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1. 发明申请

WO2011146729A3 DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS 审中-公开
标题翻译：用于密封裸露开口的装置和方法
公开(公告)号：WO2011146729A3
公开(公告)日：2012-01-12
申请号：PCT/US2011037173
申请日：2011-05-19
申请人： COOK INC , COOK BIOTECH INC , PAUL RAM H , STANLEY CLEON , BATES BRIAN L , OBERMILLER F JOSEPH , OSBORNE THOMAS A , CHAMBERS SEAN
发明人： PAUL RAM H , STANLEY CLEON , BATES BRIAN L , OBERMILLER F JOSEPH , OSBORNE THOMAS A , CHAMBERS SEAN
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/3468 , A61B2017/00004 , A61B2017/00592 , A61B2017/00597 , A61B2017/00623 , A61B2017/00628 , A61B2017/00641 , A61B2017/00659 , A61B2017/00663 , A61B2017/0496 , A61B2017/06176
摘要： Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube (24) is provided for insertion through a sheath (22) into a vessel (e.g. a blood vessel). A dome-shaped seal (26) fixed to a filament (28), an absorbent and/or compressible buffer (30), and a locking member (32) are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.
摘要翻译：除此之外，还公开了用于医疗密封容器或壁中的开口的装置和方法。例如，在医疗应用中，提供输送管（24）用于通过护套（22）插入血管（例如血管）中。固定在灯丝（28）上的圆顶形密封件（26），吸收性和/或可压缩缓冲器（30）以及锁定件（32）。输送管被构造成使得其可以通过护套插入到容器中。在灯丝上保持张力以将密封件保持在管或鞘上。护套被拉出，同时拉出管子，将密封件留在血管壁的开口处。锁定构件将缓冲器压靠在容器的外部，并且灯丝将密封件保持在与容器内部的适当位置。

2. 发明申请

WO2006041972A2 MEDICAL DEVICE WITH BIOACTIVE AGENT 审中-公开
标题翻译：具有生物活性剂的医疗器械
公开(公告)号：WO2006041972A2
公开(公告)日：2006-04-20
申请号：PCT/US2005035912
申请日：2005-10-06
申请人： COOK INC , OSBORNE THOMAS A , FLAGLE JACOB A , CASE BRIAN C , OBERMILLER JOSEPH F , PAUL RAM H
发明人： OSBORNE THOMAS A , FLAGLE JACOB A , CASE BRIAN C , OBERMILLER JOSEPH F , PAUL RAM H
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2230/0026 , A61F2230/0067 , A61F2230/008 , A61F2230/0095 , A61F2250/0067
摘要： Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.
摘要翻译：提供具有一种或更多生物活性剂的医疗装置用于调节通过身体血管的流体流动。根据本发明的医疗装置可以包括包括生物活性剂的人造瓣膜。

3. 发明申请

WO2005077432A3 CAST BIOREMODELABLE GRAFT 审中-公开
公开(公告)号：WO2005077432A3
公开(公告)日：2006-03-30
申请号：PCT/US2005003968
申请日：2005-02-09
申请人： COOK INC , COOK BIOTECH INC , EELLS SCOTT E , HILES MICHAEL C , OSBORNE THOMAS A
发明人： EELLS SCOTT E , HILES MICHAEL C , OSBORNE THOMAS A
IPC分类号： A61L27/36 , A61L27/50 , A61L27/58 , A61L31/00 , A61L27/24
CPC分类号： A61L27/507 , A61L27/3629 , A61L27/3633 , A61L27/58
摘要： A cast bioremodelable graft (22) comprising a casttubular construct (33) of a bioremodelable substance (34) . The bioremodelable substance is cast on or applied to a form and then vacuum pressed to dry or harden the substance. Expandable members (18) are disposed on, in, under or about the cast tubular construct to expand the graft when released frorn an endoluminal delivery system. A second layer (39) can be applied over the first layer (38) and the expandable stents to contain the stents there between without the need for any separate attachment. The graft is dehydrated and preferably vacuum pressed to harden the bioremodelable substance. The form is removed to form one or more lumens (23, 25) in the graft, which is then loaded on an endoluminal delivery system.
摘要翻译：包含生物可重塑物质（34）的管状构造物（33）的铸塑生物可重塑移植物（22）。将生物可重塑物质浇铸或施加到形式上，然后真空压制以干燥或硬化物质。可膨胀构件（18）设置在铸造管状构件的上方，下面或附近，以在释放内腔内输送系统时扩张移植物。第二层（39）可以施加在第一层（38）上，并且可扩展支架在其间包含支架，而不需要任何单独的附接。将移植物脱水并优选真空压制以使生物可重塑物质硬化。去除形式以在移植物中形成一个或多个腔（23,25），然后将其装载在腔内递送系统上。

