, Kenneth, C. , THAKUR, Pramodsingh , WARIAR, Ramesh
IPC分类号： A61B5/0205 , A61B5/08 , A61B5/091 , A61B5/00 , A61B5/085
CPC分类号： A61B5/091 , A61B5/02 , A61B5/0205 , A61B5/0809 , A61B5/0816 , A61B5/085 , A61B5/113 , A61B5/7275 , A61B5/746 , G06F19/00
摘要： Systems and methods for detecting a worsening of a patient's heart failure condition based, at least in part, on a declining trend in a representative tidal volume value over multiple days. The tidal volume value may be a maximum tidal volume, and more particularly, a maximum tidal volume determined for an afternoon portion of each of the multiple days or a selected portion of each of the multiple days that excludes a night portion. The maximum tidal volume during these portions of the day may be more sensitive to changes in a patient's respiration, particularly when a patient is expected to be more active, and thus, may more readily exhibit a declining trend when the patient's heart failure status is in decline.
摘要翻译：至少部分地基于多天的代表性潮气量值的下降趋势来检测患者心力衰竭状况恶化的系统和方法。潮气量值可以是最大潮气量，更具体地说，确定多天中的每一天的下午部分或排除夜间部分的多天的每一个的选定部分的最大潮气量。在一天中这些部分期间的最大潮气量可能对患者呼吸的变化更敏感，特别是当预期患者更有活力时，因此当患者的心力衰竭状态处于下降。

5. 发明申请

WO2015020979A1 SYSTEM AND METHOD FOR DETECTING WORSENING OF HEART FAILURE BASED ON RAPID SHALLOW BREATHING INDEX 审中-公开
标题翻译：基于快速呼吸指数检测心脏衰竭的威胁的系统和方法
公开(公告)号：WO2015020979A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/049643
申请日：2014-08-04
申请人： CARDIAC PACEMAKERS, INC.
发明人： ZHANG, Yi , AVERINA, Viktoria, A. , BECK, Kenneth, C. , THAKUR, Pramodsingh , WARIAR, Ramesh
IPC分类号： A61B5/0205 , A61B5/08 , A61B5/085 , A61B5/091 , A61B5/00
CPC分类号： A61B5/7275 , A61B5/0082 , A61B5/0205 , A61B5/0809 , A61B5/0816 , A61B5/085 , A61B5/091 , A61B5/113 , A61B5/746 , G06F19/00
摘要： Systems and methods for detecting a worsening of patient's heart failure condition based, at least in part, on an increasing trend in a representative rapid shallow breathing index (RSBI) value over multiple days. The RSBI value may be a minimum RSBI, and more particularly may be a minimum RSBI value determined for an afternoon portion of each of the multiple days. The minimum RSBI value measured during an afternoon portion of the day may be more sensitive to changes in a patient's respiration, particularly when a patient is expected to be more active, and thus, may more readily exhibit an increasing trend when patient's heart failure is in decline.
摘要翻译：至少部分地基于代表性的快速浅呼吸指数（RSBI）值在多天中的增加趋势来检测患者心力衰竭状况恶化的系统和方法。 RSBI值可以是最小RSBI，并且更特别地可以是为多天中的每一天的下午部分确定的最小RSBI值。在一天的下午部分测量的最小RSBI值可能对患者呼吸的变化更敏感，特别是当患者预期更活跃时，因此当患者的心力衰竭在下降。

6. 发明申请

WO2013096905A1 PHYSIOLOGICAL STATUS INDICATOR APPARATUS AND METHOD 审中-公开
标题翻译：生理状态指示器和方法
公开(公告)号：WO2013096905A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/071481
申请日：2012-12-21
申请人： CARDIAC PACEMAKERS, INC.
发明人： THAKUR, Pramodsingh, Hirasingh , HATLESTAD, John, D. , WARIAR, Ramesh , AVERINA, Viktoria, A. , SWANSON, Lynne E.
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/686 , A61B5/72
摘要： A processor circuit can be configured to obtain a first multidimensional vector. The first multidimensional vector can include dimensions corresponding to respective first conductivity characteristics obtained from different implantable electrode configurations associated with a subject. The processor circuit can also be configured to obtain a second multidimensional vector or vector space. The second multidimensional vector or vector space can include dimensions corresponding to respective second conductivity characteristics obtained from such different electrode configurations associated with the same or a different subject. The processor circuit can also provide a physiological status indicator that can be obtained at least in part by performing a vector comparison of the first multidimensional vector to the second multidimensional vector space or vector.
摘要翻译：处理器电路可以被配置为获得第一多维向量。第一多维向量可以包括对应于从与对象相关联的不同可植入电极配置获得的各自的第一导电特性的尺寸。处理器电路还可以被配置为获得第二多维向量或向量空间。第二多维向量或向量空间可以包括对应于从与相同或不同对象相关联的这种不同电极配置获得的各自的第二导电特性的尺寸。处理器电路还可以提供至少部分地通过执行第一多维向量与第二多维向量空间或向量的向量比较来获得的生理状态指示符。

