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1. 发明申请

WO2006048458A2 MICROBIAL STRAINS PRODUCING SPHINGOID BASES OR DERIVATIVES THEREOF 审中-公开
标题翻译：产生闪锌矿基的微生物菌株或其衍生物
公开(公告)号：WO2006048458A2
公开(公告)日：2006-05-11
申请号：PCT/EP2005055791
申请日：2005-11-07
申请人： COSMOFERM BV , VAN DEN BERG MARCO ALEXANDER , SCHAFFER STEFFEN
发明人： VAN DEN BERG MARCO ALEXANDER , SCHAFFER STEFFEN
CPC分类号： C12P13/001 , C12P13/02
摘要： The present invention provides microbial strains, in particular yeast strains, that produce at least 0.1 mg per g biomass dry weight of a sphingoid base. The present invention further provides a method to obtain sphingoid base-producing microbial strains comprising incubating a population of microbial cells in the presence of a suitable concentration of a toxin, selecting cells that are resistant against said toxin, and isolating cells out of the toxin- resistant cell population that produce at least 0.1 mg per g biomass dry weight of the sphingoid base of Formula (I). Optionally, the method further comprises subjecting a population of toxin-resistant microbial cells that produce at least 0.1 mg per g biomass dry weight of the sphingoid base of Formula (I) to DNA-mediated transformation with a polynucleotide encoding an enzyme of the sphingolipid metabolic pathway. The present invention further provides a polypeptide having dihydroceramide desaturase activity obtainable form Pichia ciferrii.
摘要翻译：本发明提供了产生至少0.1mg / g生物质干重的鞘氨醇碱的微生物菌株，特别是酵母菌株。本发明进一步提供了获得产鞘氨醇碱微生物菌株的方法，包括在合适浓度的毒素存在下孵育微生物细胞群，选择对所述毒素具有抗性的细胞，以及从毒素 - （I）的类鞘氨醇碱基产生至少0.1mg / g生物质干重的抗性细胞群。任选地，所述方法进一步包括使产生至少0.1mg / g生物质干重的式（I）鞘氨基醇碱基的抗毒素微生物细胞群体与编码鞘脂类代谢酶的多核苷酸的DNA介导的转化途径。本发明进一步提供了可从毕赤酵母获得的具有二氢神经酰胺去饱和酶活性的多肽。

2. 发明申请

WO2011157573A3 AN ENZYME FOR THE PREPARATION OF METHYLMALONATE SEMIALDEHYDE 审中-公开
标题翻译： AN酶甲基丙二酸二乙酯生产
公开(公告)号：WO2011157573A3
公开(公告)日：2012-04-26
申请号：PCT/EP2011059178
申请日：2011-06-03
申请人： EVONIK ROEHM GMBH , POETTER MARKUS , MARX ACHIM , SCHAFFER STEFFEN , REINECKE LIV , HAAS THOMAS
发明人： POETTER MARKUS , MARX ACHIM , SCHAFFER STEFFEN , REINECKE LIV , HAAS THOMAS
IPC分类号： C12N9/02 , C12N5/10
CPC分类号： C12P7/62 , C12N9/001
摘要： The subject matter of the invention is an enzyme for the preparation of methylmalonate semialdehyde or malonate semialdehyde, nucleic acids comprising coding sequences for this enzyme, cells which have been transformed with these nucleic acids, and the use of this enzyme.
摘要翻译：本发明是一种用于生产甲基丙或丙二酸半醛，核酸，其包含编码这种酶的序列，这些核酸，如使用这种酶的转化细胞的酶。

