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1. 发明申请

US20060015002A1 Shape memory devices and methods for reshaping heart anatomy 有权
公开(公告)号：US20060015002A1
公开(公告)日：2006-01-19
申请号：US11142078
申请日：2005-05-31
申请人： Shahram Moaddeb , Samuel Shaolian , Emanuel Shaoulian , Richard Rhee , Steven Anderson
发明人： Shahram Moaddeb , Samuel Shaolian , Emanuel Shaoulian , Richard Rhee , Steven Anderson
IPC分类号： A61F2/00
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.

2. 发明申请

US20080039681A1 SHAPE MEMORY DEVICES AND METHODS FOR RESHAPING HEART ANATOMY 失效
标题翻译：形状记忆装置和用于重建心脏解剖的方法
公开(公告)号：US20080039681A1
公开(公告)日：2008-02-14
申请号：US11876586
申请日：2007-10-22
申请人： Shahram Moaddeb , Samuel Shaolian , Emanuel Shaoulian , Richard Rhee , Steven Anderson
发明人： Shahram Moaddeb , Samuel Shaolian , Emanuel Shaoulian , Richard Rhee , Steven Anderson
IPC分类号： A61F2/02
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。形状记忆元件具有原始形状和至少一种存储器形状。当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。元件然后被激活以从原始形状转换到至少一个存储器形状之一。元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

3. 发明申请

US20060015178A1 Implants and methods for reshaping heart valves 审中-公开
标题翻译：用于重塑心脏瓣膜的植入物和方法
公开(公告)号：US20060015178A1
公开(公告)日：2006-01-19
申请号：US11181686
申请日：2005-07-14
申请人： Shahram Moaddeb , Emanuel Shaoulian , Samuel Shaolian , Michael Henson , Richard Rhee , Steven Anderson
发明人： Shahram Moaddeb , Emanuel Shaoulian , Samuel Shaolian , Michael Henson , Richard Rhee , Steven Anderson
IPC分类号： A61F2/24
CPC分类号： A61F2/2442 , A61B17/3468 , A61B2017/00243 , A61F2/2451 , A61F2002/249 , A61F2210/0076
摘要： Tissue shaping methods and devices are provided for reinforcing and/or remodeling heart valves. In certain embodiments, magnetic tissue shaping devices are implanted in tissue adjacent heart valve leaflets. The devices are mutually attractive or repulsive so as to remodel the heart tissue and improve heart valve function. In certain other embodiments, one or more tissue shaping devices including shape memory material are implanted in a patient's body within or on tissue adjacent a heart valve leaflet. The shape memory material can be activated within the patient in a less invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. The shape memory tissue shaping devices are implanted in a first configuration and then activated to remember a second configuration that displaces tissue so as to remodel the heart valve geometry and improve heart valve function. In certain other embodiments, a brace is crimped to the base of a heart valve leaflet to support the leaflet and improve valve closure.
摘要翻译：提供组织成形方法和装置用于加强和/或改造心脏瓣膜。在某些实施例中，将磁组织成形装置植入在心脏瓣膜小叶附近的组织中。这些装置是相互吸引或排斥的，以便改造心脏组织并改善心脏瓣膜功能。在某些其他实施例中，包括形状记忆材料的一个或多个组织成形装置植入在心脏瓣膜附近的组织内或组织附近的患者体内。形状记忆材料可以以较少侵入性或非侵入性方式在患者体内被激活，例如通过经皮或外部施加能量到患者身体。形状记忆组织成形装置以第一配置植入，然后被激活以记住置换组织的第二配置，以便改造心脏瓣膜几何形状并改善心脏瓣膜功能。在某些其他实施例中，支架卷曲到心脏瓣膜小叶的底部以支撑小叶并改善瓣膜关闭。

