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1. 发明申请

WO2005052147A3 METHOD OF SCREENING FOR A MODULATOR OF CDK4 审中-公开
标题翻译： CDK4调节剂筛选方法
公开(公告)号：WO2005052147A3
公开(公告)日：2005-11-24
申请号：PCT/GB2004004793
申请日：2004-11-11
申请人： CYCLACEL LTD , MCINNES CAMPBELL , THOMAS MARK , WANG SHUDONG , MCLACHLAN JANICE , MEADES CHRISTOPHER , KONTOPIDIS GEORGE , WOOD GAVIN , FISCHER PETER
发明人： MCINNES CAMPBELL , THOMAS MARK , WANG SHUDONG , MCLACHLAN JANICE , MEADES CHRISTOPHER , KONTOPIDIS GEORGE , WOOD GAVIN , FISCHER PETER
IPC分类号： C12N9/12 , C12Q1/48 , G06F19/00 , G06F19/16
CPC分类号： C12N9/1205 , C12Q1/485 , C40B30/02 , G01N2500/04 , G06F19/16 , G06F19/706 , Y02A90/24 , Y02A90/26
摘要： The present invention relates to a homology model for CDK4, and the use thereof in assays for the identification of small molecule CDK4 modulators. The invention further relates to CDK4 modulators identified by said assays, and their use in the treatment of CDK4-related disorders such as proliferative disorders.
摘要翻译：本发明涉及CDK4的同源性模型，以及其用于鉴定小分子CDK4调节剂的测定中的用途。本发明还涉及通过所述测定法鉴定的CDK4调节剂及其在治疗CDK4相关疾病如增殖性疾病中的用途。

2. 发明申请

WO2005116025A3 2-SUBSTITUTED-4-HETEROARYL-PYRIMIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗增殖性疾病的2-取代-4-异氟尿嘧啶
公开(公告)号：WO2005116025A3
公开(公告)日：2006-02-23
申请号：PCT/GB2005002134
申请日：2005-05-26
申请人： CYCLACEL LTD , WANG SHUDONG , WOOD GAVIN , DUNCAN KENNETH , MEADES CHRISTOPHER , GIBSON DARRON , MCLACHLAN JANICE , FISCHER PETER
发明人： WANG SHUDONG , WOOD GAVIN , DUNCAN KENNETH , MEADES CHRISTOPHER , GIBSON DARRON , MCLACHLAN JANICE , FISCHER PETER
IPC分类号： C07D417/00 , C07D417/04 , C07D417/14 , A61K31/505
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention relates to selected substituted pyrimidines their preparation, pharmaceutical compositions containing them and their use as inhibitors of one or more protein kinases, and hence their use in the treatment of proliferative disorders, viral disorders and/or other disorders.
摘要翻译：本发明涉及其制备的选择性取代的嘧啶，含有它们的药物组合物及其作为一种或多种蛋白激酶的抑制剂的用途，因此涉及其用于治疗增殖性病症，病毒性疾病和/或其它疾病。

3. 发明专利

CY1106933T1 ΕΝΩΣΕΙΣ ΠΥΡΙΜΙΔΙΝΗΣ 未知
公开(公告)号：CY1106933T1
公开(公告)日：2012-09-26
申请号：CY071101326
申请日：2007-10-15
申请人： CYCLACEL LTD
发明人： WANG SHUDONG , MEADES CHRISTOPHER , WOOD GAVIN , O'BOYLE JANICE , MCINNES CAMPBELL , FISCHER PETER
IPC分类号： C07D417/04 , A61K31/506 , A61K31/513 , A61P35/00
摘要： Ηπαρούσαεφεύρεσησχετίζεταιμευποκατεστημένεςπυριμιδίνεςτουτύπου (Ι), μετηνπαρασκευήτους, μεφαρμακευτικάσκευάσματαπουτιςπεριέχουνκαιμετηχρήσητουςωςαναστολέωνεξαρτώμενωναπόκυκλίνηκινασών (CDK) καισυνεπώςμετηχρήσητουςστηθεραπείαδιαταραχώντουκυτταρικούπολλαπλασιασμούκαι/ήιικώνδιαταραχών.