3. 发明申请

WO2011061032A3 CELLS, NUCLEIC ACIDS, ENZYMES, AND USE THEREOF, AND METHODS FOR THE PRODUCTION OF SOPHOROLIPIDS 审中-公开
标题翻译：细胞，NUCLEIC，酶及其用途及其制造方法槐糖脂
公开(公告)号：WO2011061032A3
公开(公告)日：2011-09-15
申请号：PCT/EP2010065713
申请日：2010-10-19
申请人： EVONIK DEGUSSA GMBH , SCHAFFER STEFFEN , WESSEL MIRJA , THIESSENHUSEN ANJA
发明人： SCHAFFER STEFFEN , WESSEL MIRJA , THIESSENHUSEN ANJA
IPC分类号： C12N15/10 , A61K31/704 , C07K14/40 , C12P19/44 , C12R1/72
CPC分类号： C12P19/44 , A61K31/704 , C12N9/0071 , C12N9/1029 , C12N9/1051 , C12P19/14
摘要： The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.
摘要翻译：本发明提供了细胞，核酸和酶和它们用于槐糖脂的制备以及方法槐糖脂的制备中使用。

4. 发明申请

WO2010127970A3 METHOD FOR THE PRODUCTION BY FERMENTATION OF (3 -HYDROXY) PROPIONALDEHYDE IN THE PRESENCE OF SEMICARBAZIDE OR CARBOHYDRAZIDE 审中-公开
标题翻译： PROCEDURE用于发酵生产（3-羟基）丙醛在存在或氨基脲肼
公开(公告)号：WO2010127970A3
公开(公告)日：2011-11-10
申请号：PCT/EP2010055683
申请日：2010-04-28
申请人： EVONIK DEGUSSA GMBH , HAAS THOMAS , KLASOVSKY FLORIAN , KRAUTER HENDRIK , SCHAFFER STEFFEN , SCHOEBEL RENE , TACKE THOMAS , VORLOP KLAUS-DIETER , WILLKE THOMAS , WESSEL MIRJA
发明人： HAAS THOMAS , KLASOVSKY FLORIAN , KRAUTER HENDRIK , SCHAFFER STEFFEN , SCHOEBEL RENE , TACKE THOMAS , VORLOP KLAUS-DIETER , WILLKE THOMAS , WESSEL MIRJA
IPC分类号： C12P7/24 , C07C29/14 , C07C45/66 , C07C51/235
CPC分类号： C12P7/24 , C07C29/14 , C07C45/66 , C07C51/235 , C07C31/205 , C07C47/22 , C07C57/04
摘要： The invention relates to methods for producing aldehydes and the oxidation and reduction products thereof.
摘要翻译：本发明涉及一种用于醛和它们的氧化和还原产物的制备方法。

5. 发明申请

WO2014198560A3 METHOD FOR PRODUCING ORGANIC COMPOSITIONS FROM OXYHYDROGEN AND CO2 VIA ACETOACETYL-COA AS INTERMEDIATE PRODUCT 审中-公开
标题翻译：工艺用于有机化合物的从燃气中邦CO2乙酰乙酰辅酶A中间体的制备
公开(公告)号：WO2014198560A3
公开(公告)日：2015-02-19
申请号：PCT/EP2014061245
申请日：2014-05-30
申请人： EVONIK INDUSTRIES AG , WITTMANN EVA MARIA , HAAS THOMAS , SCHAFFER STEFFEN , PÖTTER MARKUS , SCHIEMANN YVONNE , KIRCHNER NICOLE
发明人： WITTMANN EVA MARIA , HAAS THOMAS , SCHAFFER STEFFEN , PÖTTER MARKUS , SCHIEMANN YVONNE , KIRCHNER NICOLE
IPC分类号： C12P5/02 , C12P7/04 , C12P7/16 , C12P7/30 , C12P7/42 , C12P7/52 , C12R1/01
CPC分类号： C12P7/52 , C12N15/52 , C12P5/026 , C12P7/04 , C12P7/16 , C12P7/30 , C12P7/42 , C12Y203/01009 , Y02E50/10 , Y02E50/343
摘要： The invention relates to a method for producing organic compositions comprising the method steps: A) providing an oxyhydrogen bacterium having an activity of an enzyme E1, which is increased by comparison with the wild type thereof and which can catalyse the conversion of 2 acetyl-CoA to acetoacetyl-CoA and CoA, in an aqueous medium; B) bringing the aqueous medium into contact with a gas containing H2, CO2 and O2 in a weight ratio from 20 - 70 to 10 - 45 to 5 - 35 and optionally C) purifying the organic composition.
摘要翻译：本发明是用于生产包括以下步骤的有机化合物的方法：A）提供一种氢氧细菌具有相比增加到酶E1的以其野生型活性，这是能够催化2乙酰辅酶A到乙酰乙酰-CoA和辅酶A，反应，在水性介质中; B）用含有H 2，CO 2和O 2在20〜70的重量比为10〜45 5〜35，和任选，C的气体的含水介质接触）纯化有机化合物。

