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    • 7. 发明申请
    • METHOD OF ALTERING NUTRITIONAL COMPONENTS OF MILK PRODUCED BY A LACTATING ANIMAL
    • 改变由动物生产的奶的营养成分的方法
    • WO9966922A8
    • 2001-03-29
    • PCT/US9812970
    • 1998-06-23
    • CORNELL RES FOUNDATION INCBAUMAN DALE EMCGUIRE MARK AGRIINARI MIKKOCHOUINARD P YVAN
    • BAUMAN DALE EMCGUIRE MARK AGRIINARI MIKKOCHOUINARD P YVAN
    • A23C9/152A61K31/10A61K31/201A61K31/202A61K31/20
    • A61K31/201A23C9/1528A23C2230/10A23V2002/00A61K31/202A23V2200/308A23V2250/1866
    • The present invention alters mammary synthesis of fat to improve milk quality. These changes in milk composition represent improvements in nutritional quality consistent with contemporary dietary recommendations. Of special importance is the disclosure of new data relating to specific conjugated linoleic acids (CLA), potent naturally occuring anti-carcinogens. In the course of an investigation to enhance milk content of conjugated linoleic acid, it was discovered that abomasal infusion of a single TFA isomer caused a marked milk fat depression. This observation was unexpected because the prior art has consistently shown that body fat and milk fat always show reciprocal changes in lactating cows and indicated that CLA's generally reduced body fat in growing animals. The current disclosure demonstrates that an increase in milk fat content of a specific TFA isomer, trans-10 C18:1. (Griinari et al., 1997, 1998) causes MFD. This observation is in conflict with the prior art that taught that an increase in total TFA caused MFD. These results are applicable to other domestic lactating mammals (e.g., pigs). Upon the infusion of CLA, a portion of the CLA is transferred to the mammary gland and incorporated into milk fat. Hence, the methods disclosed increase the levels of CLA found in milk, thereby improving the nutritional benefits to human health associated with CLA.
    • 本发明改变乳脂肪的合成以提高乳品质量。 牛奶组合中的这些变化代表了与当代饮食建议一致的营养质量的改善。 特别重要的是披露与特定共轭亚油酸(CLA)相关的新数据,这是有效的天然存在的抗致癌物质。 在研究提高共轭亚油酸的牛奶含量的过程中,发现单次TFA异构体的腹腔输注导致明显的乳脂肪抑制。 这种观察是意想不到的,因为现有技术一直表明,身体脂肪和乳脂肪总是显示哺乳牛的相互变化,并且表明CLA通常在生长的动物中降低身体脂肪。 目前的公开内容表明,特定TFA异构体,反式-10 C18:1的乳脂肪含量增加。 (Griinari等,1997,1998)导致MFD。 这一观察结果与现有技术相冲突,该技术教导了总TFA的增加引起MFD。 这些结果适用于其他国内哺乳哺乳动物(如猪)。 在输注CLA时,将CLA的一部分转移到乳腺并且并入乳脂中。 因此,所公开的方法增加了在乳中发现的CLA水平,从而改善了与CLA相关的人体健康的营养益处。