4. 发明申请

WO2005011535A3 PROSTHETIC VALVE FOR IMPLANTATION IN A BODY VESSEL 审中-公开
标题翻译：用于植入体内的浮选阀
公开(公告)号：WO2005011535A3
公开(公告)日：2006-03-16
申请号：PCT/US2004024969
申请日：2004-07-30
申请人： COOK INC , CASE BRIAN C , OSBORNE THOMAS A , FLAGLE JACOB A , PARKER FRED T
发明人： CASE BRIAN C , OSBORNE THOMAS A , FLAGLE JACOB A , PARKER FRED T
IPC分类号： A61F2/06 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Prosthetic valves for implantation in a body vessel are provided. Prosthetic valves according to the invention comprise first and second frame members and a graft member at least partially disposed between the first and second frame members. The graft member forms a valve that permits fluid flow through the body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的假体瓣膜。根据本发明的假体瓣膜包括第一和第二框架构件以及至少部分地设置在第一和第二框架构件之间的移植构件。移植物构件形成允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体血管。

5. 发明申请

WO2005070337A3 ENDOLUMINAL STENT GRAFT WITH SUTURED ATTACHMENT 审中-公开
标题翻译：具有连接附件的内固定支架
公开(公告)号：WO2005070337A3
公开(公告)日：2005-09-22
申请号：PCT/US2005001830
申请日：2005-01-18
申请人： COOK INC , DEBRUYNE MICHAEL P , LAD ASHVIN , OSBORNE THOMAS A
发明人： DEBRUYNE MICHAEL P , LAD ASHVIN , OSBORNE THOMAS A
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/848 , A61F2/89 , A61F2002/067 , A61F2002/075 , A61F2220/0016 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0067
摘要： An endoluminal prosthetic device for placement in a body lumen is formed by stitching stents to a graft. A first or anchoring stent (12) is used for securing a graft made of biocompatible material that forms at least one lumen. There is also a second stent (14). The first and second stents each include a plurality of struts (15, 25) and apices (16, 26) between the struts. At least two of the apices in each of the first and second stents are secured to the graft by stitches (21, 23). A running suture (24) links at least one stitch of the first stent and one stitch of the second stent. The running suture linking the first stent and the second stent adds strength to the stitches and better secures the first stent to the device. The endoluminal prosthetic device may be used in an aortic vessel to treat stenoses or aneurysms.
摘要翻译：通过将支架缝合到移植物上而形成用于放置在体腔内的腔内假体装置。第一或锚固支架（12）用于固定由形成至少一个内腔的生物相容性材料制成的移植物。还有第二支架（14）。第一和第二支架各自包括在支柱之间的多个支柱（15,25）和顶点（16,26）。第一和第二支架中的每一个中的至少两个顶点通过针脚（21,23）固定到移植物上。运行缝合线（24）连接第一支架的至少一个线圈和第二支架的一个线圈。连接第一支架和第二支架的运行缝合线为线圈增加了强度，并且将第一支架更好地固定到装置。腔内修复装置可用于主动脉血管以治疗狭窄或动脉瘤。

