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1. 发明申请

WO2017205563A1 MAGNETIZABLE GLASS CERAMIC COMPOSITION AND METHODS THEREOF 审中-公开
标题翻译：可磁化的玻璃陶瓷组合物及其方法
公开(公告)号：WO2017205563A1
公开(公告)日：2017-11-30
申请号：PCT/US2017/034368
申请日：2017-05-25
申请人： CORNING INCORPORATED
发明人： GROSS, Timothy Michael , KEECH, John Tyler , LYNN, Jeffrey Glenn , PENG, Jinlin
IPC分类号： C03C10/00 , C03B32/02 , H01F1/37
CPC分类号： C03C10/0054 , A61K47/02 , C03C10/0081 , C03C2214/20 , C03C2214/30 , C07K1/14 , C12N15/1006 , G01N33/5091 , H01F1/37
摘要： A magnetizable glass ceramic composition including: a continuous first glass phase including SiO 2 , B 2 O 3 , P 2 O 5 , and R 2 O; a discontinuous second glass phase including at least one of SiO 2 , B 2 O 3 , P 2 O 5 , R 2 O, or mixtures thereof; and a discrete magnetizable crystalline phase dispersed in the discontinuous second glass phase, where R 2 O is selected from at least one of K 2 O, Li 2 O, Na 2 O, or mixtures thereof. Also disclosed are a method of making and a method of using the magnetizable glass ceramic composition.
摘要翻译：可磁化玻璃陶瓷组合物包括：连续的第一玻璃相，其包含SiO 2，B 2 O 3， P 2 O 5和R 2 O; 包括SiO 2，B 2 O 3，P 2 O 3，SiO 2，SiO 2，SiO 2，Al 2 O 3中的至少一种的不连续的第二玻璃相， 5R，2R或它们的混合物; 和分散在不连续第二玻璃相中的离散的可磁化结晶相，其中R 2 O选自K 2 O，Li 2 O， O 2，Na 2 O或其混合物。还公开了使用可磁化玻璃陶瓷组合物的方法和使用该方法。

2. 发明申请

WO2012074805A1 SYSTEMS AND METHODS FOR MULTI-WAVELENGTH SPR BIOSENSING WITH REDUCED CHROMATIC ABERRATION 审中-公开
标题翻译：具有减少色差的多波长SPR生物传感的系统和方法
公开(公告)号：WO2012074805A1
公开(公告)日：2012-06-07
申请号：PCT/US2011/061597
申请日：2011-11-21
申请人： CORNING INCORPORATED , FONTAINE, Norman, Henry , LI, Guangshan , LIU, Anping , PENG, Jinlin
发明人： FONTAINE, Norman, Henry , LI, Guangshan , LIU, Anping , PENG, Jinlin
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： Systems and methods for sensing a surface plasmon resonance (SPR) biosensor using two or more wavelengths and with reduced chromatic aberration are disclosed. The system includes a beam-forming optical system that has chromatic aberration at the two or more wavelengths. A light source system provides respectively light of the two or more wavelengths, with light of each wavelength provided from a different distance from the beam-forming optical system. The different distances are selected to reduce or eliminate adverse effects of chromatic aberration on the formation of a focus spot on the SPR biosensor chip. An illumination system for illuminating a SPR biosensor using different light having different wavelengths is also disclosed.
摘要翻译：公开了用于使用两个或更多个波长并且具有降低的色差来感测表面等离子体共振（SPR）生物传感器的系统和方法。该系统包括在两个或更多个波长处具有色差的波束形成光学系统。光源系统分别提供两个或多个波长的光，每个波长的光从与波束形成光学系统不同的距离提供。选择不同的距离以减少或消除色差对SPR生物传感器芯片上焦点形成的不利影响。还公开了一种用于使用具有不同波长的不同光照射SPR生物传感器的照明系统。

3. 发明申请

WO2012128962A1 LABEL-FREE RIGID CELL ASSAY METHOD 审中-公开
标题翻译：无标签电池测试方法
公开(公告)号：WO2012128962A1
公开(公告)日：2012-09-27
申请号：PCT/US2012/028241
申请日：2012-03-08
申请人： CORNING INCORPORATED , LAI, Fang , LI, Guangshan , LIU, Anping , PENG, Jinlin
发明人： LAI, Fang , LI, Guangshan , LIU, Anping , PENG, Jinlin
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A label-free cell assay method including: culturing rigid cells in a buffer, the rigid cells having a diameter of about 3 to about 7 micrometers; depositing the rigid cells on the surface of a sensor system; and detecting the rigid cells with the sensor when exposed to two or more wavelengths of light having two or more penetration depths, as defined herein. Also disclosed are assay methods for contacting the rigid cells with a substance and determining the response of the contacted rigid cells to the substance, such as a drug candidate or modulator compound, as defined herein.
摘要翻译：无标记细胞测定方法，包括：在缓冲液中培养刚性细胞，刚性细胞具有约3至约7微米的直径; 将刚性电池沉积在传感器系统的表面上; 并且当暴露于具有两个或更多个穿透深度的两个或更多波长的光，如本文所定义时，用传感器检测刚性单元。还公开了用于使刚性细胞与物质接触并测定接触的刚性细胞对如本文所定义的药物候选物或调节剂化合物的物质的反应的测定方法。

