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1. 发明申请

US20150079655A1 METHOD AND APPARATUS FOR PROCESSING SAMPLE MATERIAL 有权
标题翻译：处理样品的方法和装置
公开(公告)号：US20150079655A1
公开(公告)日：2015-03-19
申请号：US14028771
申请日：2013-09-17
申请人： Covaris, Inc.
发明人： James A. Laugharn, JR. , Xiaoyin He , Srikanth Kakumanu
IPC分类号： B01D43/00 , A61L2/10 , C12N13/00 , G01N1/34 , G01N1/38
CPC分类号： B01D43/00 , A61L2/10 , B01L7/00 , B01L2200/147 , B01L2300/0681 , B01L2300/0832 , B01L2400/0436 , B01L2400/0439 , C12N13/00 , G01N1/34 , G01N1/38
摘要： Methods and systems for treating material with focused acoustic energy and/or ultraviolet radiation are described. Sample material may be provided to a single batch vessel or may flow in a continuous or intermittent fashion into/out of a processing chamber within which the material is exposed to focused acoustic energy and/or ultraviolet radiation. Exposure to focused acoustics in a flow through environment may enhance the effects of the radiation on the sample material. Further, in flow-through or single batch arrangements, sample material may be retained exterior to or within a processing chamber by one or more retaining members (e.g., filter, valve, etc.) until a characteristic of the sample material reaches one or more particular criteria (e.g., physical, chemical, biological). Once the criteria of the sample material is attained (e.g., via further treatment), the material is then permitted to flow past the retaining member(s) and through the inlet or outlet of the chamber. Further, focused acoustic processing may be used to treat articles, such as the retaining member(s), rather than only sample material located within an internal processing volume of the chamber.
摘要翻译：描述了用聚焦声能和/或紫外线辐射处理材料的方法和系统。样品材料可以提供给单个批量容器，或者可以以连续或间歇的方式流入/离开处理室，在该处理室内材料暴露于聚焦的声能和/或紫外线辐射。在流过环境中暴露于聚焦声学可能会增强辐射对样品材料的影响。此外，在流通或单批次布置中，样品材料可以通过一个或多个保持构件（例如，过滤器，阀等）保持在处理室的外部或内部，直到样品材料的特性达到一个或多个特定标准（如物理，化学，生物学）。一旦获得样品材料的标准（例如通过进一步处理），则允许材料流过保持构件并通过腔室的入口或出口。此外，聚焦声学处理可以用于处理诸如保持构件的制品，而不仅仅是位于室的内部处理容积内的样品材料。

2. 发明申请

US20160030344A1 COMPOSITIONS INCLUDING APOLIPOPROTEIN AND METHODS USING FOCUSED ACOUSTICS FOR PREPARATION THEREOF 审中-公开
标题翻译：包括APOLIPOPROTEIN的组合物和使用焦点声学的方法进行制备
公开(公告)号：US20160030344A1
公开(公告)日：2016-02-04
申请号：US14817375
申请日：2015-08-04
申请人： Covaris, Inc.
发明人： Carl Beckett , James A. Laugharn, JR. , Srikanth Kakumanu
IPC分类号： A61K9/127 , A61K38/17
CPC分类号： A61K9/1277 , A61K9/127 , A61K38/1709
摘要： The present disclosure relates to a composition that includes an apolipoprotein and a lipid bilayer, and methods and systems for preparing the composition. The apolipoprotein may be incorporated within at least a portion of the lipid bilayer. The lipid bilayer may form a liposome or other suitable carrier for transporting the apolipoprotein. The apolipoprotein incorporated lipid bilayer may provide a suitable delivery vehicle for the apolipoprotein to the body. Compositions of the present disclosure may be formed by exposing a mixture of an apolipoprotein and a lipid formulation to focused acoustic energy which, in some embodiments, may result in a liposome that at least partially encapsulates the apolipoprotein. In some embodiments, apolipoprotein A-V may be incorporated within a liposome, where the apolipoprotein A-V is suitably bioactive, or therapeutic, when delivered to cells and/or into the body of a patient.
摘要翻译：本公开涉及包含载脂蛋白和脂质双层的组合物，以及用于制备组合物的方法和系统。载脂蛋白可以并入脂质双层的至少一部分内。脂质双层可以形成用于转运载脂蛋白的脂质体或其它合适的载体。引入载脂蛋白的脂质双层可以为载体载体提供合适的载体载体。本公开的组合物可以通过将载脂蛋白和脂质制剂的混合物暴露于聚焦的声能来形成，在一些实施方案中，其可以产生至少部分包封载脂蛋白的脂质体。在一些实施方案中，载脂蛋白A-V可以并入脂质体中，其中载体脂蛋白A-V当被递送至患者的细胞和/或进入体内时适当地是生物活性的或治疗性的。

3. 发明授权

US09776149B2 Compositions and methods for preparing nanoformulations and systems for nano-delivery using focused acoustics 有权
公开(公告)号：US09776149B2
公开(公告)日：2017-10-03
申请号：US13724796
申请日：2012-12-21
申请人： Covaris, Inc.
发明人： Carl Beckett , James A. Laugharn, Jr. , Srikanth Kakumanu
IPC分类号： B01J2/18 , B01F11/02 , B01F3/08
CPC分类号： B01F11/0283 , B01F3/0807 , B01F2215/0431 , B01F2215/0454 , B01F2215/0477 , B01J2/18 , B01J2219/00932
摘要： Focused ultrasonic acoustic processing is used to prepare formulations particles ranging between approximately 10 nm and approximately 50 microns (e.g., between 1 micron and 20 microns), or between approximately 10 nm approximately 400 nm (e.g., between 10 nm and 100 nm). Formulations (e.g., nanoformulations) may include a suspension (e.g., nanosuspension), an emulsion (e.g., nanoemulsion) or another small particle system. Formulations may be used as delivery systems for therapeutic agents, e.g., a formulation may include a bioactive agent and a carrier compound such as a surfactant that encapsulates the bioactive agent.