6. 发明申请

WO2006113863A3 MEDICAL APPARATUS FOR RAPID INSERTION 审中-公开
标题翻译：医疗器械用于快速插入
公开(公告)号：WO2006113863A3
公开(公告)日：2007-09-27
申请号：PCT/US2006014864
申请日：2006-04-20
申请人： COOK INC , PAL DHARMENDRA , AGNEW CHARLES W , FLAGLE JACOB A , LENTZ D CHRISTIAN , MELSHEIMER JEFFRY S , OSBORNE THOMAS A , PARKER FRED T
发明人： PAL DHARMENDRA , AGNEW CHARLES W , FLAGLE JACOB A , LENTZ D CHRISTIAN , MELSHEIMER JEFFRY S , OSBORNE THOMAS A , PARKER FRED T
IPC分类号： A61F2/84
CPC分类号： A61M25/0662 , A61F2/95 , A61F2002/9517 , A61M25/0045 , A61M25/005 , A61M25/0053
摘要： Delivery systems for self-expanding devices are provided having a system proximal portion with a handle, an elongate middle section delivery device with an outer sheath and inner compression member, and a system distal portion including an outer guide channel member with first and second end portions defining a guide channel that slidably receives an inner guide channel member having a guide channel, the guide channels being substantially aligned. A mounting region for self-expanding devices is disposed radially between the inner and outer guide channel members. The outer guide channel member has a stepped profile from a first outer diameter to a second smaller outer diameter located near a transition region having a breech position opening for passage of a wire guide, catheter, or other medical instrument. The outer member is axially slideable relative to the inner member to deploy a self-expanding device. Methods of using and manufacturing are also provided.
摘要翻译：提供了一种用于自扩张装置的输送系统，其具有带手柄的系统近端部分，具有外护套和内部压缩构件的细长中间部分输送装置，以及包括具有第一和第二端部的外部引导通道构件的系统远端部分限定了可滑动地容纳具有引导通道的内部引导通道构件的引导通道，所述引导通道基本对齐。用于自膨胀装置的安装区域径向地设置在内引导通道构件和外引导通道构件之间。外引导通道构件具有从第一外径到第二较小外径的阶梯轮廓，位于具有用于导线器，导管或其他医疗器械通过的后膛位置开口的过渡区域附近。外部构件相对于内部构件可轴向滑动以展开自扩张装置。还提供了使用和制造方法。

7. 发明申请

WO2007076114A3 PROSTHESIS DEPLOYMENT SYSTEM 审中-公开
标题翻译： PROSTHESIS部署系统
公开(公告)号：WO2007076114A3
公开(公告)日：2007-12-06
申请号：PCT/US2006049240
申请日：2006-12-22
申请人： COOK INC , OSBORNE THOMAS A
发明人： OSBORNE THOMAS A
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2002/9511 , A61F2002/9517 , A61F2002/9665
摘要： A trigger wire release mechanism is disclosed that includes a control member for selectively releasing a trigger wire (22, 44) from a prosthesis retaining device. The control member includes an elongate body member (36) and a guide member (24, 25, 93, 94) slidably disposed on the elongate body member. The trigger wire 1 (22, 44) includes a distal end coupled to the prosthesis retaining device and a proximal end coupled to the guide member. The guide member (24, 25, 93, 94) can lbe moved from a distal end of the elongate body (36) to a proximal end of the elongate body, thereby disengaging the trigger wire (22, 44) from the retaining device. The control member may include a locking mechanism (120) for limiting the axial position of the guide member (24, 25, 93, 94) along the elongate body member (36). A prosthesis control member (81) is also disclosed. The prosthesis control member (81) is adapted to control the position of the prosthesis during deployment.
摘要翻译：公开了一种触发线释放机构，其包括用于选择性地从假体保持装置释放触发线（22,44）的控制构件。控制构件包括细长主体构件（36）和可滑动地设置在细长主体构件上的导向构件（24,25,93,94）。触发线1（22,44）包括联接到假体保持装置的远端和联接到引导构件的近端。引导构件（24,25,93,94）可以从细长主体（36）的远端移动到细长主体的近端，由此使扳机线（22,44）与保持装置分离。控制构件可以包括用于限制引导构件（24,25,93,94）沿着细长本体构件（36）的轴向位置的锁定机构（120）。还公开了一种假体控制构件（81）。假体控制构件（81）适于在展开期间控制假体的位置。

