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1. 发明申请

WO2005047526A2 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO2005047526A2
公开(公告)日：2005-05-26
申请号：PCT/GB2004004762
申请日：2004-11-12
申请人： CYCLACEL LTD , MCINNES CAMPBELL , MCLACHLAN JANICE , MEZNA MOKDAD , FISCHER PETER
发明人： MCINNES CAMPBELL , MCLACHLAN JANICE , MEZNA MOKDAD , FISCHER PETER
IPC分类号： C07D311/22 , C07D417/04 , C07D473/16 , C07D491/16 , C07D493/06 , C07K14/47 , C12N9/12 , C12Q1/48 , G06F17/50 , C12Q1/00
CPC分类号： C07D493/06 , C07D311/22 , C07D417/04 , C07D473/16 , C07K2299/00 , C12N9/1205 , G01N2333/9121 , G01N2500/02 , Y02A90/24 , Y02A90/26
摘要： The present invention relates to a homology model for PLK, and the use thereof in assays for the indentification of small molecule PLK modulators. The invention further relates to PLK modulators identified by said assays, and their use in the treatment of PLK-related disorders such as proliferative disorders.
摘要翻译：本发明涉及PLK的同源性模型，以及其在小分子PLK调节剂识别测定中的应用。本发明还涉及通过所述测定鉴定的PLK调节剂及其在治疗PLK相关疾病如增殖性疾病中的用途。

2. 发明申请

WO2005052147A3 METHOD OF SCREENING FOR A MODULATOR OF CDK4 审中-公开
标题翻译： CDK4调节剂筛选方法
公开(公告)号：WO2005052147A3
公开(公告)日：2005-11-24
申请号：PCT/GB2004004793
申请日：2004-11-11
申请人： CYCLACEL LTD , MCINNES CAMPBELL , THOMAS MARK , WANG SHUDONG , MCLACHLAN JANICE , MEADES CHRISTOPHER , KONTOPIDIS GEORGE , WOOD GAVIN , FISCHER PETER
发明人： MCINNES CAMPBELL , THOMAS MARK , WANG SHUDONG , MCLACHLAN JANICE , MEADES CHRISTOPHER , KONTOPIDIS GEORGE , WOOD GAVIN , FISCHER PETER
IPC分类号： C12N9/12 , C12Q1/48 , G06F19/00 , G06F19/16
CPC分类号： C12N9/1205 , C12Q1/485 , C40B30/02 , G01N2500/04 , G06F19/16 , G06F19/706 , Y02A90/24 , Y02A90/26
摘要： The present invention relates to a homology model for CDK4, and the use thereof in assays for the identification of small molecule CDK4 modulators. The invention further relates to CDK4 modulators identified by said assays, and their use in the treatment of CDK4-related disorders such as proliferative disorders.
摘要翻译：本发明涉及CDK4的同源性模型，以及其用于鉴定小分子CDK4调节剂的测定中的用途。本发明还涉及通过所述测定法鉴定的CDK4调节剂及其在治疗CDK4相关疾病如增殖性疾病中的用途。

3. 发明申请

WO2005116025A3 2-SUBSTITUTED-4-HETEROARYL-PYRIMIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗增殖性疾病的2-取代-4-异氟尿嘧啶
公开(公告)号：WO2005116025A3
公开(公告)日：2006-02-23
申请号：PCT/GB2005002134
申请日：2005-05-26
申请人： CYCLACEL LTD , WANG SHUDONG , WOOD GAVIN , DUNCAN KENNETH , MEADES CHRISTOPHER , GIBSON DARRON , MCLACHLAN JANICE , FISCHER PETER
发明人： WANG SHUDONG , WOOD GAVIN , DUNCAN KENNETH , MEADES CHRISTOPHER , GIBSON DARRON , MCLACHLAN JANICE , FISCHER PETER
IPC分类号： C07D417/00 , C07D417/04 , C07D417/14 , A61K31/505
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention relates to selected substituted pyrimidines their preparation, pharmaceutical compositions containing them and their use as inhibitors of one or more protein kinases, and hence their use in the treatment of proliferative disorders, viral disorders and/or other disorders.
摘要翻译：本发明涉及其制备的选择性取代的嘧啶，含有它们的药物组合物及其作为一种或多种蛋白激酶的抑制剂的用途，因此涉及其用于治疗增殖性病症，病毒性疾病和/或其它疾病。

