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1. 发明申请

US20190240656A1 WELL PLATE DRIER AND COVER 审中-公开
公开(公告)号：US20190240656A1
公开(公告)日：2019-08-08
申请号：US16263030
申请日：2019-01-31
申请人： Covaris, Inc.
发明人： Diana Sim , Daniel Edward Zimmerman , Paulina Kocjan , Todd Anthony Basque , James A. Laugharn, JR.
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , B01L3/50851 , B01L2300/042 , B01L2300/0829
摘要： Apparatus and method for removing liquid from exterior surfaces of sample wells in a well plate. Wells that have water or other liquid on an exterior surface, e.g., after acoustic energy treatment in a water bath, may have the liquid removed by contacting the exterior surfaces of the sample wells with an absorbent material. A pad made of absorbent material may have a plurality of openings arranged to receive an array of sample wells inserted into the openings so that liquid can be removed from each of the sample wells.

2. 发明申请

US20170283788A1 EXTRACTION OF cfDNA FROM BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：US20170283788A1
公开(公告)日：2017-10-05
申请号：US15473672
申请日：2017-03-30
申请人： Covaris, Inc.
发明人： Hamid Khoja , Hans-Ulrich Thomann , James A. Laugharn, JR.
IPC分类号： C12N15/10 , C12N13/00
摘要： Focused acoustic treatment of samples including a target biomolecule, such as cfDNA, may aid in the recovery of the biomolecule from a sample. cfDNA in a sample, whether chemically stabilized or not, may be linked or otherwise bound to histones or other proteins, e.g., by hydrogen bonds of histones or chaperone proteins to DNA and/or covalent crosslinks of such proteins to the DNA. Focused acoustic energy may remove or disrupt such links, aiding in isolation of the cfDNA from the sample.

3. 发明申请

US20190144855A1 FOCUSED ACOUSTICS MEDIATED NUCLEIC ACID LIGATION 审中-公开
公开(公告)号：US20190144855A1
公开(公告)日：2019-05-16
申请号：US16182740
申请日：2018-11-07
申请人： Covaris, Inc.
发明人： Lauren E. Jansen , Hans-Ulrich Thomann , Eugenio Daviso , James A. Laugharn, JR.
IPC分类号： C12N15/10 , C12P19/34
摘要： System and method for enhancing ligation of nucleic acid portions using focused acoustic energy.

4. 发明申请

US20190002944A1 ACOUSTIC ENERGY MEDIATION OF GENETIC FRAGMENTATION 审中-公开
公开(公告)号：US20190002944A1
公开(公告)日：2019-01-03
申请号：US16122176
申请日：2018-09-05
申请人： Covaris, Inc.
发明人： James A. Laugharn, JR. , Hamid KHOJA
IPC分类号： C12P19/34 , G01N1/28 , B01F13/00 , B01F11/02 , C12Q1/6806
摘要： Method and apparatus for controlling acoustic treatment of a sample to mediate a tagmentation process used on double stranded DNA.