4. 发明专利

NZ539670A Pyrimidine compounds 未知
公开(公告)号：NZ539670A
公开(公告)日：2007-11-30
申请号：NZ53967003
申请日：2003-11-14
申请人： CYCLACEL LTD
发明人： WANG SHUDONG , MEADES CHRISTOPHER , WOOD GAVIN , O'BOYLE JANICE , MCINNES CAMPBELL , FISCHER PETER
IPC分类号： A61K31/506 , A61K31/513 , A61P35/00 , C07D417/04
摘要： Disclosed are substituted pyrimidines of formula (Ib), their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders and/or viral disorders.

5. 发明专利

DE60217140D1 未知
公开(公告)号：DE60217140D1
公开(公告)日：2007-02-08
申请号：DE60217140
申请日：2002-09-27
申请人： CYCLACEL LTD
发明人： WANG SHUDONG , MEADES CHRISTOPHER , WOOD GAVIN , OSNOWSKI ANDREW , FISCHER PETER MARTIN
IPC分类号： C07D417/04 , A61K31/506 , A61P17/06 , A61P35/00 , A61P35/02 , A61P43/00

6. 发明专利

BRPI0412351A 未知
公开(公告)号：BRPI0412351A
公开(公告)日：2006-09-05
申请号：BRPI0412351
申请日：2004-07-30
申请人： CYCLACEL LTD
发明人： WANG SHUDONG , MEADES CHRISTOPHER , GIBSON DARREN , FISCHER PETER
IPC分类号： C07D417/14 , A61K31/506

7. 发明专利

CA2542880A1 PYRIMIDIN-4-YL-3, 4-THIONE COMPOUNDS AND THEIR USE IN THERAPY 未知
公开(公告)号：CA2542880A1
公开(公告)日：2005-05-12
申请号：CA2542880
申请日：2004-10-21
申请人： CYCLACEL LTD
发明人： ZHELEVA DANIELLA I , BLAKE DAVID , PERRY ALEX , WANG SHUDONG , GIBSON DARREN , MEADES CHRISTOPHER , DUNCAN KENNETH W , WOOD GAVIN , MCLACHLAN JANICE C , FISCHER PETER M
IPC分类号： C07D417/14 , A61K31/506 , C07D417/04
摘要： The present invention relates to compounds of formula I, or pharmaceutically acceptable salts thereof, wherein R1 and R5 are each independently H, C(ORj′) or a hydrocarbyl group optionally substituted by one or more R6 groups; R2, R3, and R4 are each independently H, alkyl or alkenyl, each of which may be optionally substituted with one or more R7 groups; R6 and R7 are each independently halogen, NO2, CN, (CH2)mORa, O(CH2)nORb, (CH2)pNRcRd, CF3, COORe, CONRfRg, CORh, SO3H, SO2Ri, SO2NRjRk, (CH2)qNRa′CORg′, Rf′, (CH2)rNRb′SO2Rh′, SO2NRd′Ri′, SO2NRe′(CH2)sORc′, heterocycloalkyl or heteroaryl, wherein said heterocycloalkyl and heteroaryl may be optionally substituted by one or more substituents selected from aralkyl, sulfonyl, Rm and CORn; Rg′, Rh′, Ri′ and Rj′ are each independently selected from alkyl, aryl, aralkyl and heteroaryl, each of which may be optionally substituted with one or more substituents selected from halogen, OH, NO2, NH2 CF3 and COOH; m, p, q and r are each independently 0, 1, 2 or 3; n and s are each independently 1, 2, or 3; and Ra-n and Ra′-f′ are each independently H or alkyl. Further aspects of the invention relate to pharmaceutical compositions comprising such compounds, and their use in the preparation of a medicament for treating one or more of the following: a proliferative disorder, a viral disorder, a CNS disorder, a stroke, alopecia and diabetes.