4. 发明申请

WO2007042786A3 4 -HETEROARYL PYRIMIDINE DERIVATIVES AND USE THEREOF AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译： 4 -HETEROARYL PYRIMIDINE衍生物及其作为蛋白激酶抑制剂的用途
公开(公告)号：WO2007042786A3
公开(公告)日：2007-06-07
申请号：PCT/GB2006003751
申请日：2006-10-09
申请人： CYCLACEL LTD , WOOD GAVIN , MEADES CHRISTOPHER KEITH , FISCHER PETER , WANG SHUDONG , DUNCAN KENNETH , ZHELEVA DANIELLA , MCINNES CAMPBELL , THOMAS MARK
发明人： WOOD GAVIN , MEADES CHRISTOPHER KEITH , FISCHER PETER , WANG SHUDONG , DUNCAN KENNETH , ZHELEVA DANIELLA , MCINNES CAMPBELL , THOMAS MARK
IPC分类号： A61K31/506 , A61P29/00 , A61P31/12 , A61P35/00 , C07D401/14 , C07D403/04
CPC分类号： C07D401/14 , C07D403/04
摘要： The present invention relates to compounds of formula (I) or formula (II), or pharmaceutically acceptable salts thereof. Further aspects relate to pharmaceutical compositions comprising compounds according to the invention, and the use of said compounds in the preparation of a medicament for treating a variety of disorders, including proliferative disorders, viral disorders, stroke, etc.
摘要翻译：本发明涉及式（I）或式（II）化合物或其药学上可接受的盐。其它方面涉及包含根据本发明的化合物的药物组合物，以及所述化合物在制备用于治疗各种疾病（包括增殖性病症，病毒性疾病，中风等）的药物中的用途。

5. 发明申请

WO2004016613A3 PURINE DERIVATIVES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS 审中-公开
标题翻译：嘌呤衍生物及其作为抗增殖剂的用途
公开(公告)号：WO2004016613A3
公开(公告)日：2004-04-08
申请号：PCT/GB0303544
申请日：2003-08-13
申请人： CYCLACEL LTD , FISCHER PETER , JARMAN MICHAEL , MCDONALD EDWARD , NUTLEY BERNARD , RAYNAUD FLORENCE , WILSON STUART , WORKMAN PAUL
发明人： FISCHER PETER , JARMAN MICHAEL , MCDONALD EDWARD , NUTLEY BERNARD , RAYNAUD FLORENCE , WILSON STUART , WORKMAN PAUL
IPC分类号： A61P3/10 , A61P9/00 , A61P17/06 , A61P17/14 , A61P25/28 , A61P31/12 , A61P35/00 , A61P35/02 , C07D473/16 , A61K31/52
CPC分类号： C07D473/16
摘要： The present invention relates to compounds of formula (1) or pharmaceutically acceptable salts thereof, wherein one of R and R is methyl, ethyl or isopropyl, and the other is H; R and R are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R and R is other than H; R is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R , R , R and R are each independently H, halogen, N02, OH, OMe, CN, NH2, COOH, CONH2, or S02NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula (1), and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.
摘要翻译：本发明涉及式（1）化合物或其药学上可接受的盐，其中R 1和R 2中的一个是甲基，乙基或异丙基，另一个是H; R 3和R 4各自独立地为H，支链或无支链的C 1 -C 6烷基或芳基，并且其中R 3和R 4中的至少一个不是H; R 5是支链或无支链的C 1 -C 5烷基或C 1 -C 6环烷基，其各自可任选被一个或多个OH基团取代; R 6，R 7，R 8和R 9各自独立地为H，卤素，NO 2，OH，OMe，CN，NH 2，COOH，CONH 2或SO 2 NH 2。本发明的另一方面涉及包含式（1）化合物的药物组合物，以及所述化合物在治疗增殖性病症，病毒病症，CNS病症，糖尿病，中风，脱发或神经变性病症中的用途。

