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1. 发明授权

US5804366A Method and apparatus for sodding microvessel cells onto a synthetic vascular graft 失效
标题翻译：将微血管细胞浸泡在合成血管移植物上的方法和装置
公开(公告)号：US5804366A
公开(公告)日：1998-09-08
申请号：US386048
申请日：1995-02-09
申请人： Can B. Hu , Minh T. Ma , Than Nguyen , Richard Rhee , Keith Myers
发明人： Can B. Hu , Minh T. Ma , Than Nguyen , Richard Rhee , Keith Myers
IPC分类号： A61F2/06 , A61L27/50 , C12N5/08 , C12M3/08
CPC分类号： A61F2/062 , A61L27/507 , Y10S623/921
摘要： An apparatus for sodding onto the inner lumenal surface of a synthetic graft of harvested and concentrated microvessel endothelial cells from liposuctioned fat tissues, which harvested cells are formed into a "pellet" of isolated endothelial cells in loose aggregations, includes a sodding tube having a single rigid outer wall bounding a sodding chamber. A filter pack assembly is provided to communicate the pellet of cells from a processing vessel to the graft. This filter pack assembly includes a series of successively finer filter members cooperatively defining a series of turbulent-flow chambers in which aggregations of cells too large to pass through a particular filter are exposed to liquid flow turbulence which is effective to break up the aggregations. A check valve assembly ensures that liquid flow is unidirectional so that sodding of the cells onto the inner lumenal surface of the graft is not interfered with by possible liquid reflux, and sodded cells are similarly not dislodged from the graft by such liquid reflux.
摘要翻译：将收集的细胞收集和浓缩的微血管内皮细胞的合成移植物的内腔表面上的沉淀物形成为松散聚集的分离的内皮细胞的“沉淀”的装置，包括具有单个刚性外墙围住了一个饮料室。提供过滤器组件以将细胞团从处理容器传递到移植物。该过滤器组件包括一系列相继更细的过滤器构件，其协作地限定一系列湍流室，其中太大而不能通过特定过滤器的单元的聚集物暴露于有效破坏聚集的液体流动湍流。止回阀组件确保液体流动是单向的，使得细胞在移植物的内腔表面上的唾液分解不会被可能的液体回流干扰，并且经过这种液体回流的同样，细胞也不会从移植物移出。

2. 发明授权

US5409833A Microvessel cell isolation apparatus 失效
标题翻译：微血管细胞分离装置
公开(公告)号：US5409833A
公开(公告)日：1995-04-25
申请号：US86778
申请日：1993-07-01
申请人： Can B. Hu , Minh T. Ma , Than Nguyen , Richard Rhee , Keith Myers
发明人： Can B. Hu , Minh T. Ma , Than Nguyen , Richard Rhee , Keith Myers
IPC分类号： A61F2/06 , C12M3/00 , C12M3/08 , C12M1/42
CPC分类号： C12M45/09 , A61F2/062 , C12M45/05 , A61M2202/08 , A61M2202/097
摘要： A processing vessel for isolating microvessel endothelial cells from liposuctioned fat tissues includes a fat-receiving basket defined by polyester screen material. Fat tissue removed from a patient by liposuction is received into the basket and is rinsed and digested with an enzymatic solution. The freed microvessel endothelial cells from the fat tissues are separated from the fat cells, and from blood cells and other materials which may be present in the basket by centrifuging. A bottom chamber of the processing vessel is configured to define a "pellet" of isolated endothelial cells which may be removed from the processing vessel for deposition on the inner lumenal surface of a synthetic graft which the fat-donor patient is to receive.
摘要翻译：用于从脂肪抽吸的脂肪组织分离微血管内皮细胞的处理容器包括由聚酯筛网材料限定的脂肪接收篮。通过吸脂从患者中取出的脂肪组织被接收到篮中，并用酶溶液冲洗和消化。来自脂肪组织的释放的微血管内皮细胞从脂肪细胞以及血细胞和其它可能通过离心存在于筐中的物质中分离出来。处理容器的底部室被配置为限定分离的内皮细胞的“沉淀”，其可以从处理容器中移除，以沉积在供体患者将要接收的合成移植物的内腔表面上。

