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1. 发明申请

WO2008092011A2 BIOFILM-INHIBITING MEDICAL PRODUCTS 审中-公开
标题翻译：生物膜抑制医疗产品
公开(公告)号：WO2008092011A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/051924
申请日：2008-01-24
申请人： COOK INCORPORATED , COOK BIOTECH INCORPORATED , BATES, Brian, L. , HILES, Michael, C. , JOHNSON, Chad, E.
发明人： BATES, Brian, L. , HILES, Michael, C. , JOHNSON, Chad, E.
IPC分类号： A61L26/00
CPC分类号： A61L15/44 , A61L15/40 , A61L26/0057 , A61L26/0066 , A61L31/005 , A61L31/16 , A61L2300/216 , A61L2300/404
摘要： A biofilm-inhibiting medical product includes a carrier formed from a natural, bioremodelable material, whereby the carrier includes a biocidal bismuth thiol agent and/or one or more other biofilm-inhibiting or wound healing agents. A method for using the biofilm-inhibiting medical product to treat a wound or tissue defect in a patient's body is described.
摘要翻译：生物膜抑制医疗产品包括由天然的生物可重塑材料形成的载体，由此所述载体包含杀生物铋硫醇试剂和/或一种或多种其它生物膜抑制或伤口愈合剂。描述了使用生物膜抑制医疗产品来治疗患者体内的伤口或组织缺陷的方法。

2. 发明申请

WO2011146729A2 DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS 审中-公开
标题翻译：用于密封裸露开口的装置和方法
公开(公告)号：WO2011146729A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/037173
申请日：2011-05-19
申请人： COOK INCORPORATED , COOK BIOTECH INCORPORATED , PAUL, Ram, H. , STANLEY, Cleon , BATES, Brian, L. , OBERMILLER, F., Joseph , OSBORNE, Thomas, A. , CHAMBERS, Sean
发明人： PAUL, Ram, H. , STANLEY, Cleon , BATES, Brian, L. , OBERMILLER, F., Joseph , OSBORNE, Thomas, A. , CHAMBERS, Sean
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/3468 , A61B2017/00004 , A61B2017/00592 , A61B2017/00597 , A61B2017/00623 , A61B2017/00628 , A61B2017/00641 , A61B2017/00659 , A61B2017/00663 , A61B2017/0496 , A61B2017/06176
摘要： Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.
摘要翻译：除此之外，还公开了用于医疗密封容器或壁中的开口的装置和方法。例如，在医疗应用中，提供输送管用于通过护套插入血管（例如血管）中。固定在细丝上的圆顶状密封件，吸收性和/或可压缩缓冲器以及锁定构件设置在输送管中。输送管被构造成使得其可以通过护套插入到容器中。在灯丝上保持张力以将密封件保持在管或鞘上。护套被拉出，同时拉出管子，将密封件留在血管壁的开口处。锁定构件将缓冲器压靠在容器的外部，并且灯丝将密封件保持在容器内部的适当位置。

3. 发明申请

WO2010021969A1 DEVICE AND METHOD FOR CLOSURE OF VESSEL ACCESS SITE 审中-公开
标题翻译：用于船舶进入场地关闭的装置和方法
公开(公告)号：WO2010021969A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/053995
申请日：2009-08-17
申请人： COOK INCORPORATED , PAUL, Ram, H. , BATES, Brian, L. , TREMBACKI, Bradley, L.
发明人： PAUL, Ram, H. , BATES, Brian, L. , TREMBACKI, Bradley, L.
IPC分类号： A61B17/30 , A61B17/00
CPC分类号： A61B17/0057 , A61B18/1442 , A61B18/1445 , A61B18/1447 , A61B2017/00986 , A61B2017/2905 , A61B2017/2926 , A61B2017/2927 , A61B2017/301 , A61B2017/303 , A61B2017/305
摘要： A device for closure of an opening formed in a body vessel includes a grasping member and a sheath movable thereover. The grasping member comprises a tubular body having a plurality of grasping fingers extending from a distal end of the tubular body. The fingers radially extend from the tubular body at a first angle, and are collapsible therefrom to a second angle. The fingers have a distal tip configured for grasping an outer wall of the body vessel surrounding the vessel opening when the fingers are at the first angle. The sheath is slidable over the tubular body and at least a portion of the grasping fingers for collapsing the fingers from the first angle to the second angle, thereby causing the collapsed fingers to at least substantially close the opening.
摘要翻译：用于封闭形成在身体容器中的开口的装置包括抓握构件和可在其上移动的护套。抓持构件包括具有从管状体的远端延伸的多个抓取指状物的管状体。指状物从管状体以第一角度径向延伸，并且可从其收缩至第二角度。手指具有构造成当手指处于第一角度时抓住围绕容器开口的身体容器的外壁的远侧末端。护套可以在管状体上滑动并且至少一部分把持指状物用于将手指从第一角度折叠到第二角度，从而使折叠的手指至少基本上关闭开口。