8. 发明专利

ES2293094T3 COMPUESTOS DE PIRIMIDINA. 未知
公开(公告)号：ES2293094T3
公开(公告)日：2008-03-16
申请号：ES03811029
申请日：2003-11-14
申请人： CYCLACEL LTD
发明人： WANG SHUDONG , MEADES CHRISTOPHER , WOOD GAVIN , O'BOYLE JANICE , MCINNES CAMPBELL , FISCHER PETER
IPC分类号： C07D417/04 , A61K31/506 , A61K31/513 , A61P35/00
摘要： Compuesto de fórmula Ib, o una sal aceptable farmacéuticamente del mismo, (Ver fórmula) en la que uno de X 1 y X 2 es S, y el otro de X 1 y X 2 es N; en la que: Z es NH, NHCO, NHSO2, NHCH2, CH2, CH2CH2, CH=CH, SO2 o SO; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 y R 8 son cada uno independientemente H, alquilo, arilo, aralquilo, halógeno, NO 2, CN, OH, O-alquilo, O-arilo, NH2, NH-alquilo, NH-arilo, N-(alquilo)2, N-(arilo)2, N-(alquil)(arilo), COOH, CONH2, CONH-alquilo, CONH-arilo, SO3H, SO2-alquilo, SO2-arilo, SO2NH2, CF3, CO-alquilo, CO-arilo o R 11 , en la que los grupos alquilo, arilo, aralquilo se pueden sustituir además con uno o más grupos seleccionados de entre halógeno, NO 2, OH, O-metilo, NH 2, COOH, CONH 2 y CF 3; en la que por lo menos uno de R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 y R 8 es R 11 ; en la que cada uno de R 11 es Y, en la que Y es un grupo alicíclico que comprende una o más de las funciones -O-, NH 2, -NH-, =N- y en la que Y se sustituye opcionalmente por uno o más sustituyentes seleccionados de entre: - SO2-alquilo; - alquilo sustituido opcionalmente por uno o más grupos OH; - CO-alquilo; - aralquilo; - COO-alquilo; y - un grupo éter sustituido opcionalmente por uno o más grupos OH.

9. 发明专利

DE602004006379T2 未知
公开(公告)号：DE602004006379T2
公开(公告)日：2008-01-10
申请号：DE602004006379
申请日：2004-01-27
申请人： CYCLACEL LTD
发明人： MCINNES CAMPBELL , MEADES CHRISTOPHER , MEZNA MOKDAD , FISCHER PETER
IPC分类号： A61K31/428 , A61P35/00 , C07D277/68
摘要： The present invention relates to the use of a compound of formula I, or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , and R 4 are each independently H, NO 2 , CF 3 , SCF 3 , CN, halo, OH, OR 6 , NH 2 , NHR 6 , NR 6 R 7 , N + R 6 R 7 R 8 , COOH, COOR 6 , CONH 2 , CONHR 6 , CONR 6 R 7 , COH, COR 6 , SR 6 , SOR 6 , SO 2 R 6 , SO 2 OH, SO 2 OR 6 , SO 2 NH 2 , SO 2 NHR 6 , SO 2 NR 6 R 7 , alkyl, cycloalkyl, cycloheteroalkyl, aryl, or heteroaryl, with the proviso that at least one of R 1 , R 2 , R 3 , and R 4 is other than H; or R 1 and R 2 , R 2 and R 3 , or R 3 and R 4 , may together form part of a fused or unfused saturated or unsaturated ring system, optionally containing up to two heteroatoms selected from N, O, and S; R 5 is OH, OR 9 , CN, CONH 2 , CONHNH 2 , CONHOH, CONHR 9 , CONR 9 R 10 , NH 2 , NHR 9 , or NR 9 R 10 ; each R 6 , R 7 and R 8 is independently hydrocarbyl, or two of R 6 , R 7 and R 8 together form part of a saturated or unsaturated ring system, optionally containing up to two heteroatoms selected from N, O, and S; each R 9 and R 10 is independently hydrocarbyl, or R 9 and R 10 together form part of a saturated or unsaturated ring system, optionally containing up to two heteroatoms selected from N, O, and S; in the preparation of a medicament for treating a proliferative disorder.

10. 发明专利

AT373653T 未知
公开(公告)号：AT373653T
公开(公告)日：2007-10-15
申请号：AT03811029
申请日：2003-11-14
申请人： CYCLACEL LTD
发明人： WANG SHUDONG , MEADES CHRISTOPHER , WOOD GAVIN , O'BOYLE JANICE , MCINNES CAMPBELL , FISCHER PETER
IPC分类号： C07D417/04 , A61K31/506 , A61K31/513 , A61P35/00

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