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1. 发明申请

WO2006071696A3 POROUS SUBSTRATES AND ARRAYS COMPRISING THE SAME 审中-公开
标题翻译：多孔基片和包含它的阵列
公开(公告)号：WO2006071696A3
公开(公告)日：2009-07-23
申请号：PCT/US2005046450
申请日：2005-12-21
申请人： CORNING INC , TEPESCH PATRICK D , WIGHT JOHN F JR , YUEN PO KI , MOZDY ERIC J , COONAN EVERETT W , FANG YE , FERRIE ANN M , FU XIADONG , HONG YULONG , LESLIE THOMAS M , LI XINGHUA , MONAHAN BETH C , MUELLER DIRK , TANNER CAMERON W
发明人： TEPESCH PATRICK D , WIGHT JOHN F JR , YUEN PO KI , MOZDY ERIC J , COONAN EVERETT W , FANG YE , FERRIE ANN M , FU XIADONG , HONG YULONG , LESLIE THOMAS M , LI XINGHUA , MONAHAN BETH C , MUELLER DIRK , TANNER CAMERON W
IPC分类号： B01L3/00 , B01J19/00
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00423 , B01J2219/00639 , B01J2219/00644 , B01J2219/00722 , B01L2300/0819
摘要： The present invention relates to arrays comprising porous substrates for attachment of nucleic acids, polypeptides, membranes, or other biological or organic materials. In many embodiments, the arrays of the present invention have a flow-through configuration such that washing buffers or samples can access to the porous substrates from at least two sides of the arrays. The present invention also features arrays comprising UV-compatible porous substrates, arrays comprising three-dimensional membranes in sol-gels, and arrays comprising silica-based porous substrates prepared using a low-temperature fusion process.
摘要翻译：本发明涉及包含用于连接核酸，多肽，膜或其它生物或有机材料的多孔底物的阵列。在许多实施例中，本发明的阵列具有流通构型，使得洗涤缓冲液或样品可以从阵列的至少两侧进入多孔基底。本发明还具有包含UV兼容的多孔基材，溶胶凝胶中包含三维膜的阵列和包含使用低温熔融法制备的基于二氧化硅的多孔基材的阵列的阵列。

2. 发明申请

WO2006071696A9 POROUS SUBSTRATES AND ARRAYS COMPRISING THE SAME 审中-公开
标题翻译：多孔基片和包含它的阵列
公开(公告)号：WO2006071696A9
公开(公告)日：2006-10-19
申请号：PCT/US2005046450
申请日：2005-12-21
申请人： CORNING INC , TEPESCH PATRICK D , WIGHT JOHN F JR , YUEN PO KI , MOZDY ERIC J , COONAN EVERETT W , FANG YE , FERRIE ANN M , FU XIADONG , HONG YULONG , LESLIE THOMAS M , LI XINGHUA , MONAHAN BETH C , MUELLER DIRK , TANNER CAMERON W
发明人： TEPESCH PATRICK D , WIGHT JOHN F JR , YUEN PO KI , MOZDY ERIC J , COONAN EVERETT W , FANG YE , FERRIE ANN M , FU XIADONG , HONG YULONG , LESLIE THOMAS M , LI XINGHUA , MONAHAN BETH C , MUELLER DIRK , TANNER CAMERON W
IPC分类号： B01L3/00 , B01J19/00
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00423 , B01J2219/00639 , B01J2219/00644 , B01J2219/00722 , B01L2300/0819
摘要： The present invention relates to arrays comprising porous substrates for attachment of nucleic acids, polypeptides, membranes, or other biological or organic materials. In many embodiments, the arrays of the present invention have a flow-through configuration such that washing buffers or samples can access to the porous substrates from at least two sides of the arrays. The present invention also features arrays comprising UV-compatible porous substrates, arrays comprising three-dimensional membranes in sol-gels, and arrays comprising silica-based porous substrates prepared using a low-temperature fusion process.
摘要翻译：本发明涉及包含用于连接核酸，多肽，膜或其它生物或有机材料的多孔底物的阵列。在许多实施例中，本发明的阵列具有流通构型，使得洗涤缓冲液或样品可以从阵列的至少两侧进入多孔基底。本发明还具有包含UV兼容的多孔基材，溶胶凝胶中包含三维膜的阵列和包含使用低温熔融法制备的基于二氧化硅的多孔基材的阵列的阵列。