3. 发明授权

US06231601B1 Method of surgery including adjusting the shape of an implement handle 有权
标题翻译：手术方法包括调整工具手柄的形状
公开(公告)号：US06231601B1
公开(公告)日：2001-05-15
申请号：US09468715
申请日：1999-12-21
申请人： Keith Myers , Ross Bartholomew , Robert J. Todd , Carl Swindle , Charles Weyrauch , Richard Rhee , Jane Li , Jerry Jackman , Victor Packham
发明人： Keith Myers , Ross Bartholomew , Robert J. Todd , Carl Swindle , Charles Weyrauch , Richard Rhee , Jane Li , Jerry Jackman , Victor Packham
IPC分类号： A47F1306
CPC分类号： A61F2/2466
摘要： A method of surgery including bending a multi-purpose surgical implement handle that has proximal and distal ends. A gripping section is located toward the proximal end, and an attachment section is located toward the distal end. An adjusting section is interposed between the gripping section and the attachment section. The adjusting section may be bent by a human user at virtually any discrete location along the section. The adjusting section may include an increased-adjustability portion which is easier to bend than other portions of the adjusting section. The method includes attaching a surgical implement to the attaching section of the handle, and bending the adjusting section at least once prior to inserting the implement through a surgical opening to a surgical field. The method further may include bending the adjusting section more than once to form multiple bends therein.
摘要翻译：一种手术方法，包括弯曲具有近端和远端的多用途外科手术器具手柄。抓握部分朝向近端定位，并且附接部分朝向远端定位。调整部分夹在夹持部分和附接部分之间。调整部分可以由人类用户在实际上沿着该部分的任何离散位置弯曲。调节部可以包括比调节部的其他部分更容易弯曲的增加调节部。该方法包括将手术器械附接到手柄的附接部分，并且在将工具通过手术开口插入外科手术区域之前，将调节部分弯曲至少一次。该方法还可以包括多次弯曲调节部分以在其中形成多个弯曲部。

4. 发明授权

US6162172A Methods and apparatus for retracting tissue 失效
标题翻译：回收组织的方法和装置
公开(公告)号：US6162172A
公开(公告)日：2000-12-19
申请号：US16489
申请日：1998-01-30
申请人： Delos M. Cosgrove , Norma L. Lowe , Keith Myers , Richard Rhee
发明人： Delos M. Cosgrove , Norma L. Lowe , Keith Myers , Richard Rhee
IPC分类号： A61B17/00 , A61B17/02 , A61B19/00
CPC分类号： A61B17/0293 , A61B2017/00243 , A61B2090/306
摘要： Surgical apparatus and associated methods of use are provided for retracting tissue around an incision. The apparatus includes a member having an inner peripheral surface and an outer peripheral surface. An adjustable aperture is definable within the inner peripheral surface as the member is adjusted between a compressed condition in which the aperture is substantially closed and an expanded condition in which the aperture is substantially open. The apparatus is positioned within a surgical incision in the compressed condition, and is adjusted to the expanded condition in situ to define an opening within the incision through the aperture whereby a surgical field may be viewed and/or accessed.
摘要翻译：提供手术设备和相关联的使用方法用于缩回切口周围的组织。该装置包括具有内周面和外周面的部件。当孔被基本上封闭的压缩状态和开口基本上打开的扩张状态之间调节构件时，在内周表面内可定义可调节孔。该装置位于处于压缩状态的手术切口内，并且在原位调整到扩张状态，以在切口内通过孔限定开口，从而可以观察和/或访问外科视野。

5. 发明授权

US6004329A Shape-adjustable surgical implement handle 失效
标题翻译：形状可调外科手柄
公开(公告)号：US6004329A
公开(公告)日：1999-12-21
申请号：US31789
申请日：1998-02-27
申请人： Keith Myers , Ross Bartholomew , Robert J. Todd , Carl Swindle , Charles Weyrauch , Richard Rhee , Jane Li , Jerry Jackman , Victor Packham
发明人： Keith Myers , Ross Bartholomew , Robert J. Todd , Carl Swindle , Charles Weyrauch , Richard Rhee , Jane Li , Jerry Jackman , Victor Packham
IPC分类号： A61F2/24 , A47F13/06 , A61B17/00 , A61F11/00
CPC分类号： A61F2/2427 , A61B2017/0046 , A61B2017/00946
摘要： A multi-purpose surgical implement handle has proximal and distal ends. A gripping section is located toward the proximal end, and an attachment section is located toward the distal end. An adjusting section is interposed between the gripping section and the attachment section. The adjusting section may be bent by a human user at virtually any discrete location along the section. The adjusting section may include an increased-adjustability portion which is easier to bend than other portions of the adjusting section.
摘要翻译：多功能手术器具手柄具有近端和远端。抓握部分朝向近端定位，并且附接部分朝向远端定位。调整部分夹在夹持部分和附接部分之间。调整部分可以由人类用户在实际上沿着该部分的任何离散位置弯曲。调节部可以包括比调节部的其他部分更容易弯曲的增加调节部。