4. 发明申请

WO2010027898A1 HERNIA PATCH WITH REMOVABLE RESILIENT ELEMENT 审中-公开
标题翻译：具有可拆卸弹性元件的HERNIA配件
公开(公告)号：WO2010027898A1
公开(公告)日：2010-03-11
申请号：PCT/US2009/055171
申请日：2009-08-27
申请人： COOK INCORPORATED , BATES, Brian, L.
发明人： BATES, Brian, L.
IPC分类号： A61F2/00 , A61B17/00
CPC分类号： A61F2/0063 , A61B17/00234 , A61F2002/0072
摘要： The invention provides, in certain aspects, grafting devices deliverable into the body for repairing defects in bodily structure walls. One such grafting device comprises a compliant sheet-form material, and a removable resilient element that is retained in association with the sheet-form material. In some forms, the resilient element is adapted for delivery in its entirety into the body, and thereafter, can be disassociated from the sheet-form material for removal from the body. The sheet- form material may be formed with one or more of a variety of biocompatible materials including some that are naturally derived and some that are non-naturally derived. Illustratively, the sheet-form material may be comprised of a remodelable, angiogenic material, for example, a remodelable extracellular matrix (ECM) material. In additional embodiments, the invention provides methods and apparatuses for delivering these and other inventive grafting device into the body.
摘要翻译：本发明在某些方面提供可递送到身体中的修补器件结构壁中的缺陷的移植装置。一种这样的接枝装置包括顺应性片状材料和与片状材料相关联地保持的可移除的弹性元件。在一些形式中，弹性元件适于将其全部输送到本体中，此后可以与片状材料分离，以从身体移除。片状材料可以由各种生物相容性材料中的一种或多种形成，包括天然衍生的一些，并且一些是非天然衍生的。示例性地，片状材料可以由可重塑的血管生成材料，例如可重塑的细胞外基质（ECM）材料组成。在另外的实施例中，本发明提供了用于将这些和其他创新的移植装置递送到体内的方法和装置。

5. 发明申请

WO2006026744A1 DEVICE FOR TREATING AN ANEURYSM 审中-公开
标题翻译：用于治疗神经的装置
公开(公告)号：WO2006026744A1
公开(公告)日：2006-03-09
申请号：PCT/US2005/031277
申请日：2005-08-31
申请人： COOK INCORPORATED , BATES, Brian, L. , CONDER, Andrew, W. , BUTLER, Gary, L.
发明人： BATES, Brian, L. , CONDER, Andrew, W. , BUTLER, Gary, L.
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12013 , A61B17/12113 , A61B17/12118 , A61B17/12172 , A61B17/12181 , A61B2017/00867 , A61B2017/00898 , A61B2017/12054 , A61B2017/12063 , A61B2017/12095
摘要： A device for treating balloon-type (or berry) aneurysms is provided. The device restricts blood flow into the aneurysm with a patch that covers the neck of the aneurysm. The patch is secured within the neck of the aneurysm by an anchor member, basket, insert or other structure that engages the inner surface of the aneurysm.
摘要翻译：提供了一种用于治疗气球型（或浆果）动脉瘤的装置。该装置通过覆盖动脉瘤颈部的补片来限制血液流入动脉瘤。通过与动脉瘤的内表面接合的锚固构件，篮，插入件或其他结构，将补片固定在动脉瘤的颈部内。

6. 发明申请

WO2005118019A1 IMPLANTABLE BIOABSORBABLE VALVE SUPPORT FRAME 审中-公开
标题翻译：可植入式可生物阀支撑框架
公开(公告)号：WO2005118019A1
公开(公告)日：2005-12-15
申请号：PCT/US2005/018132
申请日：2005-05-23
申请人： COOK INCORPORATED , BATES, Brian, L.
发明人： BATES, Brian, L.
IPC分类号： A61L31/14
CPC分类号： A61F2/2475 , A61F2/2418 , A61F2210/0004 , A61F2220/0016 , A61F2220/0075 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2230/0095
摘要： Medical devices for implantation within a body vessel comprising a frame formed at least in part from a metallic bioabsorbable material are provided. The devices can be pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material, or a bioabsorbable material, including a collagen-based material such as small intestinal submucosa (SIS), may be attached to the frame to form an occlusion device, a graft, or an implantable, intraluminal valve such as for correcting incompetent venous valves.
摘要翻译：提供用于植入体内容器的医疗装置，其包括至少部分地由金属生物可吸收材料形成的框架。装置可以从输送导管推入管道或容器的内腔中，并且可以包括用于锚定目的的一个或多个倒钩。织物或其他柔性材料或包括基于胶原的材料如小肠粘膜下层（SIS）的生物可吸收材料的全部或部分覆盖物可以附着到框架上以形成闭塞装置，移植物或植入物，腔内瓣膜如纠正无力静脉瓣膜。