3. 发明申请

WO2006107506A3 SYSTEM AND METHOD FOR PERFORMING G PROTEIN COUPLED RECEPTOR (GPCR) CELL ASSAYS USING WAVEGUIDE-GRATING SENSORS 审中-公开
标题翻译：使用波导传感器执行G蛋白偶联受体（GPCR）细胞测定的系统和方法
公开(公告)号：WO2006107506A3
公开(公告)日：2006-11-16
申请号：PCT/US2006008582
申请日：2006-03-10
申请人： CORNING INC , FANG YE , FERRIE ANN M , FONTAINE NORMAN H , YUEN PO KI , LAHIRI JOYDEEP
发明人： FANG YE , FERRIE ANN M , FONTAINE NORMAN H , YUEN PO KI , LAHIRI JOYDEEP
IPC分类号： G01N33/543 , G01N21/77 , G01N33/68
CPC分类号： G01N33/5041 , G01N21/4788 , G01N21/553 , G01N2333/726 , G01N2500/10
摘要： The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells.
摘要翻译：本发明包括使用光学LID生物传感器实时监测活细胞内激动剂诱导的GPCR信号事件的系统和方法。特别地，本发明包括使用光学LID生物传感器基于由于激动剂诱导的GPCR活化导致的质量再分布来筛选活细胞内的靶GPCR的化合物的系统和方法。在扩展实施例中，本发明公开了用于自参考光学LID生物传感器以消除对环境温度，压力波动和其他环境变化的不期望的灵敏度的不同方式。在又一个扩展的实施方案中，本发明公开了在单一培养基溶液中的多种类型的细胞中单种类型细胞或多种GPCR筛选多种GPCR的不同方式。在又一个延伸的实施方案中，本发明公开了确定化合物对活细胞内特异性GPCR的生理或药理作用的不同方式。

4. 发明申请

WO2006108183A3 LABEL FREE BIOSENSORS AND CELLS 审中-公开
标题翻译：标签免费生物传感器和细胞
公开(公告)号：WO2006108183A3
公开(公告)日：2009-04-16
申请号：PCT/US2006013539
申请日：2006-04-05
申请人： CORNING INC , FANG YE , FERRIE ANN M , FONTAINE NORMAN H , LAHIRI JOYDEEP , YUEN PO KI
发明人： FANG YE , FERRIE ANN M , FONTAINE NORMAN H , LAHIRI JOYDEEP , YUEN PO KI
IPC分类号： A61B5/05 , A61N1/30 , G01N33/552
CPC分类号： G01N33/5008 , G01N33/54373 , G01N33/554
摘要： Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in highthough put methods and can be multiplexed.
摘要翻译：公开了使用无标签光学生物传感器进行细胞测定的组合物和方法。在某些实施方案中，所述测定可以以放置方式进行并且可以被复用。