8. 发明申请

WO2007053592A3 COMPOSITE STENT GRAFT 审中-公开
标题翻译：复合钢筋混凝土
公开(公告)号：WO2007053592A3
公开(公告)日：2007-08-16
申请号：PCT/US2006042402
申请日：2006-10-31
申请人： COOK INC , OSBORNE THOMAS A
发明人： OSBORNE THOMAS A
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/826 , A61F2002/828 , A61F2220/0075 , A61F2230/0054 , A61F2250/0056
摘要： A composite prosthesis (19, 99, 199) and method are disclosed herein. This endoluminal prosthesis is constructed by separately deploying a first prosthesis (9, 201 ) and a second prosthesis (14, 208), wherein the first prosthesis is deployed and secured to the interior surface of a body lumen (260). In a subsequent step, the second prosthesis is deployed substantially within and secured to the first prosthesis. Although additional prostheses may be deployed within the second prosthesis, in a preferred configuration the first and second prostheses combine to provide all of the necessary attributes associated with a functioning endoluminal prosthesis. Thus, one of the first and second prostheses is permeable to blood and exerts sufficient radial force to cause the composite prosthesis to securely engage an interior surface of the body lumen at one or both of the composite prosthesis's proximal and distal ends, while the other of the first and second prostheses is impermeable to blood flow.
摘要翻译：本文公开了一种复合假体（19,99,199）和方法。该腔内假体通过分开展开第一假体（9,201）和第二假体（14,208）来构造，其中第一假体展开并固定到体腔（260）的内表面。在随后的步骤中，第二假体基本上部署在第一假体内并固定到第一假体。虽然附加的假体可以部署在第二假体内，但是在优选的构造中，第一和第二假体组合以提供与功能性腔内假体相关联的所有必要属性。因此，第一和第二假体中的一个可渗透血液并施加足够的径向力，以使复合假体在复合假体的近端和远端中的一个或两个处牢固地接合体腔的内表面，而另一个第一和第二假体是不透血的。

9. 发明申请

WO2007136660A3 PATENT FORAMEN OVALE CLOSURE DEVICE AND METHOD 审中-公开
标题翻译：专利文献OVELL封闭装置及方法
公开(公告)号：WO2007136660A3
公开(公告)日：2008-04-03
申请号：PCT/US2007011743
申请日：2007-05-15
申请人： COOK INC , OSBORNE THOMAS A
发明人： OSBORNE THOMAS A
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00579 , A61B2017/0061 , A61B2017/00893
摘要： A device and method for closure, of a body channel of a patient, such as a patent foramen ovale. The device includes a frame member having a collapsed condition and an expanded condition. The frame member is sized and arranged to be percutaneously insertable into an area of the foramen ovale when in the collapsed condition, and to substantially span the foramen ovale when in the expanded condition. A promoter carried by the frame member, such as a clot- promoting composition and/or a tissue growth-promoting composition, is capable of promoting biological formation with the tissue bordering the foramen ovale to effect a closure of the foramen ovale.
摘要翻译：用于关闭患者身体通道的装置和方法，例如卵孔卵孔专利。该装置包括具有折叠状态和膨胀状态的框架构件。框架构件的尺寸和布置被设计成在处于折叠状态时经皮插入到卵圆孔的区域中，并且在处于扩张状态时基本跨越卵圆孔。由框架构件承载的促进剂，例如促凝组织和/或组织生长促进组合物，能够促进与卵圆孔相邻的组织的生物形成，从而实现卵圆孔闭合。

10. 发明申请

WO2007098231A3 IMPLANT RETRIEVAL ASSEMBY AND METHOD FOR RETRIEVING AN IMPLANT 审中-公开
标题翻译：植入物检索装置和用于检索植入物的方法
公开(公告)号：WO2007098231A3
公开(公告)日：2007-10-25
申请号：PCT/US2007004562
申请日：2007-02-20
申请人： COOK INC , MELSHEIMER JEFFRY S , OSBORNE THOMAS A
发明人： MELSHEIMER JEFFRY S , OSBORNE THOMAS A
IPC分类号： A61B17/22 , A61B17/00 , A61B17/28 , A61B17/32
CPC分类号： A61B17/221 , A61B17/32056 , A61B17/3468 , A61B2017/0046 , A61B2017/00477 , A61B2017/2919
摘要： An implant retrieval frame for advancement of a retrieval device to snare an implant is disclosed. The frame comprises a first arm and a second arm. The first arm has a first handle end and a first pivot end. The second arm has a second handle end and a second pivot end. The second pivot end is connected to the first pivot end to define a pivot axis about which the first and second arm pivotally move. The frame further comprises a connector to which the retrieval device is attached. The connector is configured to cooperate with the first and second arms to translate pivotal movement of one of the first and second arms to linear movement of the retrieval device relative to the pivot point.
摘要翻译：公开了用于推进取回装置以圈套植入物的植入物取回框架。该框架包括第一臂和第二臂。第一臂具有第一手柄端和第一枢轴端。第二臂具有第二手柄端和第二枢轴端。第二枢转端连接到第一枢转端以限定枢转轴线，第一臂和第二臂绕其枢转地移动。该框架还包括连接器，该收回装置附接到该连接器。连接器构造成与第一臂和第二臂协作以将第一臂和第二臂中的一个臂的枢转运动转化成回收设备相对于枢轴点的线性运动。

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