6. 发明申请

WO2005075468A3 PYRIDINYL - OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY 审中-公开
标题翻译：吡啶基或吡啶甲基噻唑类化合物与蛋白激酶抑制活性
公开(公告)号：WO2005075468A3
公开(公告)日：2005-10-13
申请号：PCT/GB2005000405
申请日：2005-02-07
申请人： CYCLACEL LTD , DUNCAN KENNETH , GIBSON DARREN , WANG SHUDONG , ZHELEVA DANIELLA , FISCHER PETER
发明人： DUNCAN KENNETH , GIBSON DARREN , WANG SHUDONG , ZHELEVA DANIELLA , FISCHER PETER
IPC分类号： C07D417/04 , C07D417/14 , A61K31/506
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salts thereof, wherein: Z :1 is N or CH; ;Z and Z are each independently N or CR ; :R , R , R , R , R , R , and R are each independently H, R , or R ; each R is independently a hydrocarbyl group; and each R is independently halo, NO2, alkoxy, CN, CF3, S03H, SO2NR R , S02R , NR R (CH2)aCOOR , (CH2)bCONR R , (CH2)C COR or (CH2)dOH; a, b, c and d are each independently 0, 1 2 3 or 4; are each independently H or alkyl; provided that when R and R are both H, Z is CH; or Z is N; or Z is CH and Z is N; and wherein the compound is other than 4-(4,5-dimethylthiazol-2-yl)-N-(3,4,5trimethoxyphenyl)-2-pyrimidineamine or 4-(5-(2-hydroxyethyl)-4-methylthiazol-2-yl)N-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine. Further aspects relate to the use of compounds of formula (I) in the preparation of a medicament for treating one or more disorders selected from a proliferative disorder, a viral disorder, a CNS disorder, diabetes, stroke or alopecia.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中：Z 1：N是N或CH; ; Z 2和Z 3各自独立地为N或CR 7; R 1，R 2，R 3，R 4，R 5，R 6和R 7各自独立地为H，R 8或R 9 >; 每个R 8独立地为烃基; 且各R 9独立地为卤素，NO 2，烷氧基，CN，CF 3，SO 3 H，SO 2 NR 10 R 11，SO 2 R 12，NR 13 R 14（CH 2）a COOR 15，（CH 2）b CONR 16 R 17，（CH 2）C COR 18或（CH 2）d OH; a，b，c和d各自独立地为0,1,2 3或4; R 10-18各自独立地为H或烷基; 条件是当R 1和R 2都是H时，Z 1是CH; 或Z 2是N; 或Z 1是CH且Z 2是N; 并且其中所述化合物不是4-（4,5-二甲基噻唑-2-基）-N-（3,4,5-三甲氧基苯基）-2-嘧啶胺或4-（5-（2-羟基乙基）-4-甲基噻唑吡啶-2-基）-N-（3,4,5-三甲氧基苯基）-2-嘧啶胺。其它方面涉及式（I）化合物在制备用于治疗选自增殖性病症，病毒性病症，CNS病症，糖尿病，中风或脱发的一种或多种病症的药物中的用途。

7. 发明申请

WO2004016612A3 NEW PURINE DERIVATIVES 审中-公开
标题翻译：新的嘌呤衍生物
公开(公告)号：WO2004016612A3
公开(公告)日：2004-07-01
申请号：PCT/GB0303554
申请日：2003-08-13
申请人： CYCLACEL LTD , FISCHER PETER , JARMAN MICHAEL , MCDONALD EDWARD , NUTLEY BERNARD , RAYNAUD FLORENCE , WILSON STUART , WORKMAN PAUL
发明人： FISCHER PETER , JARMAN MICHAEL , MCDONALD EDWARD , NUTLEY BERNARD , RAYNAUD FLORENCE , WILSON STUART , WORKMAN PAUL
IPC分类号： A61K31/52 , A61P3/10 , A61P9/00 , A61P17/06 , A61P17/14 , A61P25/28 , A61P31/12 , A61P35/00 , C07D473/16 , C07D473/00
CPC分类号： C07D473/16 , A61K31/52
摘要： The present invention relates to compounds of formula (1) or pharmaceutically acceptable salts thereof, wherein one of R and R is methyl, ethyl or isopropyl, and the other is H; R and R are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R and R is other than H; R is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R , R , R and R are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula (1), and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.
摘要翻译：本发明涉及式（1）化合物或其药学上可接受的盐，其中R 1和R 2中的一个是甲基，乙基或异丙基，另一个是H; R 3和R 4各自独立地为H，支链或无支链的C 1 -C 6烷基或芳基，并且其中R 3和R 4中的至少一个不是H; R 5是支链或无支链的C 1 -C 5烷基或C 1 -C 6环烷基，其各自可任选被一个或多个OH基团取代; R 6，R 7，R 8和R 9各自独立地为H，卤素，NO 2，OH，OMe，CN，NH 2，COOH，CONH 2或SO 2 NH 2。本发明的另一方面涉及包含式（1）化合物的药物组合物，以及所述化合物在治疗增殖性病症，病毒性病症，中风，脱发，CNS病症，神经变性病症或糖尿病中的用途。