5. 发明申请

WO2005016532A3 AUTOMATED REACTION CHAMBER SYSTEM FOR BIOLOGICAL ASSAYS 审中-公开
标题翻译：用于生物测定的自动反应室系统
公开(公告)号：WO2005016532A3
公开(公告)日：2005-10-27
申请号：PCT/US2004018716
申请日：2004-06-10
申请人： CORNING INC , FANG YE , YUEN PO KI , KUNG VINCENT T
发明人： FANG YE , YUEN PO KI , KUNG VINCENT T
IPC分类号： B01F5/06 , B01F9/00 , B01F11/00 , B01F13/00 , B01L3/00 , B01L9/00 , G01N1/31 , G01N35/00 , C12Q1/68
CPC分类号： B01F5/061 , B01F9/002 , B01F9/0021 , B01F11/0071 , B01F13/0059 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0636 , B01L2300/0877 , B01L2300/1827 , B01L2300/1844 , B01L2300/185 , B01L2400/0409 , B01L2400/0457 , B01L2400/0487 , B01L2400/0633 , G01N1/312 , G01N2035/00158 , G01N2035/00524
摘要： A device for high-capacity, multiplexed processing of a variety of solid-phase-format, biological or biochemical assays, which use fluid media, is described. The device may be part of a larger machine or system, which can be automation friendly. Generally, the device comprises a number of plates, which forms a cassette or chamber module. Each cassette or chamber module has an interior and exterior surface. At least part of an interior wall surface is displaceable. Within each cassette are a number of fluid inlet and outlet passageways and a reaction chamber for receiving at least one microarray substrate. When the cassette is ready to be used, the reaction chamber should be fluid-tight. In the larger machine, a number of cassettes are associated with a rotary drum, from which the chamber modules extend outwardly. A method relating to the use of the present device or system is also provided.
摘要翻译：描述了使用流体介质的各种固相格式，生物或生物化学测定的高容量多路复用处理装置。该设备可以是更大的机器或系统的一部分，其可以是自动化的。通常，该装置包括多个板，其形成盒或室模块。每个盒或室模块具有内部和外部表面。内壁表面的至少一部分是可移动的。在每个盒内是多个流体入口和出口通道以及用于容纳至少一个微阵列基底的反应室。当盒子准备使用时，反应室应该是流体密封的。在较大的机器中，许多盒与旋转鼓相关联，室模块从该盒向外延伸。还提供了与使用本装置或系统有关的方法。

6. 发明申请

WO2010060019A3 METHODS FOR CHARACTERIZING MOLECULES 审中-公开
标题翻译：表征分子的方法
公开(公告)号：WO2010060019A3
公开(公告)日：2010-08-05
申请号：PCT/US2009065483
申请日：2009-11-23
申请人： CORNING INC , FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , TRAN ELIZABETH
发明人： FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , TRAN ELIZABETH
IPC分类号： G01N33/543 , G01N33/50 , G06F19/00
CPC分类号： G01N33/5023 , G01N33/5041 , G01N33/54373 , G01N2800/60 , G06F19/12
摘要： Drug discovery is a complex undertaking facing many challenges, not the least of which is a high attrition rate as many promising candidates prove ineffective or toxic in the clinic owing to a poor understanding of the diseases, and thus the biological systems, they target. Therefore, it is broadly agreed that to increase the productivity of drug discovery one needs a far deeper understanding of the molecular mechanisms of diseases, taking into account the full biological context of the drug target and moving beyond individual genes and proteins. The present methods rely on the use of label-free cellular assays, particularly the DMR index, to systematically display the mode of actions, the toxicity, and the target(s) and pathway(s) of any molecules.
摘要翻译：药物发现是一项复杂的任务，面临着许多挑战，其中最重要的是耗损率高，因为许多有希望的候选人由于对疾病的了解不足以及生物系统的原因而在临床中被证明无效或有毒。因此，人们普遍认为，要提高药物开发的生产力，需要对疾病的分子机制有更深入的了解，同时考虑到药物靶点的全部生物学背景，并超越个体基因和蛋白质。本发明的方法依赖于使用无标记细胞测定法，特别是DMR指数来系统地显示任何分子的作用模式，毒性以及目标和途径。

7. 发明申请

WO2009045524A2 SYSTEM AND METHOD FOR DUAL-DETECTION OF A CELLULAR RESPONSE 审中-公开
标题翻译：用于双重检测细胞响应的系统和方法
公开(公告)号：WO2009045524A2
公开(公告)日：2009-04-09
申请号：PCT/US2008011485
申请日：2008-10-03
申请人： CORNING INC , FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , MUDALIAR DEEPTI J , WU QI
发明人： FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , MUDALIAR DEEPTI J , WU QI
IPC分类号： G01N21/55 , G01N21/64 , G01N33/543
CPC分类号： G01N21/648 , G01N21/7743
摘要： A system and method as defined herein for dual-detection of evanescent-wave label-free light and evanescent-wave excited-fluorescent label-emitted light in an optical biosensor.
摘要翻译：本文所定义的系统和方法，用于在光学生物传感器中双重检测ev逝波无标记光和ev逝波激发荧光标记发射光。