6. 发明申请

WO2013024114A3 BIOTECHNOLOGICAL SYNTHESIS PROCESS OF OMEGA-FUNCTIONALIZED CARBON ACIDS AND CARBON ACID ESTERS FROM SIMPLE CARBON SOURCES 审中-公开
标题翻译：从简单的碳源OMEGA官能化的酸和羧酸酯的生物合成方法
公开(公告)号：WO2013024114A3
公开(公告)日：2013-05-30
申请号：PCT/EP2012065941
申请日：2012-08-15
申请人： EVONIK DEGUSSA GMBH , SCHAFFER STEFFEN , DECKER NICOLE , GIELEN JASMIN , HAEGER HARALD , HAAS THOMAS , POETTER MARKUS , HENNEMANN HANS-GEORG , WESSEL MIRJA , VOLLAND MICHAEL
发明人： SCHAFFER STEFFEN , DECKER NICOLE , GIELEN JASMIN , HAEGER HARALD , HAAS THOMAS , POETTER MARKUS , HENNEMANN HANS-GEORG , WESSEL MIRJA , VOLLAND MICHAEL
IPC分类号： C12N9/10 , C12N9/00 , C12N9/88 , C12P1/04
CPC分类号： C12P13/02 , C08G69/08 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0014 , C12N9/0077 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/40 , C12P7/42 , C12P7/6409 , C12P7/6436 , C12P13/005 , Y02P20/52
摘要： The invention relates to a biotechnological process for the preparation of functionalized carbon acids and functionalized carbon acid esters from simple carbon sources.
摘要翻译：本发明涉及一种用于生产从简单碳源官能羧酸和官能化羧酸酯的生物技术方法。

7. 发明申请

WO2011057871A3 USE OF A PROTEIN HOMOLOGOUS TO A MEAB PROTEIN FOR INCREASING THE ENZYMATIC ACTIVITY OF A 3-HYDROXYCARBOXYLIC ACID-COA MUTASE 审中-公开
标题翻译： AN MEAB蛋白同源蛋白质的FOR A 3-羟基酰基-CoA变位酶增加酶活性USE
公开(公告)号：WO2011057871A3
公开(公告)日：2012-01-26
申请号：PCT/EP2010065151
申请日：2010-10-11
申请人： EVONIK ROEHM GMBH , REINECKE LIV , SCHAFFER STEFFEN , KOEHLER TIM , THIESSENHUSEN ANJA , MARX ACHIM , BUCHHAUPT MARKUS
发明人： REINECKE LIV , SCHAFFER STEFFEN , KOEHLER TIM , THIESSENHUSEN ANJA , MARX ACHIM , BUCHHAUPT MARKUS
IPC分类号： C07K14/47
CPC分类号： C12P7/52 , C07K14/195 , C07K2319/00 , C12N9/90 , C12P7/42
摘要： The invention relates to the use of a protein homologous to a MeaB protein for increasing the enzymatic activity of a 3-hydroxycarboxylic acid-CoA mutase, a fusion protein comprising a 3-hydroxycarboxylic acid-CoA mutase and a protein sequence homologous to a MeaB protein and an enzymatic method for producing 2-hydroxyisobutryric acid.
摘要翻译：本发明涉及使用一种同源MEAB蛋白蛋白质的用于增加3-羟基酰基-CoA变位酶的酶活性的融合蛋白，其包括3-羟基酰基-CoA变位酶，和同源MeaB-蛋白质蛋白质序列和用于制备2-羟基异丁酸酶促过程。