6. 发明申请

US20060015002A1 Shape memory devices and methods for reshaping heart anatomy 有权
公开(公告)号：US20060015002A1
公开(公告)日：2006-01-19
申请号：US11142078
申请日：2005-05-31
申请人： Shahram Moaddeb , Samuel Shaolian , Emanuel Shaoulian , Richard Rhee , Steven Anderson
发明人： Shahram Moaddeb , Samuel Shaolian , Emanuel Shaoulian , Richard Rhee , Steven Anderson
IPC分类号： A61F2/00
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.

7. 发明申请

US20050182487A1 Three-dimensional annuloplasty ring and template 有权
标题翻译：三维瓣膜成形术环和模板
公开(公告)号：US20050182487A1
公开(公告)日：2005-08-18
申请号：US11106421
申请日：2005-04-14
申请人： Patrick McCarthy , Richard Rhee , Stefan Schreck
发明人： Patrick McCarthy , Richard Rhee , Stefan Schreck
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2448 , A61F2/2466 , A61F2230/0091 , A61F2250/0029 , A61F2250/0036 , A61F2250/0037 , Y10S623/90
摘要： An annuloplasty ring having a three-dimensional discontinuous form generally arranged about an axis with two free ends that are axially offset. The ring is particularly suited for repair of the tricuspid valve, and more closely conforms to the annulus shape. The ring is more flexible in bending about radially extending axes than about the central axis. The ring may have an inner structural support covered by a pliable sleeve and/or a fabric tube. The structural support may have a varying cross-section, such as a C-shaped cross-section in a mid-section between two free ends and a rectangular cross-section at the free ends. A deliver template having a mounting ring with about the same shape as the ring facilitates implant, and may be releasably attached to a delivery handle. The deliver template may include a plurality of cutting guides for releasably attaching the annuloplasty ring thereto while presenting maximum outer surface area of the ring. The template may have an outwardly-facing groove to receive and retain the ring.
摘要翻译：具有三维不连续形状的瓣环成形术环通常围绕具有轴向偏移的两个自由端的轴线布置。该环特别适用于修复三尖瓣，并且更接近于环形。环绕径向延伸的轴弯曲比围绕中心轴更弯曲。环可以具有由柔韧的套筒和/或织物管覆盖的内部结构支撑。结构支撑件可以具有变化的横截面，例如两个自由端之间的中间部分中的C形横截面和在自由端处的矩形横截面。具有与环具有大致相同形状的安装环的输送模板便于植入，并且可以可释放地附接到递送手柄。递送模板可以包括多个切割引导件，用于可释放地将瓣环成形术环附接到其上，同时具有环的最大外表面面积。模板可以具有向外的凹槽以接收和保持环。

