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1. 发明申请

WO2008030488A3 STENTS WITH CONNECTORS AND STABILIZING BIODEGRADABLE ELEMENTS 审中-公开
公开(公告)号：WO2008030488A3
公开(公告)日：2008-03-13
申请号：PCT/US2007/019389
申请日：2007-09-06
申请人： MED INSTITUTE, INC. , COOK INCORPORATED , LEEWOOD, Alan, R. , GREWE, David, D. , HIATT, Mark , RAGHEB, Anthony, O. , VOORHEES, III, William, D. , ROEDER, Blayne, A. , PURDY, James, D.
发明人： LEEWOOD, Alan, R. , GREWE, David, D. , HIATT, Mark , RAGHEB, Anthony, O. , VOORHEES, III, William, D. , ROEDER, Blayne, A. , PURDY, James, D.
IPC分类号： A61F2/86 , A61F2/84
摘要： Various stent structures are provided with improved axial and torsional flexibility. One type of stent structure includes multiple segmented stent structures connected to each other by biodegradable interconnectors. A delivery system adapted to delivery the multiple segmented stents is also described. Another type of stent structure includes biodegradable connectors that are incorporated into a framework of non-biodegradable interconnecting members that form the support structure of the stent. The biodegradable connectors in both stent structures degrade or are absorbed after the stent is deployed. Stabilizing elements may be provided to the stent structures to supplement the stiffness of the stent with stability during loading and deployment.

2. 发明申请

WO2003026718A1 COATED IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：涂层可植入医疗器械
公开(公告)号：WO2003026718A1
公开(公告)日：2003-04-03
申请号：PCT/US2001/045577
申请日：2001-10-31
申请人： COOK INCORPORATED , MED INSTITUTE, INC.
发明人： RAGHEB, Anthony, O. , BATES, Brian, L. , STEWART, Joseph, M., IV , BOURDEAU, William, J. , CHOULES, Brian, D. , PURDY, James, D. , FEARNOT, Neal, E.
IPC分类号： A61L31/16
CPC分类号： A61L27/54 , A61F2/86 , A61F2250/0067 , A61L31/16 , A61L2300/252 , A61L2300/414 , A61L2300/606
摘要： A medical device (10) includes a structure (12) adapted for introduction into a patient, the structure (12) being formed of a preferably non-porous base material (14) having a roughened or textured surface (16). The structure (12) is conveniently configured as a vascular stent with a base material (14) of stainless steel, nitinol or another suitable material. The medical device (10) also includes a layer (18) of a bioactive material posited directly upon the roughened or textured surface (16) of the base material (14) of the structure (12). The surface (16) of the base material (14) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface (16) is thought to have a mean surface roughness of about 10 μin. (about 250 nm) and a surface roughness range between about 1/μin. and about 100 μin. (about 25 nm and about 2.5 μm). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface (16) of the base material (14) of the structure (12) is additionally advantageous in the low toxicity of the sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate.
摘要翻译：医疗装置（10）包括适于引入患者的结构（12），所述结构（12）由具有粗糙或纹理表面（16）的优选无孔基材（14）形成。结构（12）方便地构造为具有不锈钢，镍钛诺或其它合适材料的基础材料（14）的血管支架。医疗装置（10）还包括直接位于结构（12）的基底材料（14）的粗糙或纹理表面（16）上的生物活性材料层（18）。基体材料（14）的表面（16）通过蚀刻或用碳酸氢钠或另一种适当的砂粒磨损而粗糙化或纹理化。认为优选的粗糙化或纹理表面（16）具有约10微米（约250nm）的平均表面粗糙度和约1 /μm至约100微米（约25nm）约2.5亩）。特别优选使用碳酸氢钠作为研磨剂以对结构（12）的基础材料（14）的表面（16）提供粗糙度或织构，另外在碳酸氢钠对生产工人的低毒性方面也是有利的，易于产品和废物清理，以及任何残留碳酸氢钠的生物相容性。