4. 发明申请

WO2003022421A3 MICROCOLUMN-PLATFORM BASED ARRAY FOR HIGH-THROUGHPUT ANALYSIS 审中-公开
公开(公告)号：WO2003022421A3
公开(公告)日：2003-03-20
申请号：PCT/US2002/028481
申请日：2002-09-06
申请人： CORNING INCORPORATED
发明人： WEBB, Brian, L. , PENG, Jinlin , BRADY, Michael, D. , DESPA, Mircea , HORN, Keith, A. , LAHIRI, Joydeep , ROOT, David, M. , STAMATOFF, James, B.
IPC分类号： B01J19/00
摘要： A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns (5) projecting away from a support plate (12). Each microcolumn (15) has a relatively planar, first surface remote from the support plate (12). An array of multiple, different biological materials (1a) may be attached to the first surface. The device, when used in combination with existent micro-titer well plates (4), can improve efficiency of binding assays using microarrays for high-throughput capacity.

5. 发明申请

WO2014121242A1 PCR REACTION CLEANUP BUFFERS 审中-公开
标题翻译： PCR反应清洗缓冲液
公开(公告)号：WO2014121242A1
公开(公告)日：2014-08-07
申请号：PCT/US2014/014518
申请日：2014-02-04
申请人： CORNING INCORPORATED , LESLIE, Thomas Mark , PENG, Jinlin
发明人： LESLIE, Thomas Mark , PENG, Jinlin
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1013 , C12Q1/6806 , C12Q2527/125 , C12Q2563/143 , C12Q2563/149
摘要： The present disclosure relates to buffers containing polyols for use with affinity-binding and/or magnetically susceptible thermoplastic particles and methods of making and use thereof.
摘要翻译：本公开涉及含有用于亲和结合和/或磁敏感的热塑性颗粒的多元醇的缓冲剂及其制备和使用方法。

6. 发明申请

WO2011066097A1 VARIABLE PENETRATION DEPTH BIOSENSOR AND METHODS 审中-公开
标题翻译：可变穿透深度生物传感器和方法
公开(公告)号：WO2011066097A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/055950
申请日：2010-11-09
申请人： CORNING INCORPORATED , COUILLARD, James G , FONTAINE, Norman H , LAHIRI, Joydeep , LI, Guangshan , LIU, Anping , PENG, Jinlin , WALTON, Donnell T
发明人： COUILLARD, James G , FONTAINE, Norman H , LAHIRI, Joydeep , LI, Guangshan , LIU, Anping , PENG, Jinlin , WALTON, Donnell T
IPC分类号： G02B6/00
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：表面等离子体共振传感器系统包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电探测器，数据采集单元和如本文所定义的。传感器芯片可以包括例如在透明基板的一个面上的硅和金的薄层以及与透明基板的相对面相邻的棱镜。这样的布置提供了可变的穿透深度达约1.5微米，并具有用于感测样本中的折射率变化的动态范围，其比传统的SPR传感器的折射率的数倍大。本公开提供了使用表面等离子体共振传感器系统进行细胞测定或化学测定相关应用的方法。

7. 发明申请

WO2003022421A2 MICROCOLUMN-PLATFORM BASED ARRAY FOR HIGH-THROUGHPUT ANALYSIS 审中-公开
标题翻译：用于高通量分析的基于微阵列平台的阵列
公开(公告)号：WO2003022421A2
公开(公告)日：2003-03-20
申请号：PCT/US2002/028481
申请日：2002-09-06
申请人： CORNING INCORPORATED
发明人： WEBB, Brian, L. , PENG, Jinlin , BRADY, Michael, D. , DESPA, Mircea , HORN, Keith, A. , LAHIRI, Joydeep , ROOT, David, M. , STAMATOFF, James, B.
IPC分类号： B01J19/00
CPC分类号： B01L3/50853 , B01J2219/00317 , B01J2219/00504 , B01J2219/00511 , B01J2219/00585 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00662 , B01J2219/00707 , B01L3/5025 , B01L2200/025 , B01L2200/026 , B01L2300/046 , B01L2300/0636 , B01L2300/0829 , C12Q1/6837 , C40B60/14 , G01N33/54366 , G01N33/54373 , G01N33/54386 , G01N35/028
摘要： A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.
摘要翻译：提供了用于进行生物或化学分析的装置和方法。该装置包括从支撑板12突出的三维微柱5的阵列。每个微柱15具有远离支撑板12的相对平面的第一表面。多个不同的生物材料1a的阵列可以附接到第一表面。当与现有微量滴定板4组合使用时，该装置可以提高使用微阵列的高通量容量的结合测定的效率。