8. 发明申请

US20050171601A1 Minimally-invasive annuloplasty repair segment delivery system 有权
标题翻译：微创瓣膜成形术修复段递送系统
公开(公告)号：US20050171601A1
公开(公告)日：2005-08-04
申请号：US11095982
申请日：2005-03-30
申请人： Delos Cosgrove , Stefan Schreck , Richard Rhee
发明人： Delos Cosgrove , Stefan Schreck , Richard Rhee
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2466
摘要： An annuloplasty repair segment and template for heart valve annulus repair. The elongate flexible template may form a distal part of a holder that also has a proximal handle. Alternatively, the template may be releasably attached to a mandrel that slides within a delivery sheath, the template being released from the end of the sheath to enable manipulation by a surgeon. A tether connecting the template and mandrel may also be provided. The template may be elastic, temperature responsive, or multiple linked segments. The template may be aligned with the handle and form a two- or three-dimensional curve out of alignment with the handle such that the annuloplasty repair segment attached thereto conforms to the curve. The template may be actively or passively converted between its straight and curved positions. The combined holder and ring is especially suited for minimally-invasive surgeries in which the combination is delivered to an implantation site through a small access incision with or without a cannula, or through a catheter passed though the patient's vasculature.
摘要翻译：用于心脏瓣膜环修复的瓣膜成形术修复部分和模板。细长的柔性模板可以形成也具有近端手柄的保持器的远端部分。或者，模板可以可释放地附接到在输送护套内滑动的心轴，模板从护套的端部释放以允许外科医生进行操纵。还可以提供连接模板和心轴的系绳。模板可以是弹性的，温度敏感的或多个链接的段。模板可以与手柄对准并且形成与手柄对准的二维或三维曲线，使得附接到其上的瓣膜成形术修复段符合曲线。模板可以在其直线位置和弯曲位置之间被主动地或被动地转换。组合的保持器和环特别适用于微创手术，其中组合通过具有或不具有插管的小切口切口或通过穿过患者脉管系统的导管递送至植入部位。

9. 发明申请

US20070067027A1 Left atrial balloon catheter 审中-公开
标题翻译：左心房球囊导管
公开(公告)号：US20070067027A1
公开(公告)日：2007-03-22
申请号：US11520981
申请日：2006-09-13
申请人： Shahram Moaddeb , Richard Rhee , Steve Anderson
发明人： Shahram Moaddeb , Richard Rhee , Steve Anderson
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2466 , A61F2250/0004
摘要： Systems, methods and devices are provided for activation of an adjustable annuloplasty device. The devices may include a catheter system for percutaneously activating an adjustable annuloplasty device, including a handle assembly, a shaft assembly having at least one fluid lumen, and a distal element. The shaft assembly extends between the handle assembly and the distal element, the distal element being in fluid communication with the handle assembly via the at least one fluid lumen. The distal element includes an elongated core having a first port and an expandable member. The core extends through the expandable member and the expandable member is movable between a collapsed position and an inflated position. The distal element has a preset shape in the inflated position, having a long axis that is curvilinear. A surface of the distal element extends along the long axis and is configured to conform to a curvilinear surface of the annuloplasty device. In some arrangements, the annuloplasty device includes a ring, and the circumference of the annuloplasty device is a circumference of the ring.
摘要翻译：提供了用于激活可调节瓣环成形术装置的系统，方法和装置。装置可以包括用于经皮激活可调节瓣环成形术装置的导管系统，包括手柄组件，具有至少一个流体腔的轴组件和远端元件。轴组件在手柄组件和远侧元件之间延伸，远端元件通过至少一个流体腔与手柄组件流体连通。远侧元件包括具有第一端口和可扩张构件的细长芯。芯延伸穿过可膨胀构件，并且可膨胀构件可在折叠位置和膨胀位置之间移动。远侧元件在充气位置具有预设的形状，具有曲线的长轴。远侧元件的表面沿着长轴延伸并且构造成符合瓣环成形术装置的曲线表面。在一些布置中，瓣环成形术装置包括环，并且瓣环成形术装置的圆周是环的圆周。

10. 发明申请

US20060015003A1 Magnetic devices and methods for reshaping heart anatomy 失效
标题翻译：用于重塑心脏解剖的磁性装置和方法
公开(公告)号：US20060015003A1
公开(公告)日：2006-01-19
申请号：US11142127
申请日：2005-05-31
申请人： Shahram Moaddes , Samuel Shaolian , Emanuel Shaoulian , Richard Rhee , Steven Anderson
发明人： Shahram Moaddes , Samuel Shaolian , Emanuel Shaoulian , Richard Rhee , Steven Anderson
IPC分类号： A61N2/10 , A61F2/02 , A61B17/34
CPC分类号： A61F2/2481 , A61B17/3468 , A61B2017/00876 , A61F2/2478 , A61F2/2487 , A61F2002/249 , A61F2210/009 , A61N2/00
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用磁力重塑心脏解剖结构治疗的心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。使用一个或多个植入心脏组织内或附着在心脏外表面和/或内部的磁性元件施加磁力。磁力的各种电荷相互作用，使相关的心脏组织区域重新调整位置，例如减小心室的宽度。这种重新定位通过磁性元件的力量随着时间的推移而保持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

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