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1. 发明申请

WO9966922A8 METHOD OF ALTERING NUTRITIONAL COMPONENTS OF MILK PRODUCED BY A LACTATING ANIMAL 审中-公开
标题翻译：改变由动物生产的奶的营养成分的方法
公开(公告)号：WO9966922A8
公开(公告)日：2001-03-29
申请号：PCT/US9812970
申请日：1998-06-23
申请人： CORNELL RES FOUNDATION INC , BAUMAN DALE E , MCGUIRE MARK A , GRIINARI MIKKO , CHOUINARD P YVAN
发明人： BAUMAN DALE E , MCGUIRE MARK A , GRIINARI MIKKO , CHOUINARD P YVAN
IPC分类号： A23C9/152 , A61K31/10 , A61K31/201 , A61K31/202 , A61K31/20
CPC分类号： A61K31/201 , A23C9/1528 , A23C2230/10 , A23V2002/00 , A61K31/202 , A23V2200/308 , A23V2250/1866
摘要： The present invention alters mammary synthesis of fat to improve milk quality. These changes in milk composition represent improvements in nutritional quality consistent with contemporary dietary recommendations. Of special importance is the disclosure of new data relating to specific conjugated linoleic acids (CLA), potent naturally occuring anti-carcinogens. In the course of an investigation to enhance milk content of conjugated linoleic acid, it was discovered that abomasal infusion of a single TFA isomer caused a marked milk fat depression. This observation was unexpected because the prior art has consistently shown that body fat and milk fat always show reciprocal changes in lactating cows and indicated that CLA's generally reduced body fat in growing animals. The current disclosure demonstrates that an increase in milk fat content of a specific TFA isomer, trans-10 C18:1. (Griinari et al., 1997, 1998) causes MFD. This observation is in conflict with the prior art that taught that an increase in total TFA caused MFD. These results are applicable to other domestic lactating mammals (e.g., pigs). Upon the infusion of CLA, a portion of the CLA is transferred to the mammary gland and incorporated into milk fat. Hence, the methods disclosed increase the levels of CLA found in milk, thereby improving the nutritional benefits to human health associated with CLA.
摘要翻译：本发明改变乳脂肪的合成以提高乳品质量。牛奶组合中的这些变化代表了与当代饮食建议一致的营养质量的改善。特别重要的是披露与特定共轭亚油酸（CLA）相关的新数据，这是有效的天然存在的抗致癌物质。在研究提高共轭亚油酸的牛奶含量的过程中，发现单次TFA异构体的腹腔输注导致明显的乳脂肪抑制。这种观察是意想不到的，因为现有技术一直表明，身体脂肪和乳脂肪总是显示哺乳牛的相互变化，并且表明CLA通常在生长的动物中降低身体脂肪。目前的公开内容表明，特定TFA异构体，反式-10 C18：1的乳脂肪含量增加。（Griinari等，1997，1998）导致MFD。这一观察结果与现有技术相冲突，该技术教导了总TFA的增加引起MFD。这些结果适用于其他国内哺乳哺乳动物（如猪）。在输注CLA时，将CLA的一部分转移到乳腺并且并入乳脂中。因此，所公开的方法增加了在乳中发现的CLA水平，从而改善了与CLA相关的人体健康的营养益处。

2. 发明专利

DE69834663D1 未知
公开(公告)号：DE69834663D1
公开(公告)日：2006-06-29
申请号：DE69834663
申请日：1998-06-23
申请人： CORNELL RES FOUNDATION INC
发明人： BAUMAN DALE E , MCGUIRE MARK A , GRIINARI MIKKO , CHOUINARD P YVAN
IPC分类号： A61K31/20 , A23C9/152 , A61K31/10 , A61K31/201 , A61K31/202
摘要： The present invention alters mammary synthesis of fat to improve milk quality. These changes in milk composition represent improvements in nutritional quality consistent with contemporary dietary recommendations. Of special importance is the disclosure of new data relating to specific conjugated linoleic acids (CLA), potent naturally occurring anti-carcinogens. In the course of an investigation to enhance milk content of conjugated linoleic acid, it was discovered that abomasal infusion of a single TFA isomer caused a marked milk fat depression. This observation was unexpected because the prior art has consistently shown that body fat and milk fat always show reciprocal changes in lactating cows and indicated that CLA's generally reduced body fat in growing animals. The current disclosure demonstrates that an increase in milk fat content of a specific TFA isomer, trans-10 C18:1. (Griinari et al., 1997, 1998) causes MFD. This observation is in conflict with the prior art that taught that an increase in total TFA caused MFD. These results are applicable to other domestic lactating mammals (e.g., pigs). Upon the infusion of CLA, a portion of the CLA is transferred to the mammary gland and incorporated into milk fat. Hence, the methods disclosed increase the levels of CLA found in milk, thereby improving the nutritional benefits to human health associated with CLA.