7. 发明公开

EP2793696A1 PHYSIOLOGICAL STATUS INDICATOR APPARATUS AND METHOD 有权
标题翻译： DEVICE FOR生理状态
公开(公告)号：EP2793696A1
公开(公告)日：2014-10-29
申请号：EP12818859.6
申请日：2012-12-21
申请人： Cardiac Pacemakers, Inc.
发明人： THAKUR, Pramodsingh, Hirasingh , HATLESTAD, John, D. , WARIAR, Ramesh , AVERINA, Viktoria, A. , SWANSON, Lynne E.
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/686 , A61B5/72
摘要： A processor circuit can be configured to obtain a first multidimensional vector. The first multidimensional vector can include dimensions corresponding to respective first conductivity characteristics obtained from different implantable electrode configurations associated with a subject. The processor circuit can also be configured to obtain a second multidimensional vector or vector space. The second multidimensional vector or vector space can include dimensions corresponding to respective second conductivity characteristics obtained from such different electrode configurations associated with the same or a different subject. The processor circuit can also provide a physiological status indicator that can be obtained at least in part by performing a vector comparison of the first multidimensional vector to the second multidimensional vector space or vector.

8. 发明授权

EP2793696B1 PHYSIOLOGICAL STATUS INDICATOR APPARATUS 有权
标题翻译： DEVICE FOR生理状态
公开(公告)号：EP2793696B1
公开(公告)日：2016-03-09
申请号：EP12818859.6
申请日：2012-12-21
申请人： Cardiac Pacemakers, Inc.
发明人： THAKUR, Pramodsingh, Hirasingh , HATLESTAD, John, D. , WARIAR, Ramesh , AVERINA, Viktoria, A. , SWANSON, Lynne E.
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61B5/053 , A61B5/686 , A61B5/72

9. 发明公开

EP2956213A1 MEDICAL DEVICE FOR ALGORITHM ADAPTATION TO AN EXTERNAL IMPACT ON THE DATA 有权
标题翻译：医疗设备，算法独立调节与外部接触到数据
公开(公告)号：EP2956213A1
公开(公告)日：2015-12-23
申请号：EP14707047.8
申请日：2014-02-11
申请人： Cardiac Pacemakers, Inc.
发明人： AVERINA, Viktoria, A. , THAKUR, Pramodsingh Hirasingh , ZHANG, Yi , AN, Qi
IPC分类号： A61N1/362 , A61B5/046
CPC分类号： A61B5/7221 , A61B5/02055 , A61B5/0452 , A61B5/4839 , A61B5/686 , A61B5/7278 , A61B2560/0276 , A61N1/3627
摘要： Devices and methods for detecting a physiological target event such as events indicative of HF decompensation status are described. An ambulatory medical device is configured to determine the presence and timing of a confounding event, segment a sensed physiological signal into at least two data segments, adjust the physiological signal by removing or lessening the impact of the confounding event on the physiological signal. The adjusted data can be presented to the user, and the ambulatory medical device can detect the target events using the adjusted physiologic signal. In some embodiments, the ambulatory medical device can be configured to detect an event indicative of HF decompensation using a physiological signal and the information of the detected confounding event.
摘要翻译：装置和方法检测生理目标事件：如指示的HF失代偿状态事件描述。一个移动医疗设备被配置为确定矿混杂事件，段检测到的生理信号的存在和定时成至少两个数据段，通过去除或减轻混杂事件对生理信号的影响调节生理信号。调整过的数据可以被呈现给用户，而移动医疗设备可以检测使用调整后的生理信号中的目标的事件。在一些实施例中，移动医疗设备可以被配置在指示使用生理信号和所述检测到的事件混杂的信息HF失代偿的事件来检测。

10. 发明公开

EP2459064A1 MEDICAL DEVICE FOR TREATING HEART FAILURE THROUGH BLOOD VOLUME REDISTRIBUTION 审中-公开
标题翻译：医疗设备，治疗心脏衰竭的再分配血容量
公开(公告)号：EP2459064A1
公开(公告)日：2012-06-06
申请号：EP10742340.2
申请日：2010-07-26
申请人： Cardiac Pacemakers, Inc.
发明人： AVERINA, Viktoria, A. , HAMANN, Jason, J. , RUBLE, Stephen , SHUROS, Allan, C.
IPC分类号： A61B5/08 , A61B5/053
CPC分类号： A61N1/3601 , A61B5/0537 , A61B5/0538 , A61B5/0809 , A61B5/4035 , A61B5/4869 , A61N1/36114 , A61N1/36521 , A61N1/36585
摘要： A first fluid status indicator of a pulmonary fluid status associated with pulmonary edema and a second fluid status indicator of a non-pulmonary fluid status can be used to provide an alert or to control a therapy for pulmonary edema. Additionally, intermittent cardiac blood volume redistribution therapy can be used to provide cardiac conditioning in heart failure patients.

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