5. 发明申请

US20150079655A1 METHOD AND APPARATUS FOR PROCESSING SAMPLE MATERIAL 有权
标题翻译：处理样品的方法和装置
公开(公告)号：US20150079655A1
公开(公告)日：2015-03-19
申请号：US14028771
申请日：2013-09-17
申请人： Covaris, Inc.
发明人： James A. Laugharn, JR. , Xiaoyin He , Srikanth Kakumanu
IPC分类号： B01D43/00 , A61L2/10 , C12N13/00 , G01N1/34 , G01N1/38
CPC分类号： B01D43/00 , A61L2/10 , B01L7/00 , B01L2200/147 , B01L2300/0681 , B01L2300/0832 , B01L2400/0436 , B01L2400/0439 , C12N13/00 , G01N1/34 , G01N1/38
摘要： Methods and systems for treating material with focused acoustic energy and/or ultraviolet radiation are described. Sample material may be provided to a single batch vessel or may flow in a continuous or intermittent fashion into/out of a processing chamber within which the material is exposed to focused acoustic energy and/or ultraviolet radiation. Exposure to focused acoustics in a flow through environment may enhance the effects of the radiation on the sample material. Further, in flow-through or single batch arrangements, sample material may be retained exterior to or within a processing chamber by one or more retaining members (e.g., filter, valve, etc.) until a characteristic of the sample material reaches one or more particular criteria (e.g., physical, chemical, biological). Once the criteria of the sample material is attained (e.g., via further treatment), the material is then permitted to flow past the retaining member(s) and through the inlet or outlet of the chamber. Further, focused acoustic processing may be used to treat articles, such as the retaining member(s), rather than only sample material located within an internal processing volume of the chamber.
摘要翻译：描述了用聚焦声能和/或紫外线辐射处理材料的方法和系统。样品材料可以提供给单个批量容器，或者可以以连续或间歇的方式流入/离开处理室，在该处理室内材料暴露于聚焦的声能和/或紫外线辐射。在流过环境中暴露于聚焦声学可能会增强辐射对样品材料的影响。此外，在流通或单批次布置中，样品材料可以通过一个或多个保持构件（例如，过滤器，阀等）保持在处理室的外部或内部，直到样品材料的特性达到一个或多个特定标准（如物理，化学，生物学）。一旦获得样品材料的标准（例如通过进一步处理），则允许材料流过保持构件并通过腔室的入口或出口。此外，聚焦声学处理可以用于处理诸如保持构件的制品，而不仅仅是位于室的内部处理容积内的样品材料。

6. 发明申请

US20130177922A1 METHODS AND APPARATUS FOR TREATING SAMPLES WITH ACOUSTIC ENERGY 审中-公开
标题翻译：用声学能量处理样品的方法和装置
公开(公告)号：US20130177922A1
公开(公告)日：2013-07-11
申请号：US13711807
申请日：2012-12-12
申请人： Covaris, Inc.
发明人： James A. Laugharn, JR. , Brevard S. Garrison , Douglas A. Yates
IPC分类号： G01N1/28
CPC分类号： C12Q1/6806 , B01F11/0283 , B01F2215/0454 , B01J2219/00486 , B01L99/00 , C01B25/327 , G01N1/28 , G01N1/286 , G01N2001/2866 , G01N2035/00554 , Y10T436/25
摘要： This invention relates to systems and methods for applying acoustic energy to a sample. According to one aspect of the invention, a system comprises a housing, a chamber for receiving the sample, an acoustic energy source for providing a focused acoustic field to the sample according to a treatment protocol, a processor for determining the treatment protocol, a sensor for detecting information about the sample, and a user interface for communicating with a user.
摘要翻译：本发明涉及向样品施加声能的系统和方法。根据本发明的一个方面，一种系统包括壳体，用于接收样品的腔室，用于根据治疗方案向样品提供聚焦声场的声能源，用于确定治疗方案的处理器，传感器用于检测关于样本的信息，以及用于与用户通信的用户界面。

7. 发明申请

US20160186126A1 ACOUSTIC ENERGY TREATMENT USING PHASE CHANGE COUPLANT 审中-公开
标题翻译：使用相位变化耦合的声学能量治疗
公开(公告)号：US20160186126A1
公开(公告)日：2016-06-30
申请号：US14970969
申请日：2015-12-16
申请人： Covaris, Inc.
发明人： James A. Laugharn, JR.
IPC分类号： C12N1/06 , C12N13/00
CPC分类号： C12N1/066 , C12M45/02 , C12M47/06 , C12N13/00
摘要： Method and apparatus for transmitting acoustic energy to a sample for treatment by employing a phase change couplant at least adjacent a sample vessel. The phase change couplant may be solid before and after treatment, but liquid during treatment to improve acoustic energy transmission charactersitics.
摘要翻译：用于通过使用至少相邻于样品容器的相变耦合剂将声能传递到样品进行处理的方法和装置。相变耦合剂在处理前后可能是固体，而在处理过程中液体可以改善声能传播特性。