4. 发明申请

US20050288780A1 Adjustable cardiac valve implant with selective dimensional adjustment 有权
标题翻译：可调心脏瓣膜植入物，具有选择性尺寸调整
公开(公告)号：US20050288780A1
公开(公告)日：2005-12-29
申请号：US11124405
申请日：2005-05-06
申请人： Richard Rhee , Emanuel Shaoulian , Shahram Moaddeb , Samuel Shaolian
发明人： Richard Rhee , Emanuel Shaoulian , Shahram Moaddeb , Samuel Shaolian
IPC分类号： A61F2/00 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have, a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，装置包括前部，后部和对应于前部和后部的交叉点的两个侧部。这些装置具有第一配置中的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。该变换被配置为减小前部和后部之间的距离，而基本上不减小两个侧部之间的距离。

5. 发明申请

US20070055368A1 Slotted annuloplasty ring 审中-公开
标题翻译：开槽瓣环成形术环
公开(公告)号：US20070055368A1
公开(公告)日：2007-03-08
申请号：US11514292
申请日：2006-08-31
申请人： Richard Rhee , Emanuel Shaoulian , Shahram Moaddeb , Samuel Shaolian
发明人： Richard Rhee , Emanuel Shaoulian , Shahram Moaddeb , Samuel Shaolian
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2250/0001 , A61F2250/0004
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices comprise a shape memory material, and further include a body member and an insert member. The body member has a circumference and a slot that extends at least partially along the circumference of the body. The insert member extends at least partially along the circumference of the body. The device has a first shape in a first configuration and a second shape in a second configuration, and is configured to transform from a first configuration to a second configuration in response to a first activation energy applied thereto.
摘要翻译：提供了用于支撑身体结构的方法和装置。这些装置可以以微创或非侵入性的方式在患者身体内进行调节，例如通过经皮或外部给患者身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，装置包括形状记忆材料，并且还包括主体构件和插入构件。主体构件具有至少部分地沿主体的圆周延伸的圆周和狭槽。插入构件至少部分地沿身体的圆周延伸。该装置具有第一配置中的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的第一激活能量而从第一配置变换到第二配置。

6. 发明申请

US20050288777A1 Thermal conductor for adjustable cardiac valve implant 审中-公开
标题翻译：可调节心脏瓣膜植入物的导热体
公开(公告)号：US20050288777A1
公开(公告)日：2005-12-29
申请号：US11123852
申请日：2005-05-06
申请人： Richard Rhee , Emanuel Shaoulian , Shahram Moaddeb , Samuel Shaolian
发明人： Richard Rhee , Emanuel Shaoulian , Shahram Moaddeb , Samuel Shaolian
IPC分类号： A61F2/00 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a body member including a shape memory material. The shape memory material is configured to transform from a first shape to a second shape in response to being heated. The devices also include a thermally insulative material at least partially covering the body member and a thermally conductive material extending into the thermally insulative material. The thermally conductive material is configured to communicate thermal energy to the body member.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，装置包括包括形状记忆材料的主体构件。形状记忆材料被配置为响应于被加热而从第一形状转变成第二形状。这些装置还包括至少部分地覆盖主体构件的热绝缘材料和延伸到绝热材料中的导热材料。导热材料构造成将热能传递到主体部件。

7. 发明申请

US20060015003A1 Magnetic devices and methods for reshaping heart anatomy 失效
标题翻译：用于重塑心脏解剖的磁性装置和方法
公开(公告)号：US20060015003A1
公开(公告)日：2006-01-19
申请号：US11142127
申请日：2005-05-31
申请人： Shahram Moaddes , Samuel Shaolian , Emanuel Shaoulian , Richard Rhee , Steven Anderson
发明人： Shahram Moaddes , Samuel Shaolian , Emanuel Shaoulian , Richard Rhee , Steven Anderson
IPC分类号： A61N2/10 , A61F2/02 , A61B17/34
CPC分类号： A61F2/2481 , A61B17/3468 , A61B2017/00876 , A61F2/2478 , A61F2/2487 , A61F2002/249 , A61F2210/009 , A61N2/00
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用磁力重塑心脏解剖结构治疗的心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。使用一个或多个植入心脏组织内或附着在心脏外表面和/或内部的磁性元件施加磁力。磁力的各种电荷相互作用，使相关的心脏组织区域重新调整位置，例如减小心室的宽度。这种重新定位通过磁性元件的力量随着时间的推移而保持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

