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1. 发明申请

WO2005087017A2 COMPOSITIONS COMPRISING REVERSE ISOMERS OF CONJUGATED LINOLEIC ACID 审中-公开
标题翻译：包含连接的亚麻酸的反向异构体的组合物
公开(公告)号：WO2005087017A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/008015
申请日：2005-03-10
申请人： NATURAL ASA , SAEBO, Asgeir , SAEBO, Per, Christian , GRIINARI, Mikko , BAUMAN, Dale, E. , SHINFIELD, Kevin
发明人： SAEBO, Asgeir , SAEBO, Per, Christian , GRIINARI, Mikko , BAUMAN, Dale, E. , SHINFIELD, Kevin
IPC分类号： A23L
CPC分类号： A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , A61K31/202 , A23V2250/1866
摘要： The present invention relates to the field of human and animal nutrition, and in particular to certain novel compositions of conjugated linoleic acids (CLA). In particular, the present invention relates to CLA compositions comprising the c10,t12,c10,c12,t9,c11 and c9,c11 isomers of conjugated linoleic acid.
摘要翻译：本发明涉及人和动物营养领域，特别涉及某些共轭亚油酸（CLA）的新型组合物。特别地，本发明涉及包含共轭亚油酸的c10，t12，c10，c12，t9，c11和c9，c11异构体的CLA组合物。

2. 发明专利

UY26806A1 MODIFICACION DE LA PRODUCCION DE LECHE Y LOS COMPONENTES DE LA LECHE 未知
公开(公告)号：UY26806A1
公开(公告)日：2001-12-28
申请号：UY26806
申请日：2001-06-27
申请人： MACKLE TIM , BAUMAN DALE E
发明人： MACKLE TIM , BAUMAN DALE E
摘要： El presente invento se refiere a métodos para aumentar el rendimiento de las proteínas de la leche producida por mamíferos lactantes, métodos para aumentar la concentración de las proteínas de la leche producida por mamíferos lactantes y métodos para aumentar el rendimiento de leche producido por mamíferos lactantes, así como también a métodos para mantener el rendimiento de leche, la concentración de las proteínas de la leche o el rendimiento de las proteínas de la leche en tanto se reduce la ingesta de nutrientes, donde dichos mamíferos son sometidos a una dieta que no cubre sus requisitos nutricionales y el método comprende la administración al mamífero lactante de un compuesto que suprime la síntesis de la grasa de la leche. El compuesto preferido del invento para suprimir la grasa de la leche son los ácidos linoleicos conjugados (CLA).

3. 发明专利

AR029691A1 MODIFICACION DE LA PRODUCCION DE LECHE Y LOS COMPONENTES DE LA LECHE 未知
公开(公告)号：AR029691A1
公开(公告)日：2003-07-10
申请号：ARP010103102
申请日：2001-06-28
申请人： MACKLE TIM , BAUMAN DALE E
IPC分类号： A23C9/20 , A23K1/16 , A23K1/18 , A23K1/14 , A23C7/00 , A23C9/14 , A61K31/201
摘要： El presente invento se refiere a métodos para aumentar el rendimiento de las proteínas de la leche producida por mamíferos lactantes, métodos para aumentar la concentracion de las proteínas de la leche producida por mamíferos lactantes y métodos para aumentar el rendimiento de la leche producidos por mamíferos lactantes, así como también a métodos para mantener el rendimiento de leche, la concentracion de las proteínas de la leche o el rendimiento de las proteínas de la leche en tanto se reduce la ingesta de nutrientes, donde dichos mamíferos son sometidos a una dieta que no cubre sus requisitos nutricionales y el método comprende la administracion al mamífero lactante de un compuesto que suprime la síntesis de la grasa de la leche. El compuesto preferido del invento para suprimir la grasa de la leche son los ácidos linoleicos conjugados (CLA).

4. 发明申请

WO2008034129A2 TREATMENT OF CANCER OR OBESITY WITH CONJUGATED LINOLEIC ACIDS 审中-公开
标题翻译：治疗癌症或糖尿病与联合亚麻酸
公开(公告)号：WO2008034129A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/078641
申请日：2007-09-17
申请人： CORNELL RESEARCH FOUNDATION INC. , BAUMAN, Dale, E. , HARVATINE, Kevin, J.
发明人： BAUMAN, Dale, E. , HARVATINE, Kevin, J.
IPC分类号： A61K31/202 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： The present invention discloses a method of screening cancer or obesity patients to determine whether the form of cancer or obesity they have is suitable for treatment with conjugated linoleic acids as well as treating patients for cancer based on that determination. The screening identifies patients with tumor cells with a disregulation of lipid metabolism, patients who overexpress the Thyroid Hormone Responsive Spot 14 gene, and patients who overexpress the Sterol Responsive Element Binding Protein gene.
摘要翻译：本发明公开了一种筛选癌症或肥胖患者的方法，以确定它们所具有的癌症或肥胖症的形式是否适合于用共轭亚油酸治疗，以及基于该测定治疗癌症患者。筛查鉴定了具有脂质代谢失调的肿瘤细胞患者，过表达甲状腺激素反应点14基因的患者和过表达Sterol反应元件结合蛋白基因的患者。