7. 发明申请

WO2010025379A1 VENA CAVA FILTER HAVING PLURALITY OF HOOKS 审中-公开
标题翻译： VENA CAVA过滤器具有多样的HOOKS
公开(公告)号：WO2010025379A1
公开(公告)日：2010-03-04
申请号：PCT/US2009/055381
申请日：2009-08-28
申请人： COOK INCORPORATED , BATES, Brian, L.
发明人： BATES, Brian, L.
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/016 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： A removable filter for capturing thrombi in a body vessel is disclosed. The filter comprises a plurality of primary struts comprising proximal and distal portions. Each proximal portion has a first end, wherein the first ends are attached together along a longitudinal axis. Each primary strut extends arcuately along the longitudinal axis and linearly radially. The distal portions of the primary struts are configured to expand in the body vessel, engaging the distal hooks with the body vessel. Each distal portion integrally extends from the proximal portion to a plurality of distal hooks. The distal hooks are substantially equal in size relative to each other.
摘要翻译：公开了一种用于在身体血管中捕获血栓的可移除过滤器。过滤器包括多个主支柱，其包括近端部分和远端部分。每个近端部分具有第一端，其中第一端部沿着纵向轴线附接在一起。每个主支柱沿着纵向轴线弧线延伸并且线性地径向延伸。主支柱的远端部分构造成在身体容器中膨胀，将远端钩与身体血管接合。每个远侧部分从近端部分整体地延伸到多个远端钩。远端钩相对于彼此大小相等。

8. 发明申请

WO2007041131A2 COATED VASO-OCCLUSION DEVICE 审中-公开
标题翻译：涂层VASO-OCCLUSION设备
公开(公告)号：WO2007041131A2
公开(公告)日：2007-04-12
申请号：PCT/US2006/037595
申请日：2006-09-28
申请人： COOK INCORPORATED , BATES, Brian, L.
发明人： BATES, Brian, L.
IPC分类号： A61B17/12 , A61L31/16
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12145 , A61B17/1215 , A61B17/12181 , A61B90/39 , A61B2017/00004 , A61B2017/00893 , A61B2090/374 , A61B2090/3954 , A61L31/06 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/418 , A61L2300/42 , A61L2430/36 , C08L75/04
摘要： Compositions and methods for occluding a vessel in a subject are provided in which a vaso-occlusion device includes an occluding element having a polymeric material containing a plurality of holes at least partially filled with one or more bioactive agents, the vaso-occlusion device configured to occlude a vessel in the subject.
摘要翻译：提供了一种用于闭塞受试者中的血管的组合物和方法，其中血管闭塞装置包括具有至少部分填充有一种或多种生物活性剂的多个孔的聚合材料的阻塞元件，所述血管闭塞装置被配置为封闭受试者的血管。

9. 发明申请

WO2007002260A3 IMPLANTABLE GRAFT TO CLOSE A FISTULA 审中-公开
公开(公告)号：WO2007002260A3
公开(公告)日：2007-01-04
申请号：PCT/US2006/024260
申请日：2006-06-21
申请人： COOK INCORPORATED , COOK BIOTECH, INC. , ARMSTRONG, David, N. , BATES, Brian, L. , BLEYER, Mark, W. , OBERMILLER, F., Joseph , PATEL, Umesh, H.
发明人： ARMSTRONG, David, N. , BATES, Brian, L. , BLEYER, Mark, W. , OBERMILLER, F., Joseph , PATEL, Umesh, H.
IPC分类号： A61B17/00
摘要： An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft. The graft may also have a tail that extends from one end of the body of the graft to assist in placement of the graft in a fistula tract. The graft may be an integral unit made of a single material, such as a heterograft material, or may include distinct components made of the same or different materials. Methods for closing a fistula tract are also provided.

10. 发明申请

WO2004100836A1 STENT GRAFT 审中-公开
公开(公告)号：WO2004100836A1
公开(公告)日：2004-11-25
申请号：PCT/US2004/014689
申请日：2004-05-12
申请人： COOK INCORPORATED , COOK BIOTECH INCORPORATED , FETTE, Clay, D. , BATES, Brian, L. , PAUL, Ram, H., Jr. , AMARANT, Paul, D.
发明人： FETTE, Clay, D. , BATES, Brian, L. , PAUL, Ram, H., Jr. , AMARANT, Paul, D.
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B17/0644 , A61B2017/00252 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61F2/064 , A61F2/848 , A61F2/86 , A61F2/89 , A61F2002/8483 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2230/005
摘要： An anastomosis device (12) for advantageously bridging an artery and a vein. The anastomosis device includes a tubular graft (15) with first and second ends (47 and 48) and a longitudinal passageway extending longitudinally through the graft. The device further includes a first stent (10) disposed about the first end of the tubular graft and a second stent (10) disposed about the second end of the tubular graft. Each of the first and second stents has a plurality of hooks or barbs (11) pointed or releasable to the point toward the other end of the graft.
摘要翻译：一种用于有利地桥接动脉和静脉的吻合装置（12）。吻合装置包括具有第一和第二端（47和48）的管状移植物（15）和纵向延伸穿过移植物的纵向通道。该装置还包括围绕管状移植物的第一端设置的第一支架（10）和围绕管状移植物的第二端设置的第二支架（10）。第一和第二支架中的每一个具有多个钩或倒钩（11），所述钩或倒钩可指向或可释放到朝向移植物另一端的点。

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