8. 发明申请

US20080183285A1 ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT 审中-公开
标题翻译：可调节心脏瓣膜植入物，具有选择性的尺寸调整
公开(公告)号：US20080183285A1
公开(公告)日：2008-07-31
申请号：US12031652
申请日：2008-02-14
申请人： Emanuel Shaoulian , Samuel Shaolian , Shahram Moaddeb , Richard S. Rhee
发明人： Emanuel Shaoulian , Samuel Shaolian , Shahram Moaddeb , Richard S. Rhee
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2448 , A61F2210/0014 , A61F2210/0023 , A61F2210/009 , A61F2250/0001 , A61F2250/0004
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion more than a distance between the two lateral portions.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，装置包括前部，后部和对应于前部和后部的交叉点的两个侧部。这些装置具有第一配置的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。该变换被配置为减小前部和后部之间的距离超过两个侧向部分之间的距离。

9. 发明申请

US20050288776A1 Adjustable cardiac valve implant with coupling mechanism 有权
标题翻译：可调节心脏瓣膜植入物与联接机构
公开(公告)号：US20050288776A1
公开(公告)日：2005-12-29
申请号：US11123851
申请日：2005-05-06
申请人： Emanuel Shaoulian , Samuel Shaolian , Shahram Moaddeb
发明人： Emanuel Shaoulian , Samuel Shaolian , Shahram Moaddeb
IPC分类号： A61F2/00 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a tubular member configured to be attached to or near a cardiac valve annulus. The tubular member includes a receptacle end and an insert end configured to couple with the receptacle end of the tubular member such that the tubular member substantially forms a shape of a ring. The insert end is configured to move with respect to the receptacle end to change a circumference of the ring.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，这些装置包括构造成附接到心脏瓣膜环上或附近的管状构件。管状构件包括容置端和插入端，所述插入端构造成与管状构件的容置端相连，使得管状构件基本上形成环的形状。插入端构造成相对于插座端移动以改变环的圆周。

10. 发明申请

US20080051840A1 METHODS AND SYSTEMS FOR CARDIAC REMODELING VIA RESYNCHRONIZATION 有权
标题翻译：通过再次心脏再造的方法和系统
公开(公告)号：US20080051840A1
公开(公告)日：2008-02-28
申请号：US11773311
申请日：2007-07-03
申请人： Shahram Moaddeb , Samuel Shaolian , Emanuel Shaoulian
发明人： Shahram Moaddeb , Samuel Shaolian , Emanuel Shaoulian
IPC分类号： A61N1/368
CPC分类号： A61N1/3627
摘要： Systems, methods and devices are provided for improving the hemodynamic efficiency of a patient's heart by implanting one or more reinforcement elements on or with the heart and providing electrical stimulation to the heart. The reinforcement elements may include magnetic and/or shape memory material and are configured to reshape the heart so as to boost the heart's mechanical energy during a response to the electrical stimulation. In some embodiments, at least one reinforcement element includes an electrode configured to sense electrocardiogram signals within the heart. An electrical stimulation device such as an implantable or external pacemaker/defibrillator may be configured to control delivery of electrical pulses to the heart based on the sensed electrocardiogram signals. In addition, or in other embodiments, at least one reinforcement element includes an electrode configured to deliver the electrical pulses to the heart.
摘要翻译：提供了系统，方法和装置，用于通过在心脏上或与心脏一起植入一个或多个增强元件并向心脏提供电刺激来改善患者心脏的血液动力学效率。加强元件可以包括磁性和/或形状的记忆材料，并且被配置成重塑心脏，以便在对电刺激的响应期间增强心脏的机械能。在一些实施例中，至少一个加强元件包括被配置为感测心脏内的心电图信号的电极。诸如植入式或外部起搏器/除颤器之类的电刺激装置可以被配置成基于感测到的心电图信号来控制向心脏的电脉冲的传递。另外或在其它实施例中，至少一个加强元件包括被配置为将电脉冲传送到心脏的电极。

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