4. 发明申请

US20130155802A1 COMPOSITIONS AND METHODS FOR PREPARING NANOFORMULATIONS AND SYSTEMS FOR NANO-DELIVERY USING FOCUSED ACOUSTICS 有权
标题翻译：使用焦点声学处理纳米交付纳米生成和系统的组合物和方法
公开(公告)号：US20130155802A1
公开(公告)日：2013-06-20
申请号：US13724796
申请日：2012-12-21
申请人： Covaris, Inc.
发明人： Carl Beckett , James A. Laugharn, JR. , Srikanth Kakumanu
IPC分类号： B01F11/02
CPC分类号： B01F11/0283 , B01F3/0807 , B01F2215/0431 , B01F2215/0454 , B01F2215/0477 , B01J2/18 , B01J2219/00932
摘要： Focused ultrasonic acoustic processing is used to prepare formulations particles ranging between approximately 10 nm and approximately 50 microns (e.g., between 1 micron and 20 microns), or between approximately 10 nm approximately 400 nm (e.g., between 10 nm and 100 nm). Formulations (e.g., nanoformulations) may include a suspension (e.g., nanosuspension), an emulsion (e.g., nanoemulsion) or another small particle system. Formulations may be used as delivery systems for therapeutic agents, e.g., a formulation may include a bioactive agent and a carrier compound such as a surfactant that encapsulates the bioactive agent.
摘要翻译：聚焦超音波处理用于制备约10nm至约50微米（例如，1微米至20微米）之间或约10nm约400nm（例如，10nm至100nm）之间的制剂颗粒。制剂（例如，纳米制剂）可以包括悬浮液（例如纳米悬浮液），乳剂（例如纳米乳剂）或另一小颗粒系统。制剂可以用作治疗剂的递送系统，例如，制剂可以包括生物活性剂和载体化合物，例如包封生物活性剂的表面活性剂。

5. 发明授权

US10549213B2 Acoustic energy-based control of particle count in crystallization 有权
公开(公告)号：US10549213B2
公开(公告)日：2020-02-04
申请号：US15902022
申请日：2018-02-22
申请人： Covaris, Inc.
发明人： Carl Beckett , James A. Laugharn, Jr. , Srikanth Kakumanu
IPC分类号： B01D9/00
摘要： Methods and systems for preparing crystalline particle compositions using focused acoustic processing to control a number or count of crystalline particles generated. Peak incident power of focused acoustic energy used to cause primary nucleation kinetics of a solute may be adjusted to adjust the number or count of crystalline particles.

6. 发明授权

US09320995B2 Method and apparatus for processing sample material 有权
标题翻译：样品处理方法及装置
公开(公告)号：US09320995B2
公开(公告)日：2016-04-26
申请号：US14028771
申请日：2013-09-17
申请人： Covaris, Inc.
发明人： James A. Laugharn, Jr. , Xiaoyin He , Srikanth Kakumanu
IPC分类号： B01D43/00 , G01N1/34 , G01N1/38 , C12N13/00 , A61L2/10 , B01L7/00
CPC分类号： B01D43/00 , A61L2/10 , B01L7/00 , B01L2200/147 , B01L2300/0681 , B01L2300/0832 , B01L2400/0436 , B01L2400/0439 , C12N13/00 , G01N1/34 , G01N1/38
摘要： Methods and systems for treating material with focused acoustic energy and/or ultraviolet radiation are described. Sample material may be provided to a single batch vessel or may flow in a continuous or intermittent fashion into/out of a processing chamber within which the material is exposed to focused acoustic energy and/or ultraviolet radiation. Exposure to focused acoustics in a flow through environment may enhance the effects of the radiation on the sample material. Further, in flow-through or single batch arrangements, sample material may be retained exterior to or within a processing chamber by one or more retaining members (e.g., filter, valve, etc.) until a characteristic of the sample material reaches one or more particular criteria (e.g., physical, chemical, biological). Once the criteria of the sample material is attained (e.g., via further treatment), the material is then permitted to flow past the retaining member(s) and through the inlet or outlet of the chamber. Further, focused acoustic processing may be used to treat articles, such as the retaining member(s), rather than only sample material located within an internal processing volume of the chamber.
摘要翻译：描述了用聚焦声能和/或紫外线辐射处理材料的方法和系统。样品材料可以提供给单个批量容器，或者可以以连续或间歇的方式流入/离开处理室，在该处理室内材料暴露于聚焦的声能和/或紫外线辐射。在流过环境中暴露于聚焦声学可能会增强辐射对样品材料的影响。此外，在流通或单批次布置中，样品材料可以通过一个或多个保持构件（例如，过滤器，阀等）保持在处理室的外部或内部，直到样品材料的特性达到一个或多个特定标准（如物理，化学，生物学）。一旦获得样品材料的标准（例如通过进一步处理），则允许材料流过保持构件并通过腔室的入口或出口。此外，聚焦声学处理可以用于处理诸如保持构件的制品，而不仅仅是位于室的内部处理容积内的样品材料。

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