8. 发明授权

US1051835A Harrow-folding device. 失效
标题翻译： HARROW折叠装置。
公开(公告)号：US1051835A
公开(公告)日：1913-01-28
申请号：US1911654300
申请日：1911-10-12
申请人： ANDREW KIRSCH , FISCHER PETER
发明人： FISCHER PETER
CPC分类号： A01B73/044

9. 发明申请

WO2013026577A3 POSITION-SENSITIVE DETECTOR FOR DETECTING PHOTON OR PARTICLE DISTRIBUTIONS 审中-公开
标题翻译：用于检测光子或粒子分布的局部灵敏检测器
公开(公告)号：WO2013026577A3
公开(公告)日：2013-05-10
申请号：PCT/EP2012003581
申请日：2012-08-23
申请人： UNIV RUPRECHT KARLS HEIDELBERG , FISCHER PETER
发明人： FISCHER PETER
IPC分类号： G01T1/164 , G01T1/20 , G01T1/24
CPC分类号： G01T1/17 , G01T1/1642 , G01T1/2006 , G01T1/2018 , G01T1/248
摘要： The invention relates to a position-sensitive detector for detecting photon or particle distributions, wherein the detector receiving surface (1) is formed by a plurality of detector cells (2) from individual detector elements that are connected to a plurality of readout channels (5). The assignment of the detector cells (2) to the readout channels (5) is chosen in such a way that a position of a focal point of a photon or particle distribution impinging on the detector receiving surface (1) can be determined locally from signals of the readout channels (5). The detector enables a high spatial resolution with a small number of readout channels.
摘要翻译：本发明涉及一种用于检测光子或粒子分布的位置敏感检测器，其中，所述检测器由多个检测器单元（2）的被单独的检测器元件，其被连接到多个读出通道的形成接收表面（1）（5）。探测器单元（2）连接到读出通道（5）的分配以这样一种方式从读出信道的信号（5）的质心的在检测器上接收表面的位置（1）入射的光子或粒子可以在本地确定被选择。该检测器允许具有少量读出通道的高空间分辨率。

10. 发明申请

WO9824227A3 Configuration for a telemeasurable and/or remote-controllable installation 审中-公开
标题翻译：安排到远程可测量和/或调节fersteuerbaren
公开(公告)号：WO9824227A3
公开(公告)日：1998-07-23
申请号：PCT/EP9706567
申请日：1997-11-25
申请人： ELECTROWATT TECH INNOVAT CORP , FISCHER PETER , FOGG ANDREW
发明人： FISCHER PETER , FOGG ANDREW
IPC分类号： H04L9/00
CPC分类号： H04L9/32 , H04L2209/42 , H04L2209/80
摘要： The invention relates to a configuration for an installation (10) which can be telemeasured and/or remote controlled from a station (8), comprising an interface unit (1), a module (5) connected to the interface unit (1) and at least one measuring device (11). The interface unit (1) enabling bi-directional transfer of digital data between the interface unit (1) and the station (8) that can be reached by a cellular telecommunications network (3) has means making it possible to transfer digital data in packets via the cellular telecommunications network (3). The interface unit also comprises means allowing data to be divided up into several data units (bursts) and to be interleaved, wherein the interleaving depth is at least two but smaller than or equal to nine.

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