3. 发明专利

DE69834663T3 Methode zur Änderung der Nährmittelzusammenstellung der Milch die durch milchspendende Tiere abgesondert wird 未知
公开(公告)号：DE69834663T3
公开(公告)日：2011-03-17
申请号：DE69834663
申请日：1998-06-23
申请人： CORNELL RES FOUNDATION INC
发明人： BAUMAN DALE E , MCGUIRE MARK A , GRIINARI MIKKO , CHOUINARD P YVAN
IPC分类号： A61K31/20 , A23C9/152 , A61K31/10 , A61K31/201 , A61K31/202

4. 发明专利

CA2307941C METHOD OF ALTERING NUTRITIONAL COMPONENTS OF MILK PRODUCED BY A LACTATING ANIMAL 未知
公开(公告)号：CA2307941C
公开(公告)日：2008-09-09
申请号：CA2307941
申请日：1998-06-23
申请人： CORNELL RES FOUNDATION INC
发明人： CHOUINARD P YVAN , GRIINARI MIKKO , MCGUIRE MARK A , BAUMAN DALE E
IPC分类号： A61K31/202 , A23C9/00 , A23C9/152 , A23K1/00 , A23L1/30 , A61K31/10 , A61K31/20 , A61K31/201
摘要： The present invention alters mammary synthesis of fat to improve milk qualit y. These changes in milk composition represent improvements in nutritional quality consistent with contemporary dietary recommendations. Of special importance is the disclosure of new data relating to specific conjugated linoleic acids (CLA), potent naturally occuring anti-carcinogens. In the course of an investigation to enhance milk content of conjugated linoleic acid, it was discovered that abomasal infusion of a single TFA isomer caused a marked milk fat depression. This observation was unexpected because the prior art has consistently shown that body fat and milk fat always show reciprocal changes in lactating cows and indicated that CLA's generally reduced body fa t in growing animals. The current disclosure demonstrates that an increase in milk fat content of a specific TFA isomer, trans-10 C18: 1. (Griinari et a1., 1997, 1998) causes MFD. This observation is in conflict with the prior art that taught that an increase in total TFA caused MFD. These results are applicable to other domestic lactating mammals (e.g., pigs). Upon the infusion of CLA, a portion of the CLA is transferred to the mammary gland and incorporated into milk fat. Hence, the methods disclosed increase the levels of CLA found in milk, thereby improving the nutritional benefits to human health associated with CLA.

5. 发明专利

DK1100489T4 Fremgangsmåde til ændring af ernæringsbestanddele af mælk produceret af et lakterende dyr 未知
公开(公告)号：DK1100489T4
公开(公告)日：2010-11-29
申请号：DK98932804
申请日：1998-06-23
申请人： CORNELL RES FOUNDATION INC
发明人： BAUMAN DALE E , MCGUIRE MARK A , GRIINARI MIKKO VALIO , CHOUINARD P YVAN
IPC分类号： A23C9/20 , A61K31/201

6. 发明专利

DE69834663T2 未知
公开(公告)号：DE69834663T2
公开(公告)日：2007-04-05
申请号：DE69834663
申请日：1998-06-23
申请人： CORNELL RES FOUNDATION INC
发明人： BAUMAN DALE E , MCGUIRE MARK A , GRIINARI VALIO , CHOUINARD P YVAN
IPC分类号： A61K31/20 , A23C9/152 , A61K31/10 , A61K31/201 , A61K31/202
摘要： The present invention alters mammary synthesis of fat to improve milk quality. These changes in milk composition represent improvements in nutritional quality consistent with contemporary dietary recommendations. Of special importance is the disclosure of new data relating to specific conjugated linoleic acids (CLA), potent naturally occurring anti-carcinogens. In the course of an investigation to enhance milk content of conjugated linoleic acid, it was discovered that abomasal infusion of a single TFA isomer caused a marked milk fat depression. This observation was unexpected because the prior art has consistently shown that body fat and milk fat always show reciprocal changes in lactating cows and indicated that CLA's generally reduced body fat in growing animals. The current disclosure demonstrates that an increase in milk fat content of a specific TFA isomer, trans-10 C18:1. (Griinari et al., 1997, 1998) causes MFD. This observation is in conflict with the prior art that taught that an increase in total TFA caused MFD. These results are applicable to other domestic lactating mammals (e.g., pigs). Upon the infusion of CLA, a portion of the CLA is transferred to the mammary gland and incorporated into milk fat. Hence, the methods disclosed increase the levels of CLA found in milk, thereby improving the nutritional benefits to human health associated with CLA.

7. 发明专利

DK1100489T3 未知
公开(公告)号：DK1100489T3
公开(公告)日：2006-09-25
申请号：DK98932804
申请日：1998-06-23
申请人： CORNELL RES FOUNDATION INC
发明人： BAUMAN DALE E , MCGUIRE MARK A , GRIINARI MIKKO , CHOUINARD P YVAN
IPC分类号： A23C9/20 , A61K31/201

8. 发明专利

AU8260798A Method of altering nutritional components of milk produced by a lactating animal 未知
公开(公告)号：AU8260798A
公开(公告)日：2000-01-10
申请号：AU8260798
申请日：1998-06-24
申请人： CORNELL RES FOUNDATION INC
发明人： BAUMAN DALE E , MCGUIRE MARK A , GRIINARI MIKKO , CHOUINARD P YVAN
IPC分类号： A61K31/20