3. 发明申请

WO2006071915A2 UNIDIRECTIONAL DELIVERY SYSTEM 审中-公开
标题翻译： UNIDIRECTIONAL交付系统
公开(公告)号：WO2006071915A2
公开(公告)日：2006-07-06
申请号：PCT/US2005/047184
申请日：2005-12-27
申请人： COOK INCORPORATED
发明人： BAKER, Deborah, A. , PURDY, James, D. , PARKER, Fred, T.
IPC分类号： A61F2/84
CPC分类号： A61F2/966 , A61F2/95 , A61F2002/9517
摘要： A tubular prosthesis delivery system (20) has an inner tubular member (24) having a distal end (26) including a prosthesis-carrying portion (28) and a proximal end (30) generally intended to remain outside the patient. An outer tubular member (32) has a distal end (34) spaced from the prosthesis-carrying portion (28) of the inner member (24). A coupling member (36) couples the inner and outer tubular members (24, 32) to each other in fixed relationship generally at a location intended to remain outside the patient. An intermediate tubular member (38) located between the inner and outer tubular members has a distal end (40) adapted to cover the tubular prosthesis (22) and a proximal end (42) that projects proximally beyond the proximal ends (30, 44) of both the inner and outer tubular members (24, 32), and a slot (46) receiving the coupling member (36). The proximally projecting end (42) of the intermediate tubular member (38) is longitudinally movable with respect to the coupled inner and outer tubular members (24, 32) by a distance sufficient to retract the intermediate tubular member distal end (34) from any position covering the prosthesis (22) carried by the inner member (24).
摘要翻译：管状假体递送系统（20）具有内部管状构件（24），所述内部管状构件（24）具有包括假体承载部分（28）的远端（26）和通常旨在保持在患者外部的近端（30）。外部管状构件（32）具有与内部构件（24）的假体承载部分（28）间隔开的远端（34）。联接构件（36）以固定关系将内管状构件（24）与外管状构件（32）彼此连接，大致位于旨在保持在患者外部的位置。位于内管状构件和外管状构件之间的中间管状构件（38）具有适于覆盖管状假体（22）的远端（40）和近端突出超过近端（30,44）的近端（42）内部和外部管状构件（24,32）两者以及容纳联接构件（36）的槽（46）。中间管状构件（38）的近端突出的端部（42）可相对于联接的内部和外部管状构件（24,32）纵向移动一定距离，足以将中间管状构件远端（34）从任何覆盖由内部构件（24）承载的假体（22）的位置。

4. 发明公开

EP1833431A2 UNIDIRECTIONAL DELIVERY SYSTEM 有权
标题翻译：单程供应系统
公开(公告)号：EP1833431A2
公开(公告)日：2007-09-19
申请号：EP05855698.6
申请日：2005-12-27
申请人： Cook Incorporated
发明人： BAKER, Deborah, A. , PURDY, James, D. , PARKER, Fred, T.
IPC分类号： A61F2/84
CPC分类号： A61F2/966 , A61F2/95 , A61F2002/9517
摘要： A tubular prosthesis delivery system (20) has an inner tubular member (24) having a distal end (26) including a prosthesis-carrying portion (28). An outer tubular member (32) has a distal end (34) spaced from the prosthesis-carrying portion (28) of the inner member (24). A coupling member (36) couples the inner and outer tubular members (24, 32) to each other. An intermediate tubular member (38) located between the inner and outer tubular members covers the tubular prosthesis (22) and a slot (46) receiving the coupling member (36). The proximally projecting end (42) of the intermediate tubular member (38) is longitudinally movable with respect to the coupled inner and outer tubular members (24, 32) to retract the intermediate tubular member distal end (34) from the prosthesis (22) carried by the inner member (24).

5. 发明公开

EP1042030A2 APPARATUS FOR SUPPLYING RADIOACTIVE GAS TO A DELIVERY DEVICE 审中-公开
标题翻译：装置，用于输送放射性气体到管理单位
公开(公告)号：EP1042030A2
公开(公告)日：2000-10-11
申请号：EP98960455.8
申请日：1998-12-01
申请人： Cook Incorporated , MED INSTITUTE, INC.
发明人： APPLE, Marc, G. , BATES, Brian, L. , DEFORD, John, A. , FEARNOT, Neal, E. , PURDY, James, D.
IPC分类号： A61M36/06 , A61N5/10
CPC分类号： A61M25/10182 , A61M25/10185 , A61N5/1002 , A61N2005/1021
摘要： Disclosed is a catheter apparatus filled with a radiation carrier material such as an inert radioactive gas for the treatment of restenosis after angioplasty, and malignancies. The inflated catheter includes a single unit or alternatively, a plurality of discrete chambers for transporting the radioactive carrier material and through which, blood may continue to flow during treatment with the prescribed radiation. When the radioactive carrier is a gas such as Xenon 133, an injection apparatus (1400) may be used that permits use of a standard radioactive gas source vial (1401) that may be loaded into the radioactive source vial enclosure or chamber (1403). The means for enclosing the vial (1404) may also serve as an urging mechanism (1442) to urge the source vial (1401) toward one or more piercing cannulae (1406, 1454) which permit delivery of the radioactive gas to the catheter. In one series of embodiments, the radioactive gas is withdrawn through a selector means (1409) such as a multiple position valve into a gas-tight variable volume chamber (1411) such as a syringe which then is deployed to deliver the gas into the catheter. Following treatment, the gas is withdrawn into the syringe and returned to the source vial (1401). In another series of embodiments a syringe filled with a liquid is used to displace the gas either directly into the delivery catheter (1422), or into a second syringe which injects the gas to the delivery catheter (1422).