8. 发明申请

WO2009056423A3 FERMENTATIVE PRODUCTION OF ACETONE FROM RENEWABLE RESOURCES BY MEANS OF NOVEL METABOLIC PATHWAY 审中-公开
标题翻译：丙酮由可再生原材料BY新的代谢WAY发酵提取
公开(公告)号：WO2009056423A3
公开(公告)日：2009-07-09
申请号：PCT/EP2008063150
申请日：2008-10-01
申请人： EVONIK DEGUSSA GMBH , VERSECK STEFAN , SCHAFFER STEFFEN , FREITAG WERNER , SCHMIDT FRIEDRICH GEORG , ORSCHEL MATTHIAS , GRUND GERDA , SCHMIDT WILFRIED , BAHL HUBERT JOHANNES , FISCHER RALF-JOERG , MAY ANTJE , DUERRE PETER , LEDERLE SIMONE
发明人： VERSECK STEFAN , SCHAFFER STEFFEN , FREITAG WERNER , SCHMIDT FRIEDRICH GEORG , ORSCHEL MATTHIAS , GRUND GERDA , SCHMIDT WILFRIED , BAHL HUBERT JOHANNES , FISCHER RALF-JOERG , MAY ANTJE , DUERRE PETER , LEDERLE SIMONE
IPC分类号： C12P7/28
CPC分类号： C12P7/28 , C12N9/16 , C12N9/93 , C12Y301/02 , C12Y301/02018
摘要： The invention describes a process for the preparation of acetone starting from acetyl-coenzyme A comprising the process steps A. enzymatic conversion of acetyl-CoA to give acetoacetyl-CoA; B. enzymatic conversion of acetoacetyl-CoA into acetoacetate and CoA; and C. decarboxylation of acetoacetate to give acetone and CO2, which process is characterized in that, in process step B, the coenzyme A is not transferred to an acceptor molecule. Moreover, surprisingly, process step B is catalyzed by enzymes from the classes acyl-CoA thioesterase, acyl-CoA synthetase or acyl-CoA thiokinase.
摘要翻译：本发明描述了一种用于从乙酰辅酶A，其包含乙酰-CoA至乙酰乙酰基-CoA的A.酶转化的步骤的生产丙酮的方法; 乙酰乙酰CoA的B.酶转化为乙酰乙酸和CoA; 和C.乙酰丙酮和CO 2，其特征在于，所述辅酶A不传输到在方法步骤B.受体分子的脱羧此外，出人意料的是，过程步骤B通过酰基辅酶A硫酯酶的类的酶催化，酰基-CoA合成酶或酰基辅酶A硫激酶。

9. 发明专利

AT543909T 未知
公开(公告)号：AT543909T
公开(公告)日：2012-02-15
申请号：AT05811034
申请日：2005-11-07
申请人： COSMOFERM BV
发明人： VAN DEN BERG MARCO , SCHAFFER STEFFEN
IPC分类号： C12P13/00 , C12N1/14 , C12N9/02 , C12P13/02 , C12R1/84
摘要： The present invention provides microbial strains, in particular yeast strains, that produce at least 0.1 mg per g biomass dry weight of a sphingoid base. The present invention further provides a method to obtain sphingoid base-producing microbial strains comprising incubating a population of microbial cells in the presence of a suitable concentration of a toxin, selecting cells that are resistant against said toxin, and isolating cells out of the toxin-resistant cell population that produce at least 0.1 mg per g biomass dry weight of the sphingoid base of Formula I. Optionally, the method further comprises subjecting a population of toxin-resistant microbial cells that produce at least 0.1 mg per g biomass dry weight of the sphingoid base of Formula I to DNA-mediated transformation with a polynucleotide encoding an enzyme of the sphingolipid metabolic pathway. The present invention further provides a polypeptide having dihydroceramide desaturase activity obtainable form Pichia ciferrii.

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