9. 发明专利

CA2307941A1 METHOD OF ALTERING NUTRITIONAL COMPONENTS OF MILK PRODUCED BY A LACTATING ANIMAL 未知
公开(公告)号：CA2307941A1
公开(公告)日：1999-12-29
申请号：CA2307941
申请日：1998-06-23
申请人： CORNELL RES FOUNDATION INC
发明人： MCGUIRE MARK A , BAUMAN DALE E , GRIINARI MIKKO , CHOUINARD P YVAN
IPC分类号： A23C9/152 , A61K31/10 , A61K31/201 , A61K31/202 , A61K31/20
摘要： The present invention alters mammary synthesis of fat to improve milk quality. These changes in milk composition represent improvements in nutritional quality consistent with contemporary dietary recommendations. Of special importance is the disclosure of new data relating to specific conjugated linoleic acids (CLA), potent naturally occuring anti-carcinogens. In the course of an investigation to enhance milk content of conjugated linoleic acid, it was discovered that abomasal infusion of a single TFA isomer caused a marked milk fat depression. This observation was unexpected because the prior art has consistently shown that body fat and milk fat always show reciprocal changes in lactating cows and indicated that CLA's generally reduced body fat in growing animals. The current disclosure demonstrates that an increase in milk fat content of a specific TFA isomer, trans-10 C18:1. (Griinari et al., 1997, 1998) causes MFD. This observation is in conflict with the prior art that taught that an increase in total TFA caused MFD. These results are applicable to other domestic lactating mammals (e.g., pigs). Upon the infusion of CLA, a portion of the CLA is transferred to the mammary gland and incorporated into milk fat. Hence, the methods disclosed increase the levels of CLA found in milk, thereby improving the nutritional benefits to human health associated with CLA.

10. 发明公开

EP1100489A4 METHOD OF ALTERING NUTRITIONAL COMPONENTS OF MILK PRODUCED BY A LACTATING ANIMAL 失效
标题翻译： METHODE ZURÄNDERUNGDERNÄHRMITTELZUSAMMENSTELLUNGDER MILCH DIE DURCH MILCHSPENDENDE TIERE ABGESONDERD WIRD
公开(公告)号：EP1100489A4
公开(公告)日：2001-05-30
申请号：EP98932804
申请日：1998-06-23
申请人： CORNELL RES FOUNDATION INC
发明人： BAUMAN DALE E , MCGUIRE MARK A , GRIINARI MIKKO , CHOUINARD P YVAN
IPC分类号： A23C9/152 , A61K31/10 , A61K31/201 , A61K31/202 , A61K31/20
CPC分类号： A61K31/201 , A23C9/1528 , A23C2230/10 , A23V2002/00 , A61K31/202 , A23V2200/308 , A23V2250/1866
摘要： The present invention alters mammary synthesis of fat to improve milk quality. These changes in milk composition represent improvements in nutritional quality consistent with contemporary dietary recommendations. Of special importance is the disclosure of new data relating to specific conjugated linoleic acids (CLA), potent naturally occuring anti-carcinogens. In the course of an investigation to enhance milk content of conjugated linoleic acid, it was discovered that abomasal infusion of a single TFA isomer caused a marked milk fat depression. This observation was unexpected because the prior art has consistently shown that body fat and milk fat always show reciprocal changes in lactating cows and indicated that CLA's generally reduced body fat in growing animals. The current disclosure demonstrates that an increase in milk fat content of a specific TFA isomer, trans-10 C18:1. (Griinari et al., 1997, 1998) causes MFD. This observation is in conflict with the prior art that taught that an increase in total TFA caused MFD. These results are applicable to other domestic lactating mammals (e.g., pigs). Upon the infusion of CLA, a portion of the CLA is transferred to the mammary gland and incorporated into milk fat. Hence, the methods disclosed increase the levels of CLA found in milk, thereby improving the nutritional benefits to human health associated with CLA.
摘要翻译：本发明改变乳房合成脂肪以改善牛奶质量。这些牛奶成分的变化代表了与当前饮食建议相一致的营养质量的改善。特别重要的是披露与特定共轭亚油酸（CLA）有关的新数据，这是有效的自然发生的抗致癌物质。在调查增强共轭亚油酸的乳含量的过程中，发现单一TFA异构体的胃内输注导致明显的乳脂肪抑制。这一观察结果是出乎意料的，因为现有技术一直表明体脂肪和乳脂总是在泌乳奶牛中显示出相互变化，并且表明CLA在生长的动物中通常减少身体脂肪。目前的公开内容证明特定TFA异构体，反-10C18：1的乳脂含量增加。（Griinari等，1997,1998）导致MFD。这一观察结果与现有技术相矛盾，该现有技术教导了总TFA增加引起MFD。这些结果适用于其他家养哺乳动物（例如猪）。输注CLA后，一部分CLA转移至乳腺并掺入乳脂中。因此，所公开的方法增加了牛奶中发现的CLA水平，从而改善了与CLA相关的对人类健康的营养益处。

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