6. 发明授权

EP1833431B1 UNIDIRECTIONAL DELIVERY SYSTEM 有权
标题翻译：单程供应系统
公开(公告)号：EP1833431B1
公开(公告)日：2010-10-13
申请号：EP05855698.6
申请日：2005-12-27
申请人： Cook Incorporated
发明人： BAKER-JANIS, Deborah, A. , PURDY, James, D. , PARKER, Fred, T.
IPC分类号： A61F2/84
CPC分类号： A61F2/966 , A61F2/95 , A61F2002/9517
摘要： A tubular prosthesis delivery system (20) has an inner tubular member (24) having a distal end (26) including a prosthesis-carrying portion (28). An outer tubular member (32) has a distal end (34) spaced from the prosthesis-carrying portion (28) of the inner member (24). A coupling member (36) couples the inner and outer tubular members (24, 32) to each other. An intermediate tubular member (38) located between the inner and outer tubular members covers the tubular prosthesis (22) and a slot (46) receiving the coupling member (36). The proximally projecting end (42) of the intermediate tubular member (38) is longitudinally movable with respect to the coupled inner and outer tubular members (24, 32) to retract the intermediate tubular member distal end (34) from the prosthesis (22) carried by the inner member (24).

7. 发明授权

EP1330273B1 COATED IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：涂层纸，植入式医疗设备
公开(公告)号：EP1330273B1
公开(公告)日：2007-07-25
申请号：EP01987197.9
申请日：2001-10-31
申请人： Cook Incorporated , MED INSTITUTE, INC.
发明人： RAGHEB, Anthony, O. , BATES, Brian, L. , STEWART, Joseph, M., IV , BOURDEAU, William, J. , CHOULES, Brian, D. , PURDY, James, D. , FEARNOT, Neal, E.
IPC分类号： A61L31/16 , A61L27/54
CPC分类号： A61L27/54 , A61F2/86 , A61F2250/0067 , A61L31/16 , A61L2300/252 , A61L2300/414 , A61L2300/606
摘要： A medical device (10) includes a structure (12) adapted for introduction into a patient, the structure (12) being formed of a preferably non-porous base material (14) having a roughened or textured surface (16). The structure (12) is conveniently configured as a vascular stent with a base material (14) of stainless steel, nitinol or another suitable material. The medical device (10) also includes a layer (18) of a bioactive material posited directly upon the roughened or textured surface (16) of the base material (14) of the structure (12). The surface (16) of the base material (14) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface (16) is thought to have a mean surface roughness of about 10 νin. (about 250 nm) and a surface roughness range between about 1/νin. and about 100 νin. (about 25 nm and about 2.5 νm). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface (16) of the base material (14) of the structure (12) is additionally advantageous in the low toxicity of the sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate.

8. 发明公开

EP1330273A1 COATED IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：涂层纸，植入式医疗设备
公开(公告)号：EP1330273A1
公开(公告)日：2003-07-30
申请号：EP01987197.9
申请日：2001-10-31
申请人： Cook Incorporated , MED INSTITUTE, INC.
发明人： RAGHEB, Anthony, O. , BATES, Brian, L. , STEWART, Joseph, M., IV , BOURDEAU, William, J. , CHOULES, Brian, D. , PURDY, James, D. , FEARNOT, Neal, E.
IPC分类号： A61L31/16 , A61L27/54
CPC分类号： A61L27/54 , A61F2/86 , A61F2250/0067 , A61L31/16 , A61L2300/252 , A61L2300/414 , A61L2300/606
摘要： A medical device (10) includes a structure (12) adapted for introduction into a patient, the structure (12) being formed of a preferably non-porous base material (14) having a roughened or textured surface (16). The structure (12) is conveniently configured as a vascular stent with a base material (14) of stainless steel, nitinol or another suitable material. The medical device (10) also includes a layer (18) of a bioactive material posited directly upon the roughened or textured surface (16) of the base material (14) of the structure (12). The surface (16) of the base material (14) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface (16) is thought to have a mean surface roughness of about 10 νin. (about 250 nm) and a surface roughness range between about 1/νin. and about 100 νin. (about 25 nm and about 2.5 νm). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface (16) of the base material (14) of the structure (12) is additionally advantageous in the low toxicity of the sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate.

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