5. 发明申请

WO2005087017A3 COMPOSITIONS COMPRISING REVERSE ISOMERS OF CONJUGATED LINOLEIC ACID 审中-公开
标题翻译：包含连接的亚麻酸的反向异构体的组合物
公开(公告)号：WO2005087017A3
公开(公告)日：2006-05-04
申请号：PCT/US2005008015
申请日：2005-03-10
申请人： NATURAL ASA , SAEBO ASGEIR , SAEBO PER CHRISTIAN , GRIINARI MIKKO , BAUMAN DALE E , SHINFIELD KEVIN
发明人： SAEBO ASGEIR , SAEBO PER CHRISTIAN , GRIINARI MIKKO , BAUMAN DALE E , SHINFIELD KEVIN
IPC分类号： A23D9/00 , A23K1/16 , A23L1/30 , A61K31/202 , C07C51/347 , A61P3/04
CPC分类号： A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , A61K31/202 , A23V2250/1866
摘要： The present invention relates to the field of human and animal nutrition, and in particular to certain novel compositions of conjugated linoleic acids (CLA). In particular, the present invention relates to CLA compositions comprising the c10,t12,c10,c12,t9,c11 and c9,c11 isomers of conjugated linoleic acid.
摘要翻译：本发明涉及人和动物营养领域，特别涉及某些共轭亚油酸（CLA）的新型组合物。特别地，本发明涉及包含共轭亚油酸的c10，t12，c10，c12，t9，c11和c9，c11异构体的CLA组合物。

6. 发明申请

WO2008034129A3 TREATMENT OF CANCER OR OBESITY WITH CONJUGATED LINOLEIC ACIDS 审中-公开
标题翻译：用共轭亚油酸治疗癌症或肥胖症
公开(公告)号：WO2008034129A3
公开(公告)日：2008-11-20
申请号：PCT/US2007078641
申请日：2007-09-17
申请人： CORNELL RES FOUNDATION INC , BAUMAN DALE E , HARVATINE KEVIN J
发明人： BAUMAN DALE E , HARVATINE KEVIN J
IPC分类号： C12Q1/68 , A61K48/00 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： The present invention discloses a method of screening cancer or obesity patients to determine whether the form of cancer or obesity they have is suitable for treatment with conjugated linoleic acids as well as treating patients for cancer based on that determination. The screening identifies patients with tumor cells with a disregulation of lipid metabolism, patients who overexpress the Thyroid Hormone Responsive Spot 14 gene, and patients who overexpress the Sterol Responsive Element Binding Protein gene.
摘要翻译：本发明公开了一种筛查癌症或肥胖症患者的方法，以确定它们所具有的癌症或肥胖症的形式是否适合用共轭亚油酸治疗以及基于该确定治疗患者的癌症。筛查鉴定患有脂质代谢失调的肿瘤细胞患者，过表达甲状腺激素响应斑14基因的患者和过表达Sterol响应元件结合蛋白基因的患者。

7. 发明申请

WO9966922A8 METHOD OF ALTERING NUTRITIONAL COMPONENTS OF MILK PRODUCED BY A LACTATING ANIMAL 审中-公开
标题翻译：改变由动物生产的奶的营养成分的方法
公开(公告)号：WO9966922A8
公开(公告)日：2001-03-29
申请号：PCT/US9812970
申请日：1998-06-23
申请人： CORNELL RES FOUNDATION INC , BAUMAN DALE E , MCGUIRE MARK A , GRIINARI MIKKO , CHOUINARD P YVAN
发明人： BAUMAN DALE E , MCGUIRE MARK A , GRIINARI MIKKO , CHOUINARD P YVAN
IPC分类号： A23C9/152 , A61K31/10 , A61K31/201 , A61K31/202 , A61K31/20
CPC分类号： A61K31/201 , A23C9/1528 , A23C2230/10 , A23V2002/00 , A61K31/202 , A23V2200/308 , A23V2250/1866
摘要： The present invention alters mammary synthesis of fat to improve milk quality. These changes in milk composition represent improvements in nutritional quality consistent with contemporary dietary recommendations. Of special importance is the disclosure of new data relating to specific conjugated linoleic acids (CLA), potent naturally occuring anti-carcinogens. In the course of an investigation to enhance milk content of conjugated linoleic acid, it was discovered that abomasal infusion of a single TFA isomer caused a marked milk fat depression. This observation was unexpected because the prior art has consistently shown that body fat and milk fat always show reciprocal changes in lactating cows and indicated that CLA's generally reduced body fat in growing animals. The current disclosure demonstrates that an increase in milk fat content of a specific TFA isomer, trans-10 C18:1. (Griinari et al., 1997, 1998) causes MFD. This observation is in conflict with the prior art that taught that an increase in total TFA caused MFD. These results are applicable to other domestic lactating mammals (e.g., pigs). Upon the infusion of CLA, a portion of the CLA is transferred to the mammary gland and incorporated into milk fat. Hence, the methods disclosed increase the levels of CLA found in milk, thereby improving the nutritional benefits to human health associated with CLA.
摘要翻译：本发明改变乳脂肪的合成以提高乳品质量。牛奶组合中的这些变化代表了与当代饮食建议一致的营养质量的改善。特别重要的是披露与特定共轭亚油酸（CLA）相关的新数据，这是有效的天然存在的抗致癌物质。在研究提高共轭亚油酸的牛奶含量的过程中，发现单次TFA异构体的腹腔输注导致明显的乳脂肪抑制。这种观察是意想不到的，因为现有技术一直表明，身体脂肪和乳脂肪总是显示哺乳牛的相互变化，并且表明CLA通常在生长的动物中降低身体脂肪。目前的公开内容表明，特定TFA异构体，反式-10 C18：1的乳脂肪含量增加。（Griinari等，1997，1998）导致MFD。这一观察结果与现有技术相冲突，该技术教导了总TFA的增加引起MFD。这些结果适用于其他国内哺乳哺乳动物（如猪）。在输注CLA时，将CLA的一部分转移到乳腺并且并入乳脂中。因此，所公开的方法增加了在乳中发现的CLA水平，从而改善了与CLA相关的人体健康的营养益处。

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