8. 发明申请

US20150166979A1 METHOD AND APPARATUS FOR HEADSPACE CONTROL IN ACOUSTIC PROCESSING OF SAMPLES 有权
标题翻译：方法和装置在样本的声学处理中的头部控制
公开(公告)号：US20150166979A1
公开(公告)日：2015-06-18
申请号：US14634042
申请日：2015-02-27
申请人： Covaris, Inc.
发明人： James A. Laugharn, JR.
IPC分类号： C12N13/00
CPC分类号： C12N13/00 , B01F11/0283 , B01J2219/00308 , B01J2219/00344 , B01J2219/00486 , B01J2219/00722 , B01J2219/0074 , G01N1/286 , G01N2035/00554
摘要： Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace size at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using a headspace control element positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.
摘要翻译：用于控制包括液体的样品的声学处理的方法和装置。可以例如通过定位合适的元件来控制样品进行声学处理的处理体积，以减少和/或消除样品/气体界面处的顶空尺寸。可以例如通过使用至少部分定位在样品中的顶空控制元件来控制声能和样品之间的相互作用，所述顶空控制元件有助于减少否则会发生的飞溅或其它样品喷射。

9. 发明申请

US20130244285A1 METHOD AND SYSTEM FOR ACOUSTICALLY TREATING MATERIAL 有权
标题翻译：用于声处理材料的方法和系统
公开(公告)号：US20130244285A1
公开(公告)日：2013-09-19
申请号：US13891554
申请日：2013-05-10
申请人： COVARIS, INC.
发明人： James A. Laugharn, JR. , Carl Beckett , Xiaoyin He
IPC分类号： C12N13/00 , A61L2/025
CPC分类号： B01J19/10 , A61L2/025 , B01F3/08 , B01F3/12 , B01F11/02 , B01F11/0283 , B01F2215/0037 , B01J19/006 , B01J19/008 , B01J19/245 , B01J2219/00094 , C12N13/00
摘要： Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window, a heat exchanger, inlet/outlet flow arrangements, an inspection window, insert elements that define a treatment volume size or shape, etc. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.
摘要翻译：使用连续方法来声学处理材料的方法和系统，其中可以使材料以连续或间歇的方式流入/离开材料暴露于聚焦声能的声学处理室。方法和系统可以被布置成允许在较长时间内连续处理，同时声能源以相对高的功率输出操作。治疗室可以包括诸如声窗，热交换器，入口/出口流布置，检查窗，限定治疗体积大小或形状的插入元件等特征。与治疗室相对于治疗室的布置有关的治疗系统构型提供声源和耦合介质，材料流动路径等。

10. 发明申请

US20130160576A1 SAMPLE HOLDER AND METHOD FOR FRAGMENTING SAMPLE MATERIAL 有权
标题翻译：样品保持器和样品样品的方法
公开(公告)号：US20130160576A1
公开(公告)日：2013-06-27
申请号：US13681582
申请日：2012-11-20
申请人： Covaris, Inc.
发明人： James A. Laugharn, JR. , Ion A. Tsinteris
IPC分类号： G01N1/28
CPC分类号： G01N1/28 , G01N1/286 , G01N1/42 , G01N2001/2866
摘要： Method and apparatus for holding and/or treating a sample material. A sample may be positioned in a vessel and a crushing force may be applied to the sample material while in the vessel, e.g., by a plunger that is part of a cap to pulverize the sample at cryogenic temperatures. The sample holder may include an acoustic window arranged to admit acoustic energy into the vessel for acoustic treatment of the sample. A flexible film may be used at a portion of the vessel, e.g., at the acoustic window, to cooperate with a plunger for crushing a sample.
摘要翻译：用于保持和/或处理样品材料的方法和设备。样品可以定位在容器中，并且可以在容器中例如通过作为帽的一部分的柱塞在低温下粉碎样品的样品材料施加破碎力。样品保持器可以包括布置成将声能吸收到容器中以用于对样品进行声学处理的声窗口。可以在容器的一部分，例如在声窗上使用柔性膜，以与用于粉碎样品的柱塞配合。

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