8. 发明申请

WO2010060022A3 METHODS OF CREATING AN INDEX 审中-公开
标题翻译：创建索引的方法
公开(公告)号：WO2010060022A3
公开(公告)日：2011-05-19
申请号：PCT/US2009065490
申请日：2009-11-23
申请人： CORNING INC , FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , TRAN ELIZABETH
发明人： FANG YE , FERRIE ANN M , LAHIRI JOYDEEP , TRAN ELIZABETH
IPC分类号： G06F19/00
CPC分类号： G06F19/709 , G01N33/5041 , G01N33/54373 , G06F19/12
摘要： Drug discovery is a complex undertaking facing many challenges, not the least of which is a high attrition rate as many promising candidates prove ineffective or toxic in the clinic owing to a poor understanding of the diseases, and thus the biological systems, they target. Therefore, it is broadly agreed that to increase the productivity of drug discovery one needs a far deeper understanding of the molecular mechanisms of diseases, taking into account the full biological context of the drug target and moving beyond individual genes and proteins. The present methods rely on the use of label-free cellular assays, particularly the DMR index, to systematically display the mode of actions, the toxicity, and the target(s) and pathway(s) of any molecules.
摘要翻译：毒品发现是一项面临许多挑战的复杂工作，其中最重要的是高消耗率，因为许多有前途的候选人在诊所中证明无效或有毒，原因是对这些疾病的认识不足，从而导致其生物系统的目标。因此，普遍同意，为了提高药物发现的生产力，需要更深入地了解疾病的分子机制，同时考虑到药物靶标的完整生物学背景，超越个别基因和蛋白质。本方法依赖于使用无标记细胞测定法，特别是DMR指数来系统显示任何分子的作用模式，毒性以及靶标和途径。

9. 发明申请

WO2011081970A3 MOLECULES RELATED hERG Ion CHANNELS AND THE USE THEREOF 审中-公开
标题翻译：分子相关的离子通道及其用途
公开(公告)号：WO2011081970A3
公开(公告)日：2011-11-10
申请号：PCT/US2010060655
申请日：2010-12-16
申请人： CORNING INC , FANG YE , DENG HUAYUN , FERRIE ANN M , SUN HAIYAN , TRAN ELIZABETH , HE MINGQIAN , NIU WEIJUN , WEI YING
发明人： FANG YE , DENG HUAYUN , FERRIE ANN M , SUN HAIYAN , TRAN ELIZABETH , HE MINGQIAN , NIU WEIJUN , WEI YING
IPC分类号： A61K31/341 , A61P9/06 , A61P35/00 , G01N33/48
CPC分类号： A61K31/341 , G01N33/6872 , G01N2500/10 , G01N2800/52
摘要： Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R1, R2, R3, R6, R5, and R4 are defined herein. These compounds can be useful as therapeutic agents for modulating hERG ion channels, and for improving prevention and treatment of hERG associated cardiac repolarization disorders.
摘要翻译：公开了具有结构式（I，II）或其药学上可接受的销售，溶剂合物，包合物或前药的化合物，其中R 1，R 2，R 3，R 6，R 5和R 4在本文中定义。这些化合物可用作调节hERG离子通道的治疗剂，以及改善预防和治疗hERG相关心脏复极化障碍。

10. 发明申请

WO2011081971A3 FUSED THIOPHENES AS DUAL INHIBITORS OF EGFR/VEGFR AND THEIR USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译：作为EGFR / VEGFR的双重抑制剂的FUSED THIOPHENES及其在治疗癌症中的用途
公开(公告)号：WO2011081971A3
公开(公告)日：2011-10-27
申请号：PCT/US2010060663
申请日：2010-12-16
申请人： CORNING INC , FANG YE , DENG HUAYUN , FERRIE ANN M , SUN HAIYAN , TRAN ELIZABETH , HE MINGQIAN , NIU WEIJUN , WEI YING
发明人： FANG YE , DENG HUAYUN , FERRIE ANN M , SUN HAIYAN , TRAN ELIZABETH , HE MINGQIAN , NIU WEIJUN , WEI YING
IPC分类号： A61K31/381 , A61P35/00 , G01N33/50 , G01N33/574
CPC分类号： A61K31/381 , A61K45/06 , G01N33/5011 , A61K2300/00
摘要： Disclosed are compositions and methods related to identification of modulators of EGFR and VEGFR.
摘要翻译：公开了与鉴定EGFR和VEGFR调节剂相关的组合物和方法。

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