8. 发明申请

WO2020251799A1 DISSOLVABLE MICROCARRIERS FOR CULTURING CELLS AND RELATED METHODS 审中-公开
公开(公告)号：WO2020251799A1
公开(公告)日：2020-12-17
申请号：PCT/US2020/035693
申请日：2020-06-02
申请人： CORNING INCORPORATED
发明人： HERVY, Martial , HUANG, Liepin , PENG, Jinlin , RUSSELL, Ryann Loren , SCIBEK, Jeffery Joseph , ZHOU, Yue
IPC分类号： C08L5/06 , C12N5/00
摘要： A cell culture article is provided. The cell culture article includes a substrate of a polygalacturonic acid compound crosslinked with a divalent cation, the polygalacturonic acid compound being selected from at least one of: pectic acid; partially esterified pectic acid, partially amidated pectic acid and salts thereof. The substrate is digestible by digestion reagents into components including of galacturonic acid monomers and the divalent cation. Methods of harvesting cells from the cell culture article are also provided. The methods include performing a series of wash and/or centrifugation cycles to reduce components in the harvest solution.

9. 发明申请

WO2006072042A3 METHOD FOR CREATING A REFERENCE REGION AND A SAMPLE REGION ON A BIOSENSOR AND THE RESULTING BIOSENSOR 审中-公开
公开(公告)号：WO2006072042A3
公开(公告)日：2006-07-06
申请号：PCT/US2005/047563
申请日：2005-12-29
申请人： CORNING INCORPORATED , CARRACCI, Stephen J , FRUTOS, Anthony G , PENG, Jinlin , PIECH, Garrett A , WEBB, Michael Brian
发明人： CARRACCI, Stephen J , FRUTOS, Anthony G , PENG, Jinlin , PIECH, Garrett A , WEBB, Michael Brian
IPC分类号： G01N33/543
摘要： A method is described herein that can use any one of a number of deposition techniques to create a reference region and a sample region on a single biosensor which in the preferred embodiment is located within a single well of a microplate. The deposition techniques that can be used to help create the reference region and the sample region on a surface of the biosensor include: (1) the printing/stamping of a deactivating agent on a reactive surface of the biosensor; (2) the printing/stamping of a target molecule (target protein) on a reactive surface of the biosensor; or (3) the printing/stamping of a reactive agent on an otherwise unreactive surface of the biosensor.

10. 发明申请

WO2006071992A1 SPATIALLY SCANNED OPTICAL READER SYSTEM AND METHOD FOR USING SAME 审中-公开
标题翻译：空间扫描光学读取器系统及其使用方法
公开(公告)号：WO2006071992A1
公开(公告)日：2006-07-06
申请号：PCT/US2005/047451
申请日：2005-12-29
申请人： CORNING INCORPORATED , FRUTOS, Anthony, G. , PENG, Jinlin , PIECH, Garrett, A. , WEBB, Michael, Brian , GOLLIER, Jacques
发明人： FRUTOS, Anthony, G. , PENG, Jinlin , PIECH, Garrett, A. , WEBB, Michael, Brian , GOLLIER, Jacques
IPC分类号： G01N21/55 , G01N21/25
CPC分类号： G01N21/253 , G01N21/554 , G01N21/7743
摘要： An optical reader system is described herein that uses a scanned optical beam to interrogate a biosensor to determine if a biomolecular binding event occurred on a surface of the biosensor. In one embodiment, the optical reader system includes a light source, a detector and a processor (e.g., computer, DSP). The light source outputs an optical beam which is scanned across a moving biosensor and while this is happening the detector collects the optical beam which is reflected from the biosensor. The computer processes the collected optical beam and records the resulting raw spectral or angle data which is a function of a position (and possibly time) on the biosensor. The processor can then analyze the raw data to create a spatial map of resonant wavelength (peak position) or resonant angle which indicates whether or not a biomolecular binding event occurred on the biosensor. Several other uses of the raw data are also described herein.
摘要翻译：本文描述了一种光学阅读器系统，其使用扫描的光束来询问生物传感器以确定生物分子结合事件是否在生物传感器的表面上发生。在一个实施例中，光学读取器系统包括光源，检测器和处理器（例如，计算机，DSP）。光源输出沿着移动的生物传感器扫描的光束，并且当发生这种情况时，检测器收集从生物传感器反射的光束。计算机处理所收集的光束并记录所生成的原始光谱或角度数据，该数据是生物传感器上的位置（可能是时间）的函数。然后，处理器可以分析原始数据以创建谐振波长（峰值位置）或共振角的空间图，其指示生物传感器上是否发生生物分子结合事件。这里还描述了原